DE60021388D1 - Monomeres protein der tgf-beta familie - Google Patents

Monomeres protein der tgf-beta familie

Info

Publication number: DE60021388D1
Authority: DE; Germany
Prior art keywords: proteins; tgf; nucleic acids; monomeres; protein
Prior art date: 1999-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60021388T

Other languages

English (en)

Other versions

DE60021388T2 (de

Inventor

Gertrud Hoetten

Rolf Bechtold

Jens Pohl

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

HYGENE AG NEUHAUSEN AM RHEINFA

Original Assignee

HYGENE AG NEUHAUSEN AM RHEINFA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2000-08-04

Publication date

2005-08-25

2000-08-04 Application filed by HYGENE AG NEUHAUSEN AM RHEINFA filed Critical HYGENE AG NEUHAUSEN AM RHEINFA

2005-08-25 Application granted granted Critical

2005-08-25 Publication of DE60021388D1 publication Critical patent/DE60021388D1/de

2006-01-05 Publication of DE60021388T2 publication Critical patent/DE60021388T2/de

2020-08-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

102000004169 proteins and genes Human genes 0.000 title abstract 6
108090000623 proteins and genes Proteins 0.000 title abstract 6
102000043168 TGF-beta family Human genes 0.000 title 1
108091085018 TGF-beta family Proteins 0.000 title 1
235000018102 proteins Nutrition 0.000 abstract 5
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
150000007523 nucleic acids Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oral & Maxillofacial Surgery (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Materials For Medical Uses (AREA)

DE60021388T 1999-08-06 2000-08-04 Monomeres protein der tgf-beta familie Expired - Lifetime DE60021388T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99115613A EP1074620A1 (de)	1999-08-06	1999-08-06	Monomer Protein der TGF-beta Familie
EP99115613		1999-08-06
PCT/EP2000/007600 WO2001011041A1 (en)	1999-08-06	2000-08-04	MONOMERIC PROTEIN OF THE TGF-β FAMILY

Publications (2)

Publication Number	Publication Date
DE60021388D1 true DE60021388D1 (de)	2005-08-25
DE60021388T2 DE60021388T2 (de)	2006-01-05

Family

ID=8238746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60021388T Expired - Lifetime DE60021388T2 (de)	1999-08-06	2000-08-04	Monomeres protein der tgf-beta familie

Country Status (12)

Country	Link
US (2)	US6972321B1 (de)
EP (3)	EP1074620A1 (de)
JP (1)	JP2003506086A (de)
AT (1)	ATE299937T1 (de)
AU (1)	AU782481B2 (de)
CA (1)	CA2381219C (de)
DE (1)	DE60021388T2 (de)
DK (1)	DK1198570T3 (de)
ES (1)	ES2242630T3 (de)
NZ (1)	NZ517125A (de)
WO (1)	WO2001011041A1 (de)
ZA (1)	ZA200201032B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7811793B2 (en) *	1996-12-25	2010-10-12	Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Process for preparing purified active monomer of bone-derived factor
CA2405680C (en) *	2000-04-20	2018-02-13	St. Vincent's Hospital Sydney Limited	Diagnostic assay and method of treatment involving macrophage inhibitory cytokine -1 (mic-1)
CA2441588A1 (en)	2001-03-23	2002-10-03	Biopharm Gesellschaft Zue Biotechnologischen Entwicklung Von Pharmaka Mbh	Use of cytokines of the tgf-.beta. superfamily for the treatment and diagnosis of skin related disorders
FI116827B (fi)	2001-08-24	2006-03-15	Univ Zuerich	Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö
EG23432A (de)	2001-12-17	2005-07-25	New Zealand Dairy Board
AU2003251854A1 (en) *	2002-07-09	2004-01-23	Stryker Corporation	Compositions and methods for ligament growth and repair
EP1462126A1 (de) *	2003-03-28	2004-09-29	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Verbesserte osteoinduktive Materialien
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
JP5654730B2 (ja)	2005-11-18	2015-01-14	バイオファーム・ゲゼルシャフト・ツア・バイオテクノロジシェン・エントヴィックルング・フォン・ファーマカ・ミット・ベシュレンクテル・ハフツング	高活性の増殖因子変異体
GB0604966D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
JP5535620B2 (ja) *	2006-06-13	2014-07-02	ヘリックスバイオメディックス，インコーポレイテッド	細胞外マトリックスタンパク質の合成を誘導するペプチドフラグメント
EP1880731A1 (de)	2006-07-18	2008-01-23	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Menschlicher Wachstums und Differenzierungsfaktor GDF-5
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
ES2402672T3 (es) *	2007-01-25	2013-05-07	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Uso del GDF-5 para el mejoramiento o el mantenimiento del aspecto dérmico
JP2011522565A (ja) *	2008-06-09	2011-08-04	ワイス・エルエルシー	新規ｂｍｐ−１２関連タンパク質およびその製造方法
US20130122066A1 (en)	2010-07-30	2013-05-16	Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Drug delivery devices and growth factor formulations for accelerated wound healing
US8398611B2 (en)	2010-12-28	2013-03-19	Depuy Mitek, Inc.	Compositions and methods for treating joints
US8524662B2 (en)	2010-12-28	2013-09-03	Depuy Mitek, Llc	Compositions and methods for treating joints
US8455436B2 (en)	2010-12-28	2013-06-04	Depuy Mitek, Llc	Compositions and methods for treating joints
EP2537538A1 (de)	2011-06-22	2012-12-26	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	Bioresorbierbarer Wundverband
US8623839B2 (en)	2011-06-30	2014-01-07	Depuy Mitek, Llc	Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de)	2011-12-05	2013-06-12	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en)	2015-01-20	2017-06-20	DePuy Synthes Products, Inc.	Compositions and methods for treating joints
AU2020403846A1 (en)	2019-12-18	2022-08-11	Merck Patent Gmbh	Use of the GDF-5 mutant for the treatment of pain and cartilage destruction

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19525416A1 (de) *	1995-07-12	1997-01-16	Bioph Biotech Entw Pharm Gmbh	Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems
WO1994015949A1 (en) *	1993-01-12	1994-07-21	Johns Hopkins University School Of Medicine	Growth differentiation factor-5
US5420243A (en) *	1993-01-26	1995-05-30	Celtrix Pharmaceuticals, Inc.	Biologically active TGF-β2 peptides
IL110589A0 (en) *	1993-08-10	1994-11-11	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF- beta family
ATE319823T1 (de) *	1993-12-07	2006-03-15	Inst Genetics Llc	Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen
IL114397A0 (en) *	1994-07-01	1995-10-31	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF-beta-family
JPH09295945A (ja) *	1996-04-30	1997-11-18	Hoechst Yakuhin Kogyo Kk	成熟型骨誘導因子の製造方法
JPH11335398A (ja) *	1998-05-22	1999-12-07	Hoechst Marion Roussel Kk	新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬

1999
- 1999-08-06 EP EP99115613A patent/EP1074620A1/de not_active Withdrawn
2000
- 2000-08-04 EP EP05013166A patent/EP1574578A1/de not_active Withdrawn
- 2000-08-04 JP JP2001515827A patent/JP2003506086A/ja active Pending
- 2000-08-04 US US10/048,458 patent/US6972321B1/en not_active Expired - Lifetime
- 2000-08-04 ES ES00958383T patent/ES2242630T3/es not_active Expired - Lifetime
- 2000-08-04 CA CA002381219A patent/CA2381219C/en not_active Expired - Fee Related
- 2000-08-04 EP EP00958383A patent/EP1198570B1/de not_active Expired - Lifetime
- 2000-08-04 DK DK00958383T patent/DK1198570T3/da active
- 2000-08-04 AT AT00958383T patent/ATE299937T1/de active
- 2000-08-04 AU AU69927/00A patent/AU782481B2/en not_active Ceased
- 2000-08-04 NZ NZ517125A patent/NZ517125A/en not_active IP Right Cessation
- 2000-08-04 DE DE60021388T patent/DE60021388T2/de not_active Expired - Lifetime
- 2000-08-04 WO PCT/EP2000/007600 patent/WO2001011041A1/en active IP Right Grant
2002
- 2002-02-06 ZA ZA200201032A patent/ZA200201032B/xx unknown
2005
- 2005-07-28 US US11/191,072 patent/US7569227B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ517125A (en)	2003-08-29
EP1198570B1 (de)	2005-07-20
WO2001011041A1 (en)	2001-02-15
US6972321B1 (en)	2005-12-06
EP1574578A1 (de)	2005-09-14
AU6992700A (en)	2001-03-05
US7569227B2 (en)	2009-08-04
CA2381219C (en)	2008-11-18
ZA200201032B (en)	2002-12-24
DK1198570T3 (da)	2005-10-31
EP1074620A1 (de)	2001-02-07
DE60021388T2 (de)	2006-01-05
JP2003506086A (ja)	2003-02-18
ES2242630T3 (es)	2005-11-16
US20050282255A1 (en)	2005-12-22
EP1198570A1 (de)	2002-04-24
CA2381219A1 (en)	2001-02-15
AU782481B2 (en)	2005-08-04
ATE299937T1 (de)	2005-08-15

Legal Events

Date	Code	Title	Description
2006-08-10	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE60021388D1 (de)	2005-08-25	Monomeres protein der tgf-beta familie
BRPI0512286A (pt)	2008-03-18	proteìnas quiméricas inibidoras da angiogênese e o uso
ATE114169T1 (de)	1994-12-15	Morphogenetisches knochenprotein.
CY1113684T1 (el)	2016-06-22	Anti-mikρobiaka πεπτιδια που περιλαμβανουν μια αργινινη (arginine)- kai/ή λυσινη (lysine)- που περιεχουν υποκινητη
CY1113421T1 (el)	2016-06-22	Πυρηνικα οξεα και πολυπεπτιδια υποδοχεα
EA200400815A1 (ru)	2004-12-30	Контролируемый синтез зипразидона и его композиции
DK0625989T3 (da)	2000-06-26	DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
DE69433690D1 (de)	2004-05-13	Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
BRPI0411363A (pt)	2006-07-25	seqüências de ácidos nucléicos codificando e composições compreendendo peptìdeo sinal ige e/ou il-15 e processos para uso das mesmas
ATE258598T1 (de)	2004-02-15	Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
ES2144399T3 (es)	2000-06-16	Clonado del adn de virus de anemia de los pollos.
DK1675956T3 (da)	2010-11-22	Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression
DK0724637T3 (da)	1999-06-14	Kortikotropinfrigørende faktor2-receptorer
DK1485481T3 (da)	2010-06-07	Fflourescerende protein fra Aequorea Coerulescens og anvendelser deraf
DK1689872T3 (da)	2009-04-27	Promotorer til ekspression i modificeret vacciniavirus Ankara
DK1255829T3 (da)	2009-12-14	Inhibitor af hepatocytvækstfaktoraktivator til anvendelse i modulation af angiogenese og kardiovaskularisering
DK1279677T3 (da)	2007-05-07	GD3-mimetiske peptider
ATE449107T1 (de)	2009-12-15	Aus fisch gewonnene peptide und nukleinsäuren der cathelicidin familie und deren verwendung
WO2005042717A3 (en)	2007-08-16	Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods
DK1446733T3 (da)	2009-10-26	Glycosylphosphatidylinositol indeholdende polypeptider
DE69812597D1 (de)	2003-04-30	Peptide zur Inhibition von HPV E7 Proteinen
EA200000709A1 (ru)	2000-12-25	Бета-липотропин и его применения
ES2059801T3 (es)	1994-11-16	Nuevas linfoquinas, secuencias de adn que codifican para estas linfoquinas, y composiciones farmaceuticas conteniendo estas linfoquinas.
SE0002364D0 (sv)	2000-06-22	Growth Factors