CY1110157T1 - Χιμαιρικα ανασυνδυασμενα αντιγονα του toxoplasma gondii - Google Patents

Χιμαιρικα ανασυνδυασμενα αντιγονα του toxoplasma gondii

Info

Publication number
CY1110157T1
CY1110157T1 CY20101100583T CY101100583T CY1110157T1 CY 1110157 T1 CY1110157 T1 CY 1110157T1 CY 20101100583 T CY20101100583 T CY 20101100583T CY 101100583 T CY101100583 T CY 101100583T CY 1110157 T1 CY1110157 T1 CY 1110157T1
Authority
CY
Cyprus
Prior art keywords
toxoplasma gondii
antigens
chemical recovery
recovery
chemical
Prior art date
Application number
CY20101100583T
Other languages
English (en)
Inventor
Nicola Gargano
Elisa Beghetto
Andrea Spadoni
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of CY1110157T1 publication Critical patent/CY1110157T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/002Protozoa antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/45Toxoplasma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

Η εφεύρεση που περιγράφεται στο κείμενο σχετίζεται με μέθοδο συνδυασμού αντιγονοθραυσμάτων από πρωτεΐνες του Toxoplasma gondii, στη μορφή χιμαιρικών προϊόντων σύντηξης, και με τη χρήση τους ως διαγνωστικά και ανοσογόνα μέσα.
CY20101100583T 2005-03-08 2010-06-25 Χιμαιρικα ανασυνδυασμενα αντιγονα του toxoplasma gondii CY1110157T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05005065 2005-03-08
EP06723123A EP1856159B1 (en) 2005-03-08 2006-02-27 Chimeric recombinant antigens of toxoplasma gondii

Publications (1)

Publication Number Publication Date
CY1110157T1 true CY1110157T1 (el) 2015-01-14

Family

ID=34934134

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100583T CY1110157T1 (el) 2005-03-08 2010-06-25 Χιμαιρικα ανασυνδυασμενα αντιγονα του toxoplasma gondii

Country Status (22)

Country Link
US (3) US7790187B2 (el)
EP (1) EP1856159B1 (el)
JP (1) JP2008535481A (el)
KR (1) KR20080003330A (el)
CN (1) CN101137674A (el)
AT (1) ATE463515T1 (el)
AU (1) AU2006222315A1 (el)
BR (1) BRPI0608342A2 (el)
CA (1) CA2599620A1 (el)
CY (1) CY1110157T1 (el)
DE (1) DE602006013428D1 (el)
DK (1) DK1856159T3 (el)
EA (1) EA013349B1 (el)
ES (1) ES2342971T3 (el)
HR (1) HRP20100370T1 (el)
IL (1) IL184845A (el)
MX (1) MX2007009524A (el)
PL (1) PL1856159T3 (el)
PT (1) PT1856159E (el)
RS (1) RS51327B (el)
SI (1) SI1856159T1 (el)
WO (1) WO2006094665A1 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2687223A1 (en) * 2007-06-29 2009-01-08 Prionics Ag Diagnostic composition and method for the detection of a trichinella infection
WO2012088125A2 (en) * 2010-12-23 2012-06-28 Immport Therapeutics, Inc. Methods and compositions of protein antigens for the diagnosis and treatment of toxoplasma gondii infections and toxoplasmosis
CN102288768A (zh) * 2011-09-19 2011-12-21 厦门市湖里区妇幼保健院 弓形虫IgG抗体免疫印迹试剂盒及其制备方法
CN102492696B (zh) * 2011-12-13 2014-01-29 北京英诺特生物技术有限公司 一种重组弓形虫蛋白及其应用
CN103235119B (zh) * 2013-04-11 2015-09-16 南京农业大学 一种用于弓形虫感染的诊断抗原的应用
CN103251960B (zh) * 2013-05-27 2014-08-13 山东大学 用于预防人或动物慢性弓形虫病的dna疫苗
CN104152466A (zh) * 2014-04-04 2014-11-19 中国农业科学院兰州兽医研究所 一种用于弓形虫感染预防的疫苗和制备方法及其应用
WO2016046321A1 (en) * 2014-09-25 2016-03-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for treating cancer and infectious diseases
CN105759030B (zh) * 2016-03-15 2018-01-02 中国农业大学 一种检测弓形虫抗体的胶体金试纸条
CN106153894A (zh) * 2016-08-12 2016-11-23 江苏泽成生物技术有限公司 一种测定弓形虫IgM抗体的检测试剂盒及其检测方法
CN108265070B (zh) * 2016-12-30 2022-07-26 中国农业科学院上海兽医研究所 一种特异性的检测弓形虫的方法
CN107253983A (zh) * 2017-06-28 2017-10-17 潍坊汉唐生物工程有限公司 一种检测弓形虫抗体的重组蛋白组合物及其制备方法
CN108165569A (zh) * 2017-11-10 2018-06-15 江苏省血吸虫病防治研究所 一种快速检测弓形虫的重组蛋白及其制备方法和应用
EP3849590A4 (en) 2018-09-14 2022-09-28 Prommune, Inc. ANTIPARASITIC IMMUNOLOGICAL COMPOSITIONS
CN109369796A (zh) * 2018-09-27 2019-02-22 华中农业大学 一种检测羊弓形虫IgG抗体的酶联免疫方法
CN110540602B (zh) * 2019-08-28 2023-02-14 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) 一种弓形虫表面抗原gra1和gra7重组蛋白胶体金试纸条
CN110818787B (zh) * 2019-12-04 2023-08-04 南京医科大学 一种增加Ly6C+巨噬细胞的抗原及其应用
CN111116726A (zh) * 2020-01-14 2020-05-08 中国农业科学院北京畜牧兽医研究所 用于检测弓形虫的重组蛋白及其编码基因

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2226468A1 (en) 1973-04-18 1974-11-15 Merieux Bd Toxoplasma antigens - as agents for detecting toxoplasmosis by direct agglutination
SU533376A1 (ru) 1973-08-31 1976-10-30 Научно-исследовательский ветеринарный институт Способ получени токсоплазменного антигена
JPS5444016A (en) 1977-09-13 1979-04-07 Nippon Touketsu Kansou Kenkiyu Latex coagulation and reaction reagent for detecting toxoplasma antibody and production thereof
DE3940598A1 (de) 1989-12-08 1991-06-13 Behringwerke Ag Toxoplasma gondii-antigene, ihre herstellung und ihre verwendung
FR2518407A1 (fr) 1981-12-17 1983-06-24 Merieux Inst Nouvel antigene pour la recherche de l'immunite toxoplasmique et son procede de preparation
US6265176B1 (en) * 1985-10-29 2001-07-24 Cordis Corporation Dot immunoassay on plastic sheets
IT1196817B (it) 1986-12-03 1988-11-25 Consiglio Nazionale Ricerche Procedimento per l'ottenimento di una preparazione di antigene toxoplasmico insolubile corredo diagnostico comprendente tale preparazione e saggio diagnostico che la utilizza
FR2618680B1 (fr) 1987-07-31 1990-05-11 Pasteur Institut Antigenes d'excretion-secretion specifiques de toxoplasma gondii, leurs produits d'expression, leur procede d'obtention et leurs applications diagnostiques et prophylactiques
FR2625099B1 (fr) 1987-12-24 1991-06-14 Transgene Sa Proteines et leur procede de preparation, sequences d'adn, anticorps et leur application, poxvirus, cellules transformees ou infectees et compositions pharmaceutiques utiles dans la prevention de la toxoplasmose
US4877726A (en) * 1988-03-02 1989-10-31 Research Institute Of Palo Alto Medical Foundation Method for the detection of acute-phase toxoplasma infection
SG48953A1 (en) 1988-03-09 1998-05-18 Univ Leland Stanford Junior Diagnostic genes for toxoplasmosis
FR2633309B1 (fr) 1988-06-24 1992-04-24 Pasteur Institut Sequence d'adn codant pour la proteine p30 de toxoplasma gondii, produits d'expression de cette sequence, leurs procedes d'obtention et leurs applications
JPH02261382A (ja) 1989-04-03 1990-10-24 Mochida Pharmaceut Co Ltd トキソプラズマ由来新規dna配列およびそれによってコードされる蛋白質
US5665542A (en) * 1989-11-03 1997-09-09 Research Institute Of Palo Alto Medical Foundation Toxoplasma gondii P28 gene and methods for its use
US5215917A (en) * 1989-11-03 1993-06-01 Research Institute Of Palo Alto Medical Foundation Nucleotide sequence encoding the Toxoplasma gondii P22 gene
FR2664290B1 (fr) 1990-07-05 1993-01-29 Centre Nat Rech Scient Sondes genetiques specifiques de toxoplasma gondii, et leur utilisation pour la detection in vitro de toxoplasma gondii et pour le typage des souches toxoplasmiques.
WO1992002624A1 (en) 1990-08-10 1992-02-20 The Flinders University Of South Australia Cloning and expression of toxoplasma antigens and use of recombinant antigens
GB9027728D0 (en) 1990-12-20 1991-02-13 Smithkline Beecham Biolog Novel protein
FR2692282B1 (fr) * 1992-06-15 1995-07-13 Pasteur Institut Clonage du gene codant pour la proteine gp28.5 de t. gondii; fragments peptidiques issus de ladite proteine et leurs applications.
AU6172194A (en) 1993-02-08 1994-08-29 Paravax, Inc. Defective sindbis virus vectors that express (toxoplasma gondii) p30 antigens
FR2702491B1 (fr) 1993-03-12 1995-04-28 Pasteur Institut Clonage de gènes codant pour des antigènes d'excrétion-sécrétion P21 et P32 de toxoplasme, préparations de tels antigènes, fragments de ceux-ci et leurs applications.
US5976553A (en) * 1993-11-04 1999-11-02 The Board Of Trustees Of The Leland Stanford Junior University Transfection and genetic manipulations in obligate intracellular parasites
FR2722508B1 (fr) 1994-07-13 1996-10-04 Transgene Sa Cassette d'expression d'une proteine p30 de toxoplasma gondii
EP0710724A2 (en) 1994-10-06 1996-05-08 Akzo Nobel N.V. Toxoplasma gondii antigens
FR2729960A1 (fr) 1995-01-30 1996-08-02 Bio Merieux Polypeptides mimotopes de toxoplasma gondii et applications
JP2000506376A (ja) 1996-01-26 2000-05-30 イノジェネティックス・ナムローゼ・フェンノートシャップ トキソプラズマ・ゴンジイ抗原Tg20
SE505631C2 (sv) 1996-08-30 1997-09-22 Scania Cv Ab Buss med tvärställt bakre drivaggregat
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
JP3831754B2 (ja) 1997-10-23 2006-10-11 青才 文江 トキソプラズマ・ゴンディ抗原、これをコードする核酸並びに該抗原に対する抗体
JP3336275B2 (ja) 1997-10-23 2002-10-21 明彦 矢野 トキソプラズマ・ゴンディ抗原、該抗原に対する抗体及び該抗原又は抗体を用いた免疫測定方法
US6514694B2 (en) 1997-12-19 2003-02-04 Heska Corporation Methods for the detection of encysted parasites
US5962654A (en) * 1998-01-30 1999-10-05 International Business Machines Operation Alkoxyalkoxides and use to form films
NZ507793A (en) 1998-05-01 2003-05-30 Schering Plough Ltd Recombinant virus expressing foreign DNA encoding feline CD80, feline CTLA-4 or feline CD86 and uses thereof
US6329157B1 (en) * 1998-05-28 2001-12-11 Abbott Laboratories Antigen cocktails and uses thereof
CA2333598C (en) 1998-05-28 2009-10-13 Abbott Laboratories Toxoplasma gondii antigens, p35, and uses thereof
CA2330209A1 (en) 1998-06-12 1999-12-23 Smithkline Beecham Biologicals S.A. Recombinant production of toxoplasma sag1 antigen
JP4545869B2 (ja) 2000-02-23 2010-09-15 日本ケミファ株式会社 多孔性フィルタを用いる生理活性試料物質の測定方法
FR2805466A1 (fr) 2000-02-25 2001-08-31 Virsol Utilisation de la proteine mic3 de toxoplasma gondii ou d'un de ses derives en tant qu'agent immunogene ou en tant qu'antigene de vaccination
US7176286B2 (en) * 2002-03-21 2007-02-13 Kenton S.R.L. Antigen fragments for the diagnosis of Toxoplasma gondii
US7094879B2 (en) * 2002-10-02 2006-08-22 Abbott Laboratories Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof
CN1194991C (zh) * 2003-05-09 2005-03-30 李越希 重组弓形虫融合蛋白抗原及其制备方法、应用

Also Published As

Publication number Publication date
KR20080003330A (ko) 2008-01-07
US20080280307A1 (en) 2008-11-13
US7790187B2 (en) 2010-09-07
CA2599620A1 (en) 2006-09-14
DK1856159T3 (da) 2010-07-05
HRP20100370T1 (hr) 2010-08-31
AU2006222315A1 (en) 2006-09-14
ATE463515T1 (de) 2010-04-15
EA013349B1 (ru) 2010-04-30
EP1856159A1 (en) 2007-11-21
CN101137674A (zh) 2008-03-05
DE602006013428D1 (de) 2010-05-20
EA200701911A1 (ru) 2008-02-28
US20110027810A1 (en) 2011-02-03
PT1856159E (pt) 2010-06-22
EP1856159B1 (en) 2010-04-07
BRPI0608342A2 (pt) 2009-12-01
WO2006094665A1 (en) 2006-09-14
US7867503B2 (en) 2011-01-11
SI1856159T1 (sl) 2010-08-31
US20090092630A1 (en) 2009-04-09
JP2008535481A (ja) 2008-09-04
IL184845A (en) 2011-06-30
RS51327B (en) 2011-02-28
PL1856159T3 (pl) 2010-09-30
ES2342971T3 (es) 2010-07-20
IL184845A0 (en) 2007-12-03
MX2007009524A (es) 2008-03-04

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