CY1117106T1 - Ασυμμετρα διμερη πυρρολοβενζοδιαζεπινης για τη θεραπευτικη αντιμετωπιση των πολλαπλασιαστικων ασθενειων - Google Patents
Ασυμμετρα διμερη πυρρολοβενζοδιαζεπινης για τη θεραπευτικη αντιμετωπιση των πολλαπλασιαστικων ασθενειωνInfo
- Publication number
- CY1117106T1 CY1117106T1 CY20161100019T CY161100019T CY1117106T1 CY 1117106 T1 CY1117106 T1 CY 1117106T1 CY 20161100019 T CY20161100019 T CY 20161100019T CY 161100019 T CY161100019 T CY 161100019T CY 1117106 T1 CY1117106 T1 CY 1117106T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- benzodiazepine
- pyrrolidone
- multiple sclerosis
- therapeutic treatment
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Αξιώνονται τα ασύμμετρα διμερή πυρρολοβενζοδιαζεπίνης (διμερή PBD) του τύπου (I), τα οποία είναι ασύμμετρα λόγω τουλάχιστον των τιμών που αντιπροσωπεύουν οι μεταβλητές R12 και R2. Τύπος (I), όπου: το R2 είναι του τύπου (II), όπου το Α είναι μια ομάδα C5-7 αρυλίου, το Χ επιλέγεται από την ομάδα που περιλαμβάνει: OH, SH, CO2H, COH, N=C=O, NHRN, όπου το RΝ επιλέγεται από την ομάδα που περιλαμβάνει Η και C1-4 αλκύλιο και (OC2H4)mOCH3, όπου το m είναι 1 έως 3 και είτε: (i) το Q1 είναι ένας μονός δεσμός και το Q2 επιλέγεται από έναν μονό δεσμό και -Z-(CH2)n-, όπου το Z επιλέγεται από έναν μονό δεσμό, Ο, S και ΝΗ και το n είναι από 1 έως 3 ή (ii) το Q1 είναι -CH=CH- και το Q2 είναι ένας μοναδικός δεσμός, το R12 είναι μια ομάδα C5-10 αρυλίου, που υποκαθίσταται προαιρετικά με ένα ή περισσότερα υποκατάστατα που επιλέγονται από την ομάδα που περιλαμβάνει: αλογόνο, νίτρο, κύανο, αιθέρα, C1-7 αλκύλιο, C3-7 ετεροκυκλύλιο και δις-οξυ-C1-3 αλκυλένιο. Οι άλλες μεταβλητές είναι όπως ορίζονται στις αξιώσεις. Οι ενώσεις είναι χρήσιμες στη θεραπευτική αντιμετώπιση των πολλαπλασιαστικών παθήσεων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0819095.1A GB0819095D0 (en) | 2008-10-17 | 2008-10-17 | Pyrrolobenzodiazepines |
EP09740185.5A EP2350080B1 (en) | 2008-10-17 | 2009-10-16 | Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases |
Publications (1)
Publication Number | Publication Date |
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CY1117106T1 true CY1117106T1 (el) | 2017-04-05 |
Family
ID=40097621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100019T CY1117106T1 (el) | 2008-10-17 | 2016-01-11 | Ασυμμετρα διμερη πυρρολοβενζοδιαζεπινης για τη θεραπευτικη αντιμετωπιση των πολλαπλασιαστικων ασθενειων |
Country Status (24)
Country | Link |
---|---|
US (3) | US8592576B2 (el) |
EP (1) | EP2350080B1 (el) |
JP (2) | JP5995441B2 (el) |
KR (1) | KR101755722B1 (el) |
CN (3) | CN105732665B (el) |
AU (1) | AU2009305190B2 (el) |
BR (1) | BRPI0918476B8 (el) |
CA (1) | CA2735477C (el) |
CY (1) | CY1117106T1 (el) |
DK (1) | DK2350080T3 (el) |
ES (1) | ES2557283T3 (el) |
GB (1) | GB0819095D0 (el) |
HK (1) | HK1154575A1 (el) |
HR (1) | HRP20160003T1 (el) |
HU (1) | HUE025905T2 (el) |
IL (1) | IL211985A (el) |
MX (1) | MX2011003342A (el) |
NZ (1) | NZ591425A (el) |
PL (1) | PL2350080T3 (el) |
PT (1) | PT2350080E (el) |
SI (1) | SI2350080T1 (el) |
SM (1) | SMT201600017B (el) |
WO (1) | WO2010043880A1 (el) |
ZA (1) | ZA201101425B (el) |
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