DE19975063I2 - DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d. - Google Patents

DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d.

Info

Publication number
DE19975063I2
DE19975063I2 DE1999175063 DE19975063C DE19975063I2 DE 19975063 I2 DE19975063 I2 DE 19975063I2 DE 1999175063 DE1999175063 DE 1999175063 DE 19975063 C DE19975063 C DE 19975063C DE 19975063 I2 DE19975063 I2 DE 19975063I2
Authority
DE
Germany
Prior art keywords
necrosis factor
tumor necrosis
human tumor
dna encoding
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1999175063
Other languages
English (en)
Other versions
DE19975063I1 (de
Inventor
Masaaki Yamada
Yasuji Furutani
Mitsue Notake
Juniti Yamagishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59043617A external-priority patent/JPS60185799A/ja
Priority claimed from JP59082653A external-priority patent/JPS60232097A/ja
Priority claimed from JP59172307A external-priority patent/JP2584206B2/ja
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE19975063I1 publication Critical patent/DE19975063I1/de
Publication of DE19975063I2 publication Critical patent/DE19975063I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE1999175063 1984-03-06 1985-02-26 DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d. Active DE19975063I2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59043617A JPS60185799A (ja) 1984-03-06 1984-03-06 ヒト癌壊死因子
JP59082653A JPS60232097A (ja) 1984-04-23 1984-04-23 ヒト癌壊死因子ポリペプチドの製造法
JP59172307A JP2584206B2 (ja) 1984-08-17 1984-08-17 ヒト癌壊死因子

Publications (2)

Publication Number Publication Date
DE19975063I1 DE19975063I1 (de) 2005-07-14
DE19975063I2 true DE19975063I2 (de) 2005-08-18

Family

ID=27291610

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585102093T Expired - Lifetime DE3582183D1 (de) 1984-03-06 1985-02-26 Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
DE1999175063 Active DE19975063I2 (de) 1984-03-06 1985-02-26 DNS den menschlichen Tumornekrosisfaktor kodierendund das menschliche Tumornekronisfaktor-Polypepti d.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8585102093T Expired - Lifetime DE3582183D1 (de) 1984-03-06 1985-02-26 Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.

Country Status (11)

Country Link
EP (1) EP0155549B1 (de)
KR (1) KR920010225B1 (de)
AU (1) AU584608B2 (de)
CA (1) CA1341240C (de)
DE (2) DE3582183D1 (de)
DK (1) DK172013B1 (de)
ES (2) ES8802159A1 (de)
FR (1) FR99C0037I2 (de)
HU (1) HU202921B (de)
NL (1) NL990034I2 (de)
PH (1) PH22108A (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60112718A (ja) * 1983-11-21 1985-06-19 Kyorin Pharmaceut Co Ltd 抗腫瘍作用を示す蛋白性物質及びその製造方法
JPH0695939B2 (ja) * 1983-12-02 1994-11-30 大日本製薬株式会社 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
GR851626B (de) * 1984-07-05 1985-11-26 Genentech Inc
EP0200748B1 (de) * 1984-10-15 1991-02-06 Cetus Corporation Menschlicher tumornekrosisfaktor
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
EP0368367A1 (de) * 1984-12-21 1990-05-16 Biogen, Inc. Reinigung, Herstellung und Verwendung von Tumornekrosefaktoren
JPS6248634A (ja) * 1985-07-23 1987-03-03 Mochida Pharmaceut Co Ltd 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物
JPH064675B2 (ja) * 1985-07-29 1994-01-19 伝一 水野 抗腫瘍性ポリペプチド
US5059530A (en) * 1985-09-30 1991-10-22 Suntory Ltd. Expression vector for human TNF
JPH0698004B2 (ja) * 1985-09-30 1994-12-07 サントリー株式会社 Ｔｎｆ発現用新規プラスミド
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
CA1286843C (en) * 1985-10-30 1991-07-23 Leo S. Lin Purification method for proteins
ATE116367T1 (de) * 1986-02-04 1995-01-15 Den Ichi Mizuno Für antitumor-polypeptide kodierende dns, die polypeptide und diese polypeptide enthaltenden antitumor-wirkstoffe.
KR940005589B1 (ko) * 1986-04-02 1994-06-21 다이닛뽄세이야꾸 가부시끼가이샤 핵산 또는 엔도톡신의 제거제 및 제거방법
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3750056T2 (de) * 1986-06-20 1995-04-06 Dainippon Pharmaceutical Co Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS.
WO1988006625A2 (en) * 1987-02-26 1988-09-07 Cetus Corporation Arginine-depleted human tumor necrosis factor
DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
JP2828988B2 (ja) * 1988-04-03 1998-11-25 源一郎 杣 新規ｄｎａとその生産方法、それを有する新規プラスミド、新規ポリペプチドとその生産方法、及び該ポリペプチドからなる新規抗腫瘍剤
GB2217325B (en) * 1988-04-08 1991-11-20 British Bio Technology Synthetic gene for tumour necrosis factor alpha.
JPH0797997B2 (ja) * 1988-04-28 1995-10-25 帝人株式会社 新規生理活性ポリペプチド
DE3843534A1 (de) * 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
EP0491878B1 (de) 1989-08-16 1997-02-19 Chiron Corporation Zusammensetzungen zur hemmung der bildung von proteinhormon und deren verwendungen
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
WO1991017180A1 (en) * 1990-04-27 1991-11-14 Peptide Technology Ltd Peptides derived from human tumour necrosis factor alpha and useful against intracellular malarial parasites
KR970005042B1 (ko) * 1993-02-09 1997-04-11 한일합성섬유공업 주식회사 종양괴사인자-알파 뮤테인
CA2119089A1 (en) * 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
EP0749494A1 (de) 1994-03-07 1996-12-27 Chiron Corporation Zusammensetzungen zur hemmung der bildung von tnf und deren verwendungen
US6395273B1 (en) 1998-06-10 2002-05-28 Promega Corporation Prevention and treatment of inflammatory bowel disease
ES2151403B1 (es) * 1998-07-13 2001-07-01 Hernandez Bronchud Miguel Linea celular transformada de rata productora de tnf-alfa humano recombinante.
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
EP3936137A1 (de) 2013-02-07 2022-01-12 The General Hospital Corporation Verfahren zur expansion oder abreicherung von t-regulatorischen zellen
CN113748192B (zh) 2019-04-12 2023-08-29 埃科莱布美国股份有限公司 抗微生物多用途清洁剂及其制备和使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
JPS60260522A (ja) * 1984-06-07 1985-12-23 Asahi Chem Ind Co Ltd 遺伝子組換体が生産する生理活性物質の安定化法
GR851626B (de) * 1984-07-05 1985-11-26 Genentech Inc
EP0200748B1 (de) * 1984-10-15 1991-02-06 Cetus Corporation Menschlicher tumornekrosisfaktor
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法

Also Published As

Publication number Publication date
ES8703490A1 (es) 1987-02-16
FR99C0037I2 (de) 2000-10-27
HU202921B (en) 1991-04-29
NL990034I1 (nl) 1999-12-01
ES550939A0 (es) 1987-02-16
FR99C0037I1 (de) 1999-12-10
KR850006874A (ko) 1985-10-21
PH22108A (en) 1988-06-01
ES8802159A1 (es) 1988-04-01
EP0155549B1 (de) 1991-03-20
EP0155549A2 (de) 1985-09-25
CA1341240C (en) 2001-06-05
HUT37957A (en) 1986-03-28
AU584608B2 (en) 1989-06-01
DK100985D0 (da) 1985-03-05
KR920010225B1 (ko) 1992-11-21
DE19975063I1 (de) 2005-07-14
DK172013B1 (da) 1997-09-15
DE3582183D1 (de) 1991-04-25
AU3944885A (en) 1985-09-12
DK100985A (da) 1985-09-07
EP0155549A3 (en) 1986-12-30
NL990034I2 (nl) 2000-11-01
ES540939A0 (es) 1988-04-01

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