EE200200119A - Kinasoliini derivaadid ja nende kasutamine ravimitena - Google Patents
Kinasoliini derivaadid ja nende kasutamine ravimitenaInfo
- Publication number
- EE200200119A EE200200119A EEP200200119A EEP200200119A EE200200119A EE 200200119 A EE200200119 A EE 200200119A EE P200200119 A EEP200200119 A EE P200200119A EE P200200119 A EEP200200119 A EE P200200119A EE 200200119 A EE200200119 A EE 200200119A
- Authority
- EE
- Estonia
- Prior art keywords
- optionally substituted
- hydrogen
- 3alkyl
- organic groups
- nhc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9922170.7A GB9922170D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
GBGB9922154.1A GB9922154D0 (en) | 1999-09-21 | 1999-09-21 | Chemical compounds |
PCT/GB2000/003580 WO2001021596A1 (en) | 1999-09-21 | 2000-09-18 | Quinazoline derivatives and their use as pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
EE200200119A true EE200200119A (et) | 2003-04-15 |
Family
ID=26315940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200200119A EE200200119A (et) | 1999-09-21 | 2000-09-18 | Kinasoliini derivaadid ja nende kasutamine ravimitena |
Country Status (24)
Country | Link |
---|---|
US (1) | US7709479B1 (es) |
EP (1) | EP1218354B1 (es) |
JP (1) | JP4870304B2 (es) |
KR (1) | KR20020032612A (es) |
CN (1) | CN1391562A (es) |
AT (1) | ATE449083T1 (es) |
AU (1) | AU7301000A (es) |
BG (1) | BG106492A (es) |
BR (1) | BR0014116A (es) |
CA (1) | CA2384291A1 (es) |
CO (1) | CO5200785A1 (es) |
CZ (1) | CZ20021009A3 (es) |
DE (1) | DE60043349D1 (es) |
EE (1) | EE200200119A (es) |
ES (1) | ES2334879T3 (es) |
HK (1) | HK1046686A1 (es) |
HU (1) | HUP0300059A3 (es) |
IL (1) | IL148576A0 (es) |
IS (1) | IS6305A (es) |
NO (1) | NO20021399L (es) |
PL (1) | PL354323A1 (es) |
RU (1) | RU2002110461A (es) |
SK (1) | SK3822002A3 (es) |
WO (1) | WO2001021596A1 (es) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
JP2003506387A (ja) | 1999-08-04 | 2003-02-18 | アイカゲン インコーポレイテッド | カリウムチャンネルオープナーとしてのベンズアニリド |
UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
KR20080027400A (ko) | 2000-08-21 | 2008-03-26 | 아스트라제네카 아베 | 퀴나졸린 유도체 |
WO2002036587A2 (en) | 2000-11-01 | 2002-05-10 | Cor Therapeutics, Inc. | Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides |
WO2003000188A2 (en) * | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel quinazolines and uses thereof |
WO2003033472A1 (fr) * | 2001-10-17 | 2003-04-24 | Kirin Beer Kabushiki Kaisha | Derives de quinoline ou de quinazoline inhibant l'autophosphorylation de recepteurs du facteur de croissance des fibroblastes |
WO2003035602A1 (fr) * | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
SI1463506T1 (sl) * | 2001-12-24 | 2010-01-29 | Astrazeneca Ab | Substituirani kinazolinski derivati kot inhibitorji kinaz Aurora |
KR20040085151A (ko) | 2002-01-17 | 2004-10-07 | 뉴로젠 코포레이션 | 캡사이신 조절자로서의 치환된 퀴나졸린-4-일 아민 유사체 |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
EP2277867B1 (en) | 2002-07-15 | 2012-12-05 | Symphony Evolution, Inc. | Compounds, pharmaceutical compositions thereof and their use in treating cancer |
NZ538663A (en) * | 2002-08-29 | 2006-02-24 | Univ Temple | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
MXPA05006123A (es) | 2002-12-13 | 2005-09-30 | Neurogen Corp | Analogos de quinazolin-4-ilamina 2-sustituida como moduladores de receptores de capsaicina. |
MXPA05006335A (es) * | 2002-12-18 | 2005-08-26 | Pfizer Prod Inc | Derivados biciclicos para el tratamiento del crecimiento celular anormal. |
KR20050087863A (ko) | 2002-12-24 | 2005-08-31 | 아스트라제네카 아베 | 퀴나졸린 화합물 |
SI1578755T1 (sl) | 2002-12-24 | 2007-12-31 | Astrazeneca Ab | Fosfonooksi kinazolinski derivati in njihova farmacevtska uporaba |
CN1809557B (zh) * | 2003-04-16 | 2012-07-04 | 阿斯利康(瑞典)有限公司 | 化合物 |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
WO2005002571A1 (en) * | 2003-07-03 | 2005-01-13 | Cambridge University Technical Services Ltd | Use of aurora kinase inhibitors for reducing the resistance of cancer cells |
ES2465624T3 (es) * | 2003-07-11 | 2014-06-06 | Merck Patent Gmbh | Benzimidazol carboxamidas como inhibidores de RAF quinasa |
US7329664B2 (en) | 2003-07-16 | 2008-02-12 | Neurogen Corporation | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
GB0322409D0 (en) | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
DK2392564T3 (da) | 2003-09-26 | 2014-01-13 | Exelixis Inc | c-Met-modulatorer og anvendelsesfremgangsmåder |
US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
DE602004022318D1 (de) | 2003-10-14 | 2009-09-10 | Supergen Inc | Proteinkinaseinhibitoren |
US7767670B2 (en) | 2003-11-13 | 2010-08-03 | Ambit Biosciences Corporation | Substituted 3-carboxamido isoxazoles as kinase modulators |
GB0326459D0 (en) * | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
JP5032851B2 (ja) | 2004-02-03 | 2012-09-26 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
US7625949B2 (en) | 2004-04-23 | 2009-12-01 | Roche Palo Alto Llc | Methods for treating retroviral infections |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
TW200538453A (en) | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
US7432373B2 (en) | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US20080200433A1 (en) * | 2004-09-01 | 2008-08-21 | Tsuyoshi Suzuki | Molecular Chaperone Function Regulator |
TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
KR20070084172A (ko) | 2004-10-12 | 2007-08-24 | 아스트라제네카 아베 | 퀴나졸린 유도체 |
WO2006044687A2 (en) | 2004-10-15 | 2006-04-27 | Takeda San Diego, Inc. | Kinase inhibitors |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
WO2006108489A1 (en) | 2005-04-14 | 2006-10-19 | F. Hoffmann-La Roche Ag | Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents |
CN101189239A (zh) * | 2005-04-28 | 2008-05-28 | 休普基因公司 | 蛋白激酶抑制剂 |
GB0509227D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
WO2007033196A1 (en) | 2005-09-14 | 2007-03-22 | Bristol-Myers Squibb Company | Met kinase inhibitors |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
KR20080056220A (ko) | 2005-10-19 | 2008-06-20 | 에프. 호프만-라 로슈 아게 | 페닐-아세트아마이드 nnrt 저해제 |
NZ569327A (en) | 2005-12-28 | 2011-09-30 | Vertex Pharma | 1-(benzo [d] [1,3] dioxol-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-binding cassette transporters for the treatment of cystic fibrosis |
US7671221B2 (en) | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
CN101003514A (zh) | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
JPWO2008001886A1 (ja) | 2006-06-30 | 2009-11-26 | 協和発酵キリン株式会社 | オーロラ(Aurora)阻害剤 |
BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
EP2174938A1 (en) * | 2006-10-12 | 2010-04-14 | SuperGen, Inc. | Quinoline derivatives for modulating DNA methylation |
PT2089364E (pt) | 2006-11-08 | 2013-08-26 | Bristol Myers Squibb Co | Compostos de piridinona |
EP1921070A1 (de) | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
WO2008095847A1 (de) | 2007-02-06 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
KR20100017101A (ko) * | 2007-04-16 | 2010-02-16 | 시플라 리미티드 | 게피티닙의 제조방법 |
UA101168C2 (ru) | 2007-10-29 | 2013-03-11 | Натко Фарма Лимитед | 4-(тетразол-5-ил)хиназолиновые производные как противораковые средства |
DK2229391T3 (da) * | 2007-12-19 | 2014-10-13 | Cancer Res Inst Royal | Pyrido[2,3-B]pyrazin-8-substituerede forbindelser og deres anvendelse |
DK2235002T3 (da) | 2008-01-23 | 2013-03-11 | Bristol Myers Squibb Co | 4-pyridinonforbindelser og anvendelse heraf til behandling af cancer |
WO2009098061A1 (de) | 2008-02-07 | 2009-08-13 | Boehringer Ingelheim International Gmbh | Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
CN102083831B (zh) * | 2008-07-03 | 2014-09-03 | 默克专利有限公司 | 用作aurora激酶抑制剂的萘啶酮 |
EP2149565A1 (de) * | 2008-07-24 | 2010-02-03 | Bayer Schering Pharma AG | Sulfonsubstituierte Chinazolinderivate als Immunmodulatoren zur Behandlung von enzündlichen und allergischen Erkrankungen |
JP5539351B2 (ja) | 2008-08-08 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法 |
SG173014A1 (en) | 2009-01-16 | 2011-08-29 | Exelixis Inc | Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer |
DK2396307T3 (en) * | 2009-02-11 | 2015-01-12 | Merck Patent Gmbh | NOVEL AMINO-azaheterocyclic carboxamides |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
PL2473487T3 (pl) | 2009-09-03 | 2017-07-31 | Bristol-Myers Squibb Company | Chinazoliny jako inhibitory kanałów jonowych potasowych |
EP2519517B1 (en) * | 2009-12-29 | 2015-03-25 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
KR101217526B1 (ko) * | 2010-06-11 | 2013-01-02 | 한미사이언스 주식회사 | 아마이드 유도체 또는 이의 약학적으로 허용 가능한 염을 포함하는 약제학적 조성물 |
EP2423208A1 (en) * | 2010-08-28 | 2012-02-29 | Lead Discovery Center GmbH | Pharmaceutically active compounds as Axl inhibitors |
AU2012225735B2 (en) | 2011-03-04 | 2016-03-10 | Glaxosmithkline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
US8658655B2 (en) * | 2011-03-24 | 2014-02-25 | Fox Chase Cancer Center | Inhibition of activated cdc42-associated kinase 1 |
KR101317809B1 (ko) | 2011-06-07 | 2013-10-16 | 한미약품 주식회사 | 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물 |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
AR092529A1 (es) * | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基-喹啉類 |
KR20140096571A (ko) | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
ES2654100T3 (es) | 2013-02-21 | 2018-02-12 | Glaxosmithkline Intellectual Property Development Limited | Quinazolinas como inhibidores de quinasa |
WO2014148136A1 (ja) * | 2013-03-19 | 2014-09-25 | 岐阜市 | 抗アレルギー活性化合物及びその用途 |
KR102307175B1 (ko) | 2013-09-16 | 2021-10-01 | 아스트라제네카 아베 | 치료용 중합체 나노입자 및 이의 제조 방법과 사용 방법 |
US10550121B2 (en) | 2015-03-27 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
CA2981886A1 (en) * | 2015-04-16 | 2016-10-20 | Icahn School Of Medicine At Mount Sinai | Ksr antagonists |
EP3319938B1 (en) * | 2015-07-10 | 2022-04-06 | University of Maryland, Baltimore | Small molecule inhibitors of the mcl-1 oncoprotein and uses thereof |
AU2016333987A1 (en) | 2015-10-05 | 2018-05-10 | Ny State Psychiatric Institute | Activators of autophagic flux and phospholipase D and clearance of protein aggregates including tau and treatment of proteinopathies |
CN105384699B (zh) * | 2015-10-23 | 2016-10-12 | 中国人民解放军***南京总医院 | 一种新型喹唑啉衍生物lu1501及其制备方法和应用 |
CN105418517B (zh) * | 2015-12-03 | 2017-03-22 | 中国人民解放军***南京总医院 | 一种新型喹唑啉衍生物lu1509及其制备方法和应用 |
CN105503747B (zh) * | 2015-12-03 | 2017-12-19 | 中国人民解放军***南京总医院 | 一种喹唑啉衍生物lu1507及其制备方法和应用 |
CN105399689B (zh) * | 2015-12-03 | 2017-03-01 | 中国人民解放军***南京总医院 | 一种新型喹唑啉衍生物lu1503及其制备方法和应用 |
CN105481835B (zh) * | 2015-12-03 | 2018-09-04 | 中国人民解放军***南京总医院 | 一种喹唑啉衍生物lu1508及其制备方法和应用 |
CN105461642B (zh) * | 2015-12-03 | 2017-03-22 | 中国人民解放军***南京总医院 | 一种新型喹唑啉衍生物lu1505及其制备方法和应用 |
CN105503835B (zh) * | 2015-12-03 | 2018-04-24 | 中国人民解放军***南京总医院 | 一种新型喹唑啉衍生物lu1510及其制备方法和应用 |
CN105503836B (zh) * | 2015-12-03 | 2018-04-24 | 中国人民解放军***南京总医院 | 一种新型喹唑啉衍生物lu1502及其制备方法和应用 |
CN105541807B (zh) * | 2015-12-03 | 2018-04-24 | 中国人民解放军***南京总医院 | 一种新型喹唑啉衍生物lu1506及其制备方法和应用 |
CN105884699B (zh) * | 2016-05-11 | 2019-05-07 | 中国药科大学 | 4-取代苯胺喹唑啉类衍生物及其制备方法和用途 |
RU2769694C2 (ru) | 2017-04-27 | 2022-04-05 | Астразенека Аб | C5-Анилинохиназолиновые соединения и их использование в лечении рака |
WO2018197643A1 (en) * | 2017-04-27 | 2018-11-01 | Astrazeneca Ab | Phenoxyquinazoline compounds and their use in treating cancer |
AU2018312110B2 (en) | 2017-08-04 | 2023-03-16 | Bioventures, Llc | Linear lipopeptide paenipeptins and methods of using the same |
CN110372666B (zh) * | 2018-04-13 | 2022-11-08 | 华东理工大学 | 喹唑啉类化合物作为egfr三突变抑制剂及其应用 |
WO2020049208A1 (es) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida |
CN111303024B (zh) * | 2018-12-12 | 2023-03-28 | 安徽中科拓苒药物科学研究有限公司 | 一种喹啉结构的pan-KIT激酶抑制剂及其用途 |
CN109776432B (zh) * | 2019-03-21 | 2020-07-24 | 广州六顺生物科技股份有限公司 | 一种多靶点激酶抑制剂、药物组合物及多靶点激酶抑制剂的制备方法和应用 |
CN112778217B (zh) * | 2019-11-08 | 2024-01-26 | 沈阳化工研究院有限公司 | 一种喹唑啉类化合物及其应用 |
CN114948964B (zh) * | 2021-02-25 | 2023-10-03 | 石药集团中奇制药技术(石家庄)有限公司 | 多靶点蛋白激酶抑制剂的用途 |
CN113004211A (zh) * | 2021-03-29 | 2021-06-22 | 鲁东大学 | 喹唑啉-4-硒醚衍生物及制备方法和生物活性 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL78381B2 (es) * | 1972-08-09 | 1975-06-30 | ||
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
GB9300059D0 (en) * | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
DE4208254A1 (de) * | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
GB9510757D0 (en) * | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
TW321649B (es) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
US6143764A (en) * | 1995-11-07 | 2000-11-07 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same |
ATE315654T1 (de) | 1995-12-18 | 2006-02-15 | Sugen Inc | Diagnose und behandlung von mit aur-1 und/oder aur-2 assoziierten erkrankungen |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
IL125686A (en) * | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab | 4-anilinochinazolin derivate |
JPH107657A (ja) * | 1996-06-19 | 1998-01-13 | Sankyo Co Ltd | スルホンアミド化合物 |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
US6251912B1 (en) * | 1997-08-01 | 2001-06-26 | American Cyanamid Company | Substituted quinazoline derivatives |
RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
GB9800575D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
WO2000020402A1 (en) * | 1998-10-01 | 2000-04-13 | Astrazeneca Ab | Chemical compounds |
-
2000
- 2000-09-18 WO PCT/GB2000/003580 patent/WO2001021596A1/en not_active Application Discontinuation
- 2000-09-18 SK SK382-2002A patent/SK3822002A3/sk unknown
- 2000-09-18 EE EEP200200119A patent/EE200200119A/xx unknown
- 2000-09-18 HU HU0300059A patent/HUP0300059A3/hu unknown
- 2000-09-18 DE DE60043349T patent/DE60043349D1/de not_active Expired - Lifetime
- 2000-09-18 ES ES00960840T patent/ES2334879T3/es not_active Expired - Lifetime
- 2000-09-18 IL IL14857600A patent/IL148576A0/xx unknown
- 2000-09-18 JP JP2001524975A patent/JP4870304B2/ja not_active Expired - Fee Related
- 2000-09-18 AU AU73010/00A patent/AU7301000A/en not_active Abandoned
- 2000-09-18 KR KR1020027003704A patent/KR20020032612A/ko not_active Application Discontinuation
- 2000-09-18 AT AT00960840T patent/ATE449083T1/de not_active IP Right Cessation
- 2000-09-18 BR BR0014116-0A patent/BR0014116A/pt not_active IP Right Cessation
- 2000-09-18 RU RU2002110461/14A patent/RU2002110461A/ru unknown
- 2000-09-18 CZ CZ20021009A patent/CZ20021009A3/cs unknown
- 2000-09-18 CA CA002384291A patent/CA2384291A1/en not_active Abandoned
- 2000-09-18 CN CN00816011A patent/CN1391562A/zh active Pending
- 2000-09-18 PL PL00354323A patent/PL354323A1/xx not_active Application Discontinuation
- 2000-09-18 EP EP00960840A patent/EP1218354B1/en not_active Expired - Lifetime
- 2000-09-18 US US10/088,814 patent/US7709479B1/en not_active Expired - Fee Related
- 2000-09-21 CO CO00071837A patent/CO5200785A1/es not_active Application Discontinuation
-
2002
- 2002-03-07 BG BG106492A patent/BG106492A/bg unknown
- 2002-03-18 IS IS6305A patent/IS6305A/is unknown
- 2002-03-20 NO NO20021399A patent/NO20021399L/no unknown
- 2002-11-19 HK HK02108372.9A patent/HK1046686A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1218354B1 (en) | 2009-11-18 |
SK3822002A3 (en) | 2002-10-08 |
PL354323A1 (en) | 2004-01-12 |
WO2001021596A1 (en) | 2001-03-29 |
RU2002110461A (ru) | 2004-03-10 |
CO5200785A1 (es) | 2002-09-27 |
NO20021399D0 (no) | 2002-03-20 |
US7709479B1 (en) | 2010-05-04 |
HUP0300059A3 (en) | 2003-08-28 |
BG106492A (bg) | 2003-01-31 |
JP4870304B2 (ja) | 2012-02-08 |
DE60043349D1 (de) | 2009-12-31 |
HK1046686A1 (zh) | 2003-01-24 |
CA2384291A1 (en) | 2001-03-29 |
CZ20021009A3 (cs) | 2002-06-12 |
IS6305A (is) | 2002-03-18 |
ES2334879T3 (es) | 2010-03-17 |
CN1391562A (zh) | 2003-01-15 |
IL148576A0 (en) | 2002-09-12 |
AU7301000A (en) | 2001-04-24 |
KR20020032612A (ko) | 2002-05-03 |
ATE449083T1 (de) | 2009-12-15 |
HUP0300059A2 (hu) | 2003-07-28 |
NO20021399L (no) | 2002-04-30 |
BR0014116A (pt) | 2002-05-21 |
JP2003509499A (ja) | 2003-03-11 |
EP1218354A1 (en) | 2002-07-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE200200119A (et) | Kinasoliini derivaadid ja nende kasutamine ravimitena | |
MX9709951A (es) | Derivados de benzamida y su uso como antagonistas de vasopresina. | |
DK0876366T3 (da) | Angiogenese-inhiberende pyridazinaminer | |
TR200200749T2 (tr) | Kinazolin bileşikleri ve bunları içeren farmasötik bileşikler. | |
NO20025651D0 (no) | Adenosin A2A-reseptorantagonister | |
HUP0204226A2 (en) | Quinazoline derivatives, pharmaceutical compositions containing them, their use and process for the preparation of the compounds | |
MY108261A (en) | Water soluble camptothecin derivatives | |
HK1068334A1 (en) | Derivatives of triazolyl-imidazopyridine and of the triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments | |
DE60031577D1 (de) | Hemmer der zelladhäsion | |
CA2360360A1 (en) | Piperidyl benzamide compounds, composition containing same and their use thereof | |
PA8432901A1 (es) | Compuestos de piridilpirrol | |
AR015312A1 (es) | Compuestos inhibidores no peptidilicos de la union a las celulas dependientes de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunesy respiratorias, composicion farmaceutica y uso de los compuestos en la preparacion de medicamentos | |
DE69507293D1 (de) | Benzamid-derivate als vasopressin-antagonisten | |
CL2004001050A1 (es) | Compuesto derivado de 3'-[4-oxo-3-{[(ciclopropil o 2,2,2-trifluoroetil)amino]carbonil}-1,8-naftiridin-1(4h)-il]-3-sustituido-1-1'-bifenil-4-il; composicion farmaceutica; y uso en el tratamiento o prevencion de asma, bronquitis cronica, enfermedad pul | |
BG104717A (en) | Water soluble azoles as broad-spectrum antifungals | |
ZA935340B (en) | Phosphonated arylethanolamine compounds with anti-hyperglycemic and/or anti-obesity activity | |
IL125926A0 (en) | Compounds related to the amidinium family pharmaceutical compositions containing them and uses thereof | |
MXPA05009607A (es) | Derivados de n-fenil-[(4-piridil)-azinil]-amina como agentes protectores de plantas. | |
FI941958A0 (fi) | 2-heterosyklinenetyyliamiinijohdannaiset ja niiden käyttö lääkkeinä | |
ATE170851T1 (de) | Guanidinothiazolederivate und ihre anwendung als h2-rezeptor-antagonisten | |
ATE238274T1 (de) | Naphthalin derivate | |
SE0303542D0 (sv) | 1,2,3,4-Tetrahydroisoquinoline derivaties, preparations thereof and uses thereof | |
TH15713A (th) | 14- ซับสทิทิวเทด มาร์คฟอร์ทีน และอนุพันธ์ของสารเหล่านั้นที่ใช้ประโยชน์เป็นสารฆ่าปรสิต | |
ATE207879T1 (de) | Alkynylaminosäure derivate und ihre verwendung als pharmazeutische verbindungen | |
TH43749A (th) | อนุพันธ์เบนโซซาซีน การเตรียมและการใช้มันเพื่อการบำบัดรักษาโรค |