CN113768803B

CN113768803B - Composition of anti-hair loss and anti-dandruff spray and preparation method thereof

Info

Publication number: CN113768803B
Application number: CN202111139724.0A
Authority: CN
Inventors: 吕运一
Original assignee: Shenzhen Leafoo Biotechnology Co ltd
Current assignee: Shenzhen Leafoo Biotechnology Co ltd
Priority date: 2021-09-27
Filing date: 2021-09-27
Publication date: 2023-06-06
Anticipated expiration: 2041-09-27
Also published as: CN113768803A

Abstract

The invention relates to the technical field of cosmetics, in particular to a composition of an anti-hair loss and anti-dandruff spray and a preparation method thereof. The raw materials of the composition comprise 2-8 parts of ginseng, 2-8 parts of star anise, 4-10 parts of szechuan lovage rhizome, 4-10 parts of tall gastrodia tuber, 6-12 parts of prepared tuber fleeceflower root, 6-12 parts of ginger, 6-12 parts of rice chaff and 8-14 parts of pine needle. The preparation method comprises extracting volatile oil from fructus Anisi Stellati, folium Pini and rhizoma Zingiberis recens, filtering, adding Ginseng radix and Polygoni Multiflori radix into the residue, and extracting with ethanol; mixing the rest materials such as rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae and testa oryzae, adding ethanol solution and cosolvent, and extracting; finally, the filtrate obtained by filtering the extraction method is mixed with water-soluble azone to prepare the alopecia-preventing and dandruff-removing spray. The spray has strong penetrability, can promote blood circulation under scalp, promote hair metabolism, supplement nutrition to hair roots, nourish hair follicles, activate hair follicle tissues, promote hair growth, and effectively prevent alopecia and excessive dandruff.

Description

Composition of anti-hair loss and anti-dandruff spray and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to a composition of an anti-hair loss and anti-dandruff spray and a preparation method thereof.

Background

Alopecia is divided into physiological shedding and pathological shedding, the normal shedding range of each day is less than one hundred, and the alopecia belongs to physiological shedding; pathological alopecia refers to excessive hair loss every day, and is classified into cicatricial alopecia and non-cicatricial alopecia. The cicatricial alopecia causes inflammation reaction and damage to hair follicle while the hair falls off, and forms cicatricial change, so that the hair can not be regenerated, and the permanent alopecia is caused. Non-scar alopecia is mostly caused by factors such as medicines, environment and the like, but hair follicle structure is complete, hair can grow again after a period of recovery or treatment, and the hair belongs to temporary alopecia.

The cause of alopecia is as follows: the preparation method comprises the following steps of: for autosomal dominant inheritance, it is only shown under the action of androgens, mostly after puberty; mental alopecia: the loss of hair is often increased due to high mental stress; physical hair loss: the causes of the diseases include mechanical stimulation such as excessive traction, plastic comb hair, etc.; chemical hair loss is achieved: etiology includes perming, dyeing, etc.; infectious alopecia: infection with bacteria, fungi, treponema pallidum, parasites, etc. can cause alopecia; sixth, endocrine hair loss: alopecia diseases such as postpartum and climacteric alopecia are caused by endocrine abnormality; nutritional hair loss: such as poor nutritional status of the patient, anemia may lead to hair loss; seasonal alopecia: alternate seasons, such as in late summer and early autumn, most of the hair loss is normal; immune alopecia: belongs to one symptom of immune diseases.

In adolescence, the gonad function starts to be active, and it stimulates sebaceous glands to increase sebum secretion. Because the sebaceous gland distribution of the scalp is rich, the secreted sebum is increased, and the scalp keratinization can be stimulated to accelerate the formation of excessive dandruff. Slightly more dandruff is often a physiological phenomenon common to young and young people, but is not skin disease, and the scalp dirt is cleared in time without special treatment as long as the personal hygiene is noted. However, some young people have significantly increased dandruff, which falls off like snow and has tackiness when they are scratched by hands or comb, which is a skin disease known medically as "dry seborrheic dermatitis" or "pityriasis scalp" once attached to clothing and not easily removed. Besides greasy dandruff, the disease is subjective scalp itching, and repeated scratching can cause skin peeling or secondary infection, hair folliculitis, furuncle and the like.

The cause of excessive dandruff is microorganism infection, head skin lesion, excessive mental pressure, sunburn, etc., and its main symptoms are manifested by excessive dandruff, repeated occurrence of dandruff, easy oil discharge of scalp, scalp itching, etc. The dandruff is caused to be increased by scalp infection, excessive or insufficient times of shampoo, scalp injury caused by over-high alkalinity of shampoo, and the like. In addition, the scalp is damaged by frequent permanent waving and dyeing, and the phenomenon of excessive dandruff is also caused.

At present, a plurality of anti-hair loss and anti-dandruff spray and shampoo with medicinal properties are developed in the market, but the product has unobvious anti-hair loss and anti-dandruff effects due to damage to hair and skin caused by frequent use due to the over-strong alkalinity in the product. Meanwhile, the oral administration of the traditional Chinese medicine has no obvious effects of preventing alopecia and removing dandruff due to physique difference.

The Chinese patent application CN106620601A discloses a traditional Chinese medicine hair-growing and hair-blackening health-care medicinal liquor and a preparation method thereof, wherein the medicinal liquor is mainly prepared from the following raw materials: rhizoma Polygonati, radix Polygoni Multiflori Preparata, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix rehmanniae Preparata, fructus Chaenomelis, rhizoma Gastrodiae, fructus Rosae Laevigatae, atractylodis rhizoma, folium Pini, rhizoma Zingiberis recens, siegesbeckiae herba, sang Qiaozi, caulis Spatholobi and semen Juglandis. The method comprises the following steps: (1) Mixing the raw materials of the Chinese herbal medicines, pulverizing into coarse powder, adding Chinese liquor for soaking, and fully soaking and swelling the coarse powder to obtain a feed liquid mixture; (2) Filling the feed liquid mixture obtained in the step (1) into a white spirit steaming pot, distilling the medicinal liquor with slow fire, and collecting distillate to obtain the traditional Chinese medicine hair-growing hair-blackening health-care medicinal liquor; or further soaking the residue in the distilled liquor pot in the distillate, filtering, and standing. The health wine has certain functions of growing and blackening hair, but has no obvious functions of preventing alopecia and removing dandruff, and the health wine has more traditional Chinese medicinal materials, complex prescription and is not beneficial to blending.

Chinese patent application CN110227143A discloses an anti-alopecia liquid, which comprises the following steps: s1, selecting raw materials for preparing the anti-hair loss liquid: deionized water, polygonum multiflorum, side dead leaves, ginseng, ligusticum chuanxiong, saffron, coix seeds, angelica sinensis, thickening agent, ginger, glycerin, musk and ganoderma lucidum, S2, cleaning the selected polygonum multiflorum, side dead leaves, ginseng, ligusticum chuanxiong, coix seeds, angelica sinensis, ginger, musk and ganoderma lucidum respectively, and placing the cleaned polygonum multiflorum, side dead leaves, ginseng, ligusticum chuanxiong, saffron, coix seeds, angelica sinensis, ginger, musk and ganoderma lucidum in prepared different clean glassware respectively. The invention has limited anti-alopecia effect, has no obvious effect of removing dandruff, and has the effect to be improved.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides the composition of the hair loss prevention and dandruff removal spray and the preparation method thereof, which have the advantages of simple prescription, low cost and high extraction efficiency.

The composition of the anti-hair loss and anti-dandruff spray comprises the following raw materials in parts by weight: 2-8 parts of ginseng, 2-8 parts of star anise, 4-10 parts of ligusticum wallichii, 4-10 parts of gastrodia elata, 6-12 parts of prepared polygonum multiflorum, 6-12 parts of ginger, 6-12 parts of rice chaff and 8-14 parts of pine needles.

Pine needles: the description of Ben Cao gang mu: pine needles, known as pine needles, have the effects of warming and bitter properties, being nontoxic, entering the meridians of the liver, kidneys, lungs and spleen, treating various viscera toxic swelling and wind-cold-dampness symptoms, treating swelling and blisters, promoting hair regeneration, strengthening the liver, kidneys, hearts, spleen and lung, allaying hunger and prolonging life. Pine contains a large amount of bioflavonoids and procyanidins, is rich in chlorophyll and multiple vitamins, and the pine needle extract has the effects of dilating arterial blood vessels, increasing the oxygen carrying capacity of red blood cells, promoting blood circulation, improving the functions of capillary vessels, improving immunity, increasing hormone secretion, strengthening sperm and resisting aging.

Star anise (Chinese medicine star lotus): has effects of clearing heat, detoxicating, promoting blood circulation, and removing blood stasis, and can be used for treating snake and insect bite, sore, furuncle, carbuncle, lymphadenitis, parotitis, etc. The dysosma versipellis contains alkaloid and choline, can help the body to descend qi, eliminate stagnation, reduce swelling and detoxify, and can relieve symptoms such as carbuncle, furuncle, venomous snake bite and the like. The fructus Anisi Stellati extract can be used in cosmetics and skin care products as skin conditioner and antiinflammatory agent, and has no acne component, and is safe to use.

Ginseng radix is rich in ginsenoside active ingredients, and has skin caring and ultraviolet resisting effects. The ginseng extract has strong antibacterial and anti-inflammatory effects, is an ideal natural additive for cosmetics, and has remarkable curative effects on female freckle, brown spot, butterfly spot and senile skin pigmentation. Because the ginseng contains various ginsenosides, amino acids, vitamins and minerals, the ginseng has the effects of promoting blood circulation of subcutaneous capillaries, increasing nutrition supply of skin, preventing arteriosclerosis, regulating skin moisture balance, preventing skin from drying and dehydrating, increasing skin elasticity, protecting skin luster and tendering, and preventing and reducing skin wrinkles when added into skin care products. The ginseng active substance also has melanin reduction inhibiting effect, and can make skin white and smooth.

Prepared fleece-flower root, recorded in Ben Cao gang mu: polygonum multiflorum, strengthening tendons and bones, blackening mustache, and nourishing the color, and is a nourishing good medicine; the "Kaibao Bencao" describes: polygonum multiflorum can be used for treating scrofula, eliminating carbuncle and swelling, eliminating five hemorrhoids, removing head and face heat sores, blackening mustache and nourishing the color; the description of "true materia Medica" is: polygonum multiflorum has the effects of nourishing water, tonifying kidney, blackening hair and reducing weight. The prepared fleece-flower root is prepared from fleece-flower root, contains anthraquinone, lecithin, starch and other components, and has the functions of promoting the regeneration and development of blood cells, enhancing immunity, improving the activity of superoxide dismutase, inhibiting monoamine oxidase, reducing blood fat and resisting aging.

Ligusticum wallichii has the effects of promoting blood circulation, promoting qi circulation, dispelling wind and relieving pain. It can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, chest pain, hypochondrium pain, traumatic injury, headache, and rheumatalgia. Simultaneously, the ligusticum wallichii has good beautifying effect: the sterols contained in ligusticum wallichii have good permeability to skin, can keep moisture on the surface of the skin, promote skin metabolism, inhibit skin inflammation, and can prevent erythema solarium and skin aging; the ligustrazine contained in the ligusticum wallichii can increase the activity of superoxide dismutase, and can enhance the effect of eliminating free radicals, so that the skin is speckle-removing, wrinkle-removing, tender and elastic; the ligustrazine contained in the ligusticum wallichii can promote the opening quantity of the micro blood vessels; ferulic acid contained in rhizoma Ligustici Chuanxiong has effects of promoting blood circulation, dredging channels and collaterals, improving microcirculation, promoting skin metabolism, supplying skin nutrition, and delaying skin aging; the vitamin A contained in the ligusticum wallichii has the physiological function of maintaining normal functions of epithelial tissues, ensures normal secretion of sebaceous glands and sweat glands, and prevents rough skin, dryness, desquamation, wrinkling and excessive keratinization thickening of the skin; the ligusticum wallichii has the functions of promoting blood circulation to remove blood stasis, blackening hair and enlarging muscles, and can be used for black spots, early whitening of hair and the like. The hemlock parsley has inhibiting effect on colibacillus, dysentery bacillus, proteus bacillus, pseudomonas aeruginosa, typhoid bacillus, paratyphoid bacillus, cholera bacillus and the like, and also has inhibiting effect on pathogenic dermatophytes and viruses.

Gastrodia elata has the effects of calming endogenous wind, arresting convulsion, and tranquilizing and allaying excitement. The study shows that the gastrodia elata has the beauty effect of moisturizing and blackening hair, and has the treatment effects on alopecia, alopecia areata, baldness, sparse hair, scratching and falling off, scalp itching, excessive dandruff and the like.

Ginger is considered to have the function of "freeing vessels" by traditional Chinese medicine, and the ginger can be eaten frequently to free vessels and collaterals, so that qi and blood are harmonized smoothly, and the purpose of appearance skin is achieved. Researches show that gingerol contained in ginger has a certain stimulation effect on the cardiovascular system of a human body, can dilate blood vessels, accelerate blood circulation, enable blood to fully reach the skin, and enable the human body to be in full light. Simultaneously, the ginger also has the effect of inhibiting dermatophytes, and can treat various carbuncles, swelling and sore toxins. The fresh ginger juice is used for mashing or directly smearing the fresh ginger on the hair, so that the blood circulation of the head skin is normalized, the metabolism of the hair is promoted, the hair follicle tissue is activated, the alopecia and the white hair are effectively prevented, the new growth of the hair is stimulated, the scalp itching is inhibited, and the hair root is strengthened.

The rice chaff has good beautifying effect, has promoting effect on the formation of cholesterol and cerebral amide, wherein the cholesterol and the cerebral amide are important components of sebum, and the increase of the content of the cholesterol and the cerebral amide is beneficial to improving the softness of skin; has activating effect on glutathione reductase, and has skin activating and antiaging effects in combination with its antioxidant effect.

Wheat germ is a nutritional product with high protein, high vitamin E, low heat and low fat. Contains more than 10 mineral substances such as vitamin B group, vitamin D, unsaturated fatty acid, nucleic acid, industrial acid, octacosanol and calcium, iron, zinc, selenium, etc., and the physiological effect of wheat germ powder has the functions of resisting oxidation and regulating skin.

The water-soluble azone is an efficient water-soluble product which is modified by oil-soluble azone, has obvious transdermal permeation-assisting effect on lipophilic and hydrophilic medicines and active ingredients, enables skin horny layer to interact with lipid, reduces the phase transfer temperature of active substances to lipid in horny layer gaps, increases fluidity, reduces the diffusion resistance of medicines or active additives in horny layer, and plays a very strong role in promoting permeation.

Alcohol, i.e., ethanol, has different efficacy and effects at different concentrations: the method comprises the steps that 95% alcohol is used for sterilizing medical equipment; the sterilizing power of the alcohol solution with 70-75% is strongest, and the alcohol used clinically is 75% alcohol and is mainly used for sterilizing skin and body surfaces; the 40% -50% alcohol can dilate blood vessels and increase blood circulation, is used for wiping patients on a long-lying sickbed, and can prevent bedsores; the 20-30% alcohol bathing agent is used for nursing and cooling the high fever people.

Preferably, the raw materials of the composition comprise the following components in parts by weight: 2-4 parts of ginseng, 4-8 parts of star anise, 6-10 parts of ligusticum wallichii, 4-6 parts of gastrodia elata, 6-9 parts of prepared polygonum multiflorum, 9-12 parts of ginger, 9-12 parts of rice chaff and 10-14 parts of pine needles.

Preferably, the raw materials of the composition further comprise 9-12 parts of wheat germ powder;

preferably, the mass ratio of the pine needles to the rice chaff to the wheat germ meal is 1.0-1.3:1:1.

Preferably, the starting material of the composition further comprises a water-soluble azone.

Another object of the present invention is to provide a method for preparing the above composition, comprising the steps of:

(1) Pulverizing Ginseng radix and fructus Anisi Stellati, and cutting folium Pini;

(2) Mixing fructus Anisi Stellati, folium Pini and rhizoma Zingiberis recens, extracting volatile oil with water, filtering to obtain filtrate 1 and residue 1, mixing residue 1 with Ginseng radix and Polygoni Multiflori radix, adding ethanol, heating, reflux extracting, and filtering to obtain filtrate 2;

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae and testa oryzae, or mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae, testa oryzae and wheat germ powder, adding ethanol solution, adding cosolvent, heating, reflux extracting, and filtering to obtain filtrate 3;

(4) Mixing filtrate 1, filtrate 2 and filtrate 3, adding volatile oil and water-soluble azone, and adding ethanol or water to obtain the final product.

Preferably, the ratio of the volume of water to the total mass of star anise, pine needles and ginger in step (2) is 5-8:1ml/g; the method for extracting volatile oil is steam distillation, and the extraction time is 2-4h.

Preferably, the ethanol in the step (2) is 50-60% ethanol water solution, and the extraction time is 0.5-2h.

Preferably, in the step (3), the ethanol is 60-70% ethanol water solution, and the mass volume ratio of the cosolvent to the 60-70% ethanol water solution is 0.02-0.05mg:1mL.

Preferably, the cosolvent in the step (3) is a mixture of cellobiose and lecithin, wherein the mass ratio of cellobiose to lecithin is 1:2.5-3.5; the extraction time is 0.5-2h.

Preferably, the mass of the water-soluble azone in the step (4) is 0.5-1.5% of the total mass of filtrate 1, filtrate 2 and filtrate 3; preferably, the ethanol concentration of the alopecia preventing and anti-dandruff spray is 45-50%.

It is also an object of the present invention to provide the use of the above composition for the preparation of an anti-hair loss and anti-dandruff product.

The invention has the beneficial effects that:

(1) The invention combines the traditional Chinese medicines such as ginseng, ligusticum wallichii, gastrodia elata, ginger and the like with the functions of invigorating qi, activating blood and activating collaterals, tranquilizing and allaying excitement, and the polygonum multiflorum for strengthening bones and muscles, prolonging life, and the materials such as star anise, rice chaff, wheat germ powder and the like for conditioning skin grease, improving capillary vessel function and regulating hormone secretion, can achieve the aim of treating both principal and secondary aspect of disease by preventing and developing, can promote blood circulation under scalp, promote hair metabolism, supplement nutrition for hair roots, nourish hair follicle, activate hair follicle tissues, and can effectively prevent alopecia and excessive dandruff.

(2) The star anise has good effects of clearing heat and detoxicating and resisting inflammation, and plays an obvious synergistic effect in preventing alopecia and reducing dandruff when being matched with rice chaff for regulating the water-oil balance of sebum metabolism.

(3) The invention researches the preparation method, and discovers that when Ligusticum wallichii, gastrodia elata and rice chaff are extracted, certain dissolution assisting substances are added, so that the extraction of active ingredients of medicinal materials can be promoted, and when cellobiose and lecithin are compounded according to a certain mass ratio, the treatment effect is particularly obvious, and the dissolution promoting effect of other possible solvents is obviously better. In addition, the steps of the preparation method are thoroughly and carefully examined, the ginseng and the polygonum multiflorum of the invention are screened and decocted with other medicinal herbs, the volatile oil is extracted from the star anise, the pine needles and the Jiang Xianjin, other medicinal materials are directly extracted by alcohol, and the finally prepared active ingredient composition has the best medicinal effect and the highest medicinal material resource utilization rate.

Detailed Description

The technical scheme of the invention is further described below by combining examples.

Example 1

The composition of the anti-hair loss and anti-dandruff spray is characterized by being prepared from the following traditional Chinese medicinal materials in parts by weight:

2 parts of ginseng, 8 parts of star anise, 4 parts of ligusticum wallichii, 4 parts of gastrodia elata, 12 parts of prepared polygonum multiflorum, 6 parts of ginger, 6 parts of rice chaff and 8 parts of pine needles.

The preparation method comprises the following steps:

(2) Mixing fructus Anisi Stellati, folium Pini and rhizoma Zingiberis recens, adding 5 times of water, heating and reflux extracting for 4 hr to obtain volatile oil, filtering to obtain filtrate 1 and residue 1, mixing residue 1 with Ginseng radix and Polygoni Multiflori radix, adding 6 times of 50% ethanol water solution, heating and reflux extracting for 2 hr, and filtering to obtain filtrate 2;

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae and testa oryzae, adding 6 times of 60% ethanol water solution, adding cosolvent, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 3; wherein the mass volume ratio of the cosolvent to the 60% ethanol water solution is 0.05mg:1mL, wherein the cosolvent is a cellobiose and lecithin mixture with a mass ratio of 1:2.5;

(4) Mixing filtrate 1, filtrate 2 and filtrate 3, adding volatile oil and water-soluble azone, and adjusting ethanol concentration of the mixed solution to 45% to obtain the spray for preventing alopecia and removing dandruff. The mass of the water-soluble azone is 0.5% of the total mass of filtrate 1, filtrate 2 and filtrate 3.

Example 2

8 parts of ginseng, 2 parts of star anise, 10 parts of ligusticum wallichii, 10 parts of gastrodia elata, 6 parts of prepared polygonum multiflorum, 12 parts of ginger, 12 parts of rice chaff and 14 parts of pine needles.

The preparation method comprises the following steps:

(2) Mixing fructus Anisi Stellati, folium Pini and rhizoma Zingiberis recens, adding 8 times of water, heating and reflux extracting for 2 hr to obtain volatile oil, filtering to obtain filtrate 1 and residue 1, mixing residue 1 with Ginseng radix and Polygoni Multiflori radix, adding 8 times of 60% ethanol water solution, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 2;

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae and testa oryzae, adding 6 times of 70% ethanol water solution, adding cosolvent, heating and reflux extracting for 2 hr, and filtering to obtain filtrate 3; wherein the mass volume ratio of the cosolvent to the 70% ethanol aqueous solution is 0.02mg:1mL, wherein the cosolvent is a cellobiose and lecithin mixture with a mass ratio of 1:3.5;

(4) Mixing filtrate 1, filtrate 2 and filtrate 3, adding volatile oil and water-soluble azone, and adjusting ethanol concentration of the mixed solution to 50% with water and ethanol to obtain the final product. The mass of the water-soluble azone is 1.5% of the total mass of the filtrate 1, the filtrate 2 and the filtrate 3.

Example 3

4 parts of ginseng, 4 parts of star anise, 6 parts of szechuan lovage rhizome, 6 parts of tall gastrodia tuber, 9 parts of prepared tuber fleeceflower root, 9 parts of ginger, 9 parts of rice chaff and 11 parts of pine needle.

The preparation method comprises the following steps:

(2) Mixing fructus Anisi Stellati, folium Pini and rhizoma Zingiberis recens, adding 6 times of water, heating and reflux extracting for 3 hr to obtain volatile oil, filtering to obtain filtrate 1 and residue 1, mixing residue 1 with Ginseng radix and Polygoni Multiflori radix, adding 8 times of 55% ethanol water solution, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 2;

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae and testa oryzae, adding 6 times of 60% ethanol water solution, adding cosolvent, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 3; wherein the mass volume ratio of the cosolvent to the 60% ethanol water solution is 0.03mg:1mL, wherein the cosolvent is a cellobiose and lecithin mixture with a mass ratio of 1:3;

(4) Mixing filtrate 1, filtrate 2 and filtrate 3, adding volatile oil and water-soluble azone, and regulating ethanol concentration of the mixed solution to 45% with water and ethanol to obtain the final product. The mass of the water-soluble azone is 1.0% of the total mass of filtrate 1, filtrate 2 and filtrate 3.

Example 4

4 parts of ginseng, 4 parts of star anise, 6 parts of szechuan lovage rhizome, 6 parts of tall gastrodia tuber, 9 parts of prepared tuber fleeceflower root, 9 parts of ginger, 9 parts of rice chaff, 11 parts of pine needle and 9 parts of wheat germ.

The preparation method comprises the following steps:

(2) Mixing fructus Anisi Stellati, folium Pini and rhizoma Zingiberis recens, adding 6 times of water, heating and reflux extracting for 3 hr to obtain volatile oil, filtering to obtain filtrate 1 and residue 1, mixing residue 1 with Ginseng radix and Polygoni Multiflori radix, adding 8 times of 50% ethanol water solution, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 2;

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae, testa oryzae and wheat embryo bud, adding 6 times of 70% ethanol water solution, adding cosolvent, heating, reflux extracting for 1 hr, and filtering to obtain filtrate 3; wherein the mass volume ratio of the cosolvent to the 70% ethanol aqueous solution is 0.03mg:1mL, wherein the cosolvent is a cellobiose and lecithin mixture with a mass ratio of 1:3;

(4) Mixing filtrate 1, filtrate 2 and filtrate 3, adding volatile oil and water-soluble azone, and regulating ethanol concentration of the mixed solution to 45% with water and ethanol to obtain the final product. The mass of the water-soluble azone is 0.5% of the total mass of filtrate 1, filtrate 2 and filtrate 3.

Example 5

8 parts of ginseng, 2 parts of star anise, 10 parts of szechuan lovage rhizome, 10 parts of tall gastrodia tuber, 6 parts of prepared tuber fleeceflower root, 12 parts of ginger, 12 parts of rice chaff, 14 parts of pine needle and 12 parts of wheat germ.

The preparation method comprises the following steps:

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae, testa oryzae and wheat embryo bud, adding 6 times of 65% ethanol water solution, adding cosolvent, heating, reflux extracting for 1 hr, and filtering to obtain filtrate 3; wherein the mass volume ratio of the cosolvent to the 65% ethanol aqueous solution is 0.03mg:1mL, wherein the cosolvent is a cellobiose and lecithin mixture with a mass ratio of 1:3;

Comparative example 1

The comparative example was conducted in the same manner as in example 3 except that the illicium verum was removed and the rice chaff was adjusted to 13 parts, and the remaining parts were the same as in example 3.

The preparation method comprises the following steps:

(1) Pulverizing Ginseng radix, and cutting folium Pini;

(2) Mixing folium Pini and rhizoma Zingiberis recens, adding 6 times of water, heating and reflux extracting for 3 hr to obtain volatile oil, filtering to obtain filtrate 1 and residue 1, mixing residue 1 with Ginseng radix and Polygoni Multiflori radix, adding 8 times of 55% ethanol water solution, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 2;

Comparative example 2

The comparative example was different from example 3 in that the rice chaff was removed, the star anise was adjusted to 13 parts, and the rest was the same as example 3.

The preparation method comprises the following steps:

(3) Mixing rhizoma Ligustici Chuanxiong and rhizoma Gastrodiae, adding 6 times of 60% ethanol water solution, adding cosolvent, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 3; wherein the mass volume ratio of the cosolvent to the 60% ethanol water solution is 0.03mg:1mL, wherein the cosolvent is a cellobiose and lecithin mixture with a mass ratio of 1:3;

Comparative example 3

The difference between this comparative example and example 3 is that the cosolvent used in step (3) of the preparation method is a mixture of xylose and lecithin in a mass ratio of 1:3, and the remainder remains the same as in example 3. The method comprises the following steps:

The preparation method comprises the following steps:

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae and testa oryzae, adding 6 times of 60% ethanol water solution, adding cosolvent, heating and reflux extracting for 1 hr, and filtering to obtain filtrate 3; wherein the mass volume ratio of the cosolvent to the 60% ethanol water solution is 0.03mg:1mL, wherein the cosolvent is a mixture of xylose and lecithin in a mass ratio of 1:3;

Comparative example 4

The difference between the comparative example and the example 4 is that the total parts are unchanged, the proportion of pine needles, rice chaff and wheat germs is different, and the specific formula is as follows: 4 parts of ginseng, 4 parts of star anise, 6 parts of szechuan lovage rhizome, 6 parts of tall gastrodia tuber, 9 parts of prepared tuber fleeceflower root, 9 parts of ginger, 15 parts of rice chaff, 6 parts of pine needle and 8 parts of wheat germ. The preparation method was identical to example 4.

Test example 1

200 volunteers with volunteers who volunteered to participate in hair loss were selected, and age 25-60 years, and were grouped by taking as much factors affecting test results as possible, such as age, sex, hair loss condition, etc., into consideration to ensure comparability between groups, 6 groups were respectively example 3 group (60 persons), example 4 group (60 persons), comparative example 1 group (20 persons), comparative example 2 group (20 persons), comparative example 3 group (20 persons), comparative example 4 group (20 persons).

The using method comprises the following steps: the anti-hair loss and anti-dandruff spray prepared in the example 3, the example 4 and the comparative examples 1-4 is uniformly sprayed on the scalp, the scalp is gently combed and massaged by a plurality of rows of combs for one minute, and the spray is sprayed for 1 time each time in the morning and evening, 20mL each time, and the spray is continuously used for one month.

Efficacy index:

and (3) curing: the hair loss phenomenon is completely disappeared, the hair is hardly seen on the early-lift pillow, the hair is hardly seen when the hair is combed, the new hair is more, the thickness of the hair is close to that of normal hair, the hair is not broken when being pulled slightly, and the dandruff is completely disappeared;

the method is effective: the hair loss phenomenon is obviously reduced, the hair loss on the pillow is reduced by half compared with the hair loss before the pillow is started, the hair loss is reduced by half during hair combing, the grown new hair is visible, the hair is not easy to break when being pulled lightly, and the dandruff disappears by more than half;

invalidation: the alopecia phenomenon is reduced by less than 10 percent, no new hair growth or no obvious new hair growth and easy breakage, and the dandruff is not obviously reduced.

The distribution of the clinical volunteers is shown in Table 1, and the results after one month of continuous use are shown in Table 2.

TABLE 1 clinical observations of patient distribution data

Object of use construction	Male men	Female woman	Personnel's small meter
				Age of 25-40 years	58	54	112
41-60 years old	52	36	88
				Totalizing	110	90	200

Table 2 treatment results for each group

Test example 2 typical cases of using the alopecia preventing and antidandruff spray of the present invention

Case 1: zhang Mou Man, 28 years old, corporate technician. From 2 years ago, hair loss was found in the morning after the beginning of the hair comb, and gradually increased due to the treatment, and more hair loss was palpated by hand. The traditional Chinese medicine and the external medicine taken orally have unsatisfactory treatment effects, and the spray provided by the invention is sprayed twice a day later, so that the alopecia is reduced after 10 days, and the alopecia is obviously reduced after 30 days.

Case 2: gao Mou men, 52 years old, individual operators. Hair gradually falls off from 4 years ago, and recently, hair loss is serious, and hair is fallen off in a large amount every time, so that hair is not combed. The traditional Chinese medicine has unsatisfactory treatment effect by oral administration, and the spray provided by the invention is sprayed twice a day later, so that the hair loss is basically avoided after one month of use.

Case 3: wang Mou female, 38 years old, official high-authority. Hair loss began to gradually increase from 2 years ago with a lot of dandruff on the hair. Several alopecia preventing products have been used before, and the effect is not obvious. After the spray of the invention is sprayed twice a day, the alopecia and the dandruff are little after 15 days, the alopecia is basically avoided after the spray is used for one month, and the dandruff is not seen.

Case 4: the man, 53 years old, company high. The traditional Chinese medicine spray provided by the invention has the advantages that the traditional Chinese medicine is taken for 5 years before alopecia, the treatment effect is not ideal, and the traditional Chinese medicine spray is sprayed twice a day later, so that the alopecia is obviously less after 30 days, and the traditional Chinese medicine spray belongs to normal alopecia.

Case 5: peng Mou women, 24 years old, study student. The pillow towel falls into pieces every morning, and the scalp has lots of dandruff, so that the hair loss is serious in the recent years because the scalp is not emphasized by the completion of the academic industry. After the spray of the invention is sprayed twice a day, the alopecia is reduced after 10 days, the dandruff is obviously reduced, and the alopecia and the dandruff are basically not seen after 30 days.

Case 6: gao Mou women, 58 years old, retired workers. The alopecia time is several years, and the effects of taking traditional Chinese medicines and external anti-alopecia products before long-term hair loss are not ideal. The spray of the invention is sprayed twice a day later, and after 30 days, the alopecia is obviously less, which belongs to normal alopecia.

The examples of the present invention are used for illustrating the present invention only and are not intended to limit the scope of the present invention. Further, after reading the technical content of the present invention, those skilled in the art may make various changes, modifications or variations to the present invention, all of which are equally within the scope of protection defined by the appended claims of the present application.

Claims

1. The composition of the anti-hair loss and anti-dandruff spray is characterized by comprising the following raw materials in parts by weight: 2-8 parts of ginseng, 2-8 parts of star anise, 4-10 parts of ligusticum wallichii, 4-10 parts of gastrodia elata, 6-12 parts of prepared polygonum multiflorum, 6-12 parts of ginger, 6-12 parts of rice chaff and 8-14 parts of pine needles;

the raw materials of the composition also comprise 9-12 parts of wheat germ powder;

the mass ratio of the pine needles to the rice chaff to the wheat germ powder is 1.0-1.3:1:1;

the raw materials of the composition also comprise water-soluble azone;

the preparation method of the composition comprises the following steps:

(2) Mixing fructus Anisi Stellati, folium Pini and rhizoma Zingiberis recens, extracting volatile oil with water, filtering to obtain filtrate 1 and residue 1, mixing residue 1 with Ginseng radix and radix Polygoni Multiflori Preparata, adding ethanol solution, heating, reflux extracting, and filtering to obtain filtrate 2;

(3) Mixing rhizoma Ligustici Chuanxiong, rhizoma Gastrodiae, testa oryzae and wheat germ powder, adding ethanol solution, adding cosolvent, heating, reflux extracting, and filtering to obtain filtrate 3;

(4) Mixing filtrate 1, filtrate 2 and filtrate 3, and adding volatile oil and water-soluble azone to obtain composition of the spray for preventing alopecia and removing dandruff;

the cosolvent in the step (3) is a mixture of cellobiose and lecithin, wherein the mass ratio of the cellobiose to the lecithin is 1:2.5-3.5.

2. The composition according to claim 1, wherein the raw materials of the composition comprise the following components in parts by weight: 2-4 parts of ginseng, 4-8 parts of star anise, 6-10 parts of ligusticum wallichii, 4-6 parts of gastrodia elata, 6-9 parts of prepared polygonum multiflorum, 9-12 parts of ginger, 9-12 parts of rice chaff and 10-14 parts of pine needles.

3. A process for the preparation of a composition as claimed in any one of claims 1 to 2, comprising the steps of:

4. A method according to claim 3, wherein the ratio of the volume of water to the total mass of star anise, pine needles and ginger in step (2) is 5-8:1ml/g; the method for extracting the volatile oil is a steam distillation method, and the time for extracting the volatile oil is 2-4 hours.

5. The method according to claim 3, wherein the ethanol solution in the step (2) is a 50-60% ethanol aqueous solution, and the extraction time is 0.5-2 hours.

6. A process according to claim 3, wherein the ethanol solution in step (3) is a 60-70% ethanol aqueous solution.

7. The method according to claim 6, wherein the mass-to-volume ratio of the cosolvent to the 60-70% ethanol aqueous solution in the step (3) is 0.02-0.05mg:1mL.

8. A method according to claim 3, wherein the extraction time in step (3) is 0.5 to 2 hours.

9. A method of preparing according to claim 3, wherein the mass of the water-soluble azone in step (4) is 0.5-1.5% of the total mass of filtrate 1, filtrate 2 and filtrate 3.

10. A method according to claim 3, wherein the anti-hair loss and anti-dandruff spray composition in step (4) has an ethanol concentration of 45% -50%.

11. Use of a composition according to any one of claims 1-2 for the preparation of an anti-hair loss and anti-dandruff product.