CY1110142T1 - Ουρικη οξειδαση ελευθερη συσσωματωματων για την παρασκευη μη ανοσογονων συζευγματων με πολυμερες - Google Patents

Ουρικη οξειδαση ελευθερη συσσωματωματων για την παρασκευη μη ανοσογονων συζευγματων με πολυμερες

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Publication number
CY1110142T1
CY1110142T1 CY20101100597T CY101100597T CY1110142T1 CY 1110142 T1 CY1110142 T1 CY 1110142T1 CY 20101100597 T CY20101100597 T CY 20101100597T CY 101100597 T CY101100597 T CY 101100597T CY 1110142 T1 CY1110142 T1 CY 1110142T1
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Cyprus
Prior art keywords
polymer
immuncerable
ural
condensers
making non
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CY20101100597T
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English (en)
Inventor
Merry R Sherman
Mark G P Saifer
L David Williams
Michael S Hershfield
Susan J Kelly
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Mountain View Pharmaceuticals Inc
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Publication date
Application filed by Mountain View Pharmaceuticals Inc filed Critical Mountain View Pharmaceuticals Inc
Publication of CY1110142T1 publication Critical patent/CY1110142T1/el

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Biotechnology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Φυσικώς απαντώμενη ή ανασυνδυασμένη πρωτεΐνη, ιδίως μουτεΐνη ουρικής οξειδάσης (ουρικάση) χοίρου, που είναι κατ' ουσίαν ελεύθερη μεγάλων συσσωματωμάτων μπορεί να καταστεί κατ' ουσίαν μη ανοσογόνος μέσω σύζευξης με αρκούντως μικρό αριθμό αλυσίδων πολυμερούς ώστε η βιοενεργότητα της πρωτεΐνης στο σύζευγμα κατ'ουσίαν να διατηρείται. Τέτοια συζεύγματα είναι κατάλληλα για αγωγή χρόνιων καταστάσεων, καθώς εμφανίζουν μικρότερη πιθανότητα επαγωγής σχηματισμού αντισωμάτων και/ή ταχύτερης κάθαρσης σε σύγκριση με όμοια συζεύγματα παρασκευαζόμενα από παρασκευάσματα πρωτεΐνης που περιέχουν ίχνη μεγάλων συσσωματωμάτων.
CY20101100597T 2000-02-10 2010-06-29 Ουρικη οξειδαση ελευθερη συσσωματωματων για την παρασκευη μη ανοσογονων συζευγματων με πολυμερες CY1110142T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/501,730 US6783965B1 (en) 2000-02-10 2000-02-10 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP01923265A EP1254237B1 (en) 2000-02-10 2001-02-07 Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

Publications (1)

Publication Number Publication Date
CY1110142T1 true CY1110142T1 (el) 2015-01-14

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Application Number Title Priority Date Filing Date
CY20101100597T CY1110142T1 (el) 2000-02-10 2010-06-29 Ουρικη οξειδαση ελευθερη συσσωματωματων για την παρασκευη μη ανοσογονων συζευγματων με πολυμερες
CY2013028C CY2013028I1 (el) 2000-02-10 2013-07-04 Ουρικη οξειδαση ελευθερη συσσωματωματων για την παρασκευη μη ανοσογονων συζευγματων με πολυμερες
CY20151100129T CY1117264T1 (el) 2000-02-10 2015-02-09 Συζευγματα παρασκευαζομενα με πρωτεϊνες ελευθερες συσσωματωματων

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY2013028C CY2013028I1 (el) 2000-02-10 2013-07-04 Ουρικη οξειδαση ελευθερη συσσωματωματων για την παρασκευη μη ανοσογονων συζευγματων με πολυμερες
CY20151100129T CY1117264T1 (el) 2000-02-10 2015-02-09 Συζευγματα παρασκευαζομενα με πρωτεϊνες ελευθερες συσσωματωματων

Country Status (28)

Country Link
US (3) US6783965B1 (el)
EP (3) EP2196538B1 (el)
JP (2) JP5165826B2 (el)
KR (3) KR101054247B1 (el)
CN (2) CN100491532C (el)
AT (1) ATE463576T1 (el)
AU (3) AU4997501A (el)
BE (1) BE2013C045I2 (el)
BR (1) BRPI0108386B8 (el)
CA (1) CA2398679C (el)
CY (3) CY1110142T1 (el)
CZ (1) CZ304864B6 (el)
DE (1) DE60141742D1 (el)
DK (3) DK2196538T3 (el)
ES (2) ES2343105T3 (el)
FR (1) FR13C0036I2 (el)
HK (4) HK1056742A1 (el)
HU (1) HU227127B1 (el)
IL (3) IL151065A0 (el)
LU (1) LU92237I2 (el)
MX (1) MXPA02007545A (el)
NZ (1) NZ520434A (el)
PL (1) PL208064B1 (el)
PT (2) PT1254237E (el)
RU (3) RU2352354C2 (el)
TW (2) TW200914617A (el)
WO (1) WO2001059078A2 (el)
ZA (1) ZA200207206B (el)

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