DK2229440T3 - Rekombinante elastase-proteiner og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents

Rekombinante elastase-proteiner og fremgangsmåder til fremstilling og anvendelse deraf

Info

Publication number: DK2229440T3
Authority: DK; Denmark
Prior art keywords: elastase proteins; producing; recombinant; procedures; methods
Prior art date: 2007-12-04

Application number

DK08861467.2T

Other languages

English (en)

Inventor

F Nicholas Franano

Kimberly Bland

Marco D Wong

Bee C Ding

Original Assignee

Proteon Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-04

Filing date

2008-12-04

Publication date

2013-12-09

2008-12-04 Application filed by Proteon Therapeutics Inc filed Critical Proteon Therapeutics Inc

2013-12-09 Application granted granted Critical

2013-12-09 Publication of DK2229440T3 publication Critical patent/DK2229440T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/486—Elastase (3.4.21.36 or 3.4.21.37)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21036—Pancreatic elastase (3.4.21.36)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21037—Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Mycology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK08861467.2T 2007-12-04 2008-12-04 Rekombinante elastase-proteiner og fremgangsmåder til fremstilling og anvendelse deraf DK2229440T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US99231907P	2007-12-04	2007-12-04
US12/327,809 US8501449B2 (en)	2007-12-04	2008-12-03	Recombinant elastase proteins and methods of manufacturing and use thereof
PCT/US2008/085559 WO2009079220A2 (en)	2007-12-04	2008-12-04	Recombinant elastase proteins and methods of manufacturing and use thereof

Publications (1)

Publication Number	Publication Date
DK2229440T3 true DK2229440T3 (da)	2013-12-09

Family

ID=40344763

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK13181046.7T DK2666854T3 (da)	2007-12-04	2008-12-04	Rekombinante elastase-proteiner og fremgangsmåder til fremstilling og anvendelse deraf
DK08861467.2T DK2229440T3 (da)	2007-12-04	2008-12-04	Rekombinante elastase-proteiner og fremgangsmåder til fremstilling og anvendelse deraf

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK13181046.7T DK2666854T3 (da)	2007-12-04	2008-12-04	Rekombinante elastase-proteiner og fremgangsmåder til fremstilling og anvendelse deraf

Country Status (26)

Country	Link
US (14)	US8501449B2 (da)
EP (3)	EP2666854B1 (da)
JP (3)	JP5829808B2 (da)
KR (3)	KR101732190B1 (da)
CN (4)	CN109893647A (da)
AR (1)	AR069584A1 (da)
AU (1)	AU2008338743B2 (da)
BR (1)	BRPI0819977A2 (da)
CA (1)	CA2707051C (da)
CY (2)	CY1114724T1 (da)
DK (2)	DK2666854T3 (da)
ES (2)	ES2627066T3 (da)
HK (1)	HK1148772A1 (da)
HR (2)	HRP20131135T1 (da)
HU (1)	HUE032739T2 (da)
IL (2)	IL206157A (da)
LT (1)	LT2666854T (da)
MX (2)	MX2010006211A (da)
NZ (2)	NZ601592A (da)
PL (2)	PL2229440T3 (da)
PT (2)	PT2666854T (da)
RS (2)	RS53083B (da)
RU (1)	RU2611200C2 (da)
SI (2)	SI2666854T1 (da)
TW (2)	TWI619726B (da)
WO (1)	WO2009079220A2 (da)

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US8501449B2 (en) *	2007-12-04	2013-08-06	Proteon Therapeutics, Inc.	Recombinant elastase proteins and methods of manufacturing and use thereof
CN102250863B (zh) *	2011-04-29	2012-12-05	天津金斯坦生物科技有限公司	基因重组人中性粒细胞弹性蛋白酶及其制备方法和该弹性蛋白酶的医药用途
AU2014232813B2 (en)	2013-03-15	2017-12-07	H. Lundbeck A/S.	Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
US10202630B2 (en) *	2013-03-15	2019-02-12	Alderbio Holdings Llc	Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
EP3592762A4 (en) *	2017-03-10	2020-12-30	Bolt Threads, Inc.	COMPOSITIONS AND METHODS OF PRODUCING HIGHLY SECRETED YIELD OF RECOMBINANT PROTEIN
EP4065167A4 (en) *	2019-11-26	2024-03-27	Children's Hospital Medical Center	INHIBITION OF CELA-1 FOR THE TREATMENT OF PULMONARY DISEASE
WO2021146233A1 (en) *	2020-01-14	2021-07-22	Basf Se	Method for producing recombinant protein in yeast cells
CN116157513A (zh) *	2020-08-18	2023-05-23	昂希莱斯制药公司	经修饰的猪胰腺弹性蛋白酶蛋白
AU2021329330A1 (en) *	2020-08-18	2023-02-02	Onchilles Pharma, Inc.	Modified serine protease proproteins

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2008
- 2008-12-03 US US12/327,809 patent/US8501449B2/en active Active
- 2008-12-04 HU HUE13181046A patent/HUE032739T2/en unknown
- 2008-12-04 KR KR1020107014799A patent/KR101732190B1/ko active IP Right Grant
- 2008-12-04 SI SI200831792A patent/SI2666854T1/sl unknown
- 2008-12-04 ES ES13181046.7T patent/ES2627066T3/es active Active
- 2008-12-04 AU AU2008338743A patent/AU2008338743B2/en not_active Ceased
- 2008-12-04 PT PT131810467T patent/PT2666854T/pt unknown
- 2008-12-04 LT LTEP13181046.7T patent/LT2666854T/lt unknown
- 2008-12-04 TW TW105106918A patent/TWI619726B/zh not_active IP Right Cessation
- 2008-12-04 CN CN201811632685.6A patent/CN109893647A/zh active Pending
- 2008-12-04 EP EP13181046.7A patent/EP2666854B1/en active Active
- 2008-12-04 RS RS20130514A patent/RS53083B/en unknown
- 2008-12-04 DK DK13181046.7T patent/DK2666854T3/da active
- 2008-12-04 ES ES08861467.2T patent/ES2436783T3/es active Active
- 2008-12-04 MX MX2010006211A patent/MX2010006211A/es active IP Right Grant
- 2008-12-04 KR KR1020167020627A patent/KR101824350B1/ko active IP Right Grant
- 2008-12-04 EP EP08861467.2A patent/EP2229440B9/en active Active
- 2008-12-04 JP JP2010537075A patent/JP5829808B2/ja not_active Expired - Fee Related
- 2008-12-04 MX MX2013000540A patent/MX341317B/es unknown
- 2008-12-04 CN CN200880124812.XA patent/CN101918547B/zh not_active Expired - Fee Related
- 2008-12-04 CN CN201410187187.0A patent/CN103952388B/zh not_active Expired - Fee Related
- 2008-12-04 CA CA2707051A patent/CA2707051C/en active Active
- 2008-12-04 BR BRPI0819977-9A patent/BRPI0819977A2/pt not_active Application Discontinuation
- 2008-12-04 CN CN201410767370.8A patent/CN104711243B/zh not_active Expired - Fee Related
- 2008-12-04 DK DK08861467.2T patent/DK2229440T3/da active
- 2008-12-04 TW TW097147270A patent/TWI577385B/zh not_active IP Right Cessation
- 2008-12-04 WO PCT/US2008/085559 patent/WO2009079220A2/en active Application Filing
- 2008-12-04 RU RU2010127232A patent/RU2611200C2/ru active
- 2008-12-04 NZ NZ601592A patent/NZ601592A/en unknown
- 2008-12-04 US US12/746,509 patent/US9057060B2/en not_active Expired - Fee Related
- 2008-12-04 KR KR1020187002034A patent/KR20180011860A/ko not_active Application Discontinuation
- 2008-12-04 PL PL08861467T patent/PL2229440T3/pl unknown
- 2008-12-04 EP EP17150627.2A patent/EP3176262A1/en not_active Withdrawn
- 2008-12-04 RS RS20170443A patent/RS55982B1/sr unknown
- 2008-12-04 NZ NZ585866A patent/NZ585866A/xx unknown
- 2008-12-04 PT PT88614672T patent/PT2229440E/pt unknown
- 2008-12-04 PL PL13181046T patent/PL2666854T3/pl unknown
- 2008-12-04 SI SI200831101T patent/SI2229440T1/sl unknown
- 2008-12-05 AR ARP080105302A patent/AR069584A1/es active IP Right Grant
2010
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- 2010-06-24 US US12/823,098 patent/US20150322420A9/en not_active Abandoned
2011
- 2011-03-21 HK HK11102770.9A patent/HK1148772A1/xx not_active IP Right Cessation
2013
- 2013-06-06 IL IL226771A patent/IL226771A0/en unknown
- 2013-08-02 US US13/957,954 patent/US20130336956A1/en not_active Abandoned
- 2013-11-12 CY CY20131101003T patent/CY1114724T1/el unknown
- 2013-11-27 HR HRP20131135AT patent/HRP20131135T1/hr unknown
2014
- 2014-08-21 US US14/465,754 patent/US20150166974A1/en not_active Abandoned
2015
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- 2015-05-19 US US14/715,660 patent/US20150329846A1/en not_active Abandoned
- 2015-12-03 US US14/957,765 patent/US20160243205A1/en not_active Abandoned
2016
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2017
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- 2017-05-19 HR HRP20170755TT patent/HRP20170755T1/hr unknown
- 2017-06-02 CY CY20171100583T patent/CY1118930T1/el unknown
- 2017-10-06 US US15/726,607 patent/US20180273928A1/en not_active Abandoned
2018
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2019
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Also Published As

Publication number	Publication date
WO2009079220A2 (en)	2009-06-25
US9057060B2 (en)	2015-06-16
EP2666854A1 (en)	2013-11-27
HK1148772A1 (en)	2011-09-16
PT2229440E (pt)	2013-11-11
PL2666854T3 (pl)	2017-08-31
US10301612B2 (en)	2019-05-28
IL226771A0 (en)	2013-07-31
DK2666854T3 (da)	2017-05-22
SI2229440T1 (sl)	2013-12-31
EP2229440B9 (en)	2013-11-13
KR101824350B1 (ko)	2018-01-31
US20090162343A1 (en)	2009-06-25
EP2229440A2 (en)	2010-09-22
CN104711243B (zh)	2019-06-11
ES2436783T3 (es)	2014-01-07
JP2017104114A (ja)	2017-06-15
CN101918547A (zh)	2010-12-15
US8501449B2 (en)	2013-08-06
ES2627066T3 (es)	2017-07-26
SI2666854T1 (sl)	2017-06-30
US20200208132A1 (en)	2020-07-02
US10308924B2 (en)	2019-06-04
US20190010476A1 (en)	2019-01-10
EP2666854B1 (en)	2017-03-15
RS55982B1 (sr)	2017-09-29
US20110008315A1 (en)	2011-01-13
KR20160095184A (ko)	2016-08-10
CN103952388A (zh)	2014-07-30
US20160319267A1 (en)	2016-11-03
RU2010127232A (ru)	2012-01-10
PT2666854T (pt)	2017-06-28
RU2611200C2 (ru)	2017-02-21
CA2707051A1 (en)	2009-06-25
CN103952388B (zh)	2017-10-03
US20180273928A1 (en)	2018-09-27
AU2008338743A1 (en)	2009-06-25
AU2008338743B2 (en)	2015-02-19
JP5829808B2 (ja)	2015-12-09
JP2011505164A (ja)	2011-02-24
KR20100120639A (ko)	2010-11-16
MX2010006211A (es)	2010-10-25
US20180155703A1 (en)	2018-06-07
BRPI0819977A2 (pt)	2020-08-18
TW200938219A (en)	2009-09-16
NZ585866A (en)	2012-09-28
KR20180011860A (ko)	2018-02-02
CA2707051C (en)	2019-05-21
AR069584A1 (es)	2010-02-03
JP6084653B2 (ja)	2017-02-22
US20150166974A1 (en)	2015-06-18
JP2015172056A (ja)	2015-10-01
WO2009079220A3 (en)	2009-08-06
IL206157A0 (en)	2010-12-30
HUE032739T2 (en)	2017-10-30
US20150322420A9 (en)	2015-11-12
HRP20170755T1 (hr)	2017-07-28
CY1114724T1 (el)	2016-10-05
CN109893647A (zh)	2019-06-18
EP3176262A1 (en)	2017-06-07
US20110081705A1 (en)	2011-04-07
MX341317B (es)	2016-08-15
TWI619726B (zh)	2018-04-01
HRP20131135T1 (hr)	2014-01-03
US20190062718A1 (en)	2019-02-28
US20150329846A1 (en)	2015-11-19
IL206157A (en)	2013-07-31
CN101918547B (zh)	2015-01-14
NZ601592A (en)	2014-02-28
CY1118930T1 (el)	2018-01-10
CN104711243A (zh)	2015-06-17
RS53083B (en)	2014-06-30
US20160243205A1 (en)	2016-08-25
LT2666854T (lt)	2017-06-12
TWI577385B (zh)	2017-04-11
TW201643188A (zh)	2016-12-16
US20130336956A1 (en)	2013-12-19
US20180208918A1 (en)	2018-07-26
EP2229440B1 (en)	2013-08-28
KR101732190B1 (ko)	2017-05-04
PL2229440T3 (pl)	2014-07-31

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