CN114008035A - 一种shp2磷酸酶变构抑制剂 - Google Patents
一种shp2磷酸酶变构抑制剂 Download PDFInfo
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- CN114008035A CN114008035A CN202080043751.5A CN202080043751A CN114008035A CN 114008035 A CN114008035 A CN 114008035A CN 202080043751 A CN202080043751 A CN 202080043751A CN 114008035 A CN114008035 A CN 114008035A
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- China
- Prior art keywords
- dihydrospiro
- indene
- tert
- compound
- piperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010032107 Non-Receptor Type 11 Protein Tyrosine Phosphatase Proteins 0.000 title claims abstract description 11
- 102000007607 Non-Receptor Type 11 Protein Tyrosine Phosphatase Human genes 0.000 title claims abstract description 11
- 229940125528 allosteric inhibitor Drugs 0.000 title claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 70
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 8
- 230000003287 optical effect Effects 0.000 claims abstract description 6
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 35
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 229910052736 halogen Inorganic materials 0.000 claims description 16
- 150000002367 halogens Chemical class 0.000 claims description 12
- 239000003112 inhibitor Substances 0.000 claims description 7
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 229940125812 SHP2 phosphatase inhibitor Drugs 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 150000001924 cycloalkanes Chemical class 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 2
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 108
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
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- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
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- XWTMEQYXJSJHHO-JOCHJYFZSA-N 3-[(1S)-1-aminospiro[1,3-dihydroindene-2,4'-piperidine]-1'-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazine-2-carboxamide Chemical compound C1(C(=O)N)=NC(C2=C(C(=CC=C2)Cl)Cl)=C(N=C1N1CCC2(CC1)CC1=CC=CC=C1[C@H]2N)C XWTMEQYXJSJHHO-JOCHJYFZSA-N 0.000 description 4
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- IRKBPZGHGQPMIW-UHFFFAOYSA-N ethyl 6-bromo-3-chloropyrazine-2-carboxylate Chemical compound CCOC(=O)c1nc(Br)cnc1Cl IRKBPZGHGQPMIW-UHFFFAOYSA-N 0.000 description 1
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- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
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- NXPHGHWWQRMDIA-UHFFFAOYSA-M magnesium;carbanide;bromide Chemical compound [CH3-].[Mg+2].[Br-] NXPHGHWWQRMDIA-UHFFFAOYSA-M 0.000 description 1
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- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- KTMKRRPZPWUYKK-UHFFFAOYSA-N methylboronic acid Chemical compound CB(O)O KTMKRRPZPWUYKK-UHFFFAOYSA-N 0.000 description 1
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- 102000020233 phosphotransferase Human genes 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- AOHJOMMDDJHIJH-UHFFFAOYSA-N propylenediamine Chemical compound CC(N)CN AOHJOMMDDJHIJH-UHFFFAOYSA-N 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
- 238000004537 pulping Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
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- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
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- 229960005322 streptomycin Drugs 0.000 description 1
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- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- RRAMTOSLXCIPSZ-UHFFFAOYSA-N tert-butyl 5-bromo-3-oxospiro[1H-indene-2,4'-piperidine]-1'-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC2(CC3=CC=C(Br)C=C3C2=O)CC1 RRAMTOSLXCIPSZ-UHFFFAOYSA-N 0.000 description 1
- FQZLNQAUUMSUHT-UHFFFAOYSA-N tert-butyl n,n-bis(2-chloroethyl)carbamate Chemical compound CC(C)(C)OC(=O)N(CCCl)CCCl FQZLNQAUUMSUHT-UHFFFAOYSA-N 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- XOGGUFAVLNCTRS-UHFFFAOYSA-N tetrapotassium;iron(2+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] XOGGUFAVLNCTRS-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- JMXKSZRRTHPKDL-UHFFFAOYSA-N titanium ethoxide Chemical compound [Ti+4].CC[O-].CC[O-].CC[O-].CC[O-] JMXKSZRRTHPKDL-UHFFFAOYSA-N 0.000 description 1
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- NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Abstract
一种SHP2磷酸酶变构抑制剂，以及含有该抑制剂的药物，所述的SHP2磷酸酶变构抑制剂具有如下式(I)所示的结构，所述的SHP2磷酸酶变构抑制剂的光学异构体化合物或其药学上可接受的盐在制备用于***疾病的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (9)
- PCT国内申请，权利要求书已公开。
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310905773.3A CN117209470A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202310903760.2A CN117209475A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202310907352.4A CN117209471A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
Applications Claiming Priority (9)
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| CN2019105151960 | 2019-06-14 | ||
| CN201910515196 | 2019-06-14 | ||
| CN2019110688218 | 2019-11-04 | ||
| CN201911068821 | 2019-11-04 | ||
| CN2020100567031 | 2020-01-17 | ||
| CN202010056703 | 2020-01-17 | ||
| CN2020105173727 | 2020-06-09 | ||
| CN202010517372 | 2020-06-09 | ||
| PCT/CN2020/095795 WO2020249079A1 (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
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| CN202310903760.2A Division CN117209475A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202310907352.4A Division CN117209471A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202310905773.3A Division CN117209470A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
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| CN114008035A true CN114008035A (zh) | 2022-02-01 |
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| CN202310907352.4A Pending CN117209471A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202080043751.5A Pending CN114008035A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202310905773.3A Pending CN117209470A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202310903760.2A Pending CN117209475A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
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| CN202310907352.4A Pending CN117209471A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
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| CN202310905773.3A Pending CN117209470A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
| CN202310903760.2A Pending CN117209475A (zh) | 2019-06-14 | 2020-06-12 | 一种shp2磷酸酶变构抑制剂 |
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| Country | Link |
|---|---|
| US (1) | US20220388977A1 (zh) |
| EP (1) | EP3984999A4 (zh) |
| JP (1) | JP7335003B2 (zh) |
| KR (1) | KR20220061087A (zh) |
| CN (4) | CN117209471A (zh) |
| TW (1) | TW202112761A (zh) |
| WO (1) | WO2020249079A1 (zh) |
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| US11179397B2 (en) | 2018-10-03 | 2021-11-23 | Gilead Sciences, Inc. | Imidazopyrimidine derivatives |
| CN115916194A (zh) | 2020-06-18 | 2023-04-04 | 锐新医药公司 | 用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法 |
| EP4208261A1 (en) | 2020-09-03 | 2023-07-12 | Revolution Medicines, Inc. | Use of sos1 inhibitors to treat malignancies with shp2 mutations |
| PE20231207A1 (es) | 2020-09-15 | 2023-08-17 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer |
| IL308195A (en) | 2021-05-05 | 2024-01-01 | Revolution Medicines Inc | RAS inhibitors for cancer treatment |
| JP2024516450A (ja) | 2021-05-05 | 2024-04-15 | レボリューション メディシンズ インコーポレイテッド | 共有結合性ｒａｓ阻害剤及びその使用 |
| KR20240004960A (ko) | 2021-05-05 | 2024-01-11 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
| CN115368373A (zh) * | 2021-05-21 | 2022-11-22 | 石药集团中奇制药技术（石家庄）有限公司 | 螺环类化合物及其用途 |
| TW202313041A (zh) | 2021-06-09 | 2023-04-01 | 瑞士商諾華公司 | 包含達拉菲尼、曲美替尼和shp2抑制劑之三重藥物組合 |
| TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含ｋｒａｓ ｇ１２ｃ抑制劑的藥物組合及其用於治療癌症之用途 |
| CA3224341A1 (en) | 2021-09-01 | 2023-03-09 | Novartis Ag | Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
| WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
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| WO2018041248A1 (zh) * | 2016-09-01 | 2018-03-08 | 北京赛林泰医药技术有限公司 | Bcl-2选择性抑制剂及其制备和用途 |
| WO2018172984A1 (en) * | 2017-03-23 | 2018-09-27 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| WO2019051084A1 (en) * | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | SHP2 INHIBITOR COMPOSITIONS AND METHODS OF TREATING CANCER |
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| US8575167B2 (en) * | 2007-02-06 | 2013-11-05 | Takeda Pharmaceutical Company Limited | Spiro compounds having stearoyl-CoA desaturase action |
| EP3768668A1 (en) | 2018-03-21 | 2021-01-27 | Relay Therapeutics, Inc. | Shp2 phosphatase inhibitors and methods of use thereof |
| CN112839935A (zh) * | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| TW202028183A (zh) * | 2018-10-10 | 2020-08-01 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
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2020
- 2020-06-12 EP EP20822079.8A patent/EP3984999A4/en active Pending
- 2020-06-12 TW TW109119941A patent/TW202112761A/zh unknown
- 2020-06-12 US US17/618,835 patent/US20220388977A1/en active Pending
- 2020-06-12 CN CN202310907352.4A patent/CN117209471A/zh active Pending
- 2020-06-12 CN CN202080043751.5A patent/CN114008035A/zh active Pending
- 2020-06-12 WO PCT/CN2020/095795 patent/WO2020249079A1/zh unknown
- 2020-06-12 JP JP2021574766A patent/JP7335003B2/ja active Active
- 2020-06-12 KR KR1020227001357A patent/KR20220061087A/ko not_active Application Discontinuation
- 2020-06-12 CN CN202310905773.3A patent/CN117209470A/zh active Pending
- 2020-06-12 CN CN202310903760.2A patent/CN117209475A/zh active Pending
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| WO2018041248A1 (zh) * | 2016-09-01 | 2018-03-08 | 北京赛林泰医药技术有限公司 | Bcl-2选择性抑制剂及其制备和用途 |
| WO2018172984A1 (en) * | 2017-03-23 | 2018-09-27 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| WO2019051084A1 (en) * | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | SHP2 INHIBITOR COMPOSITIONS AND METHODS OF TREATING CANCER |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117209475A (zh) | 2023-12-12 |
| WO2020249079A1 (zh) | 2020-12-17 |
| JP2022535998A (ja) | 2022-08-10 |
| KR20220061087A (ko) | 2022-05-12 |
| EP3984999A1 (en) | 2022-04-20 |
| US20220388977A1 (en) | 2022-12-08 |
| EP3984999A4 (en) | 2023-11-22 |
| CN117209470A (zh) | 2023-12-12 |
| TW202112761A (zh) | 2021-04-01 |
| CN117209471A (zh) | 2023-12-12 |
| JP7335003B2 (ja) | 2023-08-29 |
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