CO6150192A2 - Anticuerpos monoclonales anti-il-6 y usos de los mismos - Google Patents
Anticuerpos monoclonales anti-il-6 y usos de los mismosInfo
- Publication number
- CO6150192A2 CO6150192A2 CO09007783A CO09007783A CO6150192A2 CO 6150192 A2 CO6150192 A2 CO 6150192A2 CO 09007783 A CO09007783 A CO 09007783A CO 09007783 A CO09007783 A CO 09007783A CO 6150192 A2 CO6150192 A2 CO 6150192A2
- Authority
- CO
- Colombia
- Prior art keywords
- seq
- amino acid
- acid sequence
- group
- sequence selected
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Abstract
1.- Un anticuerpo monoclonal aislado, el cual comprende: (a) una región variable de cadena pesada (VH) que comprende: (i) una VH-CDR1 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID N0:54, SEQ ID NO:55, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 51 a 55 excepto por 1 a 5 sustituciones de aminoácidos; (ii) una VH-CDR2 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:56, SEQ ID NO:57, SEQ ID N0:58, SEQ ID NO:59, SEQ ID NO:60, SEQ ID N0:61 SEQ ID NO:97, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 56 a 61 ó 97 excepto por 1 a 5 sustituciones de aminoácidos; (iii) una VH-CDR3 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ ID NO;71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:98, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 62 a 73 ó 98 excepto por 1 a 5 sustituciones de aminoácidos; y (b) una región variable de cadena ligera (VL) que comprende:(i) una VL-CDR1 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:74, SEQ ID NO:75, SEQ ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO: 79, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 74 a 79 excepto por 1 a 5 sustituciones de aminoácidos; (ii) una VL-CDR2 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:80, SEQ ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, y una secuencia de aminoácidos que es idéntica a cualquiera de las SEQ ID NOs: 80 a 85 excepto por 1 a 5 sustituciones de aminoácidos; (iii) una VL-CDR3 que comprende una secuencia de aminoácidos seleccionada a partir del grupo que consiste en las: SEQ ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ ID NO:96, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83510706P | 2006-08-03 | 2006-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6150192A2 true CO6150192A2 (es) | 2010-04-20 |
Family
ID=39033490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09007783A CO6150192A2 (es) | 2006-08-03 | 2009-01-28 | Anticuerpos monoclonales anti-il-6 y usos de los mismos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7919095B2 (es) |
| EP (1) | EP2064241B1 (es) |
| JP (1) | JP2009545319A (es) |
| KR (1) | KR101479537B1 (es) |
| CN (1) | CN101563365B (es) |
| AU (1) | AU2007282023B2 (es) |
| BR (1) | BRPI0715115A2 (es) |
| CA (1) | CA2657763C (es) |
| CO (1) | CO6150192A2 (es) |
| CR (1) | CR10563A (es) |
| EA (1) | EA200900037A1 (es) |
| IL (1) | IL196550A0 (es) |
| MA (1) | MA30653B1 (es) |
| MX (1) | MX2009001110A (es) |
| NO (1) | NO20090224L (es) |
| WO (1) | WO2008019061A2 (es) |
| ZA (1) | ZA200900514B (es) |
Families Citing this family (43)
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| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| EP2164514B1 (en) | 2007-05-21 | 2016-12-14 | AlderBio Holdings LLC | Antibodies to il-6 and use thereof |
| US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| WO2009140348A2 (en) | 2008-05-13 | 2009-11-19 | Novimmune Sa | Anti-il-6/il-6r antibodies and methods of use thereof |
| US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| JP2012503490A (ja) * | 2008-09-26 | 2012-02-09 | ワイス・エルエルシー | 単鎖抗体ライブラリー設計 |
| CA2742786A1 (en) * | 2008-11-13 | 2010-05-20 | Femta Pharmaceuticals, Inc. | Humanized anti-il-6 antibodies |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
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| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| EP2361095B1 (en) | 2008-11-25 | 2017-12-20 | AlderBio Holdings LLC | Antagonists of il-6 to raise albumin and/or lower crp |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| CA2774326C (en) | 2009-09-14 | 2023-11-07 | Donald Bellgrau | Modulation of yeast-based immunotherapy products and responses |
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| CN102971012B (zh) | 2010-03-12 | 2016-05-04 | 伊缪诺金公司 | Cd37结合分子及其免疫缀合物 |
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| WO2012098238A1 (en) | 2011-01-21 | 2012-07-26 | Novimmune S.A. | Combination therapies and methods using anti-cd3 modulating agents and anti-il-6 antagonists |
| JP6018622B2 (ja) * | 2011-04-01 | 2016-11-02 | イミュノジェン， インコーポレイテッド | Ｃｄ３７結合性分子及びその免疫複合体 |
| WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| CA2889181C (en) * | 2012-10-22 | 2021-12-07 | Fountain Biopharma Inc. | Antibodies to interleukin-6 and uses thereof |
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| MA44391A (fr) | 2015-06-08 | 2019-01-23 | Debiopharm Int Sa | Combinaisons d'immunoconjugués anti-cd37 et d'anticorps anti-cd20 |
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| JP6890581B2 (ja) | 2015-08-28 | 2021-06-18 | デビオファーム インターナショナル， エス． アー． | Ｃｄ３７の検出のための抗体およびアッセイ |
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| JP2020510608A (ja) | 2016-11-02 | 2020-04-09 | デビオファーム インターナショナル， エス． アー． | 抗ｃｄ３７イムノコンジュゲート療法を改善するための方法 |
| SG10201912128SA (en) | 2017-02-01 | 2020-02-27 | Univ Yale | Treatment of diuretic resistance |
| MA51584A (fr) | 2018-01-05 | 2020-11-11 | Corvidia Therapeutics Inc | Méthodes de traitement d'une inflammation médiée par il-6 sans immunosuppression |
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| WO2006105665A1 (en) | 2005-04-06 | 2006-10-12 | Bioartificial Gel Technologies Inc. | Hydrogel composition for modulation of topical inflammatory response |
| EP1712241A1 (en) | 2005-04-15 | 2006-10-18 | Centre National De La Recherche Scientifique (Cnrs) | Composition for treating cancer adapted for intra-tumoral administration and uses thereof |
| PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
| EP1888629B1 (en) | 2005-05-10 | 2013-04-24 | Neoloch Aps | Neuritogenic peptides |
-
2007
- 2007-08-03 AU AU2007282023A patent/AU2007282023B2/en not_active Ceased
- 2007-08-03 BR BRPI0715115-2A patent/BRPI0715115A2/pt not_active Application Discontinuation
- 2007-08-03 JP JP2009522880A patent/JP2009545319A/ja active Pending
- 2007-08-03 EP EP07811042.6A patent/EP2064241B1/en active Active
- 2007-08-03 CA CA2657763A patent/CA2657763C/en not_active Expired - Fee Related
- 2007-08-03 CN CN2007800289537A patent/CN101563365B/zh not_active Expired - Fee Related
- 2007-08-03 MX MX2009001110A patent/MX2009001110A/es not_active Application Discontinuation
- 2007-08-03 EA EA200900037A patent/EA200900037A1/ru unknown
- 2007-08-03 WO PCT/US2007/017337 patent/WO2008019061A2/en active Application Filing
- 2007-08-03 US US11/882,751 patent/US7919095B2/en not_active Expired - Fee Related
- 2007-08-03 KR KR20097003512A patent/KR101479537B1/ko not_active IP Right Cessation
-
2009
- 2009-01-15 NO NO20090224A patent/NO20090224L/no not_active Application Discontinuation
- 2009-01-15 IL IL196550A patent/IL196550A0/en unknown
- 2009-01-15 CR CR10563A patent/CR10563A/es unknown
- 2009-01-22 ZA ZA200900514A patent/ZA200900514B/xx unknown
- 2009-01-28 CO CO09007783A patent/CO6150192A2/es unknown
- 2009-02-17 MA MA31649A patent/MA30653B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR10563A (es) | 2009-04-14 |
| EP2064241A2 (en) | 2009-06-03 |
| WO2008019061A2 (en) | 2008-02-14 |
| EA200900037A1 (ru) | 2009-10-30 |
| CA2657763A1 (en) | 2008-02-14 |
| MX2009001110A (es) | 2009-05-11 |
| US7919095B2 (en) | 2011-04-05 |
| AU2007282023A1 (en) | 2008-02-14 |
| ZA200900514B (en) | 2010-04-28 |
| AU2007282023B2 (en) | 2012-09-13 |
| CN101563365B (zh) | 2012-10-31 |
| KR101479537B1 (ko) | 2015-01-07 |
| NO20090224L (no) | 2009-03-31 |
| BRPI0715115A2 (pt) | 2013-06-04 |
| CN101563365A (zh) | 2009-10-21 |
| WO2008019061A3 (en) | 2008-10-09 |
| US20080075726A1 (en) | 2008-03-27 |
| EP2064241B1 (en) | 2015-10-07 |
| IL196550A0 (en) | 2011-08-01 |
| KR20090039801A (ko) | 2009-04-22 |
| MA30653B1 (fr) | 2009-08-03 |
| CA2657763C (en) | 2016-05-31 |
| JP2009545319A (ja) | 2009-12-24 |
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