CY1112531T1 - Δραστικα για το κνς συντηγμενα δικυκλοετεροκυκλικα υποκατεστημενα αζαδικυκλικα αλκανιου παραγωγα - Google Patents
Δραστικα για το κνς συντηγμενα δικυκλοετεροκυκλικα υποκατεστημενα αζαδικυκλικα αλκανιου παραγωγαInfo
- Publication number
- CY1112531T1 CY1112531T1 CY20111101269T CY111101269T CY1112531T1 CY 1112531 T1 CY1112531 T1 CY 1112531T1 CY 20111101269 T CY20111101269 T CY 20111101269T CY 111101269 T CY111101269 T CY 111101269T CY 1112531 T1 CY1112531 T1 CY 1112531T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cyclots
- bicyclehetic
- cns
- activities
- synthesized
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/08—Diarylmethoxy radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η εφεύρεση αφορά συντηγμένα δικυκλοετεροκυκλικά υποκατεστημένα αζαδικυκλικά αλκανίου παράγωγα του τύπου (Ι) ή φαρμακευτικώς αποδεκτό άλας, εστέρα, αμίδιο ή προφάρμακο αυτών, όπου το η είναι 1, 2 ή 3, το Α είναι Ν ή Ν+-Ο- το R είναι υδρογόνο, αλκύλ, κυκλοαλκυλαλκύλ και αραλκύλ, το L επιλέγεται από την ομάδα που αποτελείται από Ο, S και -Ν(Ra)-, το Ar1 είναι 6-μελής αρυλ ή 6 μελής ετεροαρύλ δακτύλιος και το ΑR2 είναι δικυκλικό ετεροαρύλ και το Ra επιλέγεται από την ομάδα που αποτελείται από υδρογόνο, αλκύλ και αλκυλκαρβονύλ, υπό την προϋπόθεση ότι εάν το Ar2 είναι του τύπου (II), τότε το L είναι Ο ή S. Συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις και μεθόδους θεραπείας καταστάσεων και διαταραχών χρησιμοποιώντας τέτοιες ενώσεις και συνθέσεις.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80219506P | 2006-05-19 | 2006-05-19 | |
EP07797473A EP2018380B1 (en) | 2006-05-19 | 2007-05-15 | Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112531T1 true CY1112531T1 (el) | 2015-12-09 |
Family
ID=38662941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111101269T CY1112531T1 (el) | 2006-05-19 | 2011-12-20 | Δραστικα για το κνς συντηγμενα δικυκλοετεροκυκλικα υποκατεστημενα αζαδικυκλικα αλκανιου παραγωγα |
Country Status (30)
Country | Link |
---|---|
US (2) | US7872017B2 (el) |
EP (2) | EP2018380B1 (el) |
JP (3) | JP5420398B2 (el) |
KR (1) | KR20090018972A (el) |
CN (2) | CN102516241B (el) |
AT (1) | ATE529423T1 (el) |
AU (1) | AU2007253950B2 (el) |
BR (1) | BRPI0711588A2 (el) |
CA (1) | CA2647830C (el) |
CY (1) | CY1112531T1 (el) |
DK (1) | DK2018380T3 (el) |
EC (1) | ECSP088918A (el) |
ES (2) | ES2373792T3 (el) |
GT (1) | GT200800248A (el) |
HK (1) | HK1122569A1 (el) |
HR (1) | HRP20110917T1 (el) |
IL (1) | IL195234A0 (el) |
MX (1) | MX2008014672A (el) |
MY (1) | MY147661A (el) |
NO (1) | NO20085153L (el) |
NZ (2) | NZ573735A (el) |
PL (1) | PL2018380T3 (el) |
PT (1) | PT2018380E (el) |
RS (1) | RS52062B (el) |
RU (2) | RU2437884C2 (el) |
SI (1) | SI2018380T1 (el) |
TW (1) | TWI343385B (el) |
UA (1) | UA92083C2 (el) |
WO (1) | WO2007137030A2 (el) |
ZA (2) | ZA200810687B (el) |
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BR112015016992A8 (pt) | 2013-01-15 | 2018-01-23 | Novartis Ag | uso de agonistas do receptor alfa 7 nicotínico de acetilcolina |
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