CR8274A - Piridina, pirazina y pirimidinas fusionados con heteroarilos como receptores de crf1 - Google Patents
Piridina, pirazina y pirimidinas fusionados con heteroarilos como receptores de crf1Info
- Publication number
- CR8274A CR8274A CR8274A CR8274A CR8274A CR 8274 A CR8274 A CR 8274A CR 8274 A CR8274 A CR 8274A CR 8274 A CR8274 A CR 8274A CR 8274 A CR8274 A CR 8274A
- Authority
- CR
- Costa Rica
- Prior art keywords
- crf1
- receptors
- pirimidines
- heteroarilos
- pirazina
- Prior art date
Links
- 102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 title abstract 2
- 101000878678 Homo sapiens Corticotropin-releasing factor receptor 1 Proteins 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 101000948733 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Probable phospholipid translocase non-catalytic subunit CRF1 Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 108091005471 CRHR1 Proteins 0.000 abstract 3
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 abstract 2
- 108091005470 CRHR2 Proteins 0.000 abstract 1
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- -1 specifically Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invencion provee nuevos compuestos de formula I, y composiciones farmaceuticas que comprenden compuestos de formula I y al menos un portador o excipiente farmaceuticamente aceptable. Tales compuestos se unen a los receptores en la superficie de las celulas, preferentemente proteinas G receptoras unidas, especificamente, receptores CRF (incluyendo los receptores de CRF1 y CRF2), y mas preferentemente los receptores CRF1. Los compuestos preferidos de la invencion presentan una alta afinidad por los receptores de CRF, preferentemente los receptores de CRF1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50041403P | 2003-09-05 | 2003-09-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR8274A true CR8274A (es) | 2008-06-10 |
Family
ID=34272952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR8274A CR8274A (es) | 2003-09-05 | 2006-03-03 | Piridina, pirazina y pirimidinas fusionados con heteroarilos como receptores de crf1 |
Country Status (19)
Country | Link |
---|---|
US (2) | US20050113379A1 (es) |
EP (1) | EP1680424A2 (es) |
JP (1) | JP2007504271A (es) |
KR (1) | KR20060088534A (es) |
CN (1) | CN1878773A (es) |
AP (1) | AP2006003559A0 (es) |
AR (1) | AR045582A1 (es) |
AU (1) | AU2004270713A1 (es) |
BR (1) | BRPI0414087A (es) |
CA (1) | CA2537829A1 (es) |
CR (1) | CR8274A (es) |
EA (1) | EA200600372A1 (es) |
EC (1) | ECSP066408A (es) |
IL (1) | IL174084A0 (es) |
MA (1) | MA28086A1 (es) |
NO (1) | NO20061180L (es) |
TW (1) | TW200530232A (es) |
WO (1) | WO2005023806A2 (es) |
ZA (1) | ZA200601978B (es) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004274403A1 (en) * | 2003-09-03 | 2005-03-31 | Aventis Pharmaceuticals Inc. | 5-aryl-Pyrazolo(4,3-d)pyrimidines, pyridines, and pyrazines and related compounds |
AU2006255028B2 (en) | 2005-06-06 | 2012-04-19 | Intra-Cellular Therapies, Inc. | Organic compounds |
RU2008110941A (ru) | 2005-08-25 | 2009-09-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | ИНГИБИТОРЫ КИНАЗЫ p38 МАР И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
JP5147401B2 (ja) * | 2005-09-06 | 2013-02-20 | 塩野義製薬株式会社 | Pgd2受容体アンタゴニスト活性を有するインドールカルボン酸誘導体 |
US7405302B2 (en) * | 2005-10-11 | 2008-07-29 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (FLAP) inhibitors |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
SI2395002T1 (sl) | 2005-11-08 | 2014-10-30 | Vertex Pharmaceuticals Incorporated | Farmacevtski sestavek, vsebujoč heterociklični modulator prenašalcev z ATP-vezavno kaseto |
GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
JPWO2007069671A1 (ja) | 2005-12-15 | 2009-05-21 | 小野薬品工業株式会社 | 二環式複素環化合物 |
TW200812588A (en) * | 2006-05-15 | 2008-03-16 | Neurogen Corp | CRF1 receptor ligands comprising heteroaryl fused bicycles |
JO3235B1 (ar) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
JP5837278B2 (ja) | 2006-12-05 | 2015-12-24 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規使用 |
WO2008076446A1 (en) * | 2006-12-18 | 2008-06-26 | Coleman Peter R | Accelerated opiate dependence detoxification process |
EP2091952A1 (en) | 2006-12-19 | 2009-08-26 | F. Hoffmann-Roche AG | Pyrazolo ý3, 4 -d¨pyrimidine p38 map kinase inhibitors |
WO2008083070A1 (en) * | 2006-12-29 | 2008-07-10 | Neurogen Corporation | Crf1 receptor ligands comprising fused bicyclic heteroaryl moieties |
JP5497633B2 (ja) | 2007-05-09 | 2014-05-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | Cftrのモジュレーター |
WO2009073210A1 (en) * | 2007-12-06 | 2009-06-11 | Intra-Cellular Therapies, Inc | Organic compounds |
AU2008335440B2 (en) | 2007-12-07 | 2013-11-07 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
WO2009073757A1 (en) | 2007-12-07 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid |
US8299099B2 (en) | 2008-02-28 | 2012-10-30 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as CFTR modulators |
MX2010012814A (es) | 2008-05-23 | 2010-12-20 | Amira Pharmaceuticals Inc | Inhibidor de proteina activadora de 5-lipoxigenasa. |
KR101353857B1 (ko) | 2008-08-22 | 2014-01-21 | 노파르티스 아게 | Cdk 억제제로서 피롤로피리미딘 화합물 |
BRPI0922808A2 (pt) | 2008-12-06 | 2018-05-29 | Intracellular Therapies Inc | compostos orgânicos |
MX2011005935A (es) | 2008-12-06 | 2011-12-16 | Intra Cellular Therapies Inc | Compuestos organicos. |
MA32937B1 (fr) * | 2008-12-06 | 2012-01-02 | Intra Cellular Therapies Inc | Composes organiques |
MA32940B1 (fr) | 2008-12-06 | 2012-01-02 | Intra Cellular Therapies Inc | Composes organiques |
ES2638912T3 (es) | 2008-12-06 | 2017-10-24 | Intra-Cellular Therapies, Inc. | Compuestos orgánicos |
CA2740396A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
US8551996B2 (en) * | 2009-02-20 | 2013-10-08 | Emory University | Compounds, compositions, methods of synthesis, and methods of treatment |
WO2010132127A1 (en) | 2009-05-13 | 2010-11-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
WO2011127241A2 (en) | 2010-04-07 | 2011-10-13 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof |
WO2011153138A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
WO2011153136A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
WO2011153135A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX2013003913A (es) | 2010-10-08 | 2013-09-26 | Abbvie Inc | Compuestos de furo [3, 2-d] pirimidina. |
AR086554A1 (es) | 2011-05-27 | 2014-01-08 | Novartis Ag | Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina |
US10561656B2 (en) | 2011-06-10 | 2020-02-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
ES2644781T3 (es) * | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
EA201491990A1 (ru) | 2012-05-03 | 2015-02-27 | Новартис Аг | L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов |
WO2014127331A1 (en) | 2013-02-17 | 2014-08-21 | Intra-Cellular Therapies, Inc. | Novel uses |
ES2717688T3 (es) | 2013-03-15 | 2019-06-24 | Intra Cellular Therapies Inc | Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP |
JP6437519B2 (ja) | 2013-03-15 | 2018-12-12 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
WO2015073231A1 (en) | 2013-11-12 | 2015-05-21 | Vertex Pharmaceuticals Incorporated | Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases |
MX371017B (es) | 2014-02-03 | 2020-01-13 | Vitae Pharmaceuticals Llc | Inhibidores de dihidropirrolopiridina de receptor huerfano relacionado-gamma. |
EP2940022B1 (en) * | 2014-04-30 | 2020-09-02 | Masarykova Univerzita | Furopyridines as inhibitors of protein kinases |
JP6810613B2 (ja) | 2014-06-20 | 2021-01-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
JP6591530B2 (ja) | 2014-08-07 | 2019-10-16 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
CN107106563B (zh) | 2014-09-17 | 2021-05-25 | 细胞内治疗公司 | 化合物和方法 |
KR20170066628A (ko) | 2014-10-14 | 2017-06-14 | 비타이 파마슈티컬즈, 인코포레이티드 | Ror-감마의 디히드로피롤로피리딘 억제제 |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
WO2016081556A1 (en) | 2014-11-18 | 2016-05-26 | Vertex Pharmaceuticals Incorporated | Process of conducting high throughput testing high performance liquid chromatography |
TW201625635A (zh) | 2014-11-21 | 2016-07-16 | 默沙東藥廠 | 作為可溶性鳥苷酸環化酶活化劑之***并吡基衍生物 |
DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
MX2018006223A (es) | 2015-11-20 | 2018-12-19 | Vitae Pharmaceuticals Inc | Moduladores de ror-gamma. |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
KR102571296B1 (ko) | 2016-09-07 | 2023-08-28 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제 |
JP7134168B6 (ja) | 2016-09-12 | 2024-02-02 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
MA49685A (fr) | 2017-07-24 | 2021-04-14 | Vitae Pharmaceuticals Llc | INHIBITEURS DE ROR gamma |
JP7401442B2 (ja) | 2018-01-31 | 2023-12-19 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
CN110437846B (zh) * | 2019-08-30 | 2022-02-25 | 陕西师范大学 | 含炔键的氟取代苯并噁唑液晶化合物及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3398152B2 (ja) * | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | 1n−アルキル−n−アリールピリミジンアミンおよびその誘導体 |
CA2194756A1 (en) * | 1995-05-12 | 1996-11-14 | Jun Yuan | Novel deazapurine derivatives; a new class of crf1 specific ligands |
JP3964478B2 (ja) * | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
ATE340176T1 (de) * | 1996-08-28 | 2006-10-15 | Pfizer | Substituierte 6,5-heterobicyclische-derivate |
JP2002510687A (ja) * | 1998-04-02 | 2002-04-09 | ニューロゲン コーポレイション | アミノアルキル置換ピロロ[2,3−b]ピリジンおよびピロロ[2,3−d]ピリミジン誘導体:crf1レセプタのモジュレータ |
WO2002000623A2 (en) * | 2000-06-26 | 2002-01-03 | Neurogen Corporation | Aryl fused substituted 4-oxy-pyridines |
DE10229777A1 (de) * | 2002-07-03 | 2004-01-29 | Bayer Ag | Indolin-Phenylsulfonamid-Derivate |
EP1620095A4 (en) * | 2003-04-24 | 2009-04-01 | Merck & Co Inc | INHIBITORS OF AKT ACTIVITY |
-
2004
- 2004-09-03 EP EP04788585A patent/EP1680424A2/en not_active Withdrawn
- 2004-09-03 US US10/933,834 patent/US20050113379A1/en not_active Abandoned
- 2004-09-03 CA CA002537829A patent/CA2537829A1/en not_active Abandoned
- 2004-09-03 CN CNA2004800327037A patent/CN1878773A/zh active Pending
- 2004-09-03 KR KR1020067004564A patent/KR20060088534A/ko not_active Application Discontinuation
- 2004-09-03 ZA ZA200601978A patent/ZA200601978B/en unknown
- 2004-09-03 EA EA200600372A patent/EA200600372A1/ru unknown
- 2004-09-03 AP AP2006003559A patent/AP2006003559A0/xx unknown
- 2004-09-03 WO PCT/US2004/028899 patent/WO2005023806A2/en active Application Filing
- 2004-09-03 AU AU2004270713A patent/AU2004270713A1/en not_active Abandoned
- 2004-09-03 AR ARP040103174A patent/AR045582A1/es unknown
- 2004-09-03 JP JP2006526210A patent/JP2007504271A/ja active Pending
- 2004-09-03 BR BRPI0414087-7A patent/BRPI0414087A/pt not_active IP Right Cessation
- 2004-09-06 TW TW093126841A patent/TW200530232A/zh unknown
-
2006
- 2006-03-02 IL IL174084A patent/IL174084A0/en unknown
- 2006-03-03 CR CR8274A patent/CR8274A/es unknown
- 2006-03-03 EC EC2006006408A patent/ECSP066408A/es unknown
- 2006-03-14 NO NO20061180A patent/NO20061180L/no not_active Application Discontinuation
- 2006-03-24 US US11/389,646 patent/US20060199823A1/en not_active Abandoned
- 2006-04-05 MA MA28916A patent/MA28086A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
AR045582A1 (es) | 2005-11-02 |
NO20061180L (no) | 2006-03-31 |
WO2005023806A3 (en) | 2005-06-02 |
CA2537829A1 (en) | 2005-03-17 |
JP2007504271A (ja) | 2007-03-01 |
CN1878773A (zh) | 2006-12-13 |
US20050113379A1 (en) | 2005-05-26 |
US20060199823A1 (en) | 2006-09-07 |
ZA200601978B (en) | 2007-05-30 |
MA28086A1 (fr) | 2006-08-01 |
BRPI0414087A (pt) | 2006-10-31 |
IL174084A0 (en) | 2008-02-09 |
TW200530232A (en) | 2005-09-16 |
AP2006003559A0 (en) | 2006-04-30 |
EA200600372A1 (ru) | 2006-08-25 |
AU2004270713A1 (en) | 2005-03-17 |
KR20060088534A (ko) | 2006-08-04 |
ECSP066408A (es) | 2006-09-18 |
WO2005023806A2 (en) | 2005-03-17 |
EP1680424A2 (en) | 2006-07-19 |
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