DE2448392A1 - Prostaglandin-analoge - Google Patents

Prostaglandin-analoge

Info

Publication number
DE2448392A1
DE2448392A1 DE19742448392 DE2448392A DE2448392A1 DE 2448392 A1 DE2448392 A1 DE 2448392A1 DE 19742448392 DE19742448392 DE 19742448392 DE 2448392 A DE2448392 A DE 2448392A DE 2448392 A1 DE2448392 A1 DE 2448392A1
Authority
DE
Germany
Prior art keywords
group
hydroxy
carbon atoms
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19742448392
Other languages
German (de)
English (en)
Inventor
Klaus Dr Irmscher
Dieter Dr Orth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of DE2448392A1 publication Critical patent/DE2448392A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19742448392 1973-10-12 1974-10-10 Prostaglandin-analoge Pending DE2448392A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7314038A NL7314038A (nl) 1973-10-12 1973-10-12 Nieuwe prostaglandine analoga.

Publications (1)

Publication Number Publication Date
DE2448392A1 true DE2448392A1 (de) 1975-04-17

Family

ID=19819808

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19742448392 Pending DE2448392A1 (de) 1973-10-12 1974-10-10 Prostaglandin-analoge

Country Status (6)

Country Link
JP (1) JPS5077344A (ja)
BE (1) BE820988A (ja)
DE (1) DE2448392A1 (ja)
FR (1) FR2247219A1 (ja)
NL (1) NL7314038A (ja)
SE (1) SE7412813L (ja)

Also Published As

Publication number Publication date
JPS5077344A (ja) 1975-06-24
BE820988A (fr) 1975-04-11
FR2247219A1 (en) 1975-05-09
NL7314038A (nl) 1975-04-15
SE7412813L (ja) 1975-04-14

Similar Documents

Publication Publication Date Title
DE3153474C2 (ja)
DE69204627T2 (de) Prostaglandine.
DE2437388A1 (de) Prostansaeurederivate
DE2322673A1 (de) Neue verbindungen vom prostaglandintyp und verfahren zu ihrer herstellung
CH625797A5 (ja)
DE2234709C2 (de) Prostanoesäurederivate und Verfahren zu deren Herstellung
AT367747B (de) Verfahren zur herstellung von optisch aktiven oder racemischen prostaglandinen und ihren salzen
CH628316A5 (de) Verfahren zur herstellung neuer prostaglandin-analoga mit primaerer alkoholgruppe am c-1.
DE69116541T2 (de) Eine synthesemethode für prostaglandinderivate
DE2330333C2 (de) 9-Desoxy-prosta-5,9(10),13-triensäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutischen Zubereitungen
DE2539116C2 (de) ω-Nor-cycloalkyl-13,14-dehydro-prostaglandine, Verfahren zu ihrer Herstellung sowie sie enthaltende pharmazeutische Mittel
DE2910474C2 (ja)
DE2945781A1 (de) Prostacyclinzwischenprodukte und protacyclinanaloge
DE2611788C2 (de) Fluorprostaglandine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
CH618680A5 (ja)
DE2448392A1 (de) Prostaglandin-analoge
DE2044698B2 (de) Verfahren zur herstellung von cyclopentanderivaten mit der struktur der prostaglandine
DE2716075A1 (de) Neue zwischenprodukte und verfahren zur herstellung von thromboxan-analoga
DE2640692C3 (de) Optisch aktive 5- (2-Carboxythiophen5-yl)-16phenoxy- a -tetranor- w tetranor-prostaglandine
DE2847049A1 (de) 13,14-didehydro-prostaglandine, verfahren zu ihrer herstellung und sie enthaltendes pharmazeutisches oder veterinaermedizinisches mittel
DE2825855A1 (de) 15-substituierte- omega -pentanorprostaglandin-derivate
DE2731459A1 (de) Cyclohexan-analoge vom prostaglandin-typ, verfahren zu deren herstellung und diese enthaltende zusammensetzungen
CH646163A5 (de) Thromboxananaloge.
DE2626287A1 (de) Prostanderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittelzusammensetzung
DE2627422A1 (de) 16,16-dimethyl-prostaglandine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel