EA201491990A1 - L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов - Google Patents
L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторовInfo
- Publication number
- EA201491990A1 EA201491990A1 EA201491990A EA201491990A EA201491990A1 EA 201491990 A1 EA201491990 A1 EA 201491990A1 EA 201491990 A EA201491990 A EA 201491990A EA 201491990 A EA201491990 A EA 201491990A EA 201491990 A1 EA201491990 A1 EA 201491990A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diazaspiro
- dec
- malate salt
- crystalline forms
- creeline
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Изобретение касается: L-малатной соли 2-амино-N-[(R)-1-бензилоксиметил-2-((4S,5R)-2-метил-1-оксо-4-фенил-2,7-диазаспиро[4.5]дец-7-ил)-2-оксоэтил]-2-метилпропионамида, L-малатной соли 2-амино-N-((2R)-3-(бензилокси)-1-(2-метил-1-оксо-4-п-толил-2,7-диазаспиро[4.5]декан-7-ил)-1-оксопропан-2-ил)-2-метилпропанамида и L-малатной соли 2-амино-N-{[(R)-1-бензилоксиметил-2-((45,5R)-4-фторфенил)-2-метил-1-оксо-2,7-диазаспиро[4,5]дец-7-ил]-2-оксоэтил}2-метилпропионамида и их кристаллических форм; фармацевтической композиции, содержащей такие соединения, и таких соединений для лечения нарушения или заболевания, опосредованного грелиновым рецептором.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261642116P | 2012-05-03 | 2012-05-03 | |
PCT/IB2013/053492 WO2013164790A1 (en) | 2012-05-03 | 2013-05-02 | L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201491990A1 true EA201491990A1 (ru) | 2015-02-27 |
Family
ID=48626496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491990A EA201491990A1 (ru) | 2012-05-03 | 2013-05-02 | L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов |
Country Status (20)
Country | Link |
---|---|
US (1) | US20130296358A1 (ru) |
EP (1) | EP2852591A1 (ru) |
JP (1) | JP2015525202A (ru) |
KR (1) | KR20150003771A (ru) |
CN (1) | CN104271579A (ru) |
AR (1) | AR093748A1 (ru) |
AU (1) | AU2013255458A1 (ru) |
BR (1) | BR112014026210A2 (ru) |
CA (1) | CA2867043A1 (ru) |
CO (1) | CO7111286A2 (ru) |
CU (1) | CU20130159A7 (ru) |
EA (1) | EA201491990A1 (ru) |
IL (1) | IL235215A0 (ru) |
MA (1) | MA20150428A1 (ru) |
PE (1) | PE20142443A1 (ru) |
PH (1) | PH12014502446A1 (ru) |
SG (1) | SG11201405810UA (ru) |
TN (2) | TN2013000441A1 (ru) |
TW (1) | TW201348235A (ru) |
WO (1) | WO2013164790A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020005992A2 (pt) * | 2017-09-28 | 2020-09-29 | Biogen Inc | novos sais |
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-
2013
- 2013-05-02 AU AU2013255458A patent/AU2013255458A1/en not_active Abandoned
- 2013-05-02 EP EP13729090.4A patent/EP2852591A1/en not_active Withdrawn
- 2013-05-02 CA CA2867043A patent/CA2867043A1/en not_active Abandoned
- 2013-05-02 MA MA37470A patent/MA20150428A1/fr unknown
- 2013-05-02 EA EA201491990A patent/EA201491990A1/ru unknown
- 2013-05-02 JP JP2015509556A patent/JP2015525202A/ja active Pending
- 2013-05-02 SG SG11201405810UA patent/SG11201405810UA/en unknown
- 2013-05-02 US US13/875,556 patent/US20130296358A1/en not_active Abandoned
- 2013-05-02 TW TW102115769A patent/TW201348235A/zh unknown
- 2013-05-02 WO PCT/IB2013/053492 patent/WO2013164790A1/en active Application Filing
- 2013-05-02 CN CN201380023253.4A patent/CN104271579A/zh active Pending
- 2013-05-02 BR BR112014026210A patent/BR112014026210A2/pt active Search and Examination
- 2013-05-02 KR KR20147030325A patent/KR20150003771A/ko not_active Application Discontinuation
- 2013-05-02 PE PE2014001906A patent/PE20142443A1/es not_active Application Discontinuation
- 2013-05-06 AR ARP130101532A patent/AR093748A1/es unknown
- 2013-10-29 TN TNP2013000441A patent/TN2013000441A1/fr unknown
- 2013-11-27 CU CU2013000159A patent/CU20130159A7/es unknown
-
2014
- 2014-09-23 TN TNP2014000400A patent/TN2014000400A1/fr unknown
- 2014-10-20 IL IL235215A patent/IL235215A0/en unknown
- 2014-10-27 CO CO14237477A patent/CO7111286A2/es unknown
- 2014-10-31 PH PH12014502446A patent/PH12014502446A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG11201405810UA (en) | 2014-11-27 |
KR20150003771A (ko) | 2015-01-09 |
US20130296358A1 (en) | 2013-11-07 |
JP2015525202A (ja) | 2015-09-03 |
TN2014000400A1 (en) | 2015-12-21 |
PH12014502446A1 (en) | 2015-01-12 |
IL235215A0 (en) | 2014-12-31 |
AR093748A1 (es) | 2015-06-24 |
CA2867043A1 (en) | 2013-11-07 |
WO2013164790A1 (en) | 2013-11-07 |
TW201348235A (zh) | 2013-12-01 |
CN104271579A (zh) | 2015-01-07 |
EP2852591A1 (en) | 2015-04-01 |
TN2013000441A1 (en) | 2015-03-30 |
PE20142443A1 (es) | 2015-01-28 |
MA20150428A1 (fr) | 2015-11-30 |
CU20130159A7 (es) | 2014-02-28 |
BR112014026210A2 (pt) | 2017-06-27 |
CO7111286A2 (es) | 2014-11-10 |
AU2013255458A1 (en) | 2014-10-09 |
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