CY1118930T1 - Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων - Google Patents
Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτωνInfo
- Publication number
- CY1118930T1 CY1118930T1 CY20171100583T CY171100583T CY1118930T1 CY 1118930 T1 CY1118930 T1 CY 1118930T1 CY 20171100583 T CY20171100583 T CY 20171100583T CY 171100583 T CY171100583 T CY 171100583T CY 1118930 T1 CY1118930 T1 CY 1118930T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- elastase proteins
- reconstructioned
- proteins
- industrial construction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/486—Elastase (3.4.21.36 or 3.4.21.37)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21036—Pancreatic elastase (3.4.21.36)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21037—Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Μέθοδοι για την βιομηχανική κατασκευή, καθαρισμό, συνταγοποίηση και χρήση βιολογικώς δραστικών ανασυνδυασμένων πρωτεϊνών ελαστάσης. Περιγράφονται μέθοδοι ανασυνδυασμού για παραγωγή θεραπευτικώς χρήσιμων πρωτεϊνών ελαστάσης, όπως είναι φαρμακευτικές συνθέσεις που περιλαμβάνουν τις εν λόγω πρωτεΐνες ελαστάσης. Επίσης αποκαλύπτονται νέες ανασυνδυασμένες πρωτεΐνες ελαστάσης και παρασκευάσματα πρωτεΐνης. Περιγράφονται μέθοδοι για θεραπεία και αποτροπή ασθενειών βιολογικών αγωγών χρησιμοποιώντας φαρμακευτικές συνθέσεις που περιέχουν τις πρωτεΐνες ελαστάσης της εφεύρεσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99231907P | 2007-12-04 | 2007-12-04 | |
US12/327,809 US8501449B2 (en) | 2007-12-04 | 2008-12-03 | Recombinant elastase proteins and methods of manufacturing and use thereof |
EP08861467.2A EP2229440B9 (en) | 2007-12-04 | 2008-12-04 | Recombinant elastase proteins and methods of manufacturing and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118930T1 true CY1118930T1 (el) | 2018-01-10 |
Family
ID=40344763
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131101003T CY1114724T1 (el) | 2007-12-04 | 2013-11-12 | Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων |
CY20171100583T CY1118930T1 (el) | 2007-12-04 | 2017-06-02 | Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131101003T CY1114724T1 (el) | 2007-12-04 | 2013-11-12 | Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων |
Country Status (26)
Country | Link |
---|---|
US (14) | US8501449B2 (el) |
EP (3) | EP2666854B1 (el) |
JP (3) | JP5829808B2 (el) |
KR (3) | KR101824350B1 (el) |
CN (4) | CN109893647A (el) |
AR (1) | AR069584A1 (el) |
AU (1) | AU2008338743B2 (el) |
BR (1) | BRPI0819977A2 (el) |
CA (1) | CA2707051C (el) |
CY (2) | CY1114724T1 (el) |
DK (2) | DK2666854T3 (el) |
ES (2) | ES2627066T3 (el) |
HK (1) | HK1148772A1 (el) |
HR (2) | HRP20131135T1 (el) |
HU (1) | HUE032739T2 (el) |
IL (2) | IL206157A (el) |
LT (1) | LT2666854T (el) |
MX (2) | MX2010006211A (el) |
NZ (2) | NZ601592A (el) |
PL (2) | PL2229440T3 (el) |
PT (2) | PT2666854T (el) |
RS (2) | RS53083B (el) |
RU (1) | RU2611200C2 (el) |
SI (2) | SI2666854T1 (el) |
TW (2) | TWI577385B (el) |
WO (1) | WO2009079220A2 (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
CN102250863B (zh) * | 2011-04-29 | 2012-12-05 | 天津金斯坦生物科技有限公司 | 基因重组人中性粒细胞弹性蛋白酶及其制备方法和该弹性蛋白酶的医药用途 |
US10202630B2 (en) * | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
EP2971037B1 (en) | 2013-03-15 | 2019-07-10 | Alder Biopharmaceuticals, Inc. | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
KR102486713B1 (ko) * | 2017-03-10 | 2023-01-10 | 볼트 쓰레즈, 인크. | 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법 |
IL293238A (en) * | 2019-11-26 | 2022-07-01 | Childrens Hospital Med Ct | Treatment of health diseases by suppressing cela-1 |
EP4090758A1 (en) * | 2020-01-14 | 2022-11-23 | Basf Se | Method for producing recombinant protein in yeast cells |
CN116261592A (zh) * | 2020-08-18 | 2023-06-13 | 昂希莱斯制药公司 | 经修饰的丝氨酸蛋白酶前蛋白 |
KR20230054355A (ko) * | 2020-08-18 | 2023-04-24 | 온칠리스 파마 인코포레이티드 | 변형된 돼지 췌장 엘라스타아제 단백질 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2508408A (en) | 1943-10-11 | 1950-05-23 | Sidney H Liebson | Averaging indicator |
US2546308A (en) | 1948-12-29 | 1951-03-27 | Kahler John | Floor marking device |
US5212068A (en) * | 1985-04-05 | 1993-05-18 | Sankyo Company Limited | Human pancreatic elastase |
ATE141646T1 (de) | 1986-04-09 | 1996-09-15 | Genzyme Corp | Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern |
JPH0673456B2 (ja) | 1986-04-26 | 1994-09-21 | 三共株式会社 | ヒト・膵臓エラスタ−ゼ▲i▼ |
US5162205A (en) | 1986-04-26 | 1992-11-10 | Sankyo Company, Limited | Human pancreatic elastase I |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5543302A (en) * | 1988-05-27 | 1996-08-06 | Solvay Enzymes, Inc. | Proteases of altered stability to autolytic degradation |
DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
CA2045175C (en) | 1989-11-06 | 2003-03-18 | Arthur I. Skoultchi | Production of proteins using homologous recombination |
GB8927722D0 (en) | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
US5503333A (en) * | 1993-06-23 | 1996-04-02 | Laventure; David | Duster extension tube system with dust collecting region and tube cleaner and method of using the same |
US5811252A (en) * | 1994-07-07 | 1998-09-22 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Modified proenzymes as substrates for proteolytic enzymes |
US5955072A (en) * | 1994-07-13 | 1999-09-21 | Sankyo Company, Limited | Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide |
US7531325B2 (en) * | 1997-04-25 | 2009-05-12 | Sembiosys Genetics Inc. | Method for cleavage of fusion proteins |
US20030207402A1 (en) * | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
GB9817909D0 (en) * | 1998-08-17 | 1998-10-14 | Zeneca Ltd | DNA constructs |
GB9908458D0 (en) | 1999-04-13 | 1999-06-09 | Queen Mary & Westfield College | Enzyme |
WO2000068363A2 (en) | 1999-05-05 | 2000-11-16 | Genentech, Inc. | Elastase variants and substrates |
US7001892B1 (en) * | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
US7063838B1 (en) * | 1999-09-24 | 2006-06-20 | Proteon Therapeutics Llc | Methods for treating an artery or vein in a human subject |
DK1923068T3 (da) | 1999-09-24 | 2011-06-27 | Proteon Therapeutics Inc | Systemer og fremgangsmåder til åbning af blokerede biologiske kanaler |
US7351549B2 (en) * | 2000-01-24 | 2008-04-01 | Polymun Scientific Immunbiologische Forschung Gmbh | Method for the manufacture of recombinant trypsin |
CA2399241A1 (en) * | 2000-02-24 | 2001-08-30 | Phylos, Inc. | Improved methods for generating catalytic proteins |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
US20060189941A1 (en) | 2002-01-22 | 2006-08-24 | Mercator Medsystems, Inc. | Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation |
JP2007525423A (ja) | 2003-02-20 | 2007-09-06 | プロテオン セラピューティクス,インコーポレーテッド | 生体導管の疾患を治療および予防するための方法 |
US7571008B2 (en) | 2003-08-18 | 2009-08-04 | Medtronic, Inc. | System and apparatus for remote activation of implantable medical devices |
ES2427136T3 (es) * | 2004-06-21 | 2013-10-29 | Galapagos N.V. | Métodos y medios para el tratamiento de la osteoartritis |
JP2008513517A (ja) | 2004-09-22 | 2008-05-01 | プロテオン セラペウチクス インコーポレーテッド | 生物学的導管の疾患の治療方法及び予防方法 |
RU2299070C2 (ru) * | 2005-02-08 | 2007-05-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения заболевания вен и способ ее получения |
US20060193824A1 (en) * | 2005-02-28 | 2006-08-31 | Rubin Bruce K | Methods for the treatment of infectious and inflammatory airway diseases |
CN1769424A (zh) * | 2005-09-20 | 2006-05-10 | 浙江大学 | 一种芽孢杆菌菌株及其用途 |
NZ596269A (en) * | 2006-07-05 | 2012-12-21 | Catalyst Biosciences Inc | Protease screening methods and proteases identified thereby |
US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
ES2586457T3 (es) * | 2008-04-03 | 2016-10-14 | Cb Biotechnologies, Inc. | Reacción en cadena de la polimerasa múltiple de rescate de amplicón para amplificación de dianas múltiples |
-
2008
- 2008-12-03 US US12/327,809 patent/US8501449B2/en active Active
- 2008-12-04 SI SI200831792A patent/SI2666854T1/sl unknown
- 2008-12-04 WO PCT/US2008/085559 patent/WO2009079220A2/en active Application Filing
- 2008-12-04 KR KR1020167020627A patent/KR101824350B1/ko active IP Right Grant
- 2008-12-04 RS RS20130514A patent/RS53083B/en unknown
- 2008-12-04 PT PT131810467T patent/PT2666854T/pt unknown
- 2008-12-04 US US12/746,509 patent/US9057060B2/en not_active Expired - Fee Related
- 2008-12-04 TW TW097147270A patent/TWI577385B/zh not_active IP Right Cessation
- 2008-12-04 LT LTEP13181046.7T patent/LT2666854T/lt unknown
- 2008-12-04 RS RS20170443A patent/RS55982B1/sr unknown
- 2008-12-04 RU RU2010127232A patent/RU2611200C2/ru active
- 2008-12-04 EP EP13181046.7A patent/EP2666854B1/en active Active
- 2008-12-04 BR BRPI0819977-9A patent/BRPI0819977A2/pt not_active Application Discontinuation
- 2008-12-04 MX MX2010006211A patent/MX2010006211A/es active IP Right Grant
- 2008-12-04 HU HUE13181046A patent/HUE032739T2/en unknown
- 2008-12-04 CN CN201811632685.6A patent/CN109893647A/zh active Pending
- 2008-12-04 KR KR1020187002034A patent/KR20180011860A/ko not_active Application Discontinuation
- 2008-12-04 NZ NZ601592A patent/NZ601592A/en unknown
- 2008-12-04 DK DK13181046.7T patent/DK2666854T3/da active
- 2008-12-04 EP EP08861467.2A patent/EP2229440B9/en active Active
- 2008-12-04 PL PL08861467T patent/PL2229440T3/pl unknown
- 2008-12-04 SI SI200831101T patent/SI2229440T1/sl unknown
- 2008-12-04 PT PT88614672T patent/PT2229440E/pt unknown
- 2008-12-04 MX MX2013000540A patent/MX341317B/es unknown
- 2008-12-04 EP EP17150627.2A patent/EP3176262A1/en not_active Withdrawn
- 2008-12-04 CN CN200880124812.XA patent/CN101918547B/zh not_active Expired - Fee Related
- 2008-12-04 ES ES13181046.7T patent/ES2627066T3/es active Active
- 2008-12-04 PL PL13181046T patent/PL2666854T3/pl unknown
- 2008-12-04 AU AU2008338743A patent/AU2008338743B2/en not_active Ceased
- 2008-12-04 CA CA2707051A patent/CA2707051C/en active Active
- 2008-12-04 KR KR1020107014799A patent/KR101732190B1/ko active IP Right Grant
- 2008-12-04 NZ NZ585866A patent/NZ585866A/xx unknown
- 2008-12-04 CN CN201410187187.0A patent/CN103952388B/zh not_active Expired - Fee Related
- 2008-12-04 TW TW105106918A patent/TWI619726B/zh not_active IP Right Cessation
- 2008-12-04 DK DK08861467.2T patent/DK2229440T3/da active
- 2008-12-04 ES ES08861467.2T patent/ES2436783T3/es active Active
- 2008-12-04 CN CN201410767370.8A patent/CN104711243B/zh not_active Expired - Fee Related
- 2008-12-04 JP JP2010537075A patent/JP5829808B2/ja not_active Expired - Fee Related
- 2008-12-05 AR ARP080105302A patent/AR069584A1/es active IP Right Grant
-
2010
- 2010-06-03 IL IL206157A patent/IL206157A/en active IP Right Grant
- 2010-06-24 US US12/823,098 patent/US20150322420A9/en not_active Abandoned
-
2011
- 2011-03-21 HK HK11102770.9A patent/HK1148772A1/xx not_active IP Right Cessation
-
2013
- 2013-06-06 IL IL226771A patent/IL226771A0/en unknown
- 2013-08-02 US US13/957,954 patent/US20130336956A1/en not_active Abandoned
- 2013-11-12 CY CY20131101003T patent/CY1114724T1/el unknown
- 2013-11-27 HR HRP20131135AT patent/HRP20131135T1/hr unknown
-
2014
- 2014-08-21 US US14/465,754 patent/US20150166974A1/en not_active Abandoned
-
2015
- 2015-05-07 JP JP2015094887A patent/JP6084653B2/ja not_active Expired - Fee Related
- 2015-05-19 US US14/715,660 patent/US20150329846A1/en not_active Abandoned
- 2015-12-03 US US14/957,765 patent/US20160243205A1/en not_active Abandoned
-
2016
- 2016-05-04 US US15/146,098 patent/US20160319267A1/en not_active Abandoned
-
2017
- 2017-01-25 JP JP2017011160A patent/JP2017104114A/ja active Pending
- 2017-05-19 HR HRP20170755TT patent/HRP20170755T1/hr unknown
- 2017-06-02 CY CY20171100583T patent/CY1118930T1/el unknown
- 2017-10-06 US US15/726,607 patent/US20180273928A1/en not_active Abandoned
-
2018
- 2018-01-12 US US15/869,505 patent/US20190010476A1/en not_active Abandoned
- 2018-01-25 US US15/880,029 patent/US10301612B2/en not_active Expired - Fee Related
- 2018-03-13 US US15/919,814 patent/US10308924B2/en not_active Expired - Fee Related
- 2018-03-13 US US15/919,795 patent/US20190062718A1/en not_active Abandoned
-
2019
- 2019-08-09 US US16/536,814 patent/US20200208132A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1118930T1 (el) | Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων | |
CY1118038T1 (el) | Λυοφιλισμενες φαρμακοτεχνικες μορφες θεραπευτικου πεπτισωματος | |
CY1110914T1 (el) | Δικυκλο-πυραζολες δραστικες ως αναστολεις kinασων, διεργασια για την παρασκευη τους και φαρμακευτικες συνθεσεις που τις περιλαμβανουν | |
CY1112682T1 (el) | Ενεργες παραλλαγες της πρωτεϊνης προσδεσης il-18 και ιατρικες χρησεις αυτων | |
CU23208A3 (es) | Oxazolidinonas sustituidas y su uso en el campo de la coagulacion sanguinea | |
BRPI0512286B8 (pt) | proteínas quiméricas inibidoras da angiogênese e o uso | |
CY1115082T1 (el) | Υποκατεστημενα παραγωγα 1,3-διφαινυλπροπανιου, παρασκευες και χρησεις αυτων | |
DE60332358D1 (de) | Protease-resistente modifizierte interferon alpha polypeptide | |
BR112012006252A2 (pt) | "formas cristalinas de abt-263 e solvatos para o uso no tratamento de doenças relacionadas á proteína bcl-2". | |
GT200900121A (es) | Moleculas de enlace de lingo y uso farmaceutico | |
CL2007003635A1 (es) | Compuestos derivados de 6-amino-purin-8-ona; proceso de preparacion; composicion farmaceutica; proceso para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades alergicas, virales o cancer. | |
NO20055209D0 (no) | Peptabody for cancerbehandling | |
ATE424842T1 (de) | Proteine der bcl-2-familie und fragmente davon, und ihre verwendung bei krebspatienten | |
CY1105008T1 (el) | Αντιμικροβιακη ενεργοτητα του πρωτου κατιονικου συγκροτηματος της ανθρωπινης λακτοφερρινης | |
CY1108932T1 (el) | Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων | |
DE60137337D1 (de) | Vorbeugende und therapeutsche monoklonale antikörper gegen vacciniavirusantigene | |
CY1114075T1 (el) | Ενωσεις αλφα κετοαμιδιου ως αναστολεις πρωτεασης κυστεϊνης | |
CY1109537T1 (el) | Πεπτιδια και παραγωγα πεπτιδιου, παρασκευη αυτων καθως επισης χρηση αυτων για την παρασκευη θεραπευτικως η/και προληπτικως δραστικης φαρμακευτικης συνθεσης | |
BR0211761A (pt) | depsipeptìdeos e processos para preparar os mesmos | |
CY1114614T1 (el) | Αντιγονα αιμοφιλου ινφλουεντσας και αντιστοιχα dna θραυσματα | |
UY29999A1 (es) | "n-pirazinil-fenilsulfonamidas, procedimientos y compuestos intemedios utilizados en su preparacion, composiciones farmaceuticas que las contienen y aplicaciones" | |
DE602004014145D1 (de) | Von rasgap-abgeleitetes peptid zur gezielten tötung von krebszellen | |
DE602005027231D1 (de) | Cylglycerolen und therapeutischen verwendungen derselben | |
CY1111048T1 (el) | Ενωσεις που εμφανιζουν αντικαρκινικη δραστηριοτητα | |
ATE484290T1 (de) | Peptid mit antitumoraler wirkung |