CO5580788A2 - Compuestos de bencimidazol sustituidos utiles como inhibidores de proteina cinasas - Google Patents
Compuestos de bencimidazol sustituidos utiles como inhibidores de proteina cinasasInfo
- Publication number
- CO5580788A2 CO5580788A2 CO04051014A CO04051014A CO5580788A2 CO 5580788 A2 CO5580788 A2 CO 5580788A2 CO 04051014 A CO04051014 A CO 04051014A CO 04051014 A CO04051014 A CO 04051014A CO 5580788 A2 CO5580788 A2 CO 5580788A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- optionally substituted
- heteroaryl
- aryl
- heterocyclyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Un compuesto de la fórmula (I): en el que:R1 es hidrógeno o alquilo;R2 se escoge entre arilo y heteroarilo, estando cada uno de los R2 opcionalmente sustituido con uno o más Ra;R3 es una cadena de alquilo C1-10 ramificada o no ramificada, sustituida opcionalmente con uno o más Rb,o R3 es el grupo:-(CH2)n-L-R6, en el que L se escoge entre un enlace, -NH-C(O)-, -O-C(O)-, -C(O)- y -S(O)m- en el que m es 0, 1 ó 2, y en el que dicho grupo está opcionalmente sustituido con uno o más Rb;en el que R6 se escoge independientemente entre hidroxi, alquilo, alcoxi, alquiltio, aril-alquilo C0-5, ariloxi-alquilo C0-5, heteroaril-alquilo C0-5, cicloalquil-alquilo C0-5, heterociclil-alquilo C0-5 y amino, estando dicho amino opcionalmente mono- o di-sustituido con acilo, alquilo, alcoxicarbonilo, cicloalquil-alquilo C0-5, aril-alquilo C0-5, heteroaril-alquilo C0-5 o heterociclil-alquilo C0-5;n es 1-10;R4 es el grupo:en el que R4 está unido por enlace covalente en la posición 5 ó 6 indicada de la fórmula (I);R5 se escoge entre aril-alquilo C0-5, alquilo, heteroaril-alquilo C0-5, cicloalquil-alquilo C0-5 y heterociclil-alquilo C0-5, estando cada uno de los R5 opcionalmente sustituido con uno o más Rc;R7 es hidrógeno, alquenilo o alquilo;o R5 y R7 conjuntamente con el átomo de nitrógeno al que están unidos, forman:un anillo monocíclico de 4-7 miembros oun anillo bicíclico de 8-14 miembros, en el que cada anillo monocíclico o bicíclico contiene opcionalmente de 1 a 3 heteroátomos adicionales escogidos entre N, O y S y cada uno de los anillos es aromático o no aromático, y en el que cada anillo monocíclico o bicíclico está opcionalmente sustituido con uno o más Rc; ...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34463601P | 2001-11-09 | 2001-11-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5580788A2 true CO5580788A2 (es) | 2005-11-30 |
Family
ID=23351329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO04051014A CO5580788A2 (es) | 2001-11-09 | 2004-06-01 | Compuestos de bencimidazol sustituidos utiles como inhibidores de proteina cinasas |
Country Status (18)
Country | Link |
---|---|
US (1) | US6825219B2 (es) |
EP (1) | EP1448199A1 (es) |
JP (1) | JP2005509003A (es) |
KR (1) | KR20040063144A (es) |
CN (1) | CN1612733A (es) |
BR (1) | BR0214019A (es) |
CA (1) | CA2464419A1 (es) |
CO (1) | CO5580788A2 (es) |
EA (1) | EA200400595A1 (es) |
HR (1) | HRP20040416A2 (es) |
IL (1) | IL161516A0 (es) |
MX (1) | MXPA04004301A (es) |
NO (1) | NO20041887L (es) |
NZ (1) | NZ533310A (es) |
PL (1) | PL369771A1 (es) |
WO (1) | WO2003041708A1 (es) |
YU (1) | YU37904A (es) |
ZA (1) | ZA200402947B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
FR2851563B1 (fr) * | 2003-02-26 | 2005-04-22 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
FR2862971B1 (fr) * | 2003-11-28 | 2006-03-24 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
WO2005070420A1 (en) * | 2004-01-14 | 2005-08-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1h-benzimidazol-2-yl-benzamide derivatives and related compounds as itk inhibitors (interleukin-2-inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
US20050209284A1 (en) * | 2004-02-12 | 2005-09-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Tec kinase inhibitors |
WO2006053342A2 (en) * | 2004-11-12 | 2006-05-18 | Osi Pharmaceuticals, Inc. | Integrin antagonists useful as anticancer agents |
WO2006068105A1 (ja) * | 2004-12-20 | 2006-06-29 | Santen Pharmaceutical Co., Ltd. | 角結膜障害治療剤 |
NZ561029A (en) * | 2005-03-14 | 2011-03-31 | High Point Pharmaceuticals Llc | Benzazole dervatives, compositions, and method of use as beta-secretase inhibitors |
US20060235028A1 (en) * | 2005-04-14 | 2006-10-19 | Li James J | Inhibitors of 11-beta hydroxysteroid dehydrogenase type I |
GB0515025D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
JP2009515879A (ja) * | 2005-11-12 | 2009-04-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Tecキナーゼ阻害剤 |
US20110071130A1 (en) * | 2006-05-08 | 2011-03-24 | Pharmacopeia, Inc. | 2-aminobenzimidazoles for treating neurodegenerative diseases |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
UA119314C2 (uk) | 2008-01-04 | 2019-06-10 | Інтеллікіне Ллк | Спосіб отримання похідних ізохінолінону (варіанти) |
WO2009106203A1 (en) * | 2008-02-25 | 2009-09-03 | Merck Patent Gmbh | Glucokinase activators |
US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
CA2758961A1 (en) | 2009-04-27 | 2010-11-04 | High Point Pharmaceuticals, Llc | Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as .beta.-secretase inhibitors |
JP2013522364A (ja) | 2010-03-23 | 2013-06-13 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 置換イミダゾ[1,2−b]ピリダジン誘導体、医薬組成物、及びβ−セクレターゼ阻害剤としての使用の方法 |
SG187209A1 (en) | 2010-08-05 | 2013-03-28 | Amgen Inc | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase |
SG10201600179RA (en) | 2011-01-10 | 2016-02-26 | Infinity Pharmaceuticals Inc | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
JO3300B1 (ar) * | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
CN104520291A (zh) * | 2012-06-06 | 2015-04-15 | Irm责任有限公司 | 用于调节egfr活性的化合物和组合物 |
US8828998B2 (en) * | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
US9573958B2 (en) | 2012-08-31 | 2017-02-21 | Principia Biopharma, Inc. | Benzimidazole derivatives as ITK inhibitors |
WO2015081463A1 (en) * | 2013-12-02 | 2015-06-11 | Novartis Ag | Egfr inhibitor forms |
WO2015083059A1 (en) * | 2013-12-02 | 2015-06-11 | Novartis Ag | Forms of the egfr inhibitor |
US10000469B2 (en) | 2014-03-25 | 2018-06-19 | Duke University | Heat shock protein 70 (hsp-70) receptor ligands |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
KR101560338B1 (ko) | 2014-04-21 | 2015-10-19 | 건국대학교 산학협력단 | 야누스 키나아제 1의 활성을 선택적으로 저해하는 벤조이미다졸 유도체 |
US10975287B2 (en) * | 2016-04-07 | 2021-04-13 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
EP3474856B1 (en) | 2016-06-24 | 2022-09-14 | Infinity Pharmaceuticals, Inc. | Combination therapies |
EP3755694B1 (en) | 2018-02-21 | 2023-04-05 | Boehringer Ingelheim International GmbH | New benzimidazole compounds and derivatives as egfr inhibitors |
JP2022528562A (ja) * | 2019-04-05 | 2022-06-14 | ストーム・セラピューティクス・リミテッド | Mettl3阻害化合物 |
US20220380382A1 (en) | 2019-06-24 | 2022-12-01 | Boehringer Ingelheim International Gmbh | New macrocyclic compounds and derivatives as egfr inhibitors |
CN114591333B (zh) * | 2020-12-04 | 2023-08-01 | 广州嘉越医药科技有限公司 | 一种吡咯并嘧啶类化合物的制备方法 |
CN116444544A (zh) * | 2022-01-10 | 2023-07-18 | 中国科学院上海药物研究所 | 苯并咪唑类化合物及其医药用途 |
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2002
- 2002-11-05 IL IL16151602A patent/IL161516A0/xx unknown
- 2002-11-05 MX MXPA04004301A patent/MXPA04004301A/es unknown
- 2002-11-05 JP JP2003543595A patent/JP2005509003A/ja active Pending
- 2002-11-05 KR KR10-2004-7007023A patent/KR20040063144A/ko not_active Application Discontinuation
- 2002-11-05 CN CNA028270002A patent/CN1612733A/zh active Pending
- 2002-11-05 US US10/288,362 patent/US6825219B2/en not_active Expired - Lifetime
- 2002-11-05 EA EA200400595A patent/EA200400595A1/ru unknown
- 2002-11-05 WO PCT/US2002/035494 patent/WO2003041708A1/en active IP Right Grant
- 2002-11-05 EP EP02789445A patent/EP1448199A1/en not_active Withdrawn
- 2002-11-05 YU YU37904A patent/YU37904A/sh unknown
- 2002-11-05 NZ NZ533310A patent/NZ533310A/xx unknown
- 2002-11-05 BR BR0214019-5A patent/BR0214019A/pt not_active Application Discontinuation
- 2002-11-05 PL PL02369771A patent/PL369771A1/xx not_active Application Discontinuation
- 2002-11-05 CA CA002464419A patent/CA2464419A1/en not_active Abandoned
-
2004
- 2004-04-19 ZA ZA200402947A patent/ZA200402947B/en unknown
- 2004-05-07 NO NO20041887A patent/NO20041887L/no unknown
- 2004-05-07 HR HR20040416A patent/HRP20040416A2/hr not_active Application Discontinuation
- 2004-06-01 CO CO04051014A patent/CO5580788A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1448199A1 (en) | 2004-08-25 |
JP2005509003A (ja) | 2005-04-07 |
US20030144281A1 (en) | 2003-07-31 |
CA2464419A1 (en) | 2003-05-22 |
MXPA04004301A (es) | 2004-08-11 |
BR0214019A (pt) | 2004-10-13 |
YU37904A (sh) | 2006-08-17 |
HRP20040416A2 (en) | 2005-04-30 |
NO20041887L (no) | 2004-05-07 |
CN1612733A (zh) | 2005-05-04 |
ZA200402947B (en) | 2005-01-24 |
PL369771A1 (en) | 2005-05-02 |
WO2003041708A1 (en) | 2003-05-22 |
US6825219B2 (en) | 2004-11-30 |
IL161516A0 (en) | 2004-09-27 |
KR20040063144A (ko) | 2004-07-12 |
NZ533310A (en) | 2004-12-24 |
EA200400595A1 (ru) | 2004-10-28 |
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