CN107854367B - Essence for repairing sensitive skin - Google Patents
Essence for repairing sensitive skin Download PDFInfo
- Publication number
- CN107854367B CN107854367B CN201711369856.6A CN201711369856A CN107854367B CN 107854367 B CN107854367 B CN 107854367B CN 201711369856 A CN201711369856 A CN 201711369856A CN 107854367 B CN107854367 B CN 107854367B
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- parts
- plant extract
- sodium hyaluronate
- ceramide
- essence
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/88—Polyamides
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Abstract
The invention belongs to the field of daily cosmetics, and relates to a plant extract composition and essence containing the plant extract composition. The plant extract composition contains purslane, tremella, mint and liquorice, and has outstanding moisturizing and anti-allergy effects. The essence contains the plant extract composition, ceramide, sodium hyaluronate, polyglutamic acid, trehalose and allantoin, and has the effects of relieving reactions such as erythema and pruritus in skin allergic state, repairing damaged skin barrier of sensitive skin, removing red blood streak, improving skin elasticity, delaying aging, resisting oxidation and the like.
Description
Technical Field
The invention belongs to the field of daily cosmetics, and relates to essence with the effects of relieving reactions such as erythema and pruritus in skin allergic state, repairing damaged skin barrier of sensitive skin, removing red blood streak, improving skin elasticity, delaying aging, resisting oxidation and the like.
Background
Sensitive skin is a highly intolerant skin, and is vulnerable to irritation by various factors: subjective symptoms thereof: stabbing pain, burning, tightness, itching, etc.; the objective symptoms are as follows: mild erythema, telangiectasia, desquamation, dry skin.
According to 'Chinese expert consensus on sensitive skin diagnosis and treatment' 2017 edition, the incidence rate of sensitive skin in Asian women is 40% -55.98%. The incidence rate of Chinese women is lower than the average level, but also reaches 36.1 percent, namely, one sensitive muscle exists in every three Chinese women.
The characteristics of sensitive skin: skin barrier breakdown, thin epidermis, hyperemia, red blood streak; the hydration degree of the horny layer is low, a complete sebum membrane cannot be formed, the skin is easy to dry and generate scurf, particularly in autumn and winter, and the skin is lack of luster and dull; skin instability is aggravated at seasonal changes, such as autumn, winter, spring and summer; easily affected by ultraviolet rays, cold air, high temperature, water quality, animal hair, essence, pigment, etc.; when general cosmetics are used, skin is easy to be allergic, red and swollen, and stabbing pain and pruritus are caused.
Various natural plant extracts have been reported to have the effects of soothing and anti-allergy, reducing histamine release, anti-inflammatory and anti-irritant properties, repairing damaged skin barriers of sensitive skin, scavenging free radicals and the like, and are used in cosmetics. For example, patent CN104940093A discloses a cosmetic containing radix Sophorae Flavescentis water extract and folium Vignae Cylindricae total water extract as antiallergic component. Patent CN101810794A discloses the use of a combination of natural extracts oat, cogongrass rhizome, ledebouriella root and licorice for the preparation of cosmetics. Patent CN103520061A discloses that peony essential oil, 1-3 parts of peony seed essential oil, paeonol, aloe juice and other components are adopted to prepare skin lotion.
Even though various natural plant extracts disclosed in the prior art have anti-allergy effects, the effect of a single component is limited, so that the efficacy is generally enhanced by adopting a compound form in the prior art. However, when different natural plant extracts are compounded, certain components can bring the superposition of anti-allergy effects when being compounded; some components can bring antagonism of anti-allergy effect when being compounded, and some components can bring synergy of anti-allergy effect when being compounded.
Disclosure of Invention
The invention aims to provide a natural plant extract composition integrating anti-allergy, comfort and moisturizing effects.
The invention also aims to provide the essence for repairing the sensitive skin, which has the effects of repairing the damaged skin barrier of the sensitive skin and removing red blood streak.
The invention also aims to provide the essence for improving skin elasticity, resisting oxidation, improving skin color and delaying aging.
The invention also aims to provide the essence without preservatives.
The above object of the present invention is achieved by the following technical means:
on one hand, the invention provides a natural plant extract composition, which comprises the following raw materials in parts by weight:
as a preferred embodiment, the natural plant extract composition comprises the following raw materials in parts by weight:
as a more preferred embodiment, the natural plant extract composition comprises the following raw materials in parts by weight:
in another aspect, the present invention also provides a method for preparing the above natural plant extract composition, comprising the steps of:
s1: weighing the raw materials according to the weight parts of the natural plant extract, and crushing the raw materials into powder;
s2: sieving the powder with a 50-mesh sieve, soaking in anhydrous ethanol for 10-30 min, and removing the liquid;
s3, decoloring; preferably, the decolorization is repeated 3 times;
s4: according to the material-water ratio of 1: extracting for 5-7h in a water bath kettle at 85-95 ℃ at 80-100, continuously stirring in the extraction process at the stirring speed of 1000-2000rpm/S, and then filtering and collecting filtrate; preferably, the extraction is repeated at least twice, and the filtrates are combined;
s5: concentrating the filtrate by rotary evaporation to remove most of water, such as about 85-95% water; preferably, 90% of the water is removed;
90% water;
s6: vacuum freeze drying to obtain water extract.
The natural plant extract composition (purslane, tremella, mint and liquorice) has multiple effects of relieving and resisting allergy, reducing histamine release, resisting inflammation and irritation, repairing damaged skin barriers of sensitive skin, clearing free radicals and the like. Although various plant extracts have been reported to have anti-allergy and soothing effects in the prior art, experiments prove that the anti-allergy and soothing effects of different combinations show significant differences when different natural plant extracts are compounded. The inventors screened a number of anti-allergy soothing natural herbal extracts commonly used in the clinic, including: purslane, tremella, mint, liquorice, radix sophorae flavescentis, folium artemisiae argyi, honeysuckle, burdock, ginseng, green tea, coix seed and the like. In the conventional anti-allergy and soothing natural herbal extracts for clinical use, the inventor discovers unobviously that when the four components of purslane, tremella, mint and liquorice are mixed together, the effects of relieving itching of sensitive skin and eliminating skin rash such as erythema are obviously different from the effects of other components in the ratio, and the combination of the four components has a very prominent anti-allergy effect.
In addition, surprisingly and unexpectedly, the combination of purslane, tremella, mint and liquorice has an outstanding anti-allergy and relieving effect, and the moisturizing effect of the combination is also obviously different from that of other combinations. Such a combination is very advantageous and uncommon for the preparation of a cosmetic product, since the current consumer appeal for cosmetic products is mainly moisturizing, which is more desirable for sensitive muscles. The natural plant extract of the invention not only has outstanding relieving and anti-allergy effects, but also has outstanding moisturizing effects.
On the other hand, the invention also provides the application of the natural plant extract composition in preparing cosmetics. The cosmetic can be cream, emulsion, oil, astringent or facial mask.
On the other hand, the invention also provides the application of the natural plant extract composition in preparing external antiallergic drugs.
On the other hand, the invention provides essence containing the natural plant extract composition, which comprises the following components in parts by weight:
the plant extract composition comprises the following raw materials in parts by weight:
as a preferred embodiment, the essence of the invention comprises the following components in parts by weight:
the plant extract composition comprises the following raw materials in parts by weight:
preferably, the essence comprises the following components in parts by weight:
the plant extract composition comprises the following raw materials in parts by weight:
in a preferred embodiment, in the essence, the ceramide is selected from one or a combination of several ceramides 1-6. As a more preferred embodiment, the ceramide is selected from the group consisting of ceramide 1, ceramide 3, ceramide 6; further, the ceramide is selected from the group consisting of 0.5-5 parts of ceramide 1, 0.1-2 parts of ceramide 3, and 0.1-0.5 parts of ceramide 6. Ceramide, is a major repair specialist of the stratum corneum of the skin: repairing and perfecting the skin barrier; enhancing the adhesion of skin stratum corneum cells, improving dryness and desquamation; tranquilizing, relieving inflammation, and relieving skin erythema and red blood streak; replenishing moisture for skin for a long time; forming a moisture retention film to lock deep water; increasing the thickness of the epidermis, enhancing the elasticity of the skin and delaying the aging of the skin; repairing damaged fragile skin, and performing minimally invasive surgery and laser surgery. Ceramide 1, which protects a sebum membrane, improves the barrier function of the skin surface layer and reduces the loss of water; ceramide 3, which maintains the moisture retention of skin, reestablishes cell adhesiveness and quickly repairs dry and damaged skin; ceramide 6 helps keratin metabolism and promotes smooth and tender skin. The combination of the three ceramides has good water solubility and stability.
In a preferred embodiment, in the essence, the sodium hyaluronate is selected from one or a combination of several of medium molecule sodium hyaluronate, small molecule sodium hyaluronate and micro molecule sodium hyaluronate; more preferably a combination of the three. The sodium hyaluronate has the effects of compacting and moisturizing, the sodium hyaluronate can be quickly absorbed through skin, the water in the stratum corneum is supplemented, and the absorption, moisturizing and water replenishing effects of the micromolecules are stronger. The three components are mutually matched to obviously enhance the moisturizing and water replenishing effects. Furthermore, the molecular weight of the medium molecular sodium hyaluronate is 1000000-18000000 Da, the molecular weight of the small molecular sodium hyaluronate is 400000-10000000 Da, and the molecular weight of the micro molecular sodium hyaluronate is 100000-4000000 Da. Furthermore, the weight part ratio of the medium molecular sodium hyaluronate, the small molecular sodium hyaluronate to the small molecular sodium hyaluronate is 1-3:1-3: 1-3; preferably 1:1: 1.
In the essence disclosed by the invention, the polyglutamic acid has the effects of naturally moisturizing, improving skin nutrition, regulating skin elasticity, promoting cell metabolism, absorbing ultraviolet rays and relieving the damage of solar radiation to the skin; trehalose has the effects of moisturizing, resisting oxidation, resisting aging, preventing ultraviolet rays and sunburn and the like. The allantoin can keep skin moisture, maintain physiological balance of skin moisture, relieve irritation of active substances to skin, and mildly treat skin cutin to make skin smooth and well-developed.
The essence disclosed by the invention can obviously increase the skin moisture, adjust the skin in a water-oil balance state and effectively increase the skin elasticity by the compatibility of the specific natural plant combination extract, ceramide, sodium hyaluronate, polyglutamic acid, allantoin and the like. In the embodiment of the invention, the essence of the invention can improve the water content of the skin by about 5 times, but the control group (pure water group) has no obvious difference, and the oil content of the skin is improved more than that of the control group.
It is worth noting that during the development process, the inventors have unexpectedly found that when a specific plant extract is compatible with ceramide, sodium hyaluronate, polyglutamic acid and allantoin, especially a specific plant extract is compatible with ceramide and sodium hyaluronate, the effects of soothing and anti-allergy on the skin are stronger than the effects of the plant extract alone or the ceramide, sodium hyaluronate, polyglutamic acid and allantoin alone. However, in the current research, no plant extract composition (purslane, tremella, mint, liquorice) has the outstanding functions of relieving, resisting allergy, resisting inflammation and relieving itching, although the plant extract composition has been separately reported to have the anti-allergy effect. The plant extract composition is combined with the components such as ceramide, sodium hyaluronate and the like, and the soothing and anti-allergy effects are stronger than those of the plant extract.
In addition to the above components, the present invention may further comprise additives and/or other active substances as long as the properties and effects of the essence of the present invention are not affected.
The additives include, but are not limited to: thickeners, buffers, film formers, humectants, fragrances, pigments, preservatives, penetration aids, solvents, emulsifiers, detergents, solubilizers, sunscreens, antioxidants or radical scavengers, chelating agents, and the like.
The active substances include, but are not limited to: sophora flavescens extracts, artemisia argyi extracts, honeysuckle extracts, burdock extracts, centella asiatica extracts, witch hazel extracts, seaweed extracts, ginseng extracts, green tea extracts, coix seed extracts, yeast extracts, blueberry extracts, perilla extracts, rhodiola rosea extracts, pomegranate extracts, grape extracts, and the like.
As a preferred embodiment, in the essence of the present invention, the plant extract composition further comprises 1 to 5 parts of sophora flavescens ait.
As another preferred embodiment, in the essence of the present invention, the plant extract composition further comprises 1 to 5 parts of artemisia argyi extract.
As another preferred embodiment, in the essence of the present invention, the plant extract composition further includes 1 to 3 parts of a honeysuckle extract.
As another preferred embodiment, in the essence of the present invention, the plant extract composition further comprises 1 to 3 parts of burdock fruit extract.
In a more preferred embodiment, the essence of the present invention comprises the following raw materials in the plant extract composition: 12.5-17.5 parts of purslane, 10-15 parts of tremella, 6-8 parts of liquorice, 1-3 parts of mint, 1.5-3 parts of radix sophorae flavescentis extract, 1.5-3 parts of folium artemisiae argyi extract, 1-2 parts of honeysuckle extract and 1-2 parts of burdock fruit extract.
In another aspect, the present invention provides a method for preparing essence, comprising the steps of:
(1) heating deionized water to 80-90 ℃, sequentially adding sodium hyaluronate, polyglutamic acid, trehalose and allantoin, stirring and dissolving completely, wherein the stirring revolution is 3000-9000 rpm.
(2) Cooling to 50-60 deg.C, adding ceramide, stirring, and dissolving completely.
(3) Cooling to 40 deg.C, adding the plant extract composition, stirring, and dissolving completely.
The essence of the invention can be directly used and can also be used by soaking facial mask paper.
The invention has the following beneficial effects:
1) according to the invention, through screening of anti-allergy herbaceous plants commonly used in clinic, the compatibility of purslane, tremella, mint and liquorice can be obviously found to play a good anti-allergy and anti-inflammation effect. In a plurality of natural plant extract compositions, the composition is scientifically proportioned and subjected to modern extraction process, so that the composition remarkably repairs the damaged barrier of sensitive skin, relieves the stimulation and sensitive symptoms of the sensitive skin caused by various stimulators, and has an outstanding moisturizing effect.
2) According to the invention, the essence capable of relieving reactions such as erythema and pruritus in a skin allergic state, repairing damaged skin barriers of sensitive skin, removing red blood streak and the like is prepared by matching the specific combined natural plant extracts of purslane, tremella, mint and liquorice with ceramide, sodium hyaluronate, polyglutamic acid, allantoin and the like. The essence has the effects of relieving and resisting allergy, and is not benefited from a single component such as purslane extract, but from the compatibility of the plant extract composition and various components selected by the invention.
3) The invention unexpectedly discovers that the effects of relieving and resisting allergy of the specific plant extract and ceramide, sodium hyaluronate, polyglutamic acid and allantoin, especially when the specific plant extract is compatible with the ceramide and the sodium hyaluronate, are stronger than the effects of the plant extract alone or the ceramide, the sodium hyaluronate, the polyglutamic acid and the allantoin alone.
4) The essence disclosed by the invention can obviously improve the moisture content of the skin, and after the essence is applied, the moisture content of the skin is improved to about 5 times of that before the skin is applied.
5) The essence disclosed by the invention also has the effects of improving skin elasticity, improving skin color, smoothing skin, delaying aging, resisting oxidation and the like.
6) The essence of the invention is mild and non-irritating: the beverage contains a large amount of natural components, and the rest components are mild and non-irritant, do not contain preservatives and do not contain essence.
Drawings
FIG. 1 moisture retention vs. time curve for example 2.
Detailed Description
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.
Example 1 Natural plant extract composition
TABLE 1 Natural plant extract compositions (parts by weight)
| | Combination | 1 | |
|
|
|
| Herba Portulacae | 10 | 15 | 20 | 12 | 16 | |
| Tremella fuciformis berk | 20 | 18 | 10 | 16 | 14 | |
| |
1 | 3 | 2 | 4 | 5 | |
| Licorice root, |
8 | 5 | 9 | 10 | 6 |
The preparation method of the natural plant extract composition comprises the following steps:
the raw materials are weighed according to the weight parts in the table 1, crushed into powder and sieved by a 50-mesh sieve. Soaking the sieved powder in anhydrous ethanol for 15 min, discarding the liquid, and repeating for 3 times to decolorize. After decolorization, the raw materials are respectively transferred to a large beaker, and the weight ratio of the raw materials to water is 1: extracting at 90 deg.C in water bath for 6h (stirring at 1000-. All filtrates were then transferred to a round bottom beaker and concentrated on a rotary evaporator to remove 90% of the water. And finally, carrying out vacuum freeze drying to obtain the raw material water extract.
Example 2 plant extract composition screening experiment
1. Experimental Material
1.1 starting materials and reagents
Purslane, tremella, mint, liquorice, radix sophorae flavescentis, folium artemisiae argyi, honeysuckle and burdock are all purchased from a traditional Chinese medicine pharmacy in the affiliated southern hospital of southern medical university. Absolute ethyl alcohol, anhydrous calcium chloride, and Ph paper, all of which are from guangzhou yuancan laboratory instruments ltd; a medical permeable adhesive tape is used for a health care hall to be linked with a large pharmacy.
1.2 instruments
A rotary evaporator (RE5203 model, Shanghai Yangrong Biochemical apparatus factory), an electric furnace, a transformer, a culture dish (6cm, Guangzhou Yuancan laboratory apparatus, Limited liability commune), a large beaker, a small beaker, an evaporation dish, a dryer, and a glass rod.
2. Experimental methods and results
2.1 preparation of drug extract concentrate
According to the orthogonal tables (Table 2 and Table 3, below), the raw material powder passed through the 50-mesh sieve was immersed in anhydrous ethanol for 15 minutes and discarded, and decolorization was repeated 3 times. After decolorization, the raw materials are respectively transferred to a large beaker, and the weight ratio of the raw materials to water is 1: extracting at 90 deg.C in water bath for 6 hr (stirring continuously), filtering with warp cloth, collecting filtrate, and extracting the residue for 2 times. All filtrates were then transferred to a round bottom beaker and concentrated using a rotary evaporator to remove most of the water. And finally, carrying out vacuum freeze drying to obtain the raw material water extract.
Determining the moisture retention rate of the extract concentrated solution of various drug ratios by an orthogonal experimental method with deionized water as a reference, finally drawing a moisture retention rate-time curve, and comparing to obtain the optimal ratio;
2.2 measurement of moisture retention
Taking 20 culture dishes with diameter of 6cm, sticking the culture dishes on the bottom by using a breathable adhesive tape to simulate the actual situation of skin, numbering according to an orthogonal table, dividing the culture dishes into 10 groups, setting two parallel experiments in each group, and setting a blank control group by using distilled water. Precisely weighing 3-6g of extractive solution, uniformly coating on gas-permeable adhesive tape, directly pouring distilled water into culture dish, and placing in a drier at room temperature containing saturated CaCl2And (3) opening the cover of the culture dish, covering the dryer, starting timing, measuring the weight of the culture dish every 1h, 1h, 1h, 3h, 6h,12h and 12h, calculating the moisture retention rate of the culture dish, drawing a moisture retention rate-time curve, and analyzing to obtain the optimal drug ratio. The moisturizing rate calculation formula is as follows:
moisture retention rate Mt/M0×100％
Wherein Mt is the mass of the sample after the sample is placed for t hours, g; mo is the mass of the sample before placement, g.
2.3 exploration orthogonal table of optimal drug proportioning
TABLE 2 experiment factor level table
TABLE 3 orthogonal design Table
The moisturizing rates of groups 1,2,3,4,5,6,7,8,9 and the blank were tested, one parallel group for each group, and a moisturizing rate-time curve was plotted.
3. Results of the experiment
3.1 Experimental results of optimal drug proportioning
It can be derived from the moisture retention rate-time curve (fig. 1) that in an environment with RH 34%, the moisture retention rate of each experimental group is significantly higher than that of the blank control group, wherein the moisture retention rate of the group 3 is the highest, the moisture retention rate of the group 7 is the lowest, the optimal mixture ratio of the drugs is purslane, tremella, mint and licorice, the moisture retention rate of the combination is significantly higher than that of other combinations within 24 hours a day, and the moisture retention rates of the other groups except the group 7 are not much different.
4. Conclusion of the experiment
The experiment explores the water replenishing and moisture retention of the composition of purslane, tremella, mint and liquorice, and the purslane, tremella, mint and liquorice are obtained through an L9(33) orthogonal test and are in the best proportion.
Example 3 anti-irritation test of plant compositions
1 data of the test
1.1 general data observation groups of 60 cases in total are all volunteers recruited by southern medical university (former first university of military medical science), and are randomly divided into 6 groups, wherein the data of 10 persons in each group and 5 groups are statistically processed, and the differences have no significant meaning (P is more than 0.05), and the data are comparable.
1.2 inclusion criteria groups from 18 to 30 years old were selected, with no restriction.
1.3 the elimination standard excludes chronic eczema and tinea corporis; pregnant or lactating women; patients with liver and cardiovascular diseases; patients with malignant tumors; stopping treatment or replacing drugs and methods during treatment; the curative effect cannot be judged or the data is not complete to influence the judgment of the curative effect.
2. Grouping, wherein the weight parts of the raw materials of each test group are 20 parts, 10 parts, 5 parts and 5 parts from left to right in sequence; the blank was 40 parts by weight of deionized water and the raw materials for each set are shown in Table 4 below.
TABLE 4 Components used for the groups
| Test set 1 | Herba Portulacae, Tremella, herba Menthae, and radix Glycyrrhizae |
| Test set 2 | Radix Sophorae Flavescentis, folium Artemisiae Argyi, flos Lonicerae, and fructus |
| Test group | |
| 3 | Herba Portulacae, radix Sophorae Flavescentis, flos Lonicerae, and Glycyrrhrizae radix |
| Test set 4 | Radix Sophorae Flavescentis, Tremella, herba Menthae, and fructus Arctii |
| Test set 5 | Herba Portulacae, Tremella, flos Lonicerae, and fructus Arctii |
| Blank group | Deionized water |
3. The experimental method comprises the following steps: adopting 5% of fruit acid as an excitation source to stimulate the skin on the left forearm flexor side to erythema, then smearing essence containing 20% of the plant combination extract, and observing the skin erythema fading and the pruritus relieving degree in 6h,12h,24h, 48 h and 72h respectively.
4. The results are shown in Table 5
The relief of the plant composition for the pruritus and the rash after artificial treatment is observed through different proportions, and the relief of the pruritus of the test groups 1-5 is significantly different from that of a blank group (P is less than 0.01 and P is less than 0.05), wherein the difference of the test group 1 is more significant (P is less than 0.01); the resolved skin rash was significantly different in test groups 1 and 2 compared to the blank group (. P < 0.05). Test group 1 was less effective in relieving itching, although it was more effective in eliminating rash.
Although purslane, tremella, mint, liquorice, sophora flavescens, folium artemisiae argyi, honeysuckle, burdock and other natural plant extracts are reported to be used as anti-allergen materials in the prior art, and various natural plant extracts are often compounded for enhancing the anti-allergic effect. However, different combinations of plant extracts showed different abilities to enhance anti-allergy soothing effect, wherein the combination of the plant extract composition of test group 1 of the present invention, purslane, tremella, peppermint, licorice, combined with antipruritic, rash regression time, and moisturizing effect, which is the most preferable combination.
TABLE 54 clinical rehabilitation comparisons h
P <0.01, P <0.05 compared to control
EXAMPLE 4 essence
TABLE 6 essence (parts by weight)
TABLE 6 (parts by weight)
The preparation method of the essence comprises the following steps: heating deionized water to 80-90 ℃, sequentially adding sodium hyaluronate, polyglutamic acid, trehalose and allantoin, stirring and dissolving completely, wherein the stirring revolution is 3000-9000 rpm. Cooling to 50-60 deg.C, adding ceramide, stirring, and dissolving completely. Cooling to 40 deg.C, adding the plant extract, stirring, and dissolving completely. (the above components are not added if not in combination)
Example 5 clinical observations of Water and oil, elasticity, and anti-inflammatory and antipruritic
1 clinical data
1.1 general data groups of 150 cases in total, all were volunteers recruited by southern medical university (former first department of military medical university) affiliated southern hospital TCM surgery outpatient clinic 2015 from 1 month to 2017 from 8 months. Randomly divided into 6 groups, and the treatment group 1 comprises 25 cases, wherein 10 cases are male, and 15 cases are female; the age is 18-42 years, and the average age is 26.3 years; treatment group 2 consisted of 25 patients, 14 men and 11 women; the age is 20-45 years, and the average age is 29.7 years; treatment group 3 consisted of 25 patients, 14 men and 11 women; the age is 20-45 years, and the average age is 29.7 years; treatment group 4 consisted of 25 patients, 12 men and 13 women; the age is 18-43 years, and the average age is 27.3 years; treatment group 5 consisted of 25 patients, 11 men and 114 women; age 19-45 years, average 28.6 years; the control group comprises 25 cases, wherein 15 cases of men and 10 cases of women are aged 22-44 years, and the average age is 30.9 years. The data of 6 groups are statistically processed, and the differences have no significance (P is more than 0.05), and are comparable.
1.2 inclusion criteria groups from 18 to 45 years old were selected, with no restriction. Sensitive skin or sensitive skin is preferred.
1.3 the elimination standard excludes chronic eczema and tinea corporis; pregnant or lactating women; patients with liver and cardiovascular diseases; patients with malignant tumors; stopping treatment or replacing drugs and methods during treatment; the curative effect cannot be judged or the data is not complete to influence the judgment of the curative effect.
2 method of treatment
2.1
deionized water is externally used for the control group;
1ml each time, 2 times daily, and is applied topically. The results were observed after 4 weeks.
2.2 statistical methods T test was used.
3 analysis of therapeutic effects
3.1 test instruments: skin water and oil tester (Xinglin Internet technology Co., Ltd., patent No. CN:205514533U)
3.2 test methods all tests were carried out in a constant temperature, constant humidity room, temperature (22 + -1) deg.C, humidity (50 + -5)%. The subjects tested the moisture, oil and elasticity of the forehead and cheek skin before and after 4 weeks of treatment, respectively, and the test was performed 2 times per part under the resting state, and the average value was obtained. During the observation period, all the observers did not use other products for increasing the moisture and oil content of the skin.
3.3 treatment results 1 are shown in Table 7.
The addition of the plant extract into the essence has obvious improvement on the performance of the essence, and except for the treatment group 5 and the control group, the water, oil and elasticity of the treatment groups 1-4 are different before and after treatment (P is less than 0.05), namely the water, oil and elasticity of the treatment groups 1-4 are improved after treatment. It is particularly remarkable that the moisture content of the skin is increased to about 5 times before the treatment in the treatment group 2, and the improvement is particularly different from that in the treatment group 3 in the aspect of moisture supplement (P is less than 0.01), and in addition, the improvement of elasticity and grease in the treatment group 2 is also obviously higher than that in other treatment groups, and the good effect is not benefited from the efficacy of a single plant extract, but rather from the compatibility of the whole composition. The water, oil and elasticity of the control group are not different before and after treatment (P > 0.05).
TABLE 7 facial skin Properties before and after treatment of the treatment and control groups
P <0.01, P <0.05 compared to control
3.4 treatment results 2 are shown in Table 8
Compared with the control group, the treatment groups 1,2, 4 and 5 have significant differences in the days for relieving itching and eliminating rash (P is less than 0.01 and P is less than 0.05), and the plant extract with the anti-allergy effect is added into the cosmetics to endow the cosmetics with the anti-allergy effect. The days of itching relieving in the treatment group 2 are more obviously different from those in other treatment groups and the control group (P is less than 0.01), the rash regression time is obviously different from that in the control group, and the itching relieving in the treatment group 3 (without the plant extract) and the rash regression are not obviously different from those in the control group (P is more than 0.05). The 6 group comparisons are shown in Table 8.
Comparative clinical rehabilitation of 86 groups in table
P <0.01, P <0.05 compared to control
4 conclusion
Clinical observation proves that the whole composition ratio of the essence can not only enhance the hydration degree of the horny layer, adjust the water-oil balance state of the skin, and effectively increase the elasticity of the skin; and the skin care product can relieve allergy, relieve red spot, pruritus and other reactions of skin in an allergic state, and repair damaged skin barriers of sensitive skin.
Claims (19)
1. The plant extract composition is characterized by comprising the following raw materials in parts by weight:
10-20 parts of purslane
10-20 parts of tremella
1-5 parts of mint
5-10 parts of liquorice;
the preparation method of the plant extract composition comprises the following steps:
s1: weighing the raw materials in parts by weight, and crushing into powder;
s2: sieving the powder with a 50-mesh sieve, soaking in anhydrous ethanol for 10-30 min, and removing the liquid;
s3, decoloring;
s4: according to the material-water ratio of 1: extracting at 85-95 ℃ for 5-7h at 80-100, continuously stirring at 1000-2000rpm in the extraction process, and then filtering and collecting filtrate;
s5: the filtrate is subjected to rotary evaporation and concentration to remove 85-95% of water;
s6: vacuum freeze drying to obtain water extract.
2. The plant extract composition of claim 1, consisting of the following raw materials in parts by weight:
12-18 parts of purslane
12-18 parts of tremella
2-4 parts of mint
6-9 parts of liquorice.
3. The plant extract composition of claim 1, which consists of the following raw materials in parts by weight:
14-16 parts of purslane
14-16 parts of tremella
3-4 parts of mint
7-8 parts of liquorice.
4. The plant extract composition of claim 1, wherein the decolorization is repeated 3 times in step S3;
in step S4, repeating the extraction at least twice, and combining the filtrates;
in step S5, 90% of the water is removed.
5. Use of the plant extract composition of any one of claims 1 to 4 for the preparation of a cosmetic or pharmaceutical product.
6. The use according to claim 5, wherein the cosmetic is cream, emulsion, lotion or mask.
7. The use according to claim 5, wherein the medicament is a medicament for external application to the skin.
8. The essence is characterized by comprising deionized water and the following components in parts by weight:
plant extract composition 100-300 parts
0.5-20 parts of ceramide
0.1-10 parts of sodium hyaluronate
0.1-10 parts of polyglutamic acid
Trehalose 0.5-5 parts
Allantoin 0.1-2 parts
The plant extract composition is prepared from the following raw materials in parts by weight:
10-20 parts of purslane
10-20 parts of tremella
1-5 parts of mint
5-10 parts of liquorice
Wherein, the preparation method of the plant extract composition comprises the following steps:
s1: weighing the raw materials in parts by weight, and crushing into powder;
s2: sieving the powder with a 50-mesh sieve, soaking in anhydrous ethanol for 10-30 min, and removing the liquid;
s3, decoloring;
s4: according to the material-water ratio of 1: extracting at 85-95 ℃ for 5-7h at 80-100, continuously stirring at 1000-2000rpm in the extraction process, and then filtering and collecting filtrate;
s5: the filtrate is subjected to rotary evaporation and concentration to remove 85-95% of water;
s6: vacuum freeze drying to obtain water extract.
9. The essence of claim 8, which consists of deionized water and the following components in parts by weight:
plant extract composition 150-
1-5 parts of ceramide
0.5-2 parts of sodium hyaluronate
0.5-1 part of polyglutamic acid
1-2 parts of trehalose
Allantoin 1-2 parts
The plant extract composition is prepared from the following raw materials in parts by weight:
12-18 parts of purslane
12-18 parts of tremella
2-4 parts of mint
6-9 parts of liquorice.
10. The essence of claim 8, which consists of deionized water and the following components in parts by weight:
plant extract composition 175-
2-3 parts of ceramide
1-1.5 parts of sodium hyaluronate
0.6-0.8 part of polyglutamic acid
1.5-1.75 parts of trehalose
Allantoin 1.2-1.8 parts
The plant extract composition is prepared from the following raw materials in parts by weight:
14-16 parts of purslane
14-16 parts of tremella
3-4 parts of mint
7-8 parts of liquorice.
11. The essence according to any one of claims 8 to 10, wherein the ceramide is selected from one or a combination of ceramides 1 to 6.
12. The essence according to claim 11, wherein the ceramide is selected from the group consisting of ceramide 1, ceramide 3 and ceramide 6.
13. The essence of claim 12 wherein the ceramide is selected from the group consisting of ceramide 1 in an amount of 0.5-5 parts, ceramide 3 in an amount of 0.1-2 parts, and ceramide 6 in an amount of 0.1-0.5 parts.
14. The essence according to any one of claims 8 to 10, wherein the sodium hyaluronate is one or a combination of several of medium molecular sodium hyaluronate with a molecular weight of 1000000-18000000 Da, small molecular sodium hyaluronate with a molecular weight of 400000-10000000 Da and micro molecular sodium hyaluronate with a molecular weight of 100000-4000000 Da.
15. The serum of claim 14, wherein the sodium hyaluronate is selected from the group consisting of medium molecule sodium hyaluronate, small molecule sodium hyaluronate, and small molecule sodium hyaluronate.
16. The essence of claim 15, wherein the weight ratio of the medium molecular sodium hyaluronate, the small molecular sodium hyaluronate to the micro molecular sodium hyaluronate is 1-3:1-3: 1-3.
17. The essence of claim 16, wherein the weight ratio of the medium molecular sodium hyaluronate, the small molecular sodium hyaluronate to the micro molecular sodium hyaluronate is 1:1: 1.
18. The essence according to any one of claims 8 to 10, which is used for relieving erythema and pruritus in skin allergic state, repairing damaged skin barrier of sensitive skin, removing redness, improving skin elasticity, delaying aging and resisting oxidation.
19. A method for preparing the essence of any one of claims 8 to 18, characterized by comprising the steps of:
(1) heating deionized water to 80-90 ℃, sequentially adding sodium hyaluronate, polyglutamic acid, trehalose and allantoin, stirring and dissolving completely, wherein the stirring revolution is 3000-9000 rpm;
(2) cooling to 50-60 deg.C, adding ceramide, stirring, and dissolving completely;
(3) cooling to 40-50 deg.C, adding the plant extract composition, stirring, and dissolving completely.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120033377A (en) * | 2010-09-30 | 2012-04-09 | 이상수 | Method for producing functional cosmetic composition and the cosmetic |
| CN104490717A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Hyaluronic acid hydrating mask essence and preparation method thereof |
| CN105769654A (en) * | 2016-03-02 | 2016-07-20 | 名臣健康用品股份有限公司 | Anti-sensitivity skin-care composition and application thereof to cosmetics |
| CN105997793A (en) * | 2016-06-21 | 2016-10-12 | 张信环 | Mask and preparation method thereof |
| CN106074315A (en) * | 2016-08-24 | 2016-11-09 | 广东芭薇生物科技股份有限公司 | A kind of facial mask liquid with multiple skin-care effect and preparation method thereof |
| CN106333885A (en) * | 2016-08-25 | 2017-01-18 | 广州睿森生物科技有限公司 | Plant extract and eye essence liquid |
| CN106606452A (en) * | 2017-01-10 | 2017-05-03 | 广州源理生物科技有限公司 | Essence capable of adjusting moisture-oil balance and whitening skin |
-
2017
- 2017-12-19 CN CN201711369856.6A patent/CN107854367B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120033377A (en) * | 2010-09-30 | 2012-04-09 | 이상수 | Method for producing functional cosmetic composition and the cosmetic |
| CN104490717A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Hyaluronic acid hydrating mask essence and preparation method thereof |
| CN105769654A (en) * | 2016-03-02 | 2016-07-20 | 名臣健康用品股份有限公司 | Anti-sensitivity skin-care composition and application thereof to cosmetics |
| CN105997793A (en) * | 2016-06-21 | 2016-10-12 | 张信环 | Mask and preparation method thereof |
| CN106074315A (en) * | 2016-08-24 | 2016-11-09 | 广东芭薇生物科技股份有限公司 | A kind of facial mask liquid with multiple skin-care effect and preparation method thereof |
| CN106333885A (en) * | 2016-08-25 | 2017-01-18 | 广州睿森生物科技有限公司 | Plant extract and eye essence liquid |
| CN106606452A (en) * | 2017-01-10 | 2017-05-03 | 广州源理生物科技有限公司 | Essence capable of adjusting moisture-oil balance and whitening skin |
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