DE1920635C3 - 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole - Google Patents

2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole

Info

Publication number
DE1920635C3
DE1920635C3 DE1920635A DE1920635A DE1920635C3 DE 1920635 C3 DE1920635 C3 DE 1920635C3 DE 1920635 A DE1920635 A DE 1920635A DE 1920635 A DE1920635 A DE 1920635A DE 1920635 C3 DE1920635 C3 DE 1920635C3
Authority
DE
Germany
Prior art keywords
nitro
methyl
imidazolyl
benzimidazole
melting point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1920635A
Other languages
German (de)
English (en)
Other versions
DE1920635B2 (de
DE1920635A1 (de
Inventor
Hans-Joachim Dr.Agr. Kessler
Clemens Dr.Rer.Nat. Rufer
Eberhard Dr.Rer.Nat. Schroeder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE1920635A priority Critical patent/DE1920635C3/de
Priority to CS2059A priority patent/CS167896B2/cs
Priority to CH491970A priority patent/CH546774A/xx
Priority to CH1820172A priority patent/CH546768A/xx
Priority to ES70378368A priority patent/ES378368A1/es
Priority to DK188570AA priority patent/DK137758B/da
Priority to FI701070A priority patent/FI52861C/fi
Priority to FR707013970A priority patent/FR2042351B1/fr
Priority to SE05326/70A priority patent/SE364962B/xx
Priority to AT351470A priority patent/AT294075B/de
Priority to ZA702577A priority patent/ZA702577B/xx
Priority to BE749102D priority patent/BE749102A/fr
Priority to NO01455/70A priority patent/NO126624B/no
Priority to GB1874370A priority patent/GB1312056A/en
Priority to NL7005703A priority patent/NL7005703A/xx
Priority to JP45033734A priority patent/JPS4914231B1/ja
Publication of DE1920635A1 publication Critical patent/DE1920635A1/de
Priority to US05/287,852 priority patent/US4053472A/en
Publication of DE1920635B2 publication Critical patent/DE1920635B2/de
Application granted granted Critical
Publication of DE1920635C3 publication Critical patent/DE1920635C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
    • C07C209/325—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups reduction by other means than indicated in C07C209/34 or C07C209/36
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
    • C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
    • C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE1920635A 1969-04-19 1969-04-19 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole Expired DE1920635C3 (de)

Priority Applications (17)

Application Number Priority Date Filing Date Title
DE1920635A DE1920635C3 (de) 1969-04-19 1969-04-19 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole
CS2059A CS167896B2 (fr) 1969-04-19 1970-03-27
CH491970A CH546774A (de) 1969-04-19 1970-04-02 Verfahren zur herstellung von 2-(5-nitro-2-imidazolyl)benzimidazolen.
CH1820172A CH546768A (de) 1969-04-19 1970-04-02 Verfahren zur herstellung von 2-(5-nitro-2-imidazolyl)benzimidazolen.
ES70378368A ES378368A1 (es) 1969-04-19 1970-04-08 Procedimiento para la preparacion de 2 - (5-nitro-2-imida- zolil) - ben-cimidazoles.
DK188570AA DK137758B (da) 1969-04-19 1970-04-15 Analogifremgangsmåde til fremstilling af 2-(5-nitro-2-imidazolyl)-benzimidazoler eller salte deraf.
AT351470A AT294075B (de) 1969-04-19 1970-04-17 Verfahren zur Herstellung von neuen 2-(5-Nitro-2-imidazolyl)-benzimidazolen und ihren Salzen
SE05326/70A SE364962B (fr) 1969-04-19 1970-04-17
FI701070A FI52861C (fi) 1969-04-19 1970-04-17 Menetelmä antimikrobisesti vaikuttavien 2-(5-nitro-2-imidatsolyyli)-be ntsimidatsolien valmistamiseksi.
ZA702577A ZA702577B (en) 1969-04-19 1970-04-17 2-(5-nitro-2-imidazolyl)-benzimidazoles
BE749102D BE749102A (fr) 1969-04-19 1970-04-17 2-(5-nitro-2-imidazolyl)-benzimidazoles et leur procede de preparation
NO01455/70A NO126624B (fr) 1969-04-19 1970-04-17
FR707013970A FR2042351B1 (fr) 1969-04-19 1970-04-17
GB1874370A GB1312056A (en) 1969-04-19 1970-04-20 2-5,-nitro-2,-imidazolyl-benzimidazoles
NL7005703A NL7005703A (fr) 1969-04-19 1970-04-20
JP45033734A JPS4914231B1 (fr) 1969-04-19 1970-04-20
US05/287,852 US4053472A (en) 1969-04-19 1972-09-11 2-(5-nitro-2-imidazolyl)-benzimidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1920635A DE1920635C3 (de) 1969-04-19 1969-04-19 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole

Publications (3)

Publication Number Publication Date
DE1920635A1 DE1920635A1 (de) 1970-10-29
DE1920635B2 DE1920635B2 (de) 1978-11-02
DE1920635C3 true DE1920635C3 (de) 1979-06-28

Family

ID=5732064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1920635A Expired DE1920635C3 (de) 1969-04-19 1969-04-19 2-(l-MethyI-5-nitro-2-imidazolyl)benzimidazole

Country Status (15)

Country Link
JP (1) JPS4914231B1 (fr)
AT (1) AT294075B (fr)
BE (1) BE749102A (fr)
CH (2) CH546768A (fr)
CS (1) CS167896B2 (fr)
DE (1) DE1920635C3 (fr)
DK (1) DK137758B (fr)
ES (1) ES378368A1 (fr)
FI (1) FI52861C (fr)
FR (1) FR2042351B1 (fr)
GB (1) GB1312056A (fr)
NL (1) NL7005703A (fr)
NO (1) NO126624B (fr)
SE (1) SE364962B (fr)
ZA (1) ZA702577B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053472A (en) * 1969-04-19 1977-10-11 Schering Aktiengesellschaft 2-(5-nitro-2-imidazolyl)-benzimidazoles
IT1043840B (it) * 1971-05-08 1980-02-29 Poli Ind Chimica Spa Pirimidine 2 5 disostituite e processo per la loro preparazione
US3996238A (en) * 1972-02-08 1976-12-07 Ciba-Geigy Corporation 4- or 5-Nitroimidazoles and processes for their manufacture
BE795636A (fr) * 1972-02-19 1973-08-20 Schering Ag Nitroimidazolylpyrimidines, et leur procede de preparation
PT78358B (en) * 1983-04-07 1986-05-30 Smith Kline French Lab Chemical process
EP0711768B1 (fr) * 1994-05-31 2002-02-13 Mitsui Chemicals, Inc. Derive de benzimidazol
US5968933A (en) * 1994-08-26 1999-10-19 Auckland Division Cancer Society Of New Zealand Inc. DNA-targeted alkylating agents

Also Published As

Publication number Publication date
FR2042351B1 (fr) 1973-07-13
CH546768A (de) 1974-03-15
DK137758C (fr) 1978-10-09
ES378368A1 (es) 1972-06-16
DE1920635B2 (de) 1978-11-02
FI52861C (fi) 1977-12-12
BE749102A (fr) 1970-10-19
CH546774A (de) 1974-03-15
CS167896B2 (fr) 1976-05-28
DK137758B (da) 1978-05-01
ZA702577B (en) 1971-01-27
NO126624B (fr) 1973-03-05
JPS4914231B1 (fr) 1974-04-05
AT294075B (de) 1971-11-10
DE1920635A1 (de) 1970-10-29
NL7005703A (fr) 1970-10-21
FI52861B (fr) 1977-08-31
SE364962B (fr) 1974-03-11
GB1312056A (en) 1973-04-04
FR2042351A1 (fr) 1971-02-12

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee