CS991A2 - Azaoxindole derivatives and method of their production - Google Patents

Azaoxindole derivatives and method of their production Download PDF

Info

Publication number
CS991A2
CS991A2 CS919A CS991A CS991A2 CS 991 A2 CS991 A2 CS 991A2 CS 919 A CS919 A CS 919A CS 991 A CS991 A CS 991A CS 991 A2 CS991 A2 CS 991A2
Authority
CS
Czechoslovakia
Prior art keywords
carbon atoms
alkyl
phenyl
formula
mmol
Prior art date
Application number
CS919A
Other languages
Czech (cs)
English (en)
Inventor
Ralph P Robison
Anthony Marfat
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CS991A2 publication Critical patent/CS991A2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS919A 1990-01-05 1991-01-04 Azaoxindole derivatives and method of their production CS991A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/000107 WO1991009598A1 (en) 1990-01-05 1990-01-05 Azaoxindole derivatives

Publications (1)

Publication Number Publication Date
CS991A2 true CS991A2 (en) 1991-09-15

Family

ID=22220612

Family Applications (1)

Application Number Title Priority Date Filing Date
CS919A CS991A2 (en) 1990-01-05 1991-01-04 Azaoxindole derivatives and method of their production

Country Status (19)

Country Link
EP (1) EP0436333A3 (pt)
JP (1) JPH0826018B2 (pt)
KR (1) KR930005447B1 (pt)
CN (1) CN1031053C (pt)
AU (1) AU635593B2 (pt)
BR (1) BR9100046A (pt)
CA (1) CA2033531C (pt)
CS (1) CS991A2 (pt)
FI (1) FI922347A0 (pt)
IE (1) IE910022A1 (pt)
IL (1) IL96819A0 (pt)
MY (1) MY109722A (pt)
NO (1) NO922634D0 (pt)
NZ (1) NZ236582A (pt)
PL (2) PL165653B1 (pt)
PT (1) PT96411B (pt)
WO (1) WO1991009598A1 (pt)
YU (1) YU47728B (pt)
ZA (1) ZA9172B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1625192A (en) * 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
FR2722196B1 (fr) * 1994-07-07 1996-08-23 Adir Nouveaux derives amines de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2 (3h)-ones, leur procede de preparation et les compositions pharmaceutique qui les contiennent
US5618819A (en) * 1994-07-07 1997-04-08 Adir Et Compagnie 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
FR2722195B1 (fr) * 1994-07-07 1996-08-23 Adir Nouveaux derives de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2(3h)-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5939069A (en) * 1996-08-23 1999-08-17 University Of Florida Materials and methods for detection and treatment of immune system dysfunctions
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
AU770375B2 (en) * 1998-12-17 2004-02-19 F. Hoffmann-La Roche Ag 4-alkenyl (and alkynyl) oxindoles as inhibitors of cyclin-dependent kinases, in particular CDK2
WO2000035921A1 (en) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4,5-pyrazinoxindoles as protein kinase inhibitors
JP2002532493A (ja) 1998-12-17 2002-10-02 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋプロテインキナーゼ阻害剤としての４−アリールオキシインドール
US6153634A (en) * 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
CO5271715A1 (es) 1999-12-21 2003-04-30 Sugen Inc 7-aza-indolin-2-onas sustituidas en 4 y su uso como inhibidores de proteiuna quinasa
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
DE10053275A1 (de) * 2000-10-27 2002-05-02 Dresden Arzneimittel Neue 7-Azaindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
TWI262920B (en) 2000-10-27 2006-10-01 Elbion Ag New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
KR20050013534A (ko) * 2002-03-28 2005-02-04 에자이 가부시키가이샤 ｃ─Ｊｕｎ Ｎ─말단 키나아제 억제용 아자인돌
TW200611695A (en) 2004-06-09 2006-04-16 Glaxo Group Ltd Pyrrolopyridine derivatives
US7906528B2 (en) * 2004-10-05 2011-03-15 Novartis International Pharmaceutical Ltd. Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
WO2009147476A1 (en) * 2008-06-02 2009-12-10 Matrix Laboratories Ltd. Novel pde inhibitors, pharmaceutical compositions containing them and processes for their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
DE3681358D1 (de) * 1985-07-09 1991-10-17 Pfizer Substituierte oxindol-3-carboxamine als entzuendungshemmendes und schmerzstillendes mittel.
WO1989012637A1 (en) * 1988-06-14 1989-12-28 Schering Corporation Heterobicyclic compounds having antiinflammatory activity

Also Published As

Publication number Publication date
AU635593B2 (en) 1993-03-25
BR9100046A (pt) 1991-10-22
JPH04210981A (ja) 1992-08-03
WO1991009598A1 (en) 1991-07-11
MY109722A (en) 1997-05-31
EP0436333A3 (en) 1992-05-27
PL165653B1 (pl) 1995-01-31
PT96411A (pt) 1991-10-15
CA2033531C (en) 1998-06-23
KR930005447B1 (ko) 1993-06-22
PL288598A1 (en) 1991-12-02
KR910014375A (ko) 1991-08-31
EP0436333A2 (en) 1991-07-10
AU6860691A (en) 1992-03-05
NO922634L (no) 1992-07-03
NO922634D0 (no) 1992-07-03
CA2033531A1 (en) 1991-07-06
FI922347A (fi) 1992-05-22
YU47728B (sh) 1996-01-08
JPH0826018B2 (ja) 1996-03-13
CN1031053C (zh) 1996-02-21
YU791A (sh) 1994-01-20
ZA9172B (en) 1992-10-28
CN1053065A (zh) 1991-07-17
NZ236582A (en) 1993-10-26
PT96411B (pt) 1999-04-30
IL96819A0 (en) 1991-09-16
PL166512B1 (pl) 1995-05-31
IE910022A1 (en) 1991-07-17
FI922347A0 (fi) 1992-05-22

Similar Documents

Publication Publication Date Title
CS991A2 (en) Azaoxindole derivatives and method of their production
CA2977750C (en) 4-methoxy pyrrole derivatives or salts thereof for preventing or treating gastrointestinal damage
KR0174752B1 (ko) 이환식 헤테로환 함유 술폰아미드 유도체 및 그 제조방법
US5721246A (en) Heterobicyclic sulfonamide and sulfonic ester derivatives
TWI721335B (zh) 鹵代烯丙基胺類ssao/vap-1抑制劑及其用途
KR100926399B1 (ko) 디아릴아민―함유 화합물 및 조성물, 및 스테로이드 호르몬핵 수용체의 조절제로서의 그들의 용도
AU2008310874B2 (en) Heterocyclic compounds as CRTH2 receptor antagonists
EP2235015B1 (fr) Derives de carboxam i d es azabicycliques, leur preparation et leur application en therapeutique.
EP2235014B1 (fr) Dérivés bicycliques de carboxamides azabicycliques, leur préparation et leur application en thérapeutique.
EP2280706B1 (en) Lipoprotein lipase-activating compositions comprising benzene derivatives
TWI469977B (zh) ７－苯氧基唍羧酸衍生物
CZ110198A3 (cs) (Methylsulfonyl)fenyl-2-(5H)-furanonové deriváty a farmaceutický prostředek s jejich obsahem
PL163941B1 (pl) Sposób wytwarzania nowych 3-podstawionych pochodnych 2-oksindolu PL PL PL PL
WO2014104757A1 (ko) Btk 키나아제 억제제로서의 2,3-디하이드로-이소인돌-1-온 유도체 및 이를 함유하는 약학적 조성물
TW201018684A (en) New compounds
TR201807104T4 (tr) Sikloalkil asit türevi, bunun hazırlanış yöntemi ve farmasötik uygulaması.
BRPI0708507A2 (pt) Novos antagonistas de receptores de dupla ação (dara) para os receptores at1 eta
JP2005508337A (ja) 化合物
JP2002114768A (ja) ２−（２，５−ジハロゲン−３，４−ジヒドロキシフェニル）アゾール化合物及びそれを含有してなる医薬組成物
US5811432A (en) Azaoxindole derivatives
KR920007269B1 (ko) 에틸렌디아민 모노아미드 유도체의 제조방법
US5439917A (en) Active compounds
CA3128846A1 (en) Difluoromethylene compound
CA2721576A1 (en) Compound having npy y5 receptor antagonist activity
JP2002020386A (ja) ピラゾロピリジン誘導体