IL33558A - Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production - Google Patents
Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their productionInfo
- Publication number
- IL33558A IL33558A IL33558A IL3355869A IL33558A IL 33558 A IL33558 A IL 33558A IL 33558 A IL33558 A IL 33558A IL 3355869 A IL3355869 A IL 3355869A IL 33558 A IL33558 A IL 33558A
- Authority
- IL
- Israel
- Prior art keywords
- pyrrolo
- antibiotic
- derivatives
- processes
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8368 | 1968-12-30 | ||
JP44050780A JPS4843755B1 (en) | 1969-06-26 | 1969-06-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL33558A0 IL33558A0 (en) | 1970-04-20 |
IL33558A true IL33558A (en) | 1973-10-25 |
Family
ID=26332992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL33558A IL33558A (en) | 1968-12-30 | 1969-12-17 | Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production |
Country Status (6)
Country | Link |
---|---|
ES (1) | ES375013A1 (en) |
FI (1) | FI46259C (en) |
GB (1) | GB1299198A (en) |
IE (1) | IE33906B1 (en) |
IL (1) | IL33558A (en) |
RO (1) | RO55813A (en) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464467A (en) * | 1982-07-26 | 1984-08-07 | Bristol-Myers Company | Antitumor antibiotics produced by new streptomyces |
GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
DK1109812T3 (en) | 1998-08-27 | 2005-09-05 | Spirogen Ltd | pyrrolobenzodiazepines |
GB9818732D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
US6909006B1 (en) | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
EP2270010B1 (en) | 2004-03-01 | 2012-01-25 | Spirogen Limited | 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepins |
GB0404577D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
EP1723152B1 (en) | 2004-03-09 | 2015-02-11 | Spirogen Sàrl | Pyrrolobenzodiazepines |
GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
AU2011239522B2 (en) | 2010-04-15 | 2014-10-23 | Medimmune Limited | Targeted pyrrolobenzodiazapine conjugates |
AU2011239525B2 (en) | 2010-04-15 | 2015-04-09 | Medimmune Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
GB201006340D0 (en) | 2010-04-15 | 2010-06-02 | Spirogen Ltd | Synthesis method and intermediates |
AU2012311505B2 (en) | 2011-09-20 | 2016-09-29 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
EA036202B1 (en) | 2011-10-14 | 2020-10-14 | Сиэтл Дженетикс, Инк. | Pyrrolobenzodiazepines and targeted conjugates |
KR101891859B1 (en) | 2011-10-14 | 2018-08-24 | 메디뮨 리미티드 | Pyrrolobenzodiazepines |
AU2012322933B2 (en) | 2011-10-14 | 2017-02-02 | Medimmune Limited | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
JP6117801B2 (en) | 2011-10-14 | 2017-04-19 | メドイミューン・リミテッドMedImmune Limited | Pyrrolobenzodiazepine |
US9526798B2 (en) | 2011-10-14 | 2016-12-27 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
AU2013328625B2 (en) | 2012-10-12 | 2016-12-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
BR112015008238A2 (en) | 2012-10-12 | 2017-11-28 | Adc Therapeutics Sarl | pyrrolbenzodiazepine-anti-cd22 antibody conjugates |
HUE042731T2 (en) | 2012-10-12 | 2019-07-29 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
AU2013328673B2 (en) | 2012-10-12 | 2017-07-13 | Medimmune Limited | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
SI2906253T1 (en) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
WO2014057120A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
EP2906248B1 (en) | 2012-10-12 | 2018-12-05 | MedImmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
ES2680153T3 (en) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Anti-PSMA-pyrrolobenzodiazepine antibody conjugates |
HUE045435T2 (en) | 2012-10-12 | 2019-12-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
US9956299B2 (en) | 2013-10-11 | 2018-05-01 | Medimmune Limited | Pyrrolobenzodiazepine—antibody conjugates |
GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CN107148285B (en) | 2014-11-25 | 2022-01-04 | Adc治疗股份有限公司 | Pyrrolobenzodiazepine-antibody conjugates |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
JP6671555B2 (en) | 2017-02-08 | 2020-03-25 | アーデーセー セラピューティクス ソシエテ アノニム | Pyrrolobenzodiazepine antibody conjugate |
AU2018255876B2 (en) | 2017-04-18 | 2020-04-30 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
AU2018253948A1 (en) | 2017-04-20 | 2019-09-19 | Adc Therapeutics Sa | Combination therapy with an anti-AXL Antibody-Drug Conjugate |
MX2019015042A (en) | 2017-06-14 | 2020-08-06 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-cd19 adc. |
KR102270107B1 (en) | 2017-08-18 | 2021-06-30 | 메디뮨 리미티드 | pyrrolobenzodiazepine conjugate |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
-
1969
- 1969-12-17 IL IL33558A patent/IL33558A/en unknown
- 1969-12-22 FI FI693710A patent/FI46259C/en active
- 1969-12-24 GB GB62863/69A patent/GB1299198A/en not_active Expired
- 1969-12-29 ES ES375013A patent/ES375013A1/en not_active Expired
- 1969-12-30 IE IE1726/69A patent/IE33906B1/en unknown
- 1969-12-30 RO RO62025A patent/RO55813A/ro unknown
Also Published As
Publication number | Publication date |
---|---|
FI46259B (en) | 1972-10-31 |
ES375013A1 (en) | 1972-03-01 |
FI46259C (en) | 1973-02-12 |
IL33558A0 (en) | 1970-04-20 |
RO55813A (en) | 1974-02-01 |
IE33906L (en) | 1970-06-30 |
IE33906B1 (en) | 1974-12-11 |
GB1299198A (en) | 1972-12-06 |
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