CN1204885C - 含有非诺贝特的药物组合物及其制备方法 - Google Patents
含有非诺贝特的药物组合物及其制备方法 Download PDFInfo
- Publication number
- CN1204885C CN1204885C CNB008101469A CN00810146A CN1204885C CN 1204885 C CN1204885 C CN 1204885C CN B008101469 A CNB008101469 A CN B008101469A CN 00810146 A CN00810146 A CN 00810146A CN 1204885 C CN1204885 C CN 1204885C
- Authority
- CN
- China
- Prior art keywords
- fenofibrate
- compositions
- surfactant
- weight
- micronization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 title claims abstract description 103
- 229960002297 fenofibrate Drugs 0.000 title claims abstract description 73
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 7
- 238000002360 preparation method Methods 0.000 title claims description 29
- 239000000203 mixture Substances 0.000 claims abstract description 44
- 239000004094 surface-active agent Substances 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 20
- 239000001913 cellulose Substances 0.000 claims abstract description 15
- 229920002678 cellulose Polymers 0.000 claims abstract description 15
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract 2
- 239000002775 capsule Substances 0.000 claims description 23
- 239000001828 Gelatine Substances 0.000 claims description 21
- 229920000159 gelatin Polymers 0.000 claims description 21
- 235000019322 gelatine Nutrition 0.000 claims description 21
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 17
- 239000008187 granular material Substances 0.000 claims description 17
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 9
- 239000011230 binding agent Substances 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
- 241001597008 Nomeidae Species 0.000 claims description 6
- 239000007900 aqueous suspension Substances 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 6
- 239000008101 lactose Substances 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- -1 hydroxypropyl Chemical group 0.000 claims description 5
- 238000005550 wet granulation Methods 0.000 claims description 4
- 239000013530 defoamer Substances 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 229940008099 dimethicone Drugs 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
- 229950008882 polysorbate Drugs 0.000 claims description 3
- 229920000136 polysorbate Polymers 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 2
- 229940083037 simethicone Drugs 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 abstract description 3
- 239000002671 adjuvant Substances 0.000 abstract 2
- 230000003381 solubilizing effect Effects 0.000 abstract 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 description 11
- 230000007935 neutral effect Effects 0.000 description 10
- 239000002245 particle Substances 0.000 description 8
- 229960000701 fenofibric acid Drugs 0.000 description 7
- MQOBSOSZFYZQOK-UHFFFAOYSA-N fenofibric acid Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1C(=O)C1=CC=C(Cl)C=C1 MQOBSOSZFYZQOK-UHFFFAOYSA-N 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920003081 Povidone K 30 Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005563 spheronization Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
配方 | 量(%质量) |
微粉化非诺贝特中性微颗粒HPMC(Pharmacoat 603)Polysorbate80 | 64.52111.23.3 |
非诺贝特含量 | 645mg/g |
时间(分钟) | 15 | 30 |
实施例1A(%溶解) | 73 | 95 |
Lipanthyl 200M(%溶解) | 47.3 | 64.7 |
配方 | 量(%质量) |
微粉化非诺贝特中性微颗粒HPMC(Pharmacoat 603)月桂基硫酸钠 | 65.220.111.43.3 |
非诺贝特含量 | 652mg/g |
原料 | 量(%质量) |
微粉化非诺贝特中性微颗粒Pharmacoat 603(HPMC)月桂基硫酸钠35%二甲聚硅氧烷乳液滑石 | 67.117.211.73.30.20.5 |
非诺贝特含量 | 671mg/g |
时间(分钟) | 15 | 30 |
实施例1C(%溶解) | 76 | 100 |
Lipanthyl 200M(%溶解) | 47.3 | 64.7 |
溶出时间(分钟) | 保存时间 | ||
1个月(%溶解的产品) | 3个月(%溶解的产品) | 6个月(%溶解的产品) | |
5152535455565 | 25.171.895.7104.7106.4106.7106.8 | 23.065.688.798.7100.2100.5100.6 | 20.166.591.098.299.199.599.7 |
含量(mg/明胶胶囊) | 保存时间 | |||
0个月 | 1个月 | 3个月 | 6个月 | |
208.6 | 192.6 | 190.8 | 211.7 |
药动学参数 | Lipanthyl 200M | 实施例1C |
AUC0-t(μg·h/ml)AUCinf(μg·h/ml)Cmax(μg/ml)Tmax(小时)Ke(1/小时)Elim1/2(小时) | 76962.358.00.03226.7 | 1191374.715.50.02824.9 |
药动学参数 | Lipanthyl 200M | 实施例1C |
AUC0-t(μg·h/ml)AUCinf(μg·h/ml)Cmax(μg/ml)Tmax(小时)Ke(1/小时)Elim1/2(小时) | 244255125.50.0419.6 | 257270135.50.0419.3 |
配方 | 量(%质量) |
微粉化非诺贝特乳糖HPMC(Pharmacoat 603)月桂基硫酸钠 | 7121.552.5 |
压缩容量(X FEN 1992) | |
V0V10V500V1250 | 204ml186ml168ml164ml |
V10-V500 | 22ml |
粒度分布(X FEN 1992) | |
筛孔尺寸(mm) | %筛上物 |
0.60.50.3550.20.10 | 8912302318 |
配方 | 量(%质量) |
微粉化非诺贝特乳糖Pharmacoat 603(HPMC)月桂基硫酸钠 | 7021.553.5 |
含量 | 700mg/g |
压缩容量(Y FEN 002) | |
V0V10V500V1250 | 216ml200ml172ml170ml |
V10-V500 | 28ml |
粒度分布(Y FEN 002) | |
筛孔尺寸(mm) | %筛上物 |
0.60.50.3550.20.10 | 5711302522 |
时间(分钟) | 15 | 30 |
实施例2B(%溶解) | 82.2 | 88.5 |
Lipanthyl 200M(%溶解) | 47.3 | 64.7 |
溶出时间(分钟) | 保存时间 | ||
1个月(%溶解的产品) | 3个月(%溶解的产品) | 6个月(%溶解的产品) | |
5152535455565 | 54.281.186.488.890.792.193.2 | 52.975.879.681.682.983.984.7 | 49.082.287.289.891.592.793.6 |
含量(mg/明胶胶囊) | 保存时间 | |||
0个月 | 1个月 | 3个月 | 6个月 | |
196.6 | 190.0 | 199.8 | 203.3 |
药动学参数 | Lipanthyl 200M | 实施例2B |
AUC0-t(μg·h/ml)AUCinf(μg·h/ml)Cmax(μg/ml)Tmax(小时)Ke(1/小时)Elim1/2(小时) | 76962.358.00.03226.7 | 70822.85.50.03323.1 |
产品 | 理论用量(%) |
微粉化非诺贝特Montanox 80Avicel PH 101PVP K 30Explotab | 75.084.725.024.1211.06 |
时间(分钟) | 15 | 30 |
实施例3(%溶解) | 24 | 40 |
Lipanthyl 200M(%溶解) | 47.3 | 64.7 |
药动学参数 | Lipanthyl 200M | 实施例3 |
AUC0-t(μg·h/ml)AUCinf(μg·h/ml)Cmax(μg/ml)Tmax(小时)Ke(1/小时)Elim1/2(小时) | 921043.55.60.0418.9 | 47531.74.60.03820.3 |
Claims (16)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9908923A FR2795961B1 (fr) | 1999-07-09 | 1999-07-09 | Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation |
FR99/08923 | 1999-07-09 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005100648532A Division CN1682707B (zh) | 1999-07-09 | 2000-07-07 | 含有非诺贝特的药物组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1360499A CN1360499A (zh) | 2002-07-24 |
CN1204885C true CN1204885C (zh) | 2005-06-08 |
Family
ID=9547923
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005100648532A Expired - Lifetime CN1682707B (zh) | 1999-07-09 | 2000-07-07 | 含有非诺贝特的药物组合物及其制备方法 |
CNB008101469A Expired - Lifetime CN1204885C (zh) | 1999-07-09 | 2000-07-07 | 含有非诺贝特的药物组合物及其制备方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005100648532A Expired - Lifetime CN1682707B (zh) | 1999-07-09 | 2000-07-07 | 含有非诺贝特的药物组合物及其制备方法 |
Country Status (37)
Country | Link |
---|---|
US (4) | US7101574B1 (zh) |
EP (3) | EP1194140B1 (zh) |
JP (2) | JP4841092B2 (zh) |
KR (3) | KR20020025188A (zh) |
CN (2) | CN1682707B (zh) |
AT (3) | ATE291912T1 (zh) |
AU (1) | AU782282B2 (zh) |
BG (1) | BG65504B1 (zh) |
BR (1) | BR0012335A (zh) |
CA (1) | CA2377909C (zh) |
CY (1) | CY1106206T1 (zh) |
CZ (1) | CZ300094B6 (zh) |
DE (3) | DE60031184T2 (zh) |
DK (3) | DK1194140T3 (zh) |
EA (1) | EA004294B1 (zh) |
EE (1) | EE04995B1 (zh) |
ES (3) | ES2271924T3 (zh) |
FR (1) | FR2795961B1 (zh) |
GE (1) | GEP20043287B (zh) |
HK (3) | HK1044894B (zh) |
HR (1) | HRP20020111B1 (zh) |
HU (1) | HU229044B1 (zh) |
IL (2) | IL147499A0 (zh) |
IS (1) | IS2157B (zh) |
ME (1) | ME01361B (zh) |
MX (1) | MXPA02000324A (zh) |
NO (1) | NO333301B1 (zh) |
NZ (1) | NZ516416A (zh) |
PL (1) | PL212082B1 (zh) |
PT (3) | PT1194140E (zh) |
RS (1) | RS50035B (zh) |
SI (2) | SI1574214T1 (zh) |
SK (1) | SK287484B6 (zh) |
TR (1) | TR200200008T2 (zh) |
UA (1) | UA72925C2 (zh) |
WO (1) | WO2001003693A1 (zh) |
ZA (1) | ZA200200169B (zh) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2795961B1 (fr) | 1999-07-09 | 2004-05-28 | Ethypharm Lab Prod Ethiques | Composition pharmaceutique contenant du fenofibrate micronise, un tensioactif et un derive cellulosique liant et procede de preparation |
US7863331B2 (en) | 1999-07-09 | 2011-01-04 | Ethypharm | Pharmaceutical composition containing fenofibrate and method for the preparation thereof |
US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
FR2819720B1 (fr) * | 2001-01-22 | 2004-03-12 | Fournier Lab Sa | Nouveaux comprimes de fenofibrate |
GB0119480D0 (en) | 2001-08-09 | 2001-10-03 | Jagotec Ag | Novel compositions |
DK1551372T3 (en) * | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES |
WO2004028506A1 (en) * | 2002-09-24 | 2004-04-08 | Ranbaxy Laboratories Limited | Oral pharmaceutical compositions of fenofibrate having high bioavailability |
CN100367947C (zh) * | 2002-12-04 | 2008-02-13 | 徐州恩华赛德药业有限责任公司 | 具有抗高血脂症的含非诺贝特的药物组合物 |
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