DK1675956T3 - Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression - Google Patents

Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression

Info

Publication number
DK1675956T3
DK1675956T3 DK04791263.9T DK04791263T DK1675956T3 DK 1675956 T3 DK1675956 T3 DK 1675956T3 DK 04791263 T DK04791263 T DK 04791263T DK 1675956 T3 DK1675956 T3 DK 1675956T3
Authority
DK
Denmark
Prior art keywords
dna sequence
chromatin
isolator
acts
protein expression
Prior art date
Application number
DK04791263.9T
Other languages
English (en)
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of DK1675956T3 publication Critical patent/DK1675956T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK04791263.9T 2003-10-21 2004-10-20 Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression DK1675956T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03103890 2003-10-21
PCT/EP2004/052591 WO2005040384A1 (en) 2003-10-21 2004-10-20 Minimal dna sequence acting as a chromatin insulator and its use in protein expression

Publications (1)

Publication Number Publication Date
DK1675956T3 true DK1675956T3 (da) 2010-11-22

Family

ID=34486337

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04791263.9T DK1675956T3 (da) 2003-10-21 2004-10-20 Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression

Country Status (17)

Country Link
US (1) US8133699B2 (da)
EP (1) EP1675956B1 (da)
JP (1) JP4745972B2 (da)
AT (1) ATE484591T1 (da)
AU (1) AU2004284243B2 (da)
CA (1) CA2541523A1 (da)
CY (1) CY1110868T1 (da)
DE (1) DE602004029598D1 (da)
DK (1) DK1675956T3 (da)
ES (1) ES2354160T3 (da)
HR (1) HRP20100560T1 (da)
IL (1) IL175021A (da)
NO (1) NO338767B1 (da)
PL (1) PL1675956T3 (da)
PT (1) PT1675956E (da)
SI (1) SI1675956T1 (da)
WO (1) WO2005040384A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2435972C (en) 2001-01-26 2011-09-13 University Of Lausanne Matrix attachment regions and methods for use thereof
EA010096B1 (ru) * 2003-03-11 2008-06-30 Лаборатуар Сероно Са Экспрессирующие векторы, содержащие ie2-промотор mcmv
JP5074030B2 (ja) * 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
KR101229989B1 (ko) 2003-10-24 2013-02-06 셀렉시스 에스. 에이. Ｍａｒ 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
ME01198B (me) * 2003-11-05 2013-03-20 Ares Trading Sa Prečišćavanje il-18 vezujućeg proteina
ATE375385T1 (de) * 2004-03-01 2007-10-15 Ares Trading Sa Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
WO2006003134A1 (en) * 2004-06-29 2006-01-12 Ares Trading S.A. Process for the purification of il-18 binding protein
DK2267024T3 (da) * 2005-06-03 2012-06-25 Ares Trading Sa Fremstilling af rekombinant II-18 bindingsprotein
PL1891088T3 (pl) * 2005-06-10 2012-03-30 Ares Trading Sa Sposób oczyszczania białka wiążącego IL-18
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
FR2919616A1 (fr) * 2007-08-02 2009-02-06 Ecole Norm Superieure Lyon Polynucleotides insulateurs derives de l'element d4z4 et leurs utilisations en transgenese
WO2012139195A1 (en) 2011-04-13 2012-10-18 National Research Council Of Canada EXPRESSION SYSTEM WITH SAR ELEMENT FROM IFNα2
DK2794886T3 (da) * 2011-12-21 2017-02-27 Danisco Us Inc Forbedring af fungal genekspression ved anvendelse af isolator-dna- sekvenser
EP2880054B1 (en) 2012-07-31 2019-01-16 Escape Therapeutics, Inc. Hla g-modified cells and methods
KR101591823B1 (ko) 2013-12-27 2016-02-04 재단법인 목암생명공학연구소 증가된 유전자 발현능을 갖는 발현벡터
WO2017075395A1 (en) * 2015-10-28 2017-05-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tumor-specific adenovirus vectors and therapeutic uses
PE20181206A1 (es) 2015-10-28 2018-07-23 Sangamo Therapeutics Inc Construcciones especificas del higado, casetes de expresion del factor viii y metodos de uso de estos
CN106754817B (zh) * 2016-11-03 2021-02-05 山西省生物研究院有限公司 一种重组自分泌运动因子的表达方法
CN111315767A (zh) 2017-08-22 2020-06-19 萨纳生物有限责任公司 可溶性干扰素受体及其用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US6432700B1 (en) * 1997-03-03 2002-08-13 Cell Genesys, Inc. Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same
US6194152B1 (en) * 1997-08-20 2001-02-27 Dendreon Corporation Prostate tumor polynucleotide compositions and methods of detection thereof
WO2000023606A1 (en) * 1998-10-22 2000-04-27 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
JP2003504016A (ja) 1999-06-30 2003-02-04 アメリカ合衆国 遺伝子発現の制御のための特異的エンハンサー遮断活性を有する絶縁体としてのｄｎａ結合タンパク質および配列
EA010096B1 (ru) 2003-03-11 2008-06-30 Лаборатуар Сероно Са Экспрессирующие векторы, содержащие ie2-промотор mcmv
JP5074030B2 (ja) 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
ME01198B (me) 2003-11-05 2013-03-20 Ares Trading Sa Prečišćavanje il-18 vezujućeg proteina
ATE375385T1 (de) 2004-03-01 2007-10-15 Ares Trading Sa Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
WO2006003134A1 (en) 2004-06-29 2006-01-12 Ares Trading S.A. Process for the purification of il-18 binding protein
DK2267024T3 (da) 2005-06-03 2012-06-25 Ares Trading Sa Fremstilling af rekombinant II-18 bindingsprotein
PL1891088T3 (pl) 2005-06-10 2012-03-30 Ares Trading Sa Sposób oczyszczania białka wiążącego IL-18

Also Published As

Publication number Publication date
AU2004284243A1 (en) 2005-05-06
CY1110868T1 (el) 2015-06-10
IL175021A0 (en) 2006-08-20
SI1675956T1 (sl) 2010-12-31
IL175021A (en) 2011-07-31
AU2004284243B2 (en) 2010-11-04
WO2005040384A1 (en) 2005-05-06
US8133699B2 (en) 2012-03-13
JP2007508833A (ja) 2007-04-12
EP1675956B1 (en) 2010-10-13
HRP20100560T1 (hr) 2010-11-30
ATE484591T1 (de) 2010-10-15
NO20062315L (no) 2006-07-18
NO338767B1 (no) 2016-10-17
JP4745972B2 (ja) 2011-08-10
EP1675956A1 (en) 2006-07-05
CA2541523A1 (en) 2005-05-06
US20070134761A1 (en) 2007-06-14
PL1675956T3 (pl) 2011-06-30
ES2354160T3 (es) 2011-03-10
PT1675956E (pt) 2010-11-04
DE602004029598D1 (de) 2010-11-25

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