MX341317B - Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas. - Google Patents
Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas.Info
- Publication number
- MX341317B MX341317B MX2013000540A MX2013000540A MX341317B MX 341317 B MX341317 B MX 341317B MX 2013000540 A MX2013000540 A MX 2013000540A MX 2013000540 A MX2013000540 A MX 2013000540A MX 341317 B MX341317 B MX 341317B
- Authority
- MX
- Mexico
- Prior art keywords
- elastase proteins
- methods
- recombinant
- manufacturing
- proteins
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/486—Elastase (3.4.21.36 or 3.4.21.37)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21036—Pancreatic elastase (3.4.21.36)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21037—Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a métodos para la fabricación, purificación, formulación y uso de proteínas elastasa recombinantes, biológicamente activas. Se describen métodos recombinantes para producir proteínas elastasa terapéuticamente útiles, así como composiciones farmacéuticas que comprenden dichas proteínas elastasa. También se describen preparaciones de proteínas elastasa recombinantes novedosas y de proteína. Se describen métodos para tratar y prevenir enfermedades de los conductos biológicos utilizando las composiciones farmacéuticas que contienen las proteínas elastasa de la invención.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99231907P | 2007-12-04 | 2007-12-04 | |
US12/327,809 US8501449B2 (en) | 2007-12-04 | 2008-12-03 | Recombinant elastase proteins and methods of manufacturing and use thereof |
PCT/US2008/085559 WO2009079220A2 (en) | 2007-12-04 | 2008-12-04 | Recombinant elastase proteins and methods of manufacturing and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX341317B true MX341317B (es) | 2016-08-15 |
Family
ID=40344763
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010006211A MX2010006211A (es) | 2007-12-04 | 2008-12-04 | Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas. |
MX2013000540A MX341317B (es) | 2007-12-04 | 2008-12-04 | Proteinas de elastasa recombinantes y metodos de fabricacion y uso de las mismas. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010006211A MX2010006211A (es) | 2007-12-04 | 2008-12-04 | Proteínas elastasa recombinantes y métodos de fabricación y uso de las mismas. |
Country Status (26)
Country | Link |
---|---|
US (14) | US8501449B2 (es) |
EP (3) | EP3176262A1 (es) |
JP (3) | JP5829808B2 (es) |
KR (3) | KR101824350B1 (es) |
CN (4) | CN103952388B (es) |
AR (1) | AR069584A1 (es) |
AU (1) | AU2008338743B2 (es) |
BR (1) | BRPI0819977A2 (es) |
CA (1) | CA2707051C (es) |
CY (2) | CY1114724T1 (es) |
DK (2) | DK2666854T3 (es) |
ES (2) | ES2627066T3 (es) |
HK (1) | HK1148772A1 (es) |
HR (2) | HRP20131135T1 (es) |
HU (1) | HUE032739T2 (es) |
IL (2) | IL206157A (es) |
LT (1) | LT2666854T (es) |
MX (2) | MX2010006211A (es) |
NZ (2) | NZ601592A (es) |
PL (2) | PL2666854T3 (es) |
PT (2) | PT2229440E (es) |
RS (2) | RS53083B (es) |
RU (1) | RU2611200C2 (es) |
SI (2) | SI2229440T1 (es) |
TW (2) | TWI577385B (es) |
WO (1) | WO2009079220A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
CN102250863B (zh) * | 2011-04-29 | 2012-12-05 | 天津金斯坦生物科技有限公司 | 基因重组人中性粒细胞弹性蛋白酶及其制备方法和该弹性蛋白酶的医药用途 |
US10202630B2 (en) * | 2013-03-15 | 2019-02-12 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
EP2971037B1 (en) * | 2013-03-15 | 2019-07-10 | Alder Biopharmaceuticals, Inc. | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
KR102618002B1 (ko) * | 2017-03-10 | 2023-12-27 | 볼트 쓰레즈, 인크. | 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법 |
IL293238A (en) * | 2019-11-26 | 2022-07-01 | Childrens Hospital Med Ct | Treatment of health diseases by suppressing cela-1 |
US20230074785A1 (en) * | 2020-01-14 | 2023-03-09 | Basf Se | Method For Producing Recombinant Protein In Yeast Cells |
WO2022040288A1 (en) * | 2020-08-18 | 2022-02-24 | Onchilles Pharma, Inc. | Modified serine protease proproteins |
CA3184046A1 (en) * | 2020-08-18 | 2022-02-24 | Hank Michael James Petrassi | Modified porcine pancreatic elastase proteins |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2508408A (en) | 1943-10-11 | 1950-05-23 | Sidney H Liebson | Averaging indicator |
US2546308A (en) | 1948-12-29 | 1951-03-27 | Kahler John | Floor marking device |
US5212068A (en) * | 1985-04-05 | 1993-05-18 | Sankyo Company Limited | Human pancreatic elastase |
DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
JPH0673456B2 (ja) | 1986-04-26 | 1994-09-21 | 三共株式会社 | ヒト・膵臓エラスタ−ゼ▲i▼ |
US5162205A (en) | 1986-04-26 | 1992-11-10 | Sankyo Company, Limited | Human pancreatic elastase I |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5543302A (en) | 1988-05-27 | 1996-08-06 | Solvay Enzymes, Inc. | Proteases of altered stability to autolytic degradation |
DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
WO1991006666A1 (en) | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
GB8927722D0 (en) | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
NZ236819A (en) | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
US5503333A (en) | 1993-06-23 | 1996-04-02 | Laventure; David | Duster extension tube system with dust collecting region and tube cleaner and method of using the same |
ATE226642T1 (de) | 1994-07-07 | 2002-11-15 | Tno | Modifizierte proenzyme als substrate für proteolische enzyme |
US5955072A (en) | 1994-07-13 | 1999-09-21 | Sankyo Company, Limited | Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide |
US7531325B2 (en) | 1997-04-25 | 2009-05-12 | Sembiosys Genetics Inc. | Method for cleavage of fusion proteins |
US20030207402A1 (en) | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
GB9817909D0 (en) | 1998-08-17 | 1998-10-14 | Zeneca Ltd | DNA constructs |
GB9908458D0 (en) | 1999-04-13 | 1999-06-09 | Queen Mary & Westfield College | Enzyme |
WO2000068363A2 (en) | 1999-05-05 | 2000-11-16 | Genentech, Inc. | Elastase variants and substrates |
US7001892B1 (en) * | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
US7063838B1 (en) | 1999-09-24 | 2006-06-20 | Proteon Therapeutics Llc | Methods for treating an artery or vein in a human subject |
PT1923068E (pt) * | 1999-09-24 | 2011-07-29 | Proteon Therapeutics Inc | Sistema e métodos para a abertura de condutas biológicas obstruídas |
US7351549B2 (en) | 2000-01-24 | 2008-04-01 | Polymun Scientific Immunbiologische Forschung Gmbh | Method for the manufacture of recombinant trypsin |
JP2003523756A (ja) | 2000-02-24 | 2003-08-12 | フィロス インク. | 触媒蛋白質の生成のための改良された方法 |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
US20060189941A1 (en) | 2002-01-22 | 2006-08-24 | Mercator Medsystems, Inc. | Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation |
CA2517006A1 (en) | 2003-02-20 | 2004-09-02 | Proteon Therapeutics, Llc | Methods for the treatment and prevention of diseases of biological conduits |
US7571008B2 (en) | 2003-08-18 | 2009-08-04 | Medtronic, Inc. | System and apparatus for remote activation of implantable medical devices |
EP2386856B1 (en) * | 2004-06-21 | 2013-07-24 | Galapagos N.V. | Methods and means for treatment of osteoarthritis |
US20090196865A1 (en) | 2004-09-22 | 2009-08-06 | Proteon Therapeutics, Inc. | Methods for the treatment and prevention of diseases of biological conduits |
RU2299070C2 (ru) * | 2005-02-08 | 2007-05-20 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения заболевания вен и способ ее получения |
US20060193824A1 (en) | 2005-02-28 | 2006-08-31 | Rubin Bruce K | Methods for the treatment of infectious and inflammatory airway diseases |
CN1769424A (zh) * | 2005-09-20 | 2006-05-10 | 浙江大学 | 一种芽孢杆菌菌株及其用途 |
SG175602A1 (en) * | 2006-07-05 | 2011-11-28 | Catalyst Biosciences Inc | Protease screening methods and proteases identified thereby |
US8501449B2 (en) | 2007-12-04 | 2013-08-06 | Proteon Therapeutics, Inc. | Recombinant elastase proteins and methods of manufacturing and use thereof |
WO2009124293A1 (en) * | 2008-04-03 | 2009-10-08 | Hudson Alpha Institute For Biotechnology | Amplicon rescue multiplex polymerase chain reaction for amplificaton of multiple targets |
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2008
- 2008-12-03 US US12/327,809 patent/US8501449B2/en active Active
- 2008-12-04 RU RU2010127232A patent/RU2611200C2/ru active
- 2008-12-04 KR KR1020167020627A patent/KR101824350B1/ko active IP Right Grant
- 2008-12-04 WO PCT/US2008/085559 patent/WO2009079220A2/en active Application Filing
- 2008-12-04 TW TW097147270A patent/TWI577385B/zh not_active IP Right Cessation
- 2008-12-04 JP JP2010537075A patent/JP5829808B2/ja not_active Expired - Fee Related
- 2008-12-04 KR KR1020187002034A patent/KR20180011860A/ko not_active Application Discontinuation
- 2008-12-04 BR BRPI0819977-9A patent/BRPI0819977A2/pt not_active Application Discontinuation
- 2008-12-04 EP EP17150627.2A patent/EP3176262A1/en not_active Withdrawn
- 2008-12-04 NZ NZ601592A patent/NZ601592A/en unknown
- 2008-12-04 TW TW105106918A patent/TWI619726B/zh not_active IP Right Cessation
- 2008-12-04 NZ NZ585866A patent/NZ585866A/xx unknown
- 2008-12-04 LT LTEP13181046.7T patent/LT2666854T/lt unknown
- 2008-12-04 CN CN201410187187.0A patent/CN103952388B/zh not_active Expired - Fee Related
- 2008-12-04 EP EP08861467.2A patent/EP2229440B9/en active Active
- 2008-12-04 SI SI200831101T patent/SI2229440T1/sl unknown
- 2008-12-04 ES ES13181046.7T patent/ES2627066T3/es active Active
- 2008-12-04 PT PT88614672T patent/PT2229440E/pt unknown
- 2008-12-04 DK DK13181046.7T patent/DK2666854T3/da active
- 2008-12-04 SI SI200831792A patent/SI2666854T1/sl unknown
- 2008-12-04 CA CA2707051A patent/CA2707051C/en active Active
- 2008-12-04 CN CN201410767370.8A patent/CN104711243B/zh not_active Expired - Fee Related
- 2008-12-04 PT PT131810467T patent/PT2666854T/pt unknown
- 2008-12-04 HU HUE13181046A patent/HUE032739T2/en unknown
- 2008-12-04 CN CN201811632685.6A patent/CN109893647A/zh active Pending
- 2008-12-04 EP EP13181046.7A patent/EP2666854B1/en active Active
- 2008-12-04 DK DK08861467.2T patent/DK2229440T3/da active
- 2008-12-04 ES ES08861467.2T patent/ES2436783T3/es active Active
- 2008-12-04 MX MX2010006211A patent/MX2010006211A/es active IP Right Grant
- 2008-12-04 KR KR1020107014799A patent/KR101732190B1/ko active IP Right Grant
- 2008-12-04 MX MX2013000540A patent/MX341317B/es unknown
- 2008-12-04 RS RS20130514A patent/RS53083B/en unknown
- 2008-12-04 AU AU2008338743A patent/AU2008338743B2/en not_active Ceased
- 2008-12-04 PL PL13181046T patent/PL2666854T3/pl unknown
- 2008-12-04 RS RS20170443A patent/RS55982B1/sr unknown
- 2008-12-04 CN CN200880124812.XA patent/CN101918547B/zh not_active Expired - Fee Related
- 2008-12-04 PL PL08861467T patent/PL2229440T3/pl unknown
- 2008-12-04 US US12/746,509 patent/US9057060B2/en not_active Expired - Fee Related
- 2008-12-05 AR ARP080105302A patent/AR069584A1/es active IP Right Grant
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2010
- 2010-06-03 IL IL206157A patent/IL206157A/en active IP Right Grant
- 2010-06-24 US US12/823,098 patent/US20150322420A9/en not_active Abandoned
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2011
- 2011-03-21 HK HK11102770.9A patent/HK1148772A1/xx not_active IP Right Cessation
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2013
- 2013-06-06 IL IL226771A patent/IL226771A0/en unknown
- 2013-08-02 US US13/957,954 patent/US20130336956A1/en not_active Abandoned
- 2013-11-12 CY CY20131101003T patent/CY1114724T1/el unknown
- 2013-11-27 HR HRP20131135AT patent/HRP20131135T1/hr unknown
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2014
- 2014-08-21 US US14/465,754 patent/US20150166974A1/en not_active Abandoned
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2015
- 2015-05-07 JP JP2015094887A patent/JP6084653B2/ja not_active Expired - Fee Related
- 2015-05-19 US US14/715,660 patent/US20150329846A1/en not_active Abandoned
- 2015-12-03 US US14/957,765 patent/US20160243205A1/en not_active Abandoned
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2016
- 2016-05-04 US US15/146,098 patent/US20160319267A1/en not_active Abandoned
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2017
- 2017-01-25 JP JP2017011160A patent/JP2017104114A/ja active Pending
- 2017-05-19 HR HRP20170755TT patent/HRP20170755T1/hr unknown
- 2017-06-02 CY CY20171100583T patent/CY1118930T1/el unknown
- 2017-10-06 US US15/726,607 patent/US20180273928A1/en not_active Abandoned
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2018
- 2018-01-12 US US15/869,505 patent/US20190010476A1/en not_active Abandoned
- 2018-01-25 US US15/880,029 patent/US10301612B2/en not_active Expired - Fee Related
- 2018-03-13 US US15/919,814 patent/US10308924B2/en not_active Expired - Fee Related
- 2018-03-13 US US15/919,795 patent/US20190062718A1/en not_active Abandoned
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2019
- 2019-08-09 US US16/536,814 patent/US20200208132A1/en not_active Abandoned
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