NO20090224L - Anti-IL-6 monoklonale antistoffer og anvendelser derav - Google Patents
Anti-IL-6 monoklonale antistoffer og anvendelser deravInfo
- Publication number
- NO20090224L NO20090224L NO20090224A NO20090224A NO20090224L NO 20090224 L NO20090224 L NO 20090224L NO 20090224 A NO20090224 A NO 20090224A NO 20090224 A NO20090224 A NO 20090224A NO 20090224 L NO20090224 L NO 20090224L
- Authority
- NO
- Norway
- Prior art keywords
- monoclonal antibodies
- amino acid
- well
- region selected
- regions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83510706P | 2006-08-03 | 2006-08-03 | |
PCT/US2007/017337 WO2008019061A2 (en) | 2006-08-03 | 2007-08-03 | Anti-il-6 monoclonal antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20090224L true NO20090224L (no) | 2009-03-31 |
Family
ID=39033490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090224A NO20090224L (no) | 2006-08-03 | 2009-01-15 | Anti-IL-6 monoklonale antistoffer og anvendelser derav |
Country Status (17)
Country | Link |
---|---|
US (1) | US7919095B2 (es) |
EP (1) | EP2064241B1 (es) |
JP (1) | JP2009545319A (es) |
KR (1) | KR101479537B1 (es) |
CN (1) | CN101563365B (es) |
AU (1) | AU2007282023B2 (es) |
BR (1) | BRPI0715115A2 (es) |
CA (1) | CA2657763C (es) |
CO (1) | CO6150192A2 (es) |
CR (1) | CR10563A (es) |
EA (1) | EA200900037A1 (es) |
IL (1) | IL196550A0 (es) |
MA (1) | MA30653B1 (es) |
MX (1) | MX2009001110A (es) |
NO (1) | NO20090224L (es) |
WO (1) | WO2008019061A2 (es) |
ZA (1) | ZA200900514B (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
WO2009140348A2 (en) | 2008-05-13 | 2009-11-19 | Novimmune Sa | Anti-il-6/il-6r antibodies and methods of use thereof |
US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
CA2737351A1 (en) * | 2008-09-26 | 2010-04-01 | Wyeth Llc | Single chain antibody library design |
BRPI0921665A2 (pt) * | 2008-11-13 | 2019-04-16 | Femta Pharmaceuticals, Inc. | humanizado anti-il-6 anticorpos |
US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
WO2010065079A2 (en) * | 2008-11-25 | 2010-06-10 | Alder Biopharmaceuticals, Inc. | Antibodies to il-6 and use thereof |
CA2774326C (en) | 2009-09-14 | 2023-11-07 | Donald Bellgrau | Modulation of yeast-based immunotherapy products and responses |
CN102740888B (zh) | 2009-11-24 | 2016-10-12 | 奥尔德生物制药公司 | Il-6抗体及其用途 |
US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
CN102971012B (zh) | 2010-03-12 | 2016-05-04 | 伊缪诺金公司 | Cd37结合分子及其免疫缀合物 |
WO2012071554A2 (en) | 2010-11-23 | 2012-05-31 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
US20120189621A1 (en) | 2011-01-21 | 2012-07-26 | Yann Dean | Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists |
CN103596590A (zh) | 2011-04-01 | 2014-02-19 | 伊缪诺金公司 | Cd37结合分子及其免疫缀合物 |
WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
CA2889181C (en) * | 2012-10-22 | 2021-12-07 | Fountain Biopharma Inc. | Antibodies to interleukin-6 and uses thereof |
SG10201608703SA (en) * | 2012-11-08 | 2016-12-29 | Eleven Biotherapeutics Inc | Il-6 antagonists and uses thereof |
SG10202108116SA (en) | 2015-06-08 | 2021-08-30 | Debiopharm International S A | Anti-cd37 immunoconjugate and anti-cd20 antibody combinations |
JP2018529756A (ja) | 2015-07-31 | 2018-10-11 | メディミューン リミテッド | ヘプシジン媒介性障害を治療するための方法 |
BR112018003147A2 (pt) | 2015-08-28 | 2018-09-18 | Debiopharm International S.A. | anticorpos e testes para detecção de cd37 |
WO2017136562A2 (en) * | 2016-02-02 | 2017-08-10 | Kadmon Corporation, Llc | Bispecific binding proteins for pd-l1 and kdr |
CA3023089A1 (en) * | 2016-05-05 | 2017-11-09 | The Trustees Of The University Of Pennsylvania | Dna monoclonal antibodies targeting il-6 and cd126 |
JP2020510608A (ja) | 2016-11-02 | 2020-04-09 | デビオファーム インターナショナル, エス. アー. | 抗cd37イムノコンジュゲート療法を改善するための方法 |
EP3576790A4 (en) | 2017-02-01 | 2020-12-23 | Yale University | TREATMENT OF DIURETIC RESISTANCE |
BR112020013519A2 (pt) | 2018-01-05 | 2020-12-01 | Corvidia Therapeutics, Inc | método para tratamento de uma inflamação. |
CN109517064B (zh) * | 2018-10-10 | 2020-05-08 | 北京汇智和源生物技术有限公司 | 白介素-6的人源化单克隆抗体、其编码基因及应用 |
JP2022537555A (ja) | 2019-06-20 | 2022-08-26 | 武田薬品工業株式会社 | ウイルスベースの遺伝子療法による治療方法 |
CN112279913B (zh) * | 2020-10-30 | 2022-05-03 | 上海百英生物科技有限公司 | 一种抗人il-6单克隆抗体及应用 |
CA3203308A1 (en) | 2020-11-30 | 2022-06-02 | Enigma Biointelligence, Inc. | Non-invasive assessment of alzheimer's disease |
CN113980129B (zh) * | 2021-01-15 | 2023-07-28 | 东大生物技术(苏州)有限公司 | 一组il-11单克隆抗体及其医药用途 |
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JP2598666B2 (ja) * | 1987-10-19 | 1997-04-09 | 忠三 岸本 | 抗ヒトbcdfモノクローナル抗体 |
IL88375A (en) | 1988-11-14 | 1995-07-31 | Yeda Res & Dev | Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method |
KR0184860B1 (ko) | 1988-11-11 | 1999-04-01 | 메디칼 리써어치 카운실 | 단일영역 리간드와 이를 포함하는 수용체 및 이들의 제조방법과 이용(법) |
EP0399429A1 (en) * | 1989-05-22 | 1990-11-28 | Toray Industries, Inc. | Anti-human interleukin-6 monoclonal antibody |
JPH03139292A (ja) * | 1989-05-22 | 1991-06-13 | Toray Ind Inc | ヒトインタ―ロイキン―6に対するモノクロ―ナル抗体 |
JP2881311B2 (ja) | 1989-07-28 | 1999-04-12 | 味の素株式会社 | 抗ヒトbcdfモノクローナル抗体及びそれを用いたヒトbcdfの定量法 |
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US5888510A (en) | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
EP0721783B1 (en) | 1994-06-07 | 2005-03-16 | Toray Industries, Inc. | Preventive and remedy for diseases caused by fibrinoid or thrombus formation in the lung |
EP2077120A3 (en) | 1994-10-07 | 2009-07-15 | Chugai Seiyaku Kabushiki Kaisha | Rheumatoid arthritis remedy containing il-6 antagonist as active ingredient |
KR100252743B1 (ko) | 1994-12-29 | 2000-09-01 | 나가야마 오사무 | Il-6 안타고니스트를 함유하는 항종양제의 작용증강제 |
GB9702944D0 (en) | 1997-02-13 | 1997-04-02 | Univ Manchester | Reducing fibrosis |
DE69839992D1 (de) | 1997-03-21 | 2008-10-23 | Chugai Pharmaceutical Co Ltd | Vorbeugende- oder Heilmittel zur Behandlung von Multipler Sklerose, mit antagonistischen anti-IL6-Rezeptor Antikörpern als Wirkstoff |
CA2324115C (en) | 1998-03-17 | 2008-12-23 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for inflammatory bowel disease comprising il-6 antagonist as an active ingredient |
US7494652B1 (en) | 1998-06-10 | 2009-02-24 | Promega Corporation | Treatment of sepsis |
ATE350060T1 (de) | 1998-08-24 | 2007-01-15 | Chugai Pharmaceutical Co Ltd | Mittel zur vorbeugung oder behandlung von pankreatitis die anti-il-6 receptor antikörper als aktive komponente enthalten |
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AU2736400A (en) | 1999-01-27 | 2000-08-18 | University Of South Florida | Inhibition of stat3 signal transduction for human cancer therapy |
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JP4889187B2 (ja) | 2000-10-27 | 2012-03-07 | 中外製薬株式会社 | Il−6アンタゴニストを有効成分として含有する血中mmp−3濃度低下剤 |
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US20050037358A1 (en) | 2001-12-21 | 2005-02-17 | Serge Muyldermans | Method for cloning of variable domain sequences |
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CN1678744B (zh) * | 2002-08-30 | 2010-05-26 | 财团法人化学及血清疗法研究所 | 人的抗人白细胞介素-6抗体以及所述抗体的片段 |
EP1572103A4 (en) | 2002-11-15 | 2008-02-13 | Centocor Inc | ANTI-ANGIOGENIC USES OF IL-6 ANTAGONISTS |
WO2004071404A2 (en) | 2003-02-04 | 2004-08-26 | Centocor Inc. | Use of il-6 antagonists in combination with steroids to enhance apoptosis |
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GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
WO2005023193A2 (en) | 2003-09-04 | 2005-03-17 | Interleukin Genetics, Inc. | Methods of treating endometriosis |
EP1677667A2 (en) | 2003-10-24 | 2006-07-12 | Medtronic, Inc. | Techniques to treat neurological disorders by attenuating the production of pro-inflammatory mediators |
US20050100550A1 (en) | 2003-11-10 | 2005-05-12 | Mohit Trikha | Anti-angiogenic uses of IL-6 antagonists |
DE602005020743D1 (de) | 2004-02-11 | 2010-06-02 | Warner Lambert Co | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern |
KR20070095949A (ko) | 2004-12-16 | 2007-10-01 | 제넨테크, 인크. | 자가면역 장애의 치료 방법 |
US20060228416A1 (en) | 2005-04-06 | 2006-10-12 | Marie-Pierre Faure | Methods for modulating topical inflammatory response |
EP1712241A1 (en) | 2005-04-15 | 2006-10-18 | Centre National De La Recherche Scientifique (Cnrs) | Composition for treating cancer adapted for intra-tumoral administration and uses thereof |
JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
EP2377884A1 (en) | 2005-05-10 | 2011-10-19 | Neoloch Aps | Neuritogenic peptides |
-
2007
- 2007-08-03 JP JP2009522880A patent/JP2009545319A/ja active Pending
- 2007-08-03 CN CN2007800289537A patent/CN101563365B/zh not_active Expired - Fee Related
- 2007-08-03 MX MX2009001110A patent/MX2009001110A/es not_active Application Discontinuation
- 2007-08-03 WO PCT/US2007/017337 patent/WO2008019061A2/en active Application Filing
- 2007-08-03 EA EA200900037A patent/EA200900037A1/ru unknown
- 2007-08-03 EP EP07811042.6A patent/EP2064241B1/en active Active
- 2007-08-03 KR KR20097003512A patent/KR101479537B1/ko not_active IP Right Cessation
- 2007-08-03 CA CA2657763A patent/CA2657763C/en not_active Expired - Fee Related
- 2007-08-03 BR BRPI0715115-2A patent/BRPI0715115A2/pt not_active Application Discontinuation
- 2007-08-03 AU AU2007282023A patent/AU2007282023B2/en not_active Ceased
- 2007-08-03 US US11/882,751 patent/US7919095B2/en not_active Expired - Fee Related
-
2009
- 2009-01-15 IL IL196550A patent/IL196550A0/en unknown
- 2009-01-15 CR CR10563A patent/CR10563A/es unknown
- 2009-01-15 NO NO20090224A patent/NO20090224L/no not_active Application Discontinuation
- 2009-01-22 ZA ZA200900514A patent/ZA200900514B/xx unknown
- 2009-01-28 CO CO09007783A patent/CO6150192A2/es unknown
- 2009-02-17 MA MA31649A patent/MA30653B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
CN101563365A (zh) | 2009-10-21 |
US7919095B2 (en) | 2011-04-05 |
US20080075726A1 (en) | 2008-03-27 |
WO2008019061A3 (en) | 2008-10-09 |
BRPI0715115A2 (pt) | 2013-06-04 |
KR101479537B1 (ko) | 2015-01-07 |
EP2064241B1 (en) | 2015-10-07 |
ZA200900514B (en) | 2010-04-28 |
WO2008019061A2 (en) | 2008-02-14 |
CN101563365B (zh) | 2012-10-31 |
JP2009545319A (ja) | 2009-12-24 |
IL196550A0 (en) | 2011-08-01 |
MA30653B1 (fr) | 2009-08-03 |
AU2007282023A1 (en) | 2008-02-14 |
MX2009001110A (es) | 2009-05-11 |
CO6150192A2 (es) | 2010-04-20 |
EP2064241A2 (en) | 2009-06-03 |
CA2657763A1 (en) | 2008-02-14 |
KR20090039801A (ko) | 2009-04-22 |
EA200900037A1 (ru) | 2009-10-30 |
CA2657763C (en) | 2016-05-31 |
AU2007282023B2 (en) | 2012-09-13 |
CR10563A (es) | 2009-04-14 |
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