EA200801011A1 - Производные пиразина как модуляторы натриевых каналов для лечения боли - Google Patents

Производные пиразина как модуляторы натриевых каналов для лечения боли

Info

Publication number
EA200801011A1
EA200801011A1 EA200801011A EA200801011A EA200801011A1 EA 200801011 A1 EA200801011 A1 EA 200801011A1 EA 200801011 A EA200801011 A EA 200801011A EA 200801011 A EA200801011 A EA 200801011A EA 200801011 A1 EA200801011 A1 EA 200801011A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pain
treatment
pyrazine
modulators
derivatives
Prior art date
Application number
EA200801011A
Other languages
English (en)
Inventor
Карл Ричард Гибсон
Цедрик Пойнсэрд
Мелани Сьюзан Глоссоп
Марк Ян Кемп
Original Assignee
Пфайзер Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Лимитед filed Critical Пфайзер Лимитед
Publication of EA200801011A1 publication Critical patent/EA200801011A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Настоящее изобретение касается соединений формулы (I) и их фармацевтически приемлемых солей или их сольватов, процессов их приготовления, промежуточных соединений, используемых для их приготовления, и композиций, содержащих такие соединения, и применения таких соединений для лечения боли.
EA200801011A 2005-11-04 2006-10-23 Производные пиразина как модуляторы натриевых каналов для лечения боли EA200801011A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73366205P 2005-11-04 2005-11-04
PCT/IB2006/003055 WO2007052123A2 (en) 2005-11-04 2006-10-23 Pyrazine derivatives as sodium channel modulators for the treatment of pain

Publications (1)

Publication Number Publication Date
EA200801011A1 true EA200801011A1 (ru) 2009-02-27

Family

ID=37890558

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801011A EA200801011A1 (ru) 2005-11-04 2006-10-23 Производные пиразина как модуляторы натриевых каналов для лечения боли

Country Status (27)

Country Link
US (1) US7572797B2 (ru)
EP (1) EP1945630B1 (ru)
JP (1) JP2009514937A (ru)
KR (1) KR20080066073A (ru)
CN (1) CN101356169A (ru)
AP (1) AP2008004468A0 (ru)
AR (1) AR057855A1 (ru)
AT (1) ATE525372T1 (ru)
AU (1) AU2006310215A1 (ru)
BR (1) BRPI0618129A2 (ru)
CA (1) CA2624621C (ru)
CR (1) CR9954A (ru)
DO (1) DOP2006000243A (ru)
EA (1) EA200801011A1 (ru)
EC (1) ECSP088412A (ru)
ES (1) ES2371932T3 (ru)
GT (1) GT200600475A (ru)
IL (1) IL191059A0 (ru)
MA (1) MA29926B1 (ru)
NL (1) NL2000284C2 (ru)
NO (1) NO20082496L (ru)
PE (1) PE20070715A1 (ru)
TN (1) TNSN08196A1 (ru)
TW (1) TW200804353A (ru)
UY (1) UY29893A1 (ru)
WO (1) WO2007052123A2 (ru)
ZA (1) ZA200803671B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998003167A1 (en) 1996-07-24 1998-01-29 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
EP1741708A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
CA2685952C (en) * 2007-05-03 2012-03-13 Pfizer Limited N- [6-amino-5- (phenyl) pyrazin-2-yl] -isoxazole-4-carboxamide derivatives and related compounds as nav1.8 channel modulators for the treatment of pain
ES2398606T3 (es) 2007-05-03 2013-03-20 Pfizer Limited Derivados de 2-piridin-carboxamida como moduladores de los canales de sodio
WO2009026434A1 (en) * 2007-08-21 2009-02-26 Alkermes, Inc. Pulmonary pharmaceutical formulations
NZ585789A (en) 2007-12-10 2012-03-30 Novartis Ag Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel
US20100331310A1 (en) 2008-02-13 2010-12-30 Fumihiro Ozaki Bicycloamine derivatives
SG190667A1 (en) 2008-05-23 2013-06-28 Panmira Pharmaceuticals Llc 5-lipoxygenase-activating protein inhibitor
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) * 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2841435B1 (en) * 2012-04-25 2017-09-06 RaQualia Pharma Inc. Pyrrolopyridinone derivatives as ttx-s blockers
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
WO2014121055A2 (en) 2013-02-04 2014-08-07 Janssen Pharmaceutica Nv Flap modulators
EP3193603A4 (en) * 2014-09-10 2018-02-28 Epizyme, Inc. Isoxazole carboxamide compounds
BR112017018413B1 (pt) 2015-02-27 2023-05-02 CalciMedica, Inc Uso de inibidores intracelulares de sinalização de cálcio no tratamento de pancreatite, composições e compostos relacionados
US10478435B2 (en) 2015-08-07 2019-11-19 Calcimedica, Inc. Use of CRAC channel inhibitors for the treatment of stroke and traumatic brain injury

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
DK1446387T3 (da) * 2001-11-21 2009-12-21 Pharmacia & Upjohn Co Llc Substituerede aryl, 1,4-pyrazinderivater
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
KR20060123208A (ko) * 2003-10-27 2006-12-01 아스테라스 세이야쿠 가부시키가이샤 피라진 유도체 및 이의 약학적 용도
ATE437864T1 (de) * 2004-10-22 2009-08-15 Janssen Pharmaceutica Nv Aromatische amide als hemmer der c-fms-kinase

Also Published As

Publication number Publication date
CN101356169A (zh) 2009-01-28
ECSP088412A (es) 2008-05-30
NL2000284C2 (nl) 2007-09-28
TNSN08196A1 (fr) 2009-10-30
KR20080066073A (ko) 2008-07-15
CA2624621C (en) 2010-11-30
UY29893A1 (es) 2007-06-29
GT200600475A (es) 2007-07-06
ZA200803671B (en) 2009-03-25
WO2007052123A2 (en) 2007-05-10
CR9954A (es) 2008-05-28
IL191059A0 (en) 2008-12-29
ATE525372T1 (de) 2011-10-15
MA29926B1 (fr) 2008-11-03
US20070105872A1 (en) 2007-05-10
WO2007052123A3 (en) 2007-07-12
PE20070715A1 (es) 2007-08-11
US7572797B2 (en) 2009-08-11
AR057855A1 (es) 2007-12-19
NO20082496L (no) 2008-07-24
CA2624621A1 (en) 2007-05-10
AP2008004468A0 (en) 2008-06-30
EP1945630A2 (en) 2008-07-23
AU2006310215A1 (en) 2007-05-10
JP2009514937A (ja) 2009-04-09
ES2371932T3 (es) 2012-01-11
EP1945630B1 (en) 2011-09-21
NL2000284A1 (nl) 2007-05-07
BRPI0618129A2 (pt) 2011-08-16
DOP2006000243A (es) 2007-05-31
TW200804353A (en) 2008-01-16

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