DK1198570T3 - Monomert protein af TGF-Beta-familien - Google Patents

Monomert protein af TGF-Beta-familien

Info

Publication number: DK1198570T3
Authority: DK; Denmark
Prior art keywords: proteins; tgf; nucleic acids; monomeric; monomeric protein
Prior art date: 1999-08-06

Application number

DK00958383T

Other languages

Danish (da)

English (en)

Inventor

Gertrud Hoetten

Rolf Bechtold

Jens Pohl

Original Assignee

Hygene Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2000-08-04

Publication date

2005-10-31

2000-08-04 Application filed by Hygene Ag filed Critical Hygene Ag

2005-10-31 Application granted granted Critical

2005-10-31 Publication of DK1198570T3 publication Critical patent/DK1198570T3/da

Links

102000004169 proteins and genes Human genes 0.000 title abstract 6
108090000623 proteins and genes Proteins 0.000 title abstract 6
102000043168 TGF-beta family Human genes 0.000 title 1
108091085018 TGF-beta family Proteins 0.000 title 1
235000018102 proteins Nutrition 0.000 abstract 5
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
150000007523 nucleic acids Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Neurology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)

DK00958383T 1999-08-06 2000-08-04 Monomert protein af TGF-Beta-familien DK1198570T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP99115613A EP1074620A1 (de)	1999-08-06	1999-08-06	Monomer Protein der TGF-beta Familie
EP00958383A EP1198570B1 (de)	1999-08-06	2000-08-04	Monomeres protein der tgf-beta familie
PCT/EP2000/007600 WO2001011041A1 (en)	1999-08-06	2000-08-04	MONOMERIC PROTEIN OF THE TGF-β FAMILY

Publications (1)

Publication Number	Publication Date
DK1198570T3 true DK1198570T3 (da)	2005-10-31

Family

ID=8238746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00958383T DK1198570T3 (da)	1999-08-06	2000-08-04	Monomert protein af TGF-Beta-familien

Country Status (12)

Country	Link
US (2)	US6972321B1 (de)
EP (3)	EP1074620A1 (de)
JP (1)	JP2003506086A (de)
AT (1)	ATE299937T1 (de)
AU (1)	AU782481B2 (de)
CA (1)	CA2381219C (de)
DE (1)	DE60021388T2 (de)
DK (1)	DK1198570T3 (de)
ES (1)	ES2242630T3 (de)
NZ (1)	NZ517125A (de)
WO (1)	WO2001011041A1 (de)
ZA (1)	ZA200201032B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7811793B2 (en) *	1996-12-25	2010-10-12	Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Process for preparing purified active monomer of bone-derived factor
ATE470863T1 (de) *	2000-04-20	2010-06-15	St Vincents Hosp Sydney	Diagnostischer assay mit makrophagenhemmendem zytokin-1 (mic-1)
JP2004525930A (ja)	2001-03-23	2004-08-26	バイオファーム・ゲゼルシャフト・ツア・バイオテクノロジシェン・エントヴィックルング・フォン・ファーマカ・ミット・ベシュレンクテル・ハフツング	皮膚関連疾患の治療及び診断のためのＴＧＦ−βスーパーファミリーのサイトカインの使用
FI116827B (fi)	2001-08-24	2006-03-15	Univ Zuerich	Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö
EG23432A (de)	2001-12-17	2005-07-25	New Zealand Dairy Board
JP2005533089A (ja) *	2002-07-09	2005-11-04	ストライカーコーポレイション	靱帯成長および修復のための組成物および方法
EP1462126A1 (de) *	2003-03-28	2004-09-29	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Verbesserte osteoinduktive Materialien
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
PL1948689T3 (pl)	2005-11-18	2012-09-28	Biopharm Ges Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Mutanty czynników wzrostu o wysokiej aktywności
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0604966D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
PL3002294T3 (pl)	2006-06-13	2018-08-31	Helix Biomedix, Inc.	Fragmenty peptydowe do indukowania syntezy białek macierzy zewnątrzkomórkowej
EP1880731A1 (de) *	2006-07-18	2008-01-23	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Menschlicher Wachstums und Differenzierungsfaktor GDF-5
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
WO2008089987A1 (en) *	2007-01-25	2008-07-31	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Use of gdf-5 for the improvement or maintenance of dermal appearance
US20100004175A1 (en) *	2008-06-09	2010-01-07	Tanya Shang	Novel bmp-12-related proteins and methods of their manufacture
EP2598177B1 (de)	2010-07-30	2015-06-17	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	Wirkstofffreisetzungsvorrichtungen und wachstumsfaktorformulierungen für beschleunigte wundheilung
US8455436B2 (en)	2010-12-28	2013-06-04	Depuy Mitek, Llc	Compositions and methods for treating joints
US8398611B2 (en)	2010-12-28	2013-03-19	Depuy Mitek, Inc.	Compositions and methods for treating joints
US8524662B2 (en)	2010-12-28	2013-09-03	Depuy Mitek, Llc	Compositions and methods for treating joints
EP2537538A1 (de)	2011-06-22	2012-12-26	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	Bioresorbierbarer Wundverband
US8623839B2 (en)	2011-06-30	2014-01-07	Depuy Mitek, Llc	Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de)	2011-12-05	2013-06-12	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en)	2015-01-20	2017-06-20	DePuy Synthes Products, Inc.	Compositions and methods for treating joints
CN114786707A (zh)	2019-12-18	2022-07-22	默克专利股份公司	Gdf-5突变体用于治疗疼痛和软骨破坏的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19525416A1 (de) *	1995-07-12	1997-01-16	Bioph Biotech Entw Pharm Gmbh	Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems
CA2153654A1 (en) *	1993-01-12	1994-07-21	Se-Jin Lee	Growth differentiation factor-5
US5420243A (en) *	1993-01-26	1995-05-30	Celtrix Pharmaceuticals, Inc.	Biologically active TGF-β2 peptides
IL110589A0 (en) *	1993-08-10	1994-11-11	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF- beta family
WO1995016035A2 (en) *	1993-12-07	1995-06-15	Genetics Institute, Inc.	Bmp-12, bmp-13 and tendon-inducing compositions thereof
IL114397A0 (en) *	1994-07-01	1995-10-31	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF-beta-family
JPH09295945A (ja) *	1996-04-30	1997-11-18	Hoechst Yakuhin Kogyo Kk	成熟型骨誘導因子の製造方法
JPH11335398A (ja) *	1998-05-22	1999-12-07	Hoechst Marion Roussel Kk	新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬

1999
- 1999-08-06 EP EP99115613A patent/EP1074620A1/de not_active Withdrawn
2000
- 2000-08-04 NZ NZ517125A patent/NZ517125A/en not_active IP Right Cessation
- 2000-08-04 JP JP2001515827A patent/JP2003506086A/ja active Pending
- 2000-08-04 DE DE60021388T patent/DE60021388T2/de not_active Expired - Lifetime
- 2000-08-04 WO PCT/EP2000/007600 patent/WO2001011041A1/en active IP Right Grant
- 2000-08-04 EP EP00958383A patent/EP1198570B1/de not_active Expired - Lifetime
- 2000-08-04 AU AU69927/00A patent/AU782481B2/en not_active Ceased
- 2000-08-04 US US10/048,458 patent/US6972321B1/en not_active Expired - Lifetime
- 2000-08-04 DK DK00958383T patent/DK1198570T3/da active
- 2000-08-04 AT AT00958383T patent/ATE299937T1/de active
- 2000-08-04 ES ES00958383T patent/ES2242630T3/es not_active Expired - Lifetime
- 2000-08-04 EP EP05013166A patent/EP1574578A1/de not_active Withdrawn
- 2000-08-04 CA CA002381219A patent/CA2381219C/en not_active Expired - Fee Related
2002
- 2002-02-06 ZA ZA200201032A patent/ZA200201032B/xx unknown
2005
- 2005-07-28 US US11/191,072 patent/US7569227B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2381219A1 (en)	2001-02-15
ES2242630T3 (es)	2005-11-16
DE60021388D1 (de)	2005-08-25
US6972321B1 (en)	2005-12-06
CA2381219C (en)	2008-11-18
AU782481B2 (en)	2005-08-04
EP1574578A1 (de)	2005-09-14
US20050282255A1 (en)	2005-12-22
DE60021388T2 (de)	2006-01-05
EP1198570A1 (de)	2002-04-24
JP2003506086A (ja)	2003-02-18
ATE299937T1 (de)	2005-08-15
NZ517125A (en)	2003-08-29
EP1074620A1 (de)	2001-02-07
AU6992700A (en)	2001-03-05
ZA200201032B (en)	2002-12-24
US7569227B2 (en)	2009-08-04
EP1198570B1 (de)	2005-07-20
WO2001011041A1 (en)	2001-02-15

Publication	Publication Date	Title
DK1198570T3 (da)	2005-10-31	Monomert protein af TGF-Beta-familien
BRPI0512286A (pt)	2008-03-18	proteìnas quiméricas inibidoras da angiogênese e o uso
CY1113684T1 (el)	2016-06-22	Anti-mikρobiaka πεπτιδια που περιλαμβανουν μια αργινινη (arginine)- kai/ή λυσινη (lysine)- που περιεχουν υποκινητη
EA200400815A1 (ru)	2004-12-30	Контролируемый синтез зипразидона и его композиции
CY1113421T1 (el)	2016-06-22	Πυρηνικα οξεα και πολυπεπτιδια υποδοχεα
DK0625989T3 (da)	2000-06-26	DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
DE69433690D1 (de)	2004-05-13	Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
ATE258598T1 (de)	2004-02-15	Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
BRPI0411363A (pt)	2006-07-25	seqüências de ácidos nucléicos codificando e composições compreendendo peptìdeo sinal ige e/ou il-15 e processos para uso das mesmas
CY1108570T1 (el)	2014-04-09	Gd3-μιμητικα πεπτιδια
ATE463580T1 (de)	2010-04-15	Verfahren zur herstellung von rekombinantem protein und fusionsprotein
WO2001021807A8 (en)	2001-10-11	Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof
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ATE466874T1 (de)	2010-05-15	Mit scytovirin der domäne 1 verwandte polypeptide
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EA200601043A1 (ru)	2006-10-27	Промоторы для экспрессии в модифицированном вирусе осповакцины штамма анкара
WO2005042717A3 (en)	2007-08-16	Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods
BR0008589A (pt)	2002-01-29	Composto de tipirano, processo para sua preparação e seu uso
AR022150A1 (es)	2002-09-04	Acidos nucleicos derivados de monocitos y composiciones y metodos relacionados
ATE442444T1 (de)	2009-09-15	Glykosylphosphatidylinositolhaltige polypeptide
DE69812597D1 (de)	2003-04-30	Peptide zur Inhibition von HPV E7 Proteinen
EA200501508A1 (ru)	2006-02-24	Семейство секретируемых белков
ES2059801T3 (es)	1994-11-16	Nuevas linfoquinas, secuencias de adn que codifican para estas linfoquinas, y composiciones farmaceuticas conteniendo estas linfoquinas.
WO2003095482A3 (fr)	2004-04-08	Nouveaux peptides cycliques, leur utilisation comme agents anti-microbiens.