AR058885A1 - Compuestos de piperidina 3,5-sustituidos - Google Patents
Compuestos de piperidina 3,5-sustituidosInfo
- Publication number
- AR058885A1 AR058885A1 ARP060105852A ARP060105852A AR058885A1 AR 058885 A1 AR058885 A1 AR 058885A1 AR P060105852 A ARP060105852 A AR P060105852A AR P060105852 A ARP060105852 A AR P060105852A AR 058885 A1 AR058885 A1 AR 058885A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- substituted
- alkyl
- aryl
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente se refiere a compuestos de piperidina 3,5-sustituida, al uso de un compuesto de esta clase para la preparacion de una formulacion farmacéutica para el tratamiento de una enfermedad que dependa de la actividad de la renina; y a un método para la fabricacion de un compuesto de piperidina 3,5-sustituida, y a intermediarios novedosos y pasos parciales para su síntesis. Reivindicacion 1: Un compuesto de la formula (1) en donde R1 es H, alquilo insustituido o sustituido, alquenilo insustituido o sustituido, alquinilo insustituido o sustituido, arilo insustituido o sustituido, heterociclilo insustituido o sustituido, o cicloalquilo insustituido o sustituido; R2 es alquilo insustituido o sustituido, alquenilo insustituido o sustituido, alquinilo insustituido o sustituido, arilo insustituido o sustituido, heterociclilo insustituido o sustituido, cicloalquilo insustituido o sustituido, o acilo; R3 es H, arilo insustituido o sustituido, o alquilo insustituido o sustituido; R4 es alquilo insustituido o sustituido, alquenilo insustituido o sustituido, alquinilo insustituido o sustituido, arilo insustituido o sustituido, heterociclilo insustituido o sustituido, cicloalquilo insustituido o sustituido, o acilo; o R3 y R4 pueden formar juntos un anillo de hidrocarburo saturado de 3 a 7 miembros, que contiene N, el cual puede estar insustituido o sustituido; R6 es H, halogeno, alquilo insustituido o sustituido, o alcoxilo insustituido, R7 y R8 son, independientemente uno del otro, H o halogeno; y T es metileno o carbonilo; o una sal del mismo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05028771 | 2005-12-30 | ||
GB0604223A GB0604223D0 (en) | 2006-03-02 | 2006-03-02 | Organic compounds |
GB0611390A GB0611390D0 (en) | 2006-06-08 | 2006-06-08 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR058885A1 true AR058885A1 (es) | 2008-02-27 |
Family
ID=37875514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060105852A AR058885A1 (es) | 2005-12-30 | 2006-12-28 | Compuestos de piperidina 3,5-sustituidos |
Country Status (20)
Country | Link |
---|---|
US (1) | US8129411B2 (es) |
EP (2) | EP1968940B1 (es) |
JP (1) | JP5306821B2 (es) |
KR (1) | KR20080086921A (es) |
AR (1) | AR058885A1 (es) |
AU (1) | AU2006332124B2 (es) |
BR (1) | BRPI0620736A2 (es) |
CA (1) | CA2633624C (es) |
CR (1) | CR10091A (es) |
EC (1) | ECSP088587A (es) |
ES (2) | ES2430139T3 (es) |
IL (1) | IL192024A0 (es) |
MA (1) | MA30073B1 (es) |
NO (1) | NO20083315L (es) |
NZ (1) | NZ569135A (es) |
PE (2) | PE20071177A1 (es) |
PL (1) | PL2420491T3 (es) |
PT (1) | PT2420491E (es) |
TW (1) | TW200738698A (es) |
WO (1) | WO2007077005A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
ES2430139T3 (es) | 2005-12-30 | 2013-11-19 | Novartis Ag | Compuestos de piperidina 3,5-sustituido como inhibidores de renina |
CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8129538B1 (en) | 2007-03-28 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
ES2541107T3 (es) * | 2007-06-25 | 2015-07-16 | Novartis Ag | Derivados de N5-(2-etoxietil)-N3-(2-piridinil)-3,5-piperidindicarboxamida para su uso como inhibidores de renina |
WO2009051112A1 (ja) | 2007-10-15 | 2009-04-23 | Takeda Pharmaceutical Company Limited | アミド化合物およびその用途 |
CA2708866A1 (en) | 2007-12-19 | 2009-06-25 | Hiroyuki Nakahira | Bicyclic heterocyclic derivative |
WO2009135299A1 (en) | 2008-05-05 | 2009-11-12 | Merck Frosst Canada Ltd. | 3, 4 - substituted piperidine derivatives as renin inhibitors |
EA201301040A1 (ru) | 2008-06-19 | 2014-01-30 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение и его применение |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
US20120115907A1 (en) * | 2009-04-24 | 2012-05-10 | Cadila Healthcare Limited | Novel compounds as inhibitors of renin |
EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
US8658639B2 (en) | 2009-06-24 | 2014-02-25 | Dainippon Sumitomo Pharma Co., Ltd | N-substituted-cyclic amino derivative |
KR20140092696A (ko) * | 2013-01-16 | 2014-07-24 | 주식회사유한양행 | 신규의 페닐에티닐 벤즈아마이드 글루코키나제 활성화제 및 그의 제조방법 |
CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
WO2015156346A1 (ja) * | 2014-04-10 | 2015-10-15 | 武田薬品工業株式会社 | 複素環化合物の製造法 |
US9643927B1 (en) * | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
KR102579582B1 (ko) * | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
CA3035566A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
CN110506037A (zh) | 2017-03-31 | 2019-11-26 | 爱瑞制药公司 | 芳基环丙基-氨基-异喹啉酰胺化合物 |
US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW224941B (es) | 1989-11-08 | 1994-06-11 | Yamanouchi Pharma Co Ltd | |
CA2129679C (en) | 1991-12-18 | 2000-05-09 | Neng-Yang Shih | Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring |
IL111176A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them |
NZ315677A (en) | 1995-09-07 | 2000-02-28 | F | 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency |
CA2238081A1 (en) | 1995-11-22 | 1997-05-29 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
JP2001526178A (ja) | 1997-08-28 | 2001-12-18 | メルク エンド カムパニー インコーポレーテッド | ピロリジン系およびピペリジン系ケモカイン受容体活性調節剤 |
EP1087937A1 (en) | 1998-06-17 | 2001-04-04 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
US6274735B1 (en) | 1998-08-10 | 2001-08-14 | Hoffmann-La Roche Inc. | Process and intermediates for preparation of substituted piperidines |
US6610692B1 (en) | 1998-10-30 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
AU3386700A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
AU3389300A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
US6362201B1 (en) | 1999-03-02 | 2002-03-26 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
WO2000063173A1 (en) | 1999-04-14 | 2000-10-26 | F. Hoffmann-La Roche Ag | Process for the preparation of substituted piperidines |
US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
US6376672B1 (en) | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
BR0109467A (pt) | 2000-03-17 | 2003-06-03 | Bristol Myers Squibb Pharma Co | Composto derivados de (beta)-aminoácidos cìclicos, composição farmacêutica, método de tratamento de condições ou doenças mediadas por mps, tnf, aggrecanase ou uma combinação destes em mamìferos e uso de composto |
JP2003529571A (ja) * | 2000-04-04 | 2003-10-07 | ブランデイス ユニヴァーシティー | メソ形化合物の触媒的不斉非対称化 |
FR2811673B1 (fr) | 2000-07-17 | 2002-09-13 | Rhodia Chimie Sa | Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes |
EP1326619A2 (en) | 2000-10-11 | 2003-07-16 | Merck & Co., Inc. | Pyrrolidine modulators of ccr5 chemokine receptor activity |
WO2002076440A2 (en) | 2001-03-23 | 2002-10-03 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease with piperidin derivates |
EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
WO2003024899A2 (en) | 2001-09-17 | 2003-03-27 | Bristol-Myers Squibb Company | CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE) |
WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
CA2483241C (en) | 2002-04-29 | 2011-05-31 | Actelion Pharmaceuticals Ltd | Novel diazabicyclononene derivatives |
ES2315568T3 (es) | 2002-05-20 | 2009-04-01 | Bristol-Myers Squibb Company | Inhibidores del virus de la hepatitis c basados en cicloalquilo p1' sustituido. |
PL374860A1 (en) | 2002-07-09 | 2005-11-14 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
US20040204455A1 (en) | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
US20040214832A1 (en) | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
US20060217371A1 (en) | 2003-04-28 | 2006-09-28 | Olivier Bezencon | Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors |
AU2004234039A1 (en) | 2003-04-29 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Novel 3,4-disubstituted 1,2,3,6-tetrahydropyridine derivatives |
EP1622685A1 (en) | 2003-04-30 | 2006-02-08 | Actelion Pharmaceuticals Ltd. | 9-azabicyclo[3.3.1]non-6-ene derivatives with a heteroatom at the 3-position as renin inhibitors |
US20060205768A1 (en) | 2003-04-30 | 2006-09-14 | Olivier Bezencon | Tropane derivatives and their use as ace inhibitors |
JP2006524654A (ja) | 2003-04-30 | 2006-11-02 | アクテリオン ファマシューティカルズ リミテッド | 新規アザビシクロノネン誘導体 |
KR20060015573A (ko) | 2003-05-02 | 2006-02-17 | 액테리온 파마슈티칼 리미티드 | 신규한 디아자비시클로노넨 유도체 |
TW200513461A (en) | 2003-10-01 | 2005-04-16 | Speedel Experimenta Ag | Organische verbindungen |
WO2005040120A1 (en) | 2003-10-09 | 2005-05-06 | Actelion Pharmaceuticals Ltd | Tetrahydropyridine derivatives |
US7582782B2 (en) | 2003-11-26 | 2009-09-01 | Novartis Ag | Organic compounds |
RU2374228C2 (ru) * | 2003-11-26 | 2009-11-27 | Новартис Аг | Производные 4-фенилпиперидина в качестве ингибиторов ренина |
JP2007518777A (ja) | 2004-01-23 | 2007-07-12 | シュペーデル・エクスペリメンタ・アーゲー | アミノアルコール誘導体およびレニン阻害剤としてのその使用 |
WO2005070871A2 (en) | 2004-01-23 | 2005-08-04 | Speedel Experimenta Ag | Amino alcohol derivatives and their activity as renin inhibitors |
DE602005022060D1 (de) | 2004-01-23 | 2010-08-12 | Novartis Ag | Diaminoalkohole und deren verwendung als renininhibitoren |
DE602005012481D1 (de) | 2004-03-19 | 2009-03-12 | Speedel Experimenta Ag | 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck |
TW200609215A (en) | 2004-03-19 | 2006-03-16 | Speedel Experimenta Ag | Organic compounds |
AR053406A1 (es) | 2004-07-09 | 2007-05-09 | Speedel Experimenta Ag | Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas |
TW200631929A (en) | 2004-12-10 | 2006-09-16 | Speedel Experimenta Ag | ω -phenyloctanamides |
GB0428250D0 (en) | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
GB0500784D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0504850D0 (en) | 2005-03-09 | 2005-04-13 | Novartis Ag | Organic compounds |
JP2008532983A (ja) | 2005-03-11 | 2008-08-21 | シュペーデル・エクスペリメンタ・アーゲー | レニン阻害剤として有用な複素環置換アルカンアミド |
GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
BRPI0609534A2 (pt) | 2005-03-31 | 2010-04-13 | Speedel Experimenta Ag | piperidinas 3,4,5-substituìdas |
TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
GB0510810D0 (en) | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0511063D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
EP1937248B1 (en) | 2005-09-17 | 2010-06-02 | Novartis Ag | Alcanoic acid amides substituted by saturated o-heterocycles |
CA2622082A1 (en) | 2005-09-17 | 2007-03-22 | Speedel Experimenta Ag | 5-amino-4-hydroxy-7- (imidazo [1,2-a] pyridin-6- ylmethyl)-8-methyl-nonamide derivatives and related compounds as renin inhibitors for the treatment of hypertension |
PE20071079A1 (es) | 2005-11-15 | 2007-12-16 | Cytokinetics Inc | Compuestos de piperidina como inhibidores de la proliferacion celular |
ES2430139T3 (es) | 2005-12-30 | 2013-11-19 | Novartis Ag | Compuestos de piperidina 3,5-sustituido como inhibidores de renina |
EP1816122A3 (en) | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | 3,4,5-substituted piperidines as therapeutic compounds |
JP2009525304A (ja) | 2006-01-30 | 2009-07-09 | シュペーデル・エクスペリメンタ・アーゲー | α,β−不飽和化合物からのアルコールの立体選択的製造方法 |
BRPI0712430A2 (pt) | 2006-06-08 | 2012-07-03 | Speedel Experimenta Ag | piperidinas 2,5-di-substitìdas. |
GB0611696D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
GB0611697D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
EP1908471A1 (en) | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
-
2006
- 2006-12-28 ES ES11185536T patent/ES2430139T3/es active Active
- 2006-12-28 US US12/159,749 patent/US8129411B2/en not_active Expired - Fee Related
- 2006-12-28 EP EP06829892.6A patent/EP1968940B1/en not_active Revoked
- 2006-12-28 PE PE2006001709A patent/PE20071177A1/es not_active Application Discontinuation
- 2006-12-28 EP EP11185536.7A patent/EP2420491B1/en active Active
- 2006-12-28 PT PT111855367T patent/PT2420491E/pt unknown
- 2006-12-28 AR ARP060105852A patent/AR058885A1/es not_active Application Discontinuation
- 2006-12-28 NZ NZ569135A patent/NZ569135A/en not_active IP Right Cessation
- 2006-12-28 WO PCT/EP2006/012581 patent/WO2007077005A1/en active Application Filing
- 2006-12-28 AU AU2006332124A patent/AU2006332124B2/en not_active Ceased
- 2006-12-28 JP JP2008547900A patent/JP5306821B2/ja not_active Expired - Fee Related
- 2006-12-28 PL PL11185536T patent/PL2420491T3/pl unknown
- 2006-12-28 BR BRPI0620736-7A patent/BRPI0620736A2/pt not_active IP Right Cessation
- 2006-12-28 CA CA2633624A patent/CA2633624C/en not_active Expired - Fee Related
- 2006-12-28 ES ES06829892.6T patent/ES2476422T3/es active Active
- 2006-12-28 PE PE2010000928A patent/PE20110117A1/es not_active Application Discontinuation
- 2006-12-28 KR KR1020087018705A patent/KR20080086921A/ko active IP Right Grant
- 2006-12-29 TW TW095149881A patent/TW200738698A/zh unknown
-
2008
- 2008-06-10 IL IL192024A patent/IL192024A0/en unknown
- 2008-06-19 CR CR10091A patent/CR10091A/es not_active Application Discontinuation
- 2008-06-19 MA MA31057A patent/MA30073B1/fr unknown
- 2008-06-27 EC EC2008008587A patent/ECSP088587A/es unknown
- 2008-07-25 NO NO20083315A patent/NO20083315L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA30073B1 (fr) | 2008-12-01 |
JP2009522226A (ja) | 2009-06-11 |
PL2420491T3 (pl) | 2013-12-31 |
PE20110117A1 (es) | 2011-03-07 |
ES2476422T3 (es) | 2014-07-14 |
CA2633624A1 (en) | 2007-07-12 |
BRPI0620736A2 (pt) | 2011-12-20 |
PT2420491E (pt) | 2013-10-14 |
ES2430139T3 (es) | 2013-11-19 |
AU2006332124B2 (en) | 2011-03-03 |
EP1968940B1 (en) | 2014-04-02 |
US20090192148A1 (en) | 2009-07-30 |
TW200738698A (en) | 2007-10-16 |
WO2007077005A1 (en) | 2007-07-12 |
KR20080086921A (ko) | 2008-09-26 |
US8129411B2 (en) | 2012-03-06 |
EP2420491B1 (en) | 2013-07-03 |
ECSP088587A (es) | 2008-07-30 |
AU2006332124A1 (en) | 2007-07-12 |
EP2420491A1 (en) | 2012-02-22 |
EP1968940A1 (en) | 2008-09-17 |
JP5306821B2 (ja) | 2013-10-02 |
CR10091A (es) | 2008-10-27 |
NZ569135A (en) | 2011-08-26 |
CA2633624C (en) | 2013-11-19 |
NO20083315L (no) | 2008-09-19 |
PE20071177A1 (es) | 2008-01-18 |
IL192024A0 (en) | 2008-12-29 |
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