DE2136067C3 - 3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel - Google Patents

3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel

Info

Publication number
DE2136067C3
DE2136067C3 DE2136067A DE2136067A DE2136067C3 DE 2136067 C3 DE2136067 C3 DE 2136067C3 DE 2136067 A DE2136067 A DE 2136067A DE 2136067 A DE2136067 A DE 2136067A DE 2136067 C3 DE2136067 C3 DE 2136067C3
Authority
DE
Germany
Prior art keywords
alanine
fluoro
antibacterial
salts
effectiveness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2136067A
Other languages
German (de)
English (en)
Other versions
DE2136067A1 (de
DE2136067B2 (de
Inventor
Frederick Marvin Rahway Kahan
Janos Westfield Kollonitsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2136067A1 publication Critical patent/DE2136067A1/de
Publication of DE2136067B2 publication Critical patent/DE2136067B2/de
Application granted granted Critical
Publication of DE2136067C3 publication Critical patent/DE2136067C3/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04Polysiloxanes
    • C08G77/38Polysiloxanes modified by chemical after-treatment
    • C08G77/382Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon
    • C08G77/385Polysiloxanes modified by chemical after-treatment containing atoms other than carbon, hydrogen, oxygen or silicon containing halogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19Acids containing three or more carbon atoms
    • C07C53/21Acids containing three or more carbon atoms containing fluorine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE2136067A 1970-08-03 1971-07-19 3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel Expired DE2136067C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6064570A 1970-08-03 1970-08-03
US14981471A 1971-06-03 1971-06-03

Publications (3)

Publication Number Publication Date
DE2136067A1 DE2136067A1 (de) 1972-02-10
DE2136067B2 DE2136067B2 (de) 1980-01-17
DE2136067C3 true DE2136067C3 (de) 1980-09-11

Family

ID=26740157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2136067A Expired DE2136067C3 (de) 1970-08-03 1971-07-19 3-Fluor-D-alanin, 3-Fluor-D-alanin-2-d, deren Salze und diese Verbindungen enthaltende Arzneimittel

Country Status (13)

Country Link
JP (1) JPS565217B1 (nl)
AU (1) AU468229B2 (nl)
BE (1) BE770888A (nl)
CA (1) CA956646A (nl)
CH (1) CH563961A5 (nl)
DE (1) DE2136067C3 (nl)
FR (1) FR2101198B1 (nl)
GB (1) GB1367674A (nl)
HK (1) HK86379A (nl)
IE (1) IE35489B1 (nl)
IL (1) IL37429A (nl)
IT (1) IT1061753B (nl)
NL (1) NL174248C (nl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ211490A (en) * 1984-03-23 1988-10-28 Commw Scient Ind Res Org Deuterated compounds and arthropodicidal compositions
SG170729A1 (en) * 2006-03-16 2011-05-30 Vertex Pharma Processes and intermediates for preparing steric compounds
NZ571280A (en) * 2006-03-16 2011-10-28 Vertex Pharma Deuterated hepatitis C protease inhibitors
RU2465264C2 (ru) * 2006-03-16 2012-10-27 Вертекс Фармасьютикалз Инкорпорейтед Дейтерированные ингибиторы протеазы гепатита с

Also Published As

Publication number Publication date
IL37429A0 (en) 1971-11-29
CH563961A5 (nl) 1975-07-15
BE770888A (fr) 1972-02-03
HK86379A (en) 1979-12-28
GB1367674A (en) 1974-09-18
NL7109947A (nl) 1972-02-07
DE2136067A1 (de) 1972-02-10
AU468229B2 (en) 1976-01-08
IL37429A (en) 1975-05-22
FR2101198B1 (nl) 1975-08-01
IE35489L (en) 1972-02-03
NL174248B (nl) 1983-12-16
JPS565217B1 (nl) 1981-02-04
IT1061753B (it) 1983-04-30
DE2136067B2 (de) 1980-01-17
CA956646A (en) 1974-10-22
AU3146471A (en) 1973-01-25
IE35489B1 (en) 1976-03-03
NL174248C (nl) 1984-05-16
FR2101198A1 (nl) 1972-03-31

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)