CN1205954C - Hair restorer - Google Patents
Hair restorer Download PDFInfo
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- CN1205954C CN1205954C CN02131016.5A CN02131016A CN1205954C CN 1205954 C CN1205954 C CN 1205954C CN 02131016 A CN02131016 A CN 02131016A CN 1205954 C CN1205954 C CN 1205954C
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Abstract
The present invention relates to a pilatory which is mainly prepared from safe and effective Chinese traditional medicines comprising rose, fleece-flower root, oriental arborvitae, ginkgo leaf, belamcanda rhizome, hemlock parsley, ganodermas, persimmon calyx, hanmolian, prepared rhizome of rehmannia, black sesame, motherwort and licorice root. The pilatory has obvious therapeutic effects on pathologic alopecia, energy metabolism type alopecia and androgen type alopecia by reasonable preparation.
Description
Affiliated field
The present invention relates to a kind of hair growth promoter, more specifically to a kind of to the equal effective hair growth promoter of prepared from traditional Chinese medicines of multiple alopecia factor.
Background technology
Hair plays crucial effect in people's instrument is modified, be a primary condition that obtains the nature beauty in appearance.Modern medicine thinks that human hair also can obtain the information of body interior situation except the function of beauty treatment and protection scalp.Therefore, for the research of hair growth promoting, hair care, hair care, be subjected to the very big attention of whole world the world of medicine and cosmetics circle always.But along with the quickening of people's rhythm of life and the increasing of operating pressure, increasing people is subjected to the puzzlement of alopecia, improves day by day in living standard, today that doings are increased, brings great inconvenience and worries to us.The reason of alopecia is a lot, and theory of Chinese medical science is thought: senile alopecia and seborrheic alopecia main with insufficiency of the spleen wet heap soil or fertilizer over and around the roots, deficiency of kidney-QI, or excessive thinking, impairment caused by overstrain heart spleen is relevant, also has because of stagnation of liver-QI not understand person due to the disorder of QI and blood.And the generation of " alopecia areata " is many by blood deficiency, and feelings will is not relaxed, and blood is capable not normal, so that pore opens a business, ailment said due to cold or exposure attack in an opponent's defence into, it is dry that wind is contained blood, hair lose support due to.Modern medicine thinks that the mechanism of alopecia and alopecia mainly contains the reason of following several respects: 1. androgen type alopecia: claim seborrheic alopecia again, be common in the male.This alopecia shows tangible site specific, and promptly alopecia always occurs in volume temporo top, and does not involve pillow back and ear top.It is reported that the active enhancing of 5 is the decisive reason of this type of alopecia symptom in the human body, 5 is the biocatalyzer that testosterone is changed into dihydrotestosterone, and dihydrotestosterone then is the important androgen of hair growth inhibition.Therefore, suppress the activity of 5 and can block the dihydro of testosterone, thereby improve the alopecia symptom of android type.2. pathologic alopecia: as alopecia areata, radiation alopecia, alopecia medicamentosa.3. energy deficiency type alopecia: as the alopecia of brain overwork type.From above as can be seen, cause the factor of alopecia a lot.Though there are traditional theory of Chinese medical science and natural drug resource in China, but there are many problems in the research work aspect hair growth promoting, not enough as investigation for toxic and side effects, some domestic well-known for a time product for improving hair-growing, easy perspiration, symptom such as nervous are arranged after the patient uses, even forbidden input by some country.In addition, too exaggerative to the commerciality propaganda of hair growth promoter curative effect at present, the unicity of treatment is strong, and general hair growth promoter is only obvious to pathologic alopecia (as alopecia areata) effect, to seborrheic alopecia, energy deficiency type alopecia DeGrain, in addition absolutely void.
Summary of the invention
One, purpose:
The purpose of this invention is to provide a kind of hair growth promoter of natural Chinese herbal medicines preparation, used Chinese herbal medicine is all nontoxic to human body, and is without any side effects, by rational compatibility pathologic alopecia, the alopecia of energy metabolism type and the alopecia of androgen type all had significant curative effect.
Two, content:
The object of the present invention is achieved like this:
Extract in the raw material of Chinese medicine adding medical ethanol with constant weight and obtain extracting solution, add 0.2%～0.5% micro constitutents such as vitamin B6, trace element zinc and Herba Menthae in the extracting solution and form hair growth promoter of the present invention through composite, raw material of Chinese medicine weight wherein is:
Flos Rosae Rugosae 10～60 grams, Radix Polygoni Multiflori 10～80 grams, Cacumen Platycladi 10～80 grams, Folium Ginkgo 5～50 grams, Rhizoma Belamcandae 5～60 grams, Rhizoma Chuanxiong 5～40 grams, Ganoderma 10～80 grams, Calyx Kaki 5～50 grams, Herba Ecliptae 10～80 grams, Radix Rehmanniae Preparata 10～80 grams, Semen Sesami Nigrum 10～80 grams, Herba Leonuri 10～80 grams and Radix Glycyrrhizae 5～60 grams.
Preferred raw material of Chinese medicine weight is: Flos Rosae Rugosae 10～40 grams, Radix Polygoni Multiflori 10～60 grams, Cacumen Platycladi 10～60 grams, Folium Ginkgo 10～45 grams, Rhizoma Belamcandae 5～40 grams, Rhizoma Chuanxiong 5～30 grams, Ganoderma 10～60 grams, Calyx Kaki 10～40 grams, Herba Ecliptae 10～60 grams, Radix Rehmanniae Preparata 10～60 grams, Semen Sesami Nigrum 10～60 grams, Herba Leonuri 10～60 grams, Radix Glycyrrhizae 5～40 grams.
Preferred raw material of Chinese medicine weight is: Flos Rosae Rugosae 20～35 grams, Radix Polygoni Multiflori 20～40 grams, Cacumen Platycladi 20～40 grams, Folium Ginkgo 20～40 grams, Rhizoma Belamcandae 15～35 grams, Rhizoma Chuanxiong 10～25 grams, Ganoderma 20～40 grams, Calyx Kaki 10～30 grams, Herba Ecliptae 20～40 grams, Radix Rehmanniae Preparata 20～40 grams, Semen Sesami Nigrum 20～40 grams, Herba Leonuri 20～50 grams, Radix Glycyrrhizae 10～30 grams.
The preparation method of above-mentioned hair growth promoter comprises the steps:
1) selected Chinese medicine is prepared in proportion, cross 60 mesh sieves, remove earth;
2) above-mentioned Chinese medicine adds the extraction still, adds 5 times of 95% ethanol ebuillition of heated normal pressure and extracts 30 minutes, and the gained medicinal liquid is to concentrator;
3) above-mentioned medicinal residues are added 75% ethanol reheat boiling normal pressure and extracted 30 minutes, medicinal liquid is incorporated into concentrator;
4) heating of extracted twice medicinal liquid is concentrated into 0.5～0.6g crude drug/mL;
5) be cooled to room temperature, the clear liquid part is collected in sedimentation 36 hours, removes sediment;
6) filter clarification, after the assay was approved, get Chinese medicine extraction liquid, store standby;
7) Chinese medicine extraction liquid is added be stirred in the distilled water evenly;
8) under the temperature about 40 degree, add ethanol, be stirred to evenly, make ethanol content to 30～50%;
9) under the stirring condition, add vitamin B6, trace element zinc, Herba Menthae, to dissolving fully;
10) leave standstill, fill, check, finished product.
Three, beneficial effect:
1, clinical experiment:
Hair growth promoter of the present invention is through clinical trial 500 many cases, and alopecia areata patient effective percentage is wherein reached 93.36%, androgen type hair loss patient effective percentage 86.31%.
2, educate an experimental model C through international standard
3The experiment of H Mus, behind the use hair growth promoter, hair rate of increase and area are apparently higher than matched group.
3, through hair follicle clone technology, the full organ culture's screening of medicaments experiment of hair follicle, the hair length growth is 2 times of matched group.
4, hair growth promoter is to the microcirculatory facilitation of people's scalp blood flow: (measure through laser Doppler perfusion flowmeter, use hair growth promoter after one month, the alopecia areata regional blood flow increases by 3 times approximately than matched group, and androgen type alopecia regional blood flow increases more than 2 times.)
1) experimental subject:
11 routine hair loss patients, male's 8 examples, women's 3 examples, 28～50 years old age, alopecia areata 7 examples wherein, the alopecia of androgen type (is called for short: 8 examples seborrheic alopecia), alopecia course of disease March～20 years.
2) instrument: LDF-3 type laser Doppler perfusion flowmeter (Tianjin instrument plant of Nankai University).
3) hair growth promoter: the hair growth promoter of selecting embodiment 7 for use.
4) method:
Patient's scalp is divided into nine districts, and the measuring point of an acupoint as this district's scalp blood flow fixed in every district, and alopecia areata patient's alopecia district increases a measuring point.Each patient before treatment, make heal with medicine back one month above-mentioned 9 points each with laser Doppler perfusion flowmeter measurement scalp blood flow once.The patient sooner or later respectively is coated with hair growth promoter once every day during treatment.
5) effect:
Hair growth promoter to embodiment 7 is further studied detection to the microcirculatory facilitation of people's scalp blood flow, promptly measures 1 month front and back of 11 routine patient's coatings, and the variation of scalp blood flow the results are shown in Table 1.
The routine alopecia person of table 1.11 uses the comparison of hair growth promoter front and back scalp blood flow
(mv，X±SD)
| Before the treatment | Treated one month | |||
| Measuring point | Alopecia areata (n=7) | Seborrheic alopecia (n=4) | Alopecia areata (n=7) | Seborrheic alopecia (n=4) |
| 1 | 248±33 | 229±18 | 545±76 * | 740±105 * |
| 2 | 190±24 | 180±14 | 550±148 * | 830±69 * |
| 3 | 249±68 | 244±26 | 540±130 * | 840±98 * |
| 4 | 243±83 | 278±99 | 570±122 * | 950±106 * |
| 5 | 284±70 | 264±55 | 625±123 * | 870±80 * |
| 6 | 298±55 | 297±23 | 519±59 * | 690±82 * |
| 7 | 360±51 | 310±41 | 686±123 * | 760±73 * |
| 8 | 297±43 | 292±66 | 623±70 * | 896±125 * |
| 9 | 315±40 | 289±33 | 800±138 * | 690±16 * |
| The alopecia areata point | 359±104 | 1246±147 * | ||
Annotate:
*For self compares p＜0.01
Analyze above result, alopecia areata and androgen type alopecia person added up respectively show, treat after one month, both scalp blood flows all obviously increase (p＜0.01), scalp blood flow before the treatment of alopecia areata position is 359 ± 104 (mv), treats after one month, is accompanied by the New Development growth, blood flow rises to 1246 ± 147 (mv), and blood flow increases by three times.
Description of drawings
Fig. 1: alopecia areata patient is at the design sketch that uses the hair growth promoter front and back, and wherein Fig. 1 a is for using the picture at the preceding patient's alopecia position of hair growth promoter; Fig. 1 b is for using the picture at hair growth promoter patient's alopecia position after 3 months; Fig. 1 c is for using the picture at hair growth promoter patient's alopecia position after 6 months.
Fig. 2: androgen type hair loss patient is at the design sketch that uses the hair growth promoter front and back, and wherein Fig. 2 a is for using the picture at the preceding patient's alopecia position of hair growth promoter; Fig. 2 b is for using the picture at hair growth promoter patient's alopecia position after 10 months.
The specific embodiment
Embodiment 1: Flos Rosae Rugosae 10 grams, Radix Polygoni Multiflori 80 grams, Cacumen Platycladi 10 grams, Folium Ginkgo 10 grams, Rhizoma Belamcandae 60 grams, Rhizoma Chuanxiong 40 grams, Ganoderma 10 grams, Calyx Kaki 25 grams, Herba Ecliptae 80 grams, Radix Rehmanniae Preparata 40 grams, Semen Sesami Nigrum 10 grams, Herba Leonuri 60 grams, Radix Glycyrrhizae 30 grams.The hair growth promoting extracting solution that above-mentioned Chinese medicine obtains through ethanol extraction, the composite hair growth liquor that forms of vitamin B6, Herba Menthae, permeation-promoter of adding 0.02%.
Embodiment 2: Flos Rosae Rugosae 80 grams, Radix Polygoni Multiflori 10 grams, Cacumen Platycladi 10 grams, Folium Ginkgo 10 grams, Rhizoma Belamcandae 15 grams, Rhizoma Chuanxiong 10 grams, Ganoderma 80 grams, Calyx Kaki 50 grams, Herba Ecliptae 30 grams, Radix Rehmanniae Preparata 80 grams, Semen Sesami Nigrum 35 grams, Herba Leonuri 10 grams, Radix Glycyrrhizae 5 grams.The hair growth promoting extracting solution that above-mentioned Chinese medicine obtains through ethanol extraction, the composite hair growth liquor that forms of vitamin B6, Herba Menthae, permeation-promoter of adding 0.05%.
Embodiment 3: Flos Rosae Rugosae 40 grams, Radix Polygoni Multiflori 10 grams, Cacumen Platycladi 80 grams, Folium Ginkgo 50 grams, Rhizoma Belamcandae 5 grams, Rhizoma Chuanxiong 20 grams, Ganoderma 30 grams, Calyx Kaki 5 grams, Herba Ecliptae 10 grams, Radix Rehmanniae Preparata 20 grams, Semen Sesami Nigrum 80 grams, Herba Leonuri 80 grams, Radix Glycyrrhizae 60 grams.The hair growth promoting extracting solution that above-mentioned Chinese medicine obtains through ethanol extraction, the composite hair growth liquor that forms of vitamin B6, Herba Menthae, permeation-promoter of adding 0.03%.
Embodiment 4: Flos Rosae Rugosae 25 grams, Radix Polygoni Multiflori 60 grams, Cacumen Platycladi 30 grams, Folium Ginkgo 5 grams, Rhizoma Belamcandae 40 grams, Rhizoma Chuanxiong 30 grams, Ganoderma 50 grams, Calyx Kaki 40 grams, Herba Ecliptae 60 grams, Radix Rehmanniae Preparata 10 grams, Semen Sesami Nigrum 40 grams, Herba Leonuri 50 grams, Radix Glycyrrhizae 20 grams.Process for preparation is with embodiment 3.
Embodiment 5: Flos Rosae Rugosae 35 grams, Radix Polygoni Multiflori 40 grams, Cacumen Platycladi 20 grams, Folium Ginkgo 40 grams, Rhizoma Belamcandae 20 grams, Rhizoma Chuanxiong 40 grams, Ganoderma 20 grams, Calyx Kaki 30 grams, Herba Ecliptae 40 grams, Radix Rehmanniae Preparata 40 grams, Semen Sesami Nigrum 30 grams, Herba Leonuri 40 grams, Radix Glycyrrhizae 30 grams.Process for preparation is with embodiment 3.
Embodiment 6: Flos Rosae Rugosae 20 grams, Radix Polygoni Multiflori 30 grams, Cacumen Platycladi 40 grams, Folium Ginkgo 30 grams, Rhizoma Belamcandae 35 grams, Rhizoma Chuanxiong 40 grams, Ganoderma 10 grams, Calyx Kaki 25 grams, Herba Ecliptae 80 grams, Radix Rehmanniae Preparata 40 grams, Semen Sesami Nigrum 10 grams, Herba Leonuri 60 grams, Radix Glycyrrhizae 10 grams.Process for preparation is with embodiment 3.
Embodiment 7: Flos Rosae Rugosae 30 grams, Radix Polygoni Multiflori 30 grams, Cacumen Platycladi 40 grams, Folium Ginkgo 30 grams, Rhizoma Belamcandae 30 grams, Rhizoma Chuanxiong 20 grams, Ganoderma 30 grams, Calyx Kaki 25 grams, Herba Ecliptae 20 grams, Radix Rehmanniae Preparata 40 grams, Semen Sesami Nigrum 20 grams, Herba Leonuri 45 grams, Radix Glycyrrhizae 30 grams.Process for preparation is with embodiment 3.
Annotate: the same summary of the invention of hair growth promoter preparation method among the embodiment.
Claims (5)
1. hair growth promoter, it is characterized in that it is the extracting solution that is got through the medical ethanol extraction by following traditional Chinese medicine raw: Flos Rosae Rugosae 10～60 restrains, Radix Polygoni Multiflori 10～80 restrains, Cacumen Platycladi 10～80 restrains, Folium Ginkgo 5～50 restrains, Rhizoma Belamcandae 5～60 restrains, Rhizoma Chuanxiong 5～40 restrains, Ganoderma 10～80 restrains, Calyx Kaki 5～50 restrains, Herba Ecliptae 10～80 restrains, Radix Rehmanniae Preparata 10～80 restrains, Semen Sesami Nigrum 10～80 restrains, Herba Leonuri 10～80 restrains, Radix Glycyrrhizae 5～60 restrains; 0.2%～0.5% vitamin B6 and trace element zinc and 0.2%～0.5% Herba Menthae are formed.
2. hair growth promoter as claimed in claim 1, it is characterized in that the weight of described raw material of Chinese medicine is: Flos Rosae Rugosae 10～40 grams, Radix Polygoni Multiflori 10～60 grams, Cacumen Platycladi 10～60 grams, Folium Ginkgo 10～45 grams, Rhizoma Belamcandae 5～40 grams, Rhizoma Chuanxiong 5～30 grams, Ganoderma 10～60 grams, Calyx Kaki 10～40 grams, Herba Ecliptae 10～60 grams, Radix Rehmanniae Preparata 10～60 grams, Semen Sesami Nigrum 10～60 grams, Herba Leonuri 10～60 grams, Radix Glycyrrhizae 5～40 grams.
3. hair growth promoter as claimed in claim 1, it is characterized in that the weight of described raw material of Chinese medicine is: Flos Rosae Rugosae 20～35 grams, Radix Polygoni Multiflori 20～40 grams, Cacumen Platycladi 20～40 grams, Folium Ginkgo 20～40 grams, Rhizoma Belamcandae 15～35 grams, Rhizoma Chuanxiong 10～25 grams, Ganoderma 20～40 grams, Calyx Kaki 10～30 grams, Herba Ecliptae 20～40 grams, Radix Rehmanniae Preparata 20～40 grams, Semen Sesami Nigrum 20～40 grams, Herba Leonuri 20～50 grams, Radix Glycyrrhizae 10～30 grams.
4. as claim 1,2 or 3 described hair growth promoters, it is characterized in that described concentration of alcohol is 75～95%.
5. a preparation method for preparing as claim 1,2 or 3 described hair growth promoters comprises the steps:
1) raw material of Chinese medicine is prepared in proportion, cross 60 mesh sieves, remove earth;
2) above-mentioned raw material of Chinese medicine is added the extraction still, add 5 times of 95% ethanol ebuillition of heated normal pressure and extracted 30 minutes, the gained medicinal liquid is to concentrator;
3) above-mentioned medicinal residues are added 75% ethanol reheat boiling normal pressure and extracted 30 minutes, medicinal liquid is incorporated into concentrator;
4) heating of extracted twice medicinal liquid is concentrated into 0.5～0.6g crude drug/mL;
5) be cooled to room temperature, the clear liquid part is collected in sedimentation 36 hours, removes sediment;
6) filter clarification, after the assay was approved, get Chinese medicine extraction liquid, store standby;
7) Chinese medicine extraction liquid is added be stirred in the distilled water evenly;
8) under the temperature of 40 degree, add ethanol, be stirred to evenly, make ethanol content to 30～50%;
9) under the stirring condition, add vitamin B6, trace element zinc and Herba Menthae, to dissolving fully;
10) leave standstill, fill, check, finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02131016.5A CN1205954C (en) | 2002-09-24 | 2002-09-24 | Hair restorer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02131016.5A CN1205954C (en) | 2002-09-24 | 2002-09-24 | Hair restorer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1408409A CN1408409A (en) | 2003-04-09 |
| CN1205954C true CN1205954C (en) | 2005-06-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02131016.5A Expired - Lifetime CN1205954C (en) | 2002-09-24 | 2002-09-24 | Hair restorer |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101293040B (en) * | 2008-06-06 | 2011-08-24 | 思雪花 | Chinese medicine for generating and nourishing hair |
| CN105616701A (en) * | 2016-01-12 | 2016-06-01 | 刘建国 | Traditional Chinese medicinal hair restoring agent |
| CN106236652A (en) * | 2016-08-29 | 2016-12-21 | 张悦辉 | A kind of hair-care essence liquid and preparation method thereof |
| CN108096546A (en) * | 2017-12-23 | 2018-06-01 | 洛阳名力科技开发有限公司 | Preparation for baldness and preparation method thereof |
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2002
- 2002-09-24 CN CN02131016.5A patent/CN1205954C/en not_active Expired - Lifetime
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