GB9205051D0 - Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them - Google Patents

Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Info

Publication number
GB9205051D0
GB9205051D0 GB929205051A GB9205051A GB9205051D0 GB 9205051 D0 GB9205051 D0 GB 9205051D0 GB 929205051 A GB929205051 A GB 929205051A GB 9205051 A GB9205051 A GB 9205051A GB 9205051 D0 GB9205051 D0 GB 9205051D0
Authority
GB
United Kingdom
Prior art keywords
preparation
compositions containing
pyrrolobenzodiazepine derivatives
pyrrolobenzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB929205051A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
Original Assignee
Cancer Research Campaign Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Campaign Technology Ltd filed Critical Cancer Research Campaign Technology Ltd
Priority to GB929205051A priority Critical patent/GB9205051D0/en
Publication of GB9205051D0 publication Critical patent/GB9205051D0/en
Priority to ZA931637A priority patent/ZA931637B/en
Priority to AU36435/93A priority patent/AU3643593A/en
Priority to PCT/GB1993/000483 priority patent/WO1993018045A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
GB929205051A 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them Pending GB9205051D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB929205051A GB9205051D0 (en) 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
ZA931637A ZA931637B (en) 1992-03-09 1993-03-08 Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them
AU36435/93A AU3643593A (en) 1992-03-09 1993-03-08 Anti-cancer pyrrolobenzodiazepine derivatives
PCT/GB1993/000483 WO1993018045A1 (en) 1992-03-09 1993-03-08 Anti-cancer pyrrolobenzodiazepine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929205051A GB9205051D0 (en) 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Publications (1)

Publication Number Publication Date
GB9205051D0 true GB9205051D0 (en) 1992-04-22

Family

ID=10711735

Family Applications (1)

Application Number Title Priority Date Filing Date
GB929205051A Pending GB9205051D0 (en) 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Country Status (3)

Country Link
GB (1) GB9205051D0 (en)
WO (1) WO1993018045A1 (en)
ZA (1) ZA931637B (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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DE69930328T2 (en) 1998-08-27 2006-12-14 Spirogen Ltd., Ryde Dimer pyrrolobenzodiazepines
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
US6362331B1 (en) 2001-03-30 2002-03-26 Council Of Scientific And Industrial Research Process for the preparation of antitumor agents
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
ATE413407T1 (en) * 2003-03-31 2008-11-15 Council Scient Ind Res PYRROLO(2,1-C)(1,4)BENZODIAZEPINE DIMERS AS ANTI-TUMOR AGENTS AND METHOD THEREOF
EP1608664B1 (en) * 2003-03-31 2009-01-28 Council of Scientific and Industrial Research Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines as potential antitumour agents and process thereof
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
AU2004284075A1 (en) 2003-10-22 2005-05-06 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
GB0416511D0 (en) 2003-10-22 2004-08-25 Spirogen Ltd Pyrrolobenzodiazepines
GB2425309B (en) * 2003-12-31 2008-07-09 Council Scient Ind Res C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers
SI1720881T1 (en) 2004-03-01 2013-04-30 Spirogen Sarl 11-hydroxy-5h-pyrrolos2,1-ccs1,4cbenzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
JP5166861B2 (en) * 2004-03-09 2013-03-21 スピロゲン リミティッド Pyrrolobenzodiazepine
US7189710B2 (en) 2004-03-30 2007-03-13 Council Of Scientific And Industrial Research C2-fluoro pyrrolo [2,1−c][1,4]benzodiazepine dimers
GB0410725D0 (en) * 2004-05-13 2004-06-16 Spirogen Ltd Pyrrolobenzodiazepine therapeutic agents
PL1879901T3 (en) 2005-04-21 2010-06-30 Medimmune Ltd Pyrrolobenzodiazepines
EP2001894B1 (en) * 2006-03-10 2010-12-22 Council of Scientific and Industrial Research Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers
ATE543826T1 (en) * 2007-08-01 2012-02-15 Council Scient Ind Res PYRROLOÄ2,1-CUÄ1,4ÜBENZODIAZEPINE GLYCOSIDE-PRODRU S SUITABLE AS SELECTIVE ANTITUMOR AGENTS
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US8426402B2 (en) 2009-02-05 2013-04-23 Immunogen, Inc. Benzodiazepine derivatives
FR2949469A1 (en) * 2009-08-25 2011-03-04 Sanofi Aventis ANTICANCER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
CN102971329B (en) 2010-04-15 2016-06-29 麦迪穆有限责任公司 Pyrrolobenzodiazepines for treating proliferative disease is tall and erect
CN103068405A (en) 2010-04-15 2013-04-24 西雅图基因公司 Targeted pyrrolobenzodiazapine conjugates
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
WO2012112708A1 (en) 2011-02-15 2012-08-23 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and methods of preparation
AU2012311505B2 (en) 2011-09-20 2016-09-29 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
CN110183470A (en) 2011-10-14 2019-08-30 麦迪穆有限责任公司 Pyrrolobenzodiazepines are tall and erect
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
KR101961976B1 (en) 2011-10-14 2019-03-25 시애틀 지네틱스, 인크. Pyrrolobenzodiazepines and targeted conjugates
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WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
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GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
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GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
WO2018071455A1 (en) 2016-10-10 2018-04-19 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepine (iqb)-1(chloromethyl)-2,3-dihydro-1h-benzo[e]indole (cbi) dimers
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
WO2018075842A1 (en) 2016-10-20 2018-04-26 Bristol-Myers Squibb Company Condensed benzodiazepine derivatives and conjugates made therefrom
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
LT3544636T (en) 2017-02-08 2021-06-25 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
EP3612537B1 (en) 2017-04-18 2022-07-13 Medimmune Limited Pyrrolobenzodiazepine conjugates
WO2018193102A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
UA127900C2 (en) 2017-06-14 2024-02-07 Ейдісі Терапьютікс Са Dosage regimes for the administration of an anti-cd19 adc
MX2020001880A (en) 2017-08-18 2021-07-06 Medimmune Ltd Pyrrolobenzodiazepine conjugates.
CN111164208B (en) 2017-09-29 2023-08-04 第一三共株式会社 Antibody-pyrrolobenzodiazepine derivative conjugates
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof

Also Published As

Publication number Publication date
ZA931637B (en) 1993-10-04
WO1993018045A1 (en) 1993-09-16

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