CO5200785A1 - Uso terapeutico de quinazolina - Google Patents
Uso terapeutico de quinazolinaInfo
- Publication number
- CO5200785A1 CO5200785A1 CO00071837A CO00071837A CO5200785A1 CO 5200785 A1 CO5200785 A1 CO 5200785A1 CO 00071837 A CO00071837 A CO 00071837A CO 00071837 A CO00071837 A CO 00071837A CO 5200785 A1 CO5200785 A1 CO 5200785A1
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- nhc
- hydrogen
- quinazoline
- therapeutic use
- Prior art date
Links
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- -1 amide ester Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
El uso de un compuesto de fórmula (I)<EMI FILE="00071837_1" ID="1" IMF=JPEG >o una sal, éster amida o prodroga de él;donde X es O, o S, S(O) o S(O)2, NH o NR12 es hidrógeno o C1-6 alquilo;R5 se selecciona a partir de un grupo NHC(O)OR9, NHC(O)R9, NHS(O)2R9, C(O)R9, C(O)OR9, S(O)R9, S(O)OR9, S(O)2OR9, C(O)NR10R11, S(O)NRO10R11, S(O)ONR10R11 donde R9, R10 o R11 se seleccionan independientemente a partir de hidrógeno, hidrocarbilo opcionalmente sustituido y heterociclilo opcionalmente sustituido y R10 y R11 conjuntamente con el átomo de nitrógeno al cual están unidos pueden formar adicionalmente un anillo heterocíclico opcionalmente sustituido el cual contiene opcionalmente adicionales heteroátomos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9922170.7A GB9922170D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
GBGB9922154.1A GB9922154D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5200785A1 true CO5200785A1 (es) | 2002-09-27 |
Family
ID=26315940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO00071837A CO5200785A1 (es) | 1999-09-21 | 2000-09-21 | Uso terapeutico de quinazolina |
Country Status (24)
Country | Link |
---|---|
US (1) | US7709479B1 (es) |
EP (1) | EP1218354B1 (es) |
JP (1) | JP4870304B2 (es) |
KR (1) | KR20020032612A (es) |
CN (1) | CN1391562A (es) |
AT (1) | ATE449083T1 (es) |
AU (1) | AU7301000A (es) |
BG (1) | BG106492A (es) |
BR (1) | BR0014116A (es) |
CA (1) | CA2384291A1 (es) |
CO (1) | CO5200785A1 (es) |
CZ (1) | CZ20021009A3 (es) |
DE (1) | DE60043349D1 (es) |
EE (1) | EE200200119A (es) |
ES (1) | ES2334879T3 (es) |
HK (1) | HK1046686A1 (es) |
HU (1) | HUP0300059A3 (es) |
IL (1) | IL148576A0 (es) |
IS (1) | IS6305A (es) |
NO (1) | NO20021399L (es) |
PL (1) | PL354323A1 (es) |
RU (1) | RU2002110461A (es) |
SK (1) | SK3822002A3 (es) |
WO (1) | WO2001021596A1 (es) |
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-
2000
- 2000-09-18 RU RU2002110461/14A patent/RU2002110461A/ru unknown
- 2000-09-18 US US10/088,814 patent/US7709479B1/en not_active Expired - Fee Related
- 2000-09-18 DE DE60043349T patent/DE60043349D1/de not_active Expired - Lifetime
- 2000-09-18 ES ES00960840T patent/ES2334879T3/es not_active Expired - Lifetime
- 2000-09-18 EP EP00960840A patent/EP1218354B1/en not_active Expired - Lifetime
- 2000-09-18 SK SK382-2002A patent/SK3822002A3/sk unknown
- 2000-09-18 JP JP2001524975A patent/JP4870304B2/ja not_active Expired - Fee Related
- 2000-09-18 WO PCT/GB2000/003580 patent/WO2001021596A1/en not_active Application Discontinuation
- 2000-09-18 CN CN00816011A patent/CN1391562A/zh active Pending
- 2000-09-18 IL IL14857600A patent/IL148576A0/xx unknown
- 2000-09-18 EE EEP200200119A patent/EE200200119A/xx unknown
- 2000-09-18 AT AT00960840T patent/ATE449083T1/de not_active IP Right Cessation
- 2000-09-18 CZ CZ20021009A patent/CZ20021009A3/cs unknown
- 2000-09-18 AU AU73010/00A patent/AU7301000A/en not_active Abandoned
- 2000-09-18 HU HU0300059A patent/HUP0300059A3/hu unknown
- 2000-09-18 PL PL00354323A patent/PL354323A1/xx not_active Application Discontinuation
- 2000-09-18 CA CA002384291A patent/CA2384291A1/en not_active Abandoned
- 2000-09-18 BR BR0014116-0A patent/BR0014116A/pt not_active IP Right Cessation
- 2000-09-18 KR KR1020027003704A patent/KR20020032612A/ko not_active Application Discontinuation
- 2000-09-21 CO CO00071837A patent/CO5200785A1/es not_active Application Discontinuation
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- 2002-03-07 BG BG106492A patent/BG106492A/bg unknown
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IL148576A0 (en) | 2002-09-12 |
NO20021399D0 (no) | 2002-03-20 |
CA2384291A1 (en) | 2001-03-29 |
IS6305A (is) | 2002-03-18 |
EP1218354B1 (en) | 2009-11-18 |
NO20021399L (no) | 2002-04-30 |
ES2334879T3 (es) | 2010-03-17 |
DE60043349D1 (de) | 2009-12-31 |
SK3822002A3 (en) | 2002-10-08 |
BR0014116A (pt) | 2002-05-21 |
CZ20021009A3 (cs) | 2002-06-12 |
CN1391562A (zh) | 2003-01-15 |
HUP0300059A3 (en) | 2003-08-28 |
EE200200119A (et) | 2003-04-15 |
EP1218354A1 (en) | 2002-07-03 |
RU2002110461A (ru) | 2004-03-10 |
JP4870304B2 (ja) | 2012-02-08 |
HK1046686A1 (zh) | 2003-01-24 |
PL354323A1 (en) | 2004-01-12 |
AU7301000A (en) | 2001-04-24 |
ATE449083T1 (de) | 2009-12-15 |
KR20020032612A (ko) | 2002-05-03 |
BG106492A (bg) | 2003-01-31 |
US7709479B1 (en) | 2010-05-04 |
WO2001021596A1 (en) | 2001-03-29 |
HUP0300059A2 (hu) | 2003-07-28 |
JP2003509499A (ja) | 2003-03-11 |
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