BR0308243A - Composto, formulação farmacêutica, e, métodos de tratar diabetes, doença de alzheimer, e de inibir gsk-3 em um mamìfero - Google Patents
Composto, formulação farmacêutica, e, métodos de tratar diabetes, doença de alzheimer, e de inibir gsk-3 em um mamìferoInfo
- Publication number
- BR0308243A BR0308243A BR0308243-1A BR0308243A BR0308243A BR 0308243 A BR0308243 A BR 0308243A BR 0308243 A BR0308243 A BR 0308243A BR 0308243 A BR0308243 A BR 0308243A
- Authority
- BR
- Brazil
- Prior art keywords
- alzheimer
- mammal
- disease
- compound
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Abstract
"COMPOSTO, FORMULAçãO FARMACêUTICA, E MéTODOS DE TRATAR DIABETES, DOENçA DE ALZHEIMER, E DE INIBIR GSK-3 EM UM MAMìFERO". A presente invenção proporciona inibidores de quinase de Fórmula I.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36224502P | 2002-03-05 | 2002-03-05 | |
US60/362245 | 2002-03-05 | ||
PCT/US2003/005050 WO2003076442A1 (en) | 2002-03-05 | 2003-03-04 | Purine derivatives as kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0308243A true BR0308243A (pt) | 2005-01-11 |
BR0308243B1 BR0308243B1 (pt) | 2014-08-26 |
Family
ID=27805149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0308243-1A BR0308243B1 (pt) | 2002-03-05 | 2003-03-04 | Derivados de purina como inibidores de quinase, seu uso para tratar diabetes e doença de alzheimer, para estimular deposição óssea e inibir gsk-3, bem como formulação farmacêutica compreendendo os referidos derivados |
Country Status (16)
Country | Link |
---|---|
US (4) | US7491716B2 (pt) |
EP (1) | EP1483265B1 (pt) |
JP (1) | JP4414232B2 (pt) |
KR (1) | KR100974770B1 (pt) |
CN (1) | CN1312154C (pt) |
AT (1) | ATE346070T1 (pt) |
AU (1) | AU2003215325B8 (pt) |
BR (1) | BR0308243B1 (pt) |
CA (1) | CA2477967C (pt) |
CY (1) | CY1109006T1 (pt) |
DE (1) | DE60309848T2 (pt) |
DK (1) | DK1483265T3 (pt) |
ES (1) | ES2276048T3 (pt) |
IL (2) | IL163781A0 (pt) |
PT (1) | PT1483265E (pt) |
WO (1) | WO2003076442A1 (pt) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003217596A1 (en) * | 2002-03-08 | 2003-09-22 | Eli Lilly And Company | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors |
GB0212049D0 (en) * | 2002-05-24 | 2002-07-03 | Merck Sharp & Dohme | Therapeutic agents |
SI1846406T1 (sl) | 2005-02-09 | 2011-02-28 | Arqule Inc | Maleimidni derivati, farmacevtski sestavki in postopki za zdravljenje raka |
US7968535B2 (en) * | 2005-05-04 | 2011-06-28 | Develogen Atkiengesellschaft | Use of azapaullones for preventing and treating pancreatic autoimmune disorders |
US20080207594A1 (en) * | 2005-05-04 | 2008-08-28 | Davelogen Aktiengesellschaft | Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
TW200800203A (en) | 2006-03-08 | 2008-01-01 | Astrazeneca Ab | New use |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
PL2383271T3 (pl) * | 2006-03-13 | 2013-12-31 | Kyorin Seiyaku Kk | Aminochinolony jako inhibitory GSK-3 |
EP1845098A1 (en) | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
RU2009108280A (ru) | 2006-08-08 | 2010-09-20 | Санофи-Авентис (Fr) | Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
CN101302216B (zh) * | 2007-05-11 | 2011-08-10 | 上海睿智化学研究有限公司 | 稠环吲哚类化合物的制备方法 |
WO2009002806A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
MX2009013815A (es) | 2007-06-22 | 2010-03-01 | Arqule Inc | Compuestos de quinazolinona y metodos de uso para los mismos. |
WO2009002807A2 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
TWI428132B (zh) | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
UA103792C2 (uk) * | 2009-04-14 | 2013-11-25 | Елі Ліллі Енд Компані | Похідна бензодіазепіну для лікування гемопоетичної неоплазми та лейкозу |
WO2011023754A1 (en) | 2009-08-26 | 2011-03-03 | Sanofi-Aventis | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
CN102596961B (zh) | 2009-10-30 | 2015-12-02 | 詹森药业有限公司 | 咪唑并[1,2-b]哒嗪衍生物及其作为PDE10抑制剂的用途 |
US8563567B2 (en) | 2009-12-30 | 2013-10-22 | Arqule, Inc. | Substituted heterocyclic compounds |
CN102812017A (zh) | 2010-01-19 | 2012-12-05 | 阿斯利康(瑞典)有限公司 | 吡嗪衍生物 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
WO2012088491A2 (en) * | 2010-12-23 | 2012-06-28 | Arqule, Inc. | Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
AU2013283426B2 (en) | 2012-06-26 | 2018-02-22 | Janssen Pharmaceutica Nv | Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders |
ES2607184T3 (es) | 2012-07-09 | 2017-03-29 | Janssen Pharmaceutica, N.V. | Inhibidores de la enzima fosfodiesterasa 10 |
WO2014098000A1 (en) * | 2012-12-17 | 2014-06-26 | Daiichi Sankyo Company, Limited | Process for preparation of a tricyclic heterocycle |
US20160137644A1 (en) | 2013-06-26 | 2016-05-19 | Daiichi Sankyo Company, Limited | Method for producing tricyclic heterocyclic compound |
EP2818471A1 (en) * | 2013-06-27 | 2014-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 |
SG10201910821XA (en) * | 2016-12-30 | 2020-01-30 | Frequency Therapeutics Inc | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
JP2020516282A (ja) | 2017-04-11 | 2020-06-11 | フリークエンシー セラピューティクス インコーポレイテッド | 毛包幹細胞増殖のための方法 |
WO2019126686A1 (en) * | 2017-12-21 | 2019-06-27 | Frequency Therapeutics, Inc. | 1,2-dihydro-3h-pyrazol-3-one compounds and methods of using same |
US10526343B2 (en) | 2018-03-26 | 2020-01-07 | University Of Sharjah | Heterocyclic systems and pharmaceutical applications thereof |
US20200121681A1 (en) | 2018-10-17 | 2020-04-23 | Frequency Therapeutics, Inc. | Methods for hair follicle stem cell proliferation |
EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
CN112390794B (zh) * | 2019-08-19 | 2023-05-26 | 鲁南制药集团股份有限公司 | 一种米诺膦酸关键中间体的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
AU4920397A (en) | 1996-10-11 | 1998-05-11 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
GB9828640D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
WO2001044247A2 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
EP1250334B1 (en) | 1999-12-16 | 2004-05-19 | Eli Lilly And Company | Medicaments useful for the treatment of proliferative diseases |
IL153851A0 (en) | 2000-07-27 | 2003-07-31 | Hoffmann La Roche | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
PT1362047E (pt) | 2000-12-08 | 2006-09-29 | Ortho Mcneil Pharm Inc | Compostos de pirrolina substituidos com indazolilo como inibidores de cinase |
EP1345946B1 (en) | 2000-12-08 | 2005-08-10 | Ortho-McNeil Pharmaceutical, Inc. | Macroheterocylic compounds useful as kinase inhibitors |
-
2003
- 2003-03-04 AU AU2003215325A patent/AU2003215325B8/en not_active Ceased
- 2003-03-04 KR KR1020047013828A patent/KR100974770B1/ko not_active IP Right Cessation
- 2003-03-04 DK DK03711146T patent/DK1483265T3/da active
- 2003-03-04 WO PCT/US2003/005050 patent/WO2003076442A1/en active IP Right Grant
- 2003-03-04 US US10/506,459 patent/US7491716B2/en not_active Expired - Fee Related
- 2003-03-04 BR BRPI0308243-1A patent/BR0308243B1/pt not_active IP Right Cessation
- 2003-03-04 CA CA2477967A patent/CA2477967C/en not_active Expired - Fee Related
- 2003-03-04 ES ES03711146T patent/ES2276048T3/es not_active Expired - Lifetime
- 2003-03-04 AT AT03711146T patent/ATE346070T1/de active
- 2003-03-04 IL IL16378103A patent/IL163781A0/xx unknown
- 2003-03-04 CN CNB03805292XA patent/CN1312154C/zh not_active Expired - Fee Related
- 2003-03-04 DE DE60309848T patent/DE60309848T2/de not_active Expired - Lifetime
- 2003-03-04 EP EP03711146A patent/EP1483265B1/en not_active Expired - Lifetime
- 2003-03-04 JP JP2003574659A patent/JP4414232B2/ja not_active Expired - Fee Related
- 2003-03-04 PT PT03711146T patent/PT1483265E/pt unknown
-
2004
- 2004-08-26 IL IL163781A patent/IL163781A/en not_active IP Right Cessation
-
2007
- 2007-01-18 CY CY20071100071T patent/CY1109006T1/el unknown
-
2008
- 2008-12-12 US US12/333,775 patent/US8022065B2/en not_active Expired - Fee Related
-
2011
- 2011-05-04 US US13/100,618 patent/US8058425B2/en not_active Expired - Fee Related
- 2011-08-09 US US13/206,057 patent/US20110294792A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP4414232B2 (ja) | 2010-02-10 |
CA2477967A1 (en) | 2003-09-18 |
AU2003215325A1 (en) | 2003-09-22 |
ES2276048T3 (es) | 2007-06-16 |
US7491716B2 (en) | 2009-02-17 |
CN1312154C (zh) | 2007-04-25 |
JP2005526072A (ja) | 2005-09-02 |
US20050090483A1 (en) | 2005-04-28 |
CN1639165A (zh) | 2005-07-13 |
ATE346070T1 (de) | 2006-12-15 |
US20110294792A1 (en) | 2011-12-01 |
KR20040087338A (ko) | 2004-10-13 |
BR0308243B1 (pt) | 2014-08-26 |
US8058425B2 (en) | 2011-11-15 |
US20090105229A1 (en) | 2009-04-23 |
PT1483265E (pt) | 2007-01-31 |
KR100974770B1 (ko) | 2010-08-06 |
CY1109006T1 (el) | 2014-07-02 |
US8022065B2 (en) | 2011-09-20 |
EP1483265A1 (en) | 2004-12-08 |
US20110207721A1 (en) | 2011-08-25 |
IL163781A (en) | 2010-04-15 |
IL163781A0 (en) | 2005-12-18 |
WO2003076442A1 (en) | 2003-09-18 |
DE60309848T2 (de) | 2007-05-16 |
DK1483265T3 (da) | 2007-03-19 |
EP1483265B1 (en) | 2006-11-22 |
AU2003215325B2 (en) | 2008-09-18 |
AU2003215325B8 (en) | 2008-10-09 |
DE60309848D1 (de) | 2007-01-04 |
CA2477967C (en) | 2010-08-10 |
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