ECSP088549A - Nuevos derivados de pirrol fusionado - Google Patents
Nuevos derivados de pirrol fusionadoInfo
- Publication number
- ECSP088549A ECSP088549A EC2008008549A ECSP088549A ECSP088549A EC SP088549 A ECSP088549 A EC SP088549A EC 2008008549 A EC2008008549 A EC 2008008549A EC SP088549 A ECSP088549 A EC SP088549A EC SP088549 A ECSP088549 A EC SP088549A
- Authority
- EC
- Ecuador
- Prior art keywords
- fusionated
- pirrol
- new derivatives
- medicaments
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
La invención se refiere a nuevos derivados de pirrol fusionado de la fórmula (I) (I)en la que A, Ar, R1, R2, R2' y R2" y n tienen los significados definidos en la descripción y en las reivindicaciones, así como las sales farmacéuticamente aceptables de los mismos. Estos compuestos inhiben la quimasa y pueden utilizarse como medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05112210 | 2005-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088549A true ECSP088549A (es) | 2008-07-30 |
Family
ID=37782002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008549A ECSP088549A (es) | 2005-12-15 | 2008-06-13 | Nuevos derivados de pirrol fusionado |
Country Status (21)
Country | Link |
---|---|
US (1) | US7696240B2 (es) |
EP (1) | EP1966134B1 (es) |
JP (1) | JP4955012B2 (es) |
KR (1) | KR101355754B1 (es) |
CN (1) | CN101351446B (es) |
AR (1) | AR058338A1 (es) |
AU (1) | AU2006326136B2 (es) |
BR (1) | BRPI0619963A2 (es) |
CA (1) | CA2637740A1 (es) |
CR (1) | CR10027A (es) |
EC (1) | ECSP088549A (es) |
HK (1) | HK1127058A1 (es) |
IL (1) | IL191768A0 (es) |
MA (1) | MA30162B1 (es) |
MY (1) | MY146491A (es) |
NO (1) | NO20082561L (es) |
NZ (1) | NZ568594A (es) |
RU (1) | RU2434853C2 (es) |
TW (1) | TWI363755B (es) |
UA (1) | UA95788C2 (es) |
WO (1) | WO2007068621A1 (es) |
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KR101381768B1 (ko) * | 2006-01-06 | 2014-04-07 | 선오비온 파마슈티컬스 인코포레이티드 | 테트랄론-기재 모노아민 재흡수 저해제 |
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JP5662319B2 (ja) * | 2008-09-09 | 2015-01-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アザ−ベンゾイミダゾロンキマーゼ阻害剤 |
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NZ600748A (en) | 2009-12-25 | 2014-06-27 | Daiichi Sankyo Co Ltd | Seven-membered ring compound and pharmaceutical use therefor |
WO2013009582A1 (en) * | 2011-07-12 | 2013-01-17 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
KR101739259B1 (ko) | 2015-04-22 | 2017-05-25 | 광운대학교 산학협력단 | 신규 피롤 단량체 및 그 제조방법, 피롤 단량체로부터 합성된 고분자 또는 화합물 및 그 제조방법 |
EP3370518B1 (en) | 2015-10-14 | 2023-08-23 | X-Therma, Inc. | Compositions and methods for reducing ice crystal formation |
US20200262794A1 (en) * | 2015-12-07 | 2020-08-20 | Wake Forest University Health Sciences | Glycolate oxidase inhibitors and methods of use for the treatment of kidney stones |
EP3615025A4 (en) * | 2017-04-26 | 2020-11-25 | The Board of Trustees of the University of Illionis | NRF AND HIF ACTIVATORS / HDAC INHIBITORS AND THERAPEUTIC METHODS USING THEM |
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EP1646624A1 (en) * | 2003-07-09 | 2006-04-19 | Biolipox AB | Indoles useful in the treatment of inflammation |
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JP2008545663A (ja) * | 2005-05-27 | 2008-12-18 | クイーンズ ユニバーシティ アット キングストン | タンパク質フォールディング障害の治療 |
-
2006
- 2006-05-12 UA UAA200808861A patent/UA95788C2/ru unknown
- 2006-12-05 CN CN2006800471484A patent/CN101351446B/zh not_active Expired - Fee Related
- 2006-12-05 KR KR1020087014264A patent/KR101355754B1/ko active IP Right Grant
- 2006-12-05 NZ NZ568594A patent/NZ568594A/en not_active IP Right Cessation
- 2006-12-05 CA CA002637740A patent/CA2637740A1/en not_active Abandoned
- 2006-12-05 BR BRPI0619963-1A patent/BRPI0619963A2/pt not_active IP Right Cessation
- 2006-12-05 EP EP06841282.4A patent/EP1966134B1/en active Active
- 2006-12-05 AU AU2006326136A patent/AU2006326136B2/en not_active Ceased
- 2006-12-05 JP JP2008544957A patent/JP4955012B2/ja not_active Expired - Fee Related
- 2006-12-05 RU RU2008128347/04A patent/RU2434853C2/ru not_active IP Right Cessation
- 2006-12-05 MY MYPI20081926A patent/MY146491A/en unknown
- 2006-12-05 US US11/634,584 patent/US7696240B2/en not_active Expired - Fee Related
- 2006-12-05 WO PCT/EP2006/069292 patent/WO2007068621A1/en active Application Filing
- 2006-12-13 AR ARP060105492A patent/AR058338A1/es not_active Application Discontinuation
- 2006-12-13 TW TW095146710A patent/TWI363755B/zh not_active IP Right Cessation
-
2008
- 2008-05-27 IL IL191768A patent/IL191768A0/en unknown
- 2008-05-28 CR CR10027A patent/CR10027A/es not_active Application Discontinuation
- 2008-06-02 NO NO20082561A patent/NO20082561L/no not_active Application Discontinuation
- 2008-06-13 EC EC2008008549A patent/ECSP088549A/es unknown
- 2008-07-11 MA MA31116A patent/MA30162B1/fr unknown
-
2009
- 2009-07-21 HK HK09106622.4A patent/HK1127058A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2434853C2 (ru) | 2011-11-27 |
HK1127058A1 (en) | 2009-09-18 |
AR058338A1 (es) | 2008-01-30 |
CN101351446B (zh) | 2011-10-05 |
NZ568594A (en) | 2011-08-26 |
TW200732303A (en) | 2007-09-01 |
IL191768A0 (en) | 2008-12-29 |
UA95788C2 (en) | 2011-09-12 |
JP2009519291A (ja) | 2009-05-14 |
US20070142452A1 (en) | 2007-06-21 |
KR101355754B1 (ko) | 2014-01-27 |
MA30162B1 (fr) | 2009-01-02 |
BRPI0619963A2 (pt) | 2011-10-25 |
CR10027A (es) | 2008-07-29 |
MY146491A (en) | 2012-08-15 |
KR20080070062A (ko) | 2008-07-29 |
US7696240B2 (en) | 2010-04-13 |
EP1966134B1 (en) | 2014-03-12 |
WO2007068621A1 (en) | 2007-06-21 |
CN101351446A (zh) | 2009-01-21 |
NO20082561L (no) | 2008-08-27 |
RU2008128347A (ru) | 2010-01-20 |
EP1966134A1 (en) | 2008-09-10 |
JP4955012B2 (ja) | 2012-06-20 |
TWI363755B (en) | 2012-05-11 |
AU2006326136A1 (en) | 2007-06-21 |
CA2637740A1 (en) | 2007-06-21 |
AU2006326136B2 (en) | 2012-08-16 |
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