ATE258598T1 - Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht - Google Patents
Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewichtInfo
- Publication number
- ATE258598T1 ATE258598T1 AT98943346T AT98943346T ATE258598T1 AT E258598 T1 ATE258598 T1 AT E258598T1 AT 98943346 T AT98943346 T AT 98943346T AT 98943346 T AT98943346 T AT 98943346T AT E258598 T1 ATE258598 T1 AT E258598T1
- Authority
- AT
- Austria
- Prior art keywords
- molecular weight
- low molecular
- protein refolding
- refolding method
- zwitterionic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/946,839 US20020052026A1 (en) | 1997-10-08 | 1997-10-08 | Methods of refolding proteins |
PCT/US1998/017499 WO1999018196A1 (en) | 1997-10-08 | 1998-08-24 | Methods of refolding proteins by use of zwitterionic low molecular weight agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE258598T1 true ATE258598T1 (de) | 2004-02-15 |
Family
ID=25485053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98943346T ATE258598T1 (de) | 1997-10-08 | 1998-08-24 | Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht |
Country Status (8)
Country | Link |
---|---|
US (5) | US20020052026A1 (de) |
EP (1) | EP1021528B1 (de) |
JP (1) | JP2001519149A (de) |
AT (1) | ATE258598T1 (de) |
AU (1) | AU757692B2 (de) |
CA (1) | CA2305559A1 (de) |
DE (1) | DE69821376D1 (de) |
WO (1) | WO1999018196A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19755960C1 (de) * | 1997-12-16 | 1998-11-26 | Hoechst Ag | Verfahren zum Aufschluß von biologischem Material |
FR2801219A1 (fr) * | 2000-09-18 | 2001-05-25 | Pf Medicament | Procede de preparation de proteine recombinante renaturee en presence de detergent |
EP1314739A1 (de) * | 2001-11-22 | 2003-05-28 | Bayer Ag | Verfahren zur Renaturierung rekombinanter, Disulfid-enthaltender Proteine bei hohen Proteinkonzentrationen in Gegenwart von Aminen |
DK1572127T4 (da) | 2002-02-14 | 2014-11-24 | Univ Leland Stanford Junior | Enzymbehandling af fødevarer til cøliaki |
US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
JP4401618B2 (ja) | 2002-04-15 | 2010-01-20 | キヤノン株式会社 | 記録装置、及び、バッファ管理方法 |
SI21273A (sl) * | 2002-07-31 | 2004-02-29 | LEK farmacevtska dru�ba d.d. | Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina |
ATE554392T1 (de) | 2002-11-20 | 2012-05-15 | Univ Leland Stanford Junior | Diagnoseverfahren für sprue/zöliakie |
EP1449848A1 (de) * | 2003-02-20 | 2004-08-25 | GBF German Research Centre for Biotechnology | Verfahren zur Herstellung von Proteinen aus der Cystine-Knoten-Familie |
US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
GB0604964D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Protein folding |
GB0604938D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Proteins, nucleic acids and medicaments |
GB0604966D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
WO2008115411A1 (en) * | 2007-03-16 | 2008-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Combination enzyme therapy for digestion of dietary gluten |
WO2008115428A2 (en) * | 2007-03-16 | 2008-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | A scaleable manufacturing process for cysteine endoprotease b, isoform 2 |
CN101815944A (zh) * | 2007-07-03 | 2010-08-25 | 安姆根有限公司 | 利用包含体干重的蛋白测量 |
EP3660032A1 (de) | 2009-06-25 | 2020-06-03 | Amgen, Inc | Erfassungs-/reinigungsverfahren für in einem nichtsäugersystem exprimierte proteine |
WO2012029148A1 (ja) | 2010-09-01 | 2012-03-08 | 株式会社オステオファーマ | 組換えヒト骨形成タンパク質-2凍結乾燥製剤 |
US9630916B2 (en) | 2014-08-19 | 2017-04-25 | Wisconsin Alumni Research Foundation | Organocatalysts of oxidative protein folding |
WO2017040363A1 (en) | 2015-09-02 | 2017-03-09 | Merck Sharp & Dohme Corp. | A process for obtaining insulin with correctly formed disulfide bonds |
WO2021050009A2 (en) * | 2019-09-13 | 2021-03-18 | National Science And Technology Development Agency | Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU597924B2 (en) * | 1985-12-11 | 1990-06-14 | Natinco Nv | Solubilization of protein aggregates |
US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US5187076A (en) | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
DE69132823T2 (de) | 1990-05-16 | 2002-07-18 | Genetics Institute, Inc. | Knochen- und knorpel-bildung hervorrufende proteine |
KR100255415B1 (ko) | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
WO1993016099A2 (en) | 1992-02-12 | 1993-08-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Dna sequences encoding novel growth/differentiation factors |
DE4208568A1 (de) | 1992-03-18 | 1993-09-23 | Zimmer Ag | Verfahren und vorrichtung zur herstellung synthetischer endlosfilamente |
IL106278A0 (en) | 1992-07-13 | 1993-11-15 | Sumitomo Metal Ind | Bone formation-inducing protein |
EP1475440A3 (de) | 1993-01-12 | 2004-11-17 | The Johns Hopkins University School Of Medicine | Wachstums-Differentierungsfaktor-3 |
CA2153653C (en) | 1993-01-12 | 2010-12-07 | Se-Jin Lee | Growth differentiation factor-9 |
CA2153654A1 (en) | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Growth differentiation factor-5 |
CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
KR100231640B1 (ko) | 1993-05-12 | 1999-12-01 | 토마스 제이 데스로저 | Bmp-10 조성물 |
EP2272959A1 (de) | 1993-05-12 | 2011-01-12 | Genetics Institute, LLC | BMP-11 Zusammenstellungen |
CA2165776A1 (en) | 1993-07-09 | 1995-01-19 | Se-Jin Lee | Growth differentiation factor-6 |
JPH09503904A (ja) | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−7 |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
US5407810A (en) * | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
EP0725796A4 (de) | 1993-10-08 | 1999-12-01 | Univ Johns Hopkins | Wachstumsdifferenzierungsfaktor-10 |
WO1995016035A2 (en) | 1993-12-07 | 1995-06-15 | Genetics Institute, Inc. | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
FR2714906B1 (fr) | 1994-01-12 | 1996-02-02 | Commissariat Energie Atomique | Agents de solubilisation de biomolécules constitués par des zwitterions non détergents et leurs utilisations. |
JPH07250688A (ja) | 1994-01-28 | 1995-10-03 | Sagami Chem Res Center | TGF−βスーパーファミリー蛋白質をコードするヒト新規cDNA |
WO1996001845A1 (en) | 1994-07-08 | 1996-01-25 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
DE69518760T2 (de) | 1994-07-13 | 2001-05-23 | The Johns Hopkins University School Of Medicine, Baltimore | Wachstumsdifferenzierungsfaktor-12 |
US5635372A (en) | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
-
1997
- 1997-10-08 US US08/946,839 patent/US20020052026A1/en not_active Abandoned
-
1998
- 1998-08-24 JP JP2000514994A patent/JP2001519149A/ja not_active Withdrawn
- 1998-08-24 CA CA002305559A patent/CA2305559A1/en not_active Abandoned
- 1998-08-24 DE DE69821376T patent/DE69821376D1/de not_active Expired - Lifetime
- 1998-08-24 AT AT98943346T patent/ATE258598T1/de not_active IP Right Cessation
- 1998-08-24 WO PCT/US1998/017499 patent/WO1999018196A1/en active IP Right Grant
- 1998-08-24 AU AU91167/98A patent/AU757692B2/en not_active Ceased
- 1998-08-24 EP EP98943346A patent/EP1021528B1/de not_active Expired - Lifetime
-
2000
- 2000-02-18 US US09/507,289 patent/US6596511B1/en not_active Expired - Lifetime
- 2000-02-18 US US09/507,290 patent/US6593106B1/en not_active Expired - Lifetime
- 2000-05-22 US US09/575,274 patent/US6593107B1/en not_active Expired - Lifetime
- 2000-05-22 US US09/575,273 patent/US6632635B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU9116798A (en) | 1999-04-27 |
JP2001519149A (ja) | 2001-10-23 |
US6593107B1 (en) | 2003-07-15 |
US6596511B1 (en) | 2003-07-22 |
US20020052026A1 (en) | 2002-05-02 |
EP1021528B1 (de) | 2004-01-28 |
WO1999018196A1 (en) | 1999-04-15 |
CA2305559A1 (en) | 1999-04-15 |
AU757692B2 (en) | 2003-03-06 |
EP1021528A1 (de) | 2000-07-26 |
US6632635B1 (en) | 2003-10-14 |
DE69821376D1 (de) | 2004-03-04 |
US6593106B1 (en) | 2003-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |