CO5261527A1 - Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina - Google Patents

Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina

Info

Publication number
CO5261527A1
CO5261527A1 CO00094338A CO00094338A CO5261527A1 CO 5261527 A1 CO5261527 A1 CO 5261527A1 CO 00094338 A CO00094338 A CO 00094338A CO 00094338 A CO00094338 A CO 00094338A CO 5261527 A1 CO5261527 A1 CO 5261527A1
Authority
CO
Colombia
Prior art keywords
4alkyl
hydroxyacetilepiperazine
eteres
oxazolidinones
substituent
Prior art date
Application number
CO00094338A
Other languages
English (en)
Inventor
Jr Jackson B Hester
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CO5261527A1 publication Critical patent/CO5261527A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Un compuesto de la fórmula I:<EMI FILE="00094338_1" ID="1" IMF=JPEG >o una sal farmacéuticamente aceptable del mismo, en donde:A es una estructura i, ii o iii<EMI FILE="00094338_2" ID="2" IMF=JPEG >X es O o S;R1 es(a) H,(b) NH2,(c) NHC1-4alquilo,(d) C1-4alquilo, opcionaImente substituido con uno o más F, Cl o CN,(e) C2-4 alquenilo,(f) OC1-4 alquilo,(g) SC1-4alquilo, o(h) (CH2)nC3-6cicloalquilo;R2 y R3 son independientemente H, F, CI o C1-2 alquilo;R4 está ubicado en C-3 ó en C-4 y es:<EMI FILE="00094338_3" ID="3" IMF=JPEG >R5 es H O CH3;R6 es H O C1-4alquilo, opcionalmente substituido con OH, SH, SCH3, NH2 o NHC(=NH)NH2;R7 y R8 son independientemente(a) H,(b) C1-4 alquilo, o(c) R7 y R8 conjuntamente con el nitrógeno al cual están adjuntos forman un anillo heterocíclico saturado de 5,6 ó 7 miembros que puede tener heteroátomos adicionales seleccionados del grupo constituido de O, S(O)n o N-R5;n es 0, 1 ó 2; ycon la condición de que cuando X es O, R4 no está en la subsección (a).
CO00094338A 1999-12-14 2000-12-12 Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina CO5261527A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17067599P 1999-12-14 1999-12-14

Publications (1)

Publication Number Publication Date
CO5261527A1 true CO5261527A1 (es) 2003-03-31

Family

ID=22620832

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00094338A CO5261527A1 (es) 1999-12-14 2000-12-12 Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina

Country Status (26)

Country Link
US (1) US6281210B1 (es)
EP (1) EP1242395B1 (es)
JP (1) JP2003516977A (es)
KR (1) KR20020062332A (es)
CN (1) CN1390211A (es)
AR (1) AR026547A1 (es)
AT (1) ATE288423T1 (es)
AU (1) AU1805801A (es)
BR (1) BR0015177A (es)
CA (1) CA2387047A1 (es)
CO (1) CO5261527A1 (es)
CZ (1) CZ20022389A3 (es)
DE (1) DE60017941T2 (es)
EA (1) EA200200673A1 (es)
ES (1) ES2236006T3 (es)
HU (1) HUP0203787A3 (es)
IL (1) IL150031A0 (es)
MX (1) MXPA02005909A (es)
NO (1) NO20022811D0 (es)
PE (1) PE20010851A1 (es)
PL (1) PL355369A1 (es)
PT (1) PT1242395E (es)
SK (1) SK5972002A3 (es)
TW (1) TW544449B (es)
WO (1) WO2001044212A1 (es)
ZA (1) ZA200202953B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
ATE321024T1 (de) * 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
TW200404069A (en) * 2002-06-28 2004-03-16 Upjohn Co Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent
TW200403240A (en) * 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents
ES2271660T3 (es) * 2002-11-21 2007-04-16 PHARMACIA &amp; UPJOHN COMPANY LLC Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos.
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) * 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
PL1934208T3 (pl) 2005-10-04 2011-09-30 Bayer Ip Gmbh Nowa polimorficzna postać 5-chloro-N-({ (5S)-2-okso-3-[4-( 3-okso-4-morfolinylo)-fenylo]-1,3-oksazolidyn-5-ylo}-metylo)-2-tiofenokarboksamidu
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
WO2008073444A2 (en) * 2006-12-12 2008-06-19 The Johns Hopkins University Phou (perf), a persistence switch involved in persister formation as a drug target for persister bacteria
EP2170874A4 (en) * 2007-06-22 2011-08-31 Orchid Res Lab Ltd NEW COMPOUNDS AND THEIR USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3698724B2 (ja) * 1993-11-22 2005-09-21 ファルマシア・アンド・アップジョン・カンパニー 置換−ヒドロキシアセチルピペラジンフェニルオキサゾリジノンのエステル
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
EP0984947B8 (en) * 1997-05-30 2005-06-15 Pharmacia & Upjohn Company LLC Oxazolidinone antibacterial agents having a thiocarbonyl functionality
GB9812019D0 (en) * 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
DE60017941D1 (de) 2005-03-10
EP1242395B1 (en) 2005-02-02
PL355369A1 (en) 2004-04-19
PE20010851A1 (es) 2001-08-17
TW544449B (en) 2003-08-01
AR026547A1 (es) 2003-02-19
EP1242395A1 (en) 2002-09-25
CN1390211A (zh) 2003-01-08
NO20022811L (no) 2002-06-13
ZA200202953B (en) 2003-09-23
MXPA02005909A (es) 2002-10-23
BR0015177A (pt) 2002-06-18
HUP0203787A2 (hu) 2003-07-28
WO2001044212A1 (en) 2001-06-21
AU1805801A (en) 2001-06-25
NO20022811D0 (no) 2002-06-13
ES2236006T3 (es) 2005-07-16
CA2387047A1 (en) 2001-06-21
HUP0203787A3 (en) 2005-06-28
KR20020062332A (ko) 2002-07-25
US6281210B1 (en) 2001-08-28
SK5972002A3 (en) 2003-01-09
ATE288423T1 (de) 2005-02-15
DE60017941T2 (de) 2006-03-30
CZ20022389A3 (cs) 2002-10-16
PT1242395E (pt) 2005-05-31
EA200200673A1 (ru) 2002-12-26
IL150031A0 (en) 2002-12-01
JP2003516977A (ja) 2003-05-20

Similar Documents

Publication Publication Date Title
CO5261527A1 (es) Eteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
CO5200785A1 (es) Uso terapeutico de quinazolina
CO5150150A1 (es) 4-oxo-1,4-dihidro-3-quinoleincarboxamidas como agentes antivirales
CO5251427A1 (es) Oxazolidinonas que tienen la fucion de sulfoximina
BRPI0014526B8 (pt) compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo
CO5261559A1 (es) Antagonistas de neurokinina selectivos
CO5251381A1 (es) Derivados de adamantano, un proceso para su preparacion y composiciones farmaceuticas que los contienen
EP1241528A3 (en) Radical polymerizable compounds for image forming materials
UY26093A1 (es) Inhibidores de ap2 de bifenilos que contienen compuestos heterociclicos y metodo
CY1111951T1 (el) Φαινυλο-καρβοξαμιδικες ενωσεις χρησιμες για την αντιμετωπιση πονου
CO5060482A1 (es) Derivados terapeuticos de biarilo
RU2009115963A (ru) Производные оксадиазола, обладающие противовоспалительными и иммунодепрессантными свойствами
AR020250A1 (es) Compueto de isoxazolinona, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
CA2324418A1 (en) Novel opiate compounds, methods of making and methods of use
EA200000400A1 (ru) Галогензамещенные тетрациклические производные тетрагидрофурана
EA199901075A1 (ru) Лечение резистентности к инсулину средствами, стимулирующими секрецию гормона роста
CO5180605A1 (es) Compuestos de indol
TW340115B (en) Triazine derivatives and pharmaceutical composition for hepatitis the invention relates to triazine derivatives and pharmaceutical composition for hepatitis
ES2078356T3 (es) Derivados de la pirrolidina y de la piperidina.
CO5140104A1 (es) Derivados de mevinolina y preparacion farmaceuticas que los contienen
CO5251439A1 (es) Compuestos calciliticos
AR018632A1 (es) Compuestos derivados de acido 1,2,3,4-tetrahidroquinolin-2-carboxilico, su uso en la fabricacion de medicamentos, composicion farmaceutica que los contiene, proceso para su preparacion.
CO5271679A1 (es) Inhibidores de proteasa 7-14 miembros
CO5251424A1 (es) Oxazinquinolonas utiles en el tratamiento de infecciones virales
EA200401077A1 (ru) 2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b

Legal Events

Date Code Title Description
FC Application refused