DE2652678A1 - Antibiotica und verfahren zur herstellung derselben - Google Patents
Antibiotica und verfahren zur herstellung derselbenInfo
- Publication number
- DE2652678A1 DE2652678A1 DE19762652678 DE2652678A DE2652678A1 DE 2652678 A1 DE2652678 A1 DE 2652678A1 DE 19762652678 DE19762652678 DE 19762652678 DE 2652678 A DE2652678 A DE 2652678A DE 2652678 A1 DE2652678 A1 DE 2652678A1
- Authority
- DE
- Germany
- Prior art keywords
- fractions
- solution
- amidohydrolase
- medium
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63456075A | 1975-11-24 | 1975-11-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2652678A1 true DE2652678A1 (de) | 1977-06-02 |
Family
ID=24544292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19762652678 Withdrawn DE2652678A1 (de) | 1975-11-24 | 1976-11-19 | Antibiotica und verfahren zur herstellung derselben |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS5265295A (ja) |
AR (1) | AR224224A1 (ja) |
AU (1) | AU510252B2 (ja) |
BE (1) | BE848349A (ja) |
CH (1) | CH625803A5 (ja) |
DE (1) | DE2652678A1 (ja) |
DK (1) | DK497476A (ja) |
ES (1) | ES453508A1 (ja) |
FR (1) | FR2351979A1 (ja) |
GB (1) | GB1561108A (ja) |
GR (1) | GR61407B (ja) |
HU (1) | HU175266B (ja) |
NL (1) | NL7612932A (ja) |
PT (1) | PT65845B (ja) |
SE (1) | SE7612295L (ja) |
ZA (1) | ZA766986B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0000931A1 (en) * | 1977-08-19 | 1979-03-07 | Merck & Co. Inc. | Enzymatic cleavage of N-acyl-thienamycins |
EP0080166A1 (de) * | 1981-11-21 | 1983-06-01 | Hoechst Aktiengesellschaft | Isolierung von chemisch instabilen Antibiotika aus Fermentationslösungen |
WO2017132321A1 (en) * | 2016-01-29 | 2017-08-03 | The Johns Hopkins University | Novel inhibitors of bacterial growth |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7800978L (sv) * | 1977-02-11 | 1978-08-12 | Merck & Co Inc | Antibiotikum |
SE7800979L (sv) * | 1977-02-11 | 1978-08-12 | Merck & Co Inc | Antibiotikum |
PH16708A (en) | 1978-07-24 | 1984-01-20 | Merck & Co Inc | Z-2-acylamino-3-monosubstituted propenoates |
DE2965923D1 (en) * | 1979-08-28 | 1983-08-25 | Merck & Co Inc | Process for purifying thienamycin |
-
1976
- 1976-11-03 DK DK497476A patent/DK497476A/da not_active Application Discontinuation
- 1976-11-04 SE SE7612295A patent/SE7612295L/xx not_active Application Discontinuation
- 1976-11-15 AU AU19645/76A patent/AU510252B2/en not_active Expired
- 1976-11-16 AR AR265526A patent/AR224224A1/es active
- 1976-11-16 BE BE172363A patent/BE848349A/xx not_active IP Right Cessation
- 1976-11-16 PT PT65845A patent/PT65845B/pt unknown
- 1976-11-18 HU HUME002031 patent/HU175266B/hu unknown
- 1976-11-19 FR FR7634889A patent/FR2351979A1/fr active Granted
- 1976-11-19 NL NL7612932A patent/NL7612932A/xx not_active Application Discontinuation
- 1976-11-19 DE DE19762652678 patent/DE2652678A1/de not_active Withdrawn
- 1976-11-19 GB GB48233/76A patent/GB1561108A/en not_active Expired
- 1976-11-19 ES ES453508A patent/ES453508A1/es not_active Expired
- 1976-11-19 CH CH1459976A patent/CH625803A5/de not_active IP Right Cessation
- 1976-11-20 GR GR52224A patent/GR61407B/el unknown
- 1976-11-22 JP JP51139656A patent/JPS5265295A/ja active Pending
- 1976-11-23 ZA ZA00766986A patent/ZA766986B/xx unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0000931A1 (en) * | 1977-08-19 | 1979-03-07 | Merck & Co. Inc. | Enzymatic cleavage of N-acyl-thienamycins |
EP0080166A1 (de) * | 1981-11-21 | 1983-06-01 | Hoechst Aktiengesellschaft | Isolierung von chemisch instabilen Antibiotika aus Fermentationslösungen |
WO2017132321A1 (en) * | 2016-01-29 | 2017-08-03 | The Johns Hopkins University | Novel inhibitors of bacterial growth |
US10695322B2 (en) | 2016-01-29 | 2020-06-30 | The Johns Hopkins University | Inhibitors of bacterial growth |
Also Published As
Publication number | Publication date |
---|---|
CH625803A5 (en) | 1981-10-15 |
PT65845B (en) | 1978-10-10 |
ES453508A1 (es) | 1978-03-01 |
SE7612295L (sv) | 1977-05-25 |
AU510252B2 (en) | 1980-06-19 |
NL7612932A (nl) | 1977-05-26 |
GR61407B (en) | 1978-11-11 |
FR2351979B1 (ja) | 1982-08-13 |
PT65845A (en) | 1976-12-01 |
BE848349A (fr) | 1977-05-16 |
FR2351979A1 (fr) | 1977-12-16 |
AR224224A1 (es) | 1981-11-13 |
HU175266B (hu) | 1980-06-28 |
JPS5265295A (en) | 1977-05-30 |
DK497476A (da) | 1977-05-25 |
ZA766986B (en) | 1978-06-28 |
AU1964576A (en) | 1978-05-25 |
GB1561108A (en) | 1980-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
8181 | Inventor (new situation) |
Free format text: SAWYER KAHAN, GEB. SAWYER, JEAN KAHAN, FREDERICK MARVIN, RAHWAY, N.J., US |
|
8139 | Disposal/non-payment of the annual fee |