CN110559231A - Whitening and freckle-removing essence and preparation method thereof - Google Patents
Whitening and freckle-removing essence and preparation method thereof Download PDFInfo
- Publication number
- CN110559231A CN110559231A CN201910895714.6A CN201910895714A CN110559231A CN 110559231 A CN110559231 A CN 110559231A CN 201910895714 A CN201910895714 A CN 201910895714A CN 110559231 A CN110559231 A CN 110559231A
- Authority
- CN
- China
- Prior art keywords
- extract
- whitening
- percent
- cbd
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a whitening and freckle-removing essence which is characterized by being prepared from the following raw materials in percentage by mass: 2-20% of cannabidiol CBD, 2-20% of mineral concentrate, 402-8% of hydrogenated castor oil polyoxyethylene ether, 601-10% of castor oil polyoxyethylene ether, 2-15% of medium-chain triglyceride, 1-5% of glycerol, 0.1-0.5% of sodium hyaluronate, 1-5% of dogwood extract, 1-5% of rhodiola rosea extract, 1-5% of breviscapine extract, 0.02-0.1% of salicylic acid and the balance of water, wherein the total amount of the components is 100%. The bioavailability of the CBD is improved, the curative effect of the CBD is enhanced, the CBD can rapidly provide energy for skin by being mixed with mineral concentrated solution, the intercellular water retention capacity and the moisture of skin tissues can be increased when the CBD is absorbed into skin cells, the CBD plays an important role in whitening, moisturizing, freckle lightening and removing freckles, and the CBD can whiten the skin and restore the skin luster while removing freckles by combining the synergistic effect of the rhodiola rosea, the dogwood and the erigeron breviscapus extracts.
Description
Technical Field
The invention relates to a whitening and freckle-removing essence and a preparation method thereof, belonging to the technical field of cosmetics.
Background
The essence is also called as repairing stock solution, and has the effects of repairing, resisting aging, resisting wrinkle, whitening, moisturizing, removing freckles and the like. Is suitable for various skin problems caused by aging, improper nursing and the like. The essence is extracted from high-nutrient substances and concentrated, and generally contains more active ingredients, small molecules and strong permeability. With the continuous development of the professional field of cosmetics, besides basic functions of skin moistening, water replenishing, moisture keeping and the like, more and more products are added with functional components with the effects of whitening, sun screening, anti-allergy, anti-inflammation, anti-aging and the like so as to meet the requirements of markets and consumers. At present, the sources of the functional components are mainly divided into chemical types and plant types, wherein natural plants have the characteristics of naturalness, mildness, no toxic or side effect and the like, are well favored by consumers and have wide market prospects, however, most of the natural plants have the defects of poor stability, single function and the like, and the development of the natural plants is limited to a certain extent. The cannabidiol CBD is an effective component extracted from industrial hemp, is an extract of dry matter of flowers and leaves of the industrial hemp, is applied to the field of cosmetics, can mainly repair nerve fibers of a human body, and has pharmacological activities of resisting inflammation, allergy, aging, bacteria, oxidation, ultraviolet rays and the like, and in the application of the cannabidiol or the hemp extract in preparing whitening products, the application of the cannabidiol in the reported patent CN 107982080A can be used for inhibiting tyrosinase activity, inhibiting melanin formation or inhibiting melanocyte formation, effectively inhibiting the activity of tyrosinase and having good skin whitening effect, but the application value of the cannabidiol is limited to a certain extent because the cannabidiol is a fat-soluble and water-insoluble substance.
disclosure of Invention
The first purpose of the invention is to provide a whitening and freckle-removing nano-emulsion essence.
the second purpose of the invention is to provide a preparation method of the whitening and freckle-removing essence.
The first purpose of the invention is realized by the following technical scheme: the whitening and freckle-removing essence is characterized by being prepared from the following raw materials in percentage by mass:
The sum of the above components is 100%.
the cannabidiol CBD is a commercial product, is an effective component extracted from industrial cannabis with THC content lower than 0.3 percent, belongs to a non-addictive active substance, has the functions of analgesia, anti-tumor, anti-nausea and vomiting, treatment of mental and cerebral diseases, anti-inflammation, antibiosis and the like, can mainly repair nerve fibers of a human body in the field of cosmetics, and has pharmacological activities of anti-inflammation, anti-allergy, anti-aging, antibiosis, antioxidation, ultraviolet resistance and the like.
the mineral substance concentrated solution is a commercial product and is a green and healthy raw material type component. The components of the product are close to body fluid of human body, contain balanced minerals, are easily absorbed by skin, and can promote differentiation and proliferation of epidermal cells, make stratum corneum become solid, promote cell metabolism, and improve natural healing force of skin
The Corni fructus extract is powder extract extracted from Corni fructus belonging to family Cornaceae of Umbelliferae of family Dicotyledoneae of phylum angiospermae, and has sour and astringent taste and mild properties
The rhodiola rosea extract is an aqueous extract extracted from flowers, stems and leaves of rhodiola rosea, is a perennial herb, can be used as a medicine, can tonify qi, clear away the lung-heat, benefit intelligence and nourish the heart, and is a traditional Chinese medicine with wide effect. Can be used as skin care product or edible product
The erigeron breviscapus extract is an alcohol extract extracted from erigeron breviscapus and leaves, and is prepared from the following componentsCompositae plantThe dried whole herb of erigeron breviscapus has the functions of dispelling wind heat and clearing away blood toxin.
The castor oil polyoxyethylene ether-60 is a commercially available cosmetic grade emulsifier and is used as a surfactant or an emulsifier of the essence milk.
The hydrogenated castor oil polyoxyethylene ether-40 is a cosmetic grade emulsifier and is used as a surfactant or an emulsifier of the essence milk.
the medium chain triglyceride is main base liquid oil phase
The sodium hyaluronate is a commercially available cosmetic grade product and is used as a main moisturizing raw material of essence milk.
The glycerin is a commercially available cosmetic grade product and is used as an essence milk humectant.
The salicylic acid is a medical preservative and a preservative which are commercially available.
The second purpose of the invention is realized by the following technical scheme: the preparation method of the whitening and freckle-removing essence is characterized by comprising the following steps of:
1) preparing the following raw materials in percentage by mass:
The sum of all the combinations is 100 percent;
(2) Placing cannabidiol CBD into medium-chain triglyceride, heating to 40-70 deg.C, stirring at 10-20r/s to dissolve cannabidiol completely, and standing to room temperature to obtain oil solution;
(3) uniformly mixing castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, sodium hyaluronate, a dogwood extract, a rhodiola rosea extract and a erigeron breviscapus extract, adding water to dilute into a mineral concentrate with volume concentration of 10% -50%, and stirring at the speed of 10-40r/s until the mineral concentrate is completely dissolved to obtain a base material;
(4) And (3) dropwise adding the oil soluble substance in the step (2) into the base material in the step (3), stirring at the speed of 20-80r/s until the solid substance is completely dissolved, and adding salicylic acid to adjust the pH value to 5-6, so as to obtain the whitening and freckle-removing essence.
the rhodiola rosea extract adopts the following steps: oven drying flos Rhodiolae, stems and leaves at 60-80 deg.C, pulverizing, sieving with 60 mesh sieve, adding 10-15 times of water, soaking for 8-12 hr, filtering, collecting filtrate, distilling the filtrate for 2-4 hr, and collecting distillate to obtain radix Rhodiolae extract.
the dogwood extract is prepared by the following operations: pulverizing dried Corni fructus, sieving with 20 mesh sieve, extracting with 6-9 times of water under reflux for 2 times (each time for 2 hr), filtering, mixing filtrates, standing for 4-6 hr, collecting supernatant, and concentrating to obtain extract.
The erigeron breviscapus extract is prepared by the following operations: adding 95v/v% ethanol into herba Erigerontis at material liquid mass ratio of 1: 4-10, stirring for 20-40min to swell, adding 95v/v% ethanol at material liquid mass ratio of 1: 4-10, soaking for 20-26h, percolating, collecting filtrate, and concentrating the filtrate into extract to obtain herba Erigerontis extract.
The invention has the following advantages and effects: by adopting the scheme, the problem that the CBD is difficult to dissolve is solved, the bioavailability of the CBD is improved, the curative effect of the CBD is enhanced, the concentrated mineral substance solution is added, energy can be rapidly provided for skin, the intercellular water retention capacity and the moisture of skin tissues can be increased when the CBD is absorbed into skin cells, the CBD plays an important role in whitening, moisturizing, lightening spots and removing spots, and the synergistic effect of the rhodiola rosea, the dogwood and the erigeron breviscapus extracts is combined, so that the skin can be whitened and the skin luster can be recovered while the spots are removed.
Detailed description of the invention
the present invention will be further described with reference to the following examples.
Example 1
A preparation method of whitening and freckle-removing essence comprises the following steps:
1) Preparing the following raw materials in percentage by mass:
(2) Placing cannabidiol CBD into medium-chain triglyceride, heating to 40 deg.C, stirring at 20r/s to dissolve cannabidiol completely, and standing to room temperature to obtain oil solution;
(3) mixing oleum ricini polyoxyethylene ether-60, hydrogenated oleum ricini polyoxyethylene ether-40, glycerol, sodium hyaluronate, Corni fructus extract, radix Rhodiolae extract and herba Erigerontis extract, diluting with water to obtain 50% mineral concentrate, and stirring at 40r/s until completely dissolved to obtain base material;
(4) And (3) dropwise adding the oil soluble substance in the step (2) into the base material in the step (3), stirring at the speed of 80r/s until the solid substance is completely dissolved, and adding salicylic acid to adjust the pH value to 6, so as to obtain the whitening and freckle-removing essence.
The rhodiola rosea extract adopts the following steps: oven drying flos Rhodiolae, stems and leaves at 60 deg.C, pulverizing, sieving with 60 mesh sieve, adding 10 times of water, soaking for 8 hr, filtering, collecting filtrate, distilling the filtrate for 2 hr, and collecting distillate to obtain radix Rhodiolae extract.
the dogwood extract is prepared by the following operations: pulverizing dried Corni fructus, sieving with 20 mesh sieve, extracting with 6 times of water under reflux for 2 times (each time for 2 hr), filtering, mixing filtrates, standing for 4 hr, collecting supernatant, and concentrating into extract to obtain Corni fructus extract.
the erigeron breviscapus extract is prepared by the following operations: adding 95v/v% ethanol into herba Erigerontis at material liquid mass ratio of 1: 4, stirring for 20min to swell, adding 95v/v% ethanol at material liquid mass ratio of 1: 4, soaking for 26h, percolating, collecting filtrate, and concentrating the filtrate into extract to obtain herba Erigerontis extract.
Example 2
A preparation method of whitening and freckle-removing essence comprises the following steps:
1) Preparing the following raw materials in percentage by mass:
(2) Placing cannabidiol CBD into medium-chain triglyceride, heating to 70 deg.C, stirring at 10r/s to dissolve cannabidiol completely, and standing to room temperature to obtain oil solution;
(3) mixing oleum ricini polyoxyethylene ether-60, hydrogenated oleum ricini polyoxyethylene ether-40, glycerol, sodium hyaluronate, Corni fructus extract, radix Rhodiolae extract and herba Erigerontis extract, diluting with water to obtain 10% mineral concentrate, and stirring at 40r/s until completely dissolved to obtain base material;
(4) And (3) dropwise adding the oil soluble substance in the step (2) into the base material in the step (3), stirring at the speed of 20r/s until the solid substance is completely dissolved, and adding salicylic acid to adjust the pH value to 5, so as to obtain the whitening and freckle-removing essence.
The rhodiola rosea extract adopts the following steps: oven drying flos Rhodiolae, stems and leaves at 80 deg.C, pulverizing, sieving with 60 mesh sieve, adding 15 times of water, soaking for 12 hr, filtering, collecting filtrate, distilling the filtrate for 4 hr, and collecting distillate to obtain radix Rhodiolae extract.
the dogwood extract is prepared by the following operations: pulverizing dried Corni fructus, sieving with 20 mesh sieve, reflux extracting with 9 times of water for 2 times (each time for 2 hr), filtering, mixing filtrates, standing for 6 hr, collecting supernatant, and concentrating into extract to obtain Corni fructus extract.
The erigeron breviscapus extract is prepared by the following operations: adding 95v/v% ethanol into herba Erigerontis at a material liquid mass ratio of 1: 10, stirring for 20min to swell, adding 95v/v% ethanol at a material liquid mass ratio of 1: 10, soaking for 20h, percolating, collecting filtrate, and concentrating the filtrate into extract to obtain herba Erigerontis extract.
Example 3
a preparation method of whitening and freckle-removing essence comprises the following steps:
(1) Preparing the following raw materials in percentage by mass:
(2) placing cannabidiol CBD into medium-chain triglyceride, heating to 50 deg.C, stirring at 15r/s to dissolve cannabidiol completely, and standing to room temperature to obtain oil solution;
(3) Mixing oleum ricini polyoxyethylene ether-60, hydrogenated oleum ricini polyoxyethylene ether-40, glycerol, sodium hyaluronate, Corni fructus extract, radix Rhodiolae extract and herba Erigerontis extract, diluting with water to obtain 30% mineral concentrate, and stirring at 20r/s until completely dissolved to obtain base material;
(4) And (3) dropwise adding the oil soluble substance in the step (2) into the base material in the step (3), stirring at the speed of 60r/s until the solid substance is completely dissolved, and adding salicylic acid to adjust the pH value to 6, so as to obtain the whitening and freckle-removing essence.
The rhodiola rosea extract adopts the following steps: oven drying flos Rhodiolae, stems and leaves at 70 deg.C, pulverizing, sieving with 60 mesh sieve, adding 12 times of water, soaking for 10 hr, filtering, collecting filtrate, distilling the filtrate for 3 hr, and collecting distillate to obtain radix Rhodiolae extract.
The dogwood extract is prepared by the following operations: pulverizing dried Corni fructus, sieving with 20 mesh sieve, extracting with 7 times of water under reflux for 2 times (each time for 2 hr), filtering, mixing filtrates, standing for 5 hr, collecting supernatant, and concentrating into extract to obtain Corni fructus extract.
The erigeron breviscapus extract is prepared by the following operations: adding 95v/v% ethanol into herba Erigerontis at material liquid mass ratio of 1: 8, stirring for 30min to swell, adding 95v/v% ethanol at material liquid mass ratio of 1: 8, soaking for 22h, percolating, collecting filtrate, and concentrating the filtrate into extract to obtain herba Erigerontis extract.
Example 4
A preparation method of whitening and freckle-removing essence comprises the following steps:
(1) Preparing the following raw materials in percentage by mass:
(2) Placing cannabidiol CBD into medium-chain triglyceride, heating to 60 deg.C, stirring at 20r/s to dissolve cannabidiol completely, and standing to room temperature to obtain oil solution;
(3) Mixing oleum ricini polyoxyethylene ether-60, hydrogenated oleum ricini polyoxyethylene ether-40, glycerol, sodium hyaluronate, Corni fructus extract, radix Rhodiolae extract and herba Erigerontis extract, diluting with water to obtain 40% mineral concentrate, and stirring at 30r/s until completely dissolved to obtain base material;
(4) And (3) dropwise adding the oil soluble substance in the step (2) into the base material in the step (3), stirring at the speed of 50r/s until the solid substance is completely dissolved, and adding salicylic acid to adjust the pH value to 6, so as to obtain the whitening and freckle-removing essence.
The rhodiola rosea extract adopts the following steps: oven drying flos Rhodiolae, stems and leaves at 70 deg.C, pulverizing, sieving with 60 mesh sieve, adding 15 times of water, soaking for 9 hr, filtering, collecting filtrate, distilling the filtrate for 3 hr, and collecting distillate to obtain radix Rhodiolae extract.
The dogwood extract is prepared by the following operations: pulverizing dried Corni fructus, sieving with 20 mesh sieve, extracting with 8 times of water under reflux for 2 times (each time for 2 hr), filtering, mixing filtrates, standing for 5 hr, collecting supernatant, and concentrating into extract to obtain Corni fructus extract.
The erigeron breviscapus extract is prepared by the following operations: adding 95v/v% ethanol into herba Erigerontis at material liquid mass ratio of 1: 7, stirring for 25min to swell, adding 95v/v% ethanol at material liquid mass ratio of 1: 7, soaking for 23h, percolating, collecting filtrate, and concentrating the filtrate into extract to obtain herba Erigerontis extract.
Example 5
A preparation method of whitening and freckle-removing essence comprises the following steps:
(1) Preparing the following raw materials in percentage by mass:
(2) Placing cannabidiol CBD into medium-chain triglyceride, heating to 60 deg.C, stirring at 13r/s to dissolve cannabidiol completely, and standing to room temperature to obtain oil solution;
(3) Uniformly mixing castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, sodium hyaluronate, a dogwood extract, a rhodiola rosea extract and a erigeron breviscapus extract, adding water to dilute into a mineral concentrate with volume concentration of 40%, and stirring at the speed of 35r/s until the mineral concentrate is completely dissolved to obtain a base material;
(4) And (3) dropwise adding the oil soluble substance in the step (2) into the base material in the step (3), stirring at a speed of 66r/s until the solid substance is completely dissolved, and adding salicylic acid to adjust the pH value to 5, so as to obtain the whitening and freckle-removing essence.
the rhodiola rosea extract adopts the following steps: oven drying flos Rhodiolae, stems and leaves at 75 deg.C, pulverizing, sieving with 60 mesh sieve, adding 15 times of water, soaking for 12 hr, filtering, collecting filtrate, distilling the filtrate for 4 hr, and collecting distillate to obtain radix Rhodiolae extract.
The dogwood extract is prepared by the following operations: pulverizing dried Corni fructus, sieving with 20 mesh sieve, extracting with 6 times of water under reflux for 2 times (each time for 2 hr), filtering, mixing filtrates, standing for 6 hr, collecting supernatant, and concentrating into extract to obtain Corni fructus extract.
The erigeron breviscapus extract is prepared by the following operations: adding 95v/v% ethanol into herba Erigerontis at material liquid mass ratio of 1: 9, stirring for 25min to swell, adding 95v/v% ethanol at material liquid mass ratio of 1: 9, soaking for 26h, percolating, collecting filtrate, and concentrating the filtrate into extract to obtain herba Erigerontis extract.
Examples of the experiments
The product is subjected to efficacy tests through the following experimental examples.
Experimental example A human skin patch test is used for evaluating the safety of the whitening and freckle-removing essence prepared in the examples 1-5.
the tested population is female and is between 25 and 55 years old. The skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary entry standard of the subject: the skin of a volunteer who has skin problems such as dry skin, reduced elasticity, wrinkles, dark yellow skin color and the like has no history of skin and systemic diseases, and hormone medicines are not used in the last month; groups were randomized, 10 people each. Selecting a qualified spot tester, dripping 0.015-0.025 mL of a tested substance into the spot tester in a closed spot patch test mode, externally applying a special adhesive tape to the back of a tested subject, removing the tested substance after 24 hours, observing skin reaction after 24 hours after the tested substance is removed respectively, and recording the result according to the skin reaction grading standard in the cosmetic hygiene standard.
the following table shows the adverse skin reaction grade criteria
patch test results
The experimental result of the patch on the skin of the human body shows
The results of applying the whitening and freckle-removing essence and the control essence of the embodiments 1-5 of the invention through the patch experiments of the whitening and freckle-removing essence to all groups of test subjects show that: skin reactions are observed within 24 hours, wherein 0 case has adverse skin reactions, which indicates that the whitening and spot-lightening essence prepared by the invention is safe to use.
Experimental example II, evaluation of safety of freckle removing effect in human trial experiment
The experimental method comprises the following steps: refer to technical Specification for safety of cosmetics 2002
Evaluation indexes are as follows: referring to the technical Specification for cosmetic safety, 2002 edition-skin trial experiment safety evaluation main reagents: the test subjects of the whitening and freckle-removing essence samples of examples 1 to 5 required: referring to technical Specification for safety of cosmetics 2002, a subject selects a specific experimental method:
Trial evaluation was performed on the whitening and spot-removing essence liquids prepared in examples 1 to 5.
trial subjects are 120, the age interval is 20-55 years, wherein 100 female subjects and 20 male subjects are selected. The skin of the subject is healthy, the skin disease has no allergic history, the face has different degrees of color spots, and the voluntary selection standard of the subject is met. Randomly dividing the test result into 6 groups, namely a test group I, a test group II, a test group III, a test group V and a control group, wherein the gender and the age degree of the test group I, the test group II, the test group III, the test group V and the control group have no significant difference (P is more than 0.05) after statistical treatment, and respectively trying the test result to experience the whitening and freckle removing essence liquid samples of the examples 1 to 5, using the whitening and freckle removing essence liquid for 30 days and smearing the whitening and freckle removing essence liquid; the control group was prepared by applying the commercially available general essence product for 30 days, 2 times per day, and the skin reactions of the subjects were scored according to Table 3 until the end of the 30d experiment.
and (3) evaluating the curative effect:
The subjects used the whitening and freckle-removing essence prepared in examples 1 to 5, respectively, to observe and feel the use effect. After a subject cleans the face, a proper amount of the whitening and freckle-removing essence is uniformly applied to the face, gently massaged until the skin is absorbed, the whitening and freckle-removing essence is used once every morning and evening with a service cycle of 30 days, and the condition of the facial skin of the subject is analyzed by adopting a VISIAC facial imaging analyzer. In the test, a natural light source, an ultraviolet light source and a cross-polarized light source (brown) are selected to image the skin of the volunteer. The imaging under the natural light source can directly observe the change of the facial skin. Under the ultraviolet light source, ultraviolet spots can be observed, namely, melanin is generated under the skin due to the damage of sunlight to the skin, the lighter the image color is, the less the skin melanin is gathered. Imaging under a cross-polarized light source (brown) can observe brown spots and pigmentation, and the lighter the image color is, the less pigmentation is on the skin. The results are the average values after removing the lowest and highest values.
Test results
| Group of | ratio of increase in luminance (%) |
| Experiment set 1 | 29.76％ |
| experiment group two | 27.97％ |
| Experiment group III | 28.17％ |
| experiment group four | 22.58％ |
| Experiment group five | 27.02％ |
| control group | 16.54％ |
And (4) conclusion: in the examples 1 to 5, the addition amounts of cannabidiol CBD are 20%, 15%, 5%, 10% and 2%, respectively, and the data in the table show that the effect of the example 1 is the best and is compared with the common essence in the market, that is, the effect of the whitening and freckle-removing essence prepared by the invention is the best when the addition amount of the composition is 20%.
Claims (5)
1. the whitening and freckle-removing essence is characterized by being prepared from the following raw materials in percentage by mass:
2 to 20 percent of cannabidiol CBD,
2 to 20 percent of mineral concentrated solution
Hydrogenated castor oil polyoxyethylene ether-402-8%
601-10% of castor oil polyoxyethylene ether,
Medium chain triglycerides 2-15%
1-5% of glycerin
0.1 to 0.5 percent of sodium hyaluronate
1 to 5 percent of dogwood extract
1 to 5 percent of rhodiola root extract
1 to 5 percent of erigeron breviscapus extract
Salicylic acid 0.02-0.1%
Balance of water
the sum of the above components is 100%.
2. The preparation method of the whitening and freckle-removing essence is characterized by comprising the following steps of:
(1) preparing the following raw materials in percentage by mass:
2 to 20 percent of cannabidiol CBD,
2 to 20 percent of mineral concentrated solution
hydrogenated castor oil polyoxyethylene ether-402-8%
601-10% of castor oil polyoxyethylene ether,
Medium chain triglycerides 2-15%
1-5% of glycerin
0.1 to 0.5 percent of sodium hyaluronate
1 to 5 percent of dogwood extract
1 to 5 percent of rhodiola root extract
1 to 5 percent of erigeron breviscapus extract
Salicylic acid 0.02-0.1%
balance of water
The sum of all the combinations is 100 percent;
(2) Placing cannabidiol CBD into medium-chain triglyceride, heating to 40-70 deg.C, stirring at 10-20r/s to dissolve cannabidiol completely, and standing to room temperature to obtain oil solution;
(3) Uniformly mixing castor oil polyoxyethylene ether-60, hydrogenated castor oil polyoxyethylene ether-40, glycerol, sodium hyaluronate, a dogwood extract, a rhodiola rosea extract and a erigeron breviscapus extract, adding water to dilute into a mineral concentrate with volume concentration of 10% -50%, and stirring at the speed of 10-40r/s until the mineral concentrate is completely dissolved to obtain a base material;
(4) And (3) dropwise adding the oil soluble substance in the step (2) into the base material in the step (3), stirring at the speed of 20-80r/s until the solid substance is completely dissolved, and adding salicylic acid to adjust the pH value to 5-6, so as to obtain the whitening and freckle-removing essence.
3. The essence for whitening and removing freckles according to claim 1, wherein the rhodiola rosea extract is prepared by the following steps: oven drying flos Rhodiolae, stems and leaves at 60-80 deg.C, pulverizing, sieving with 60 mesh sieve, adding 10-15 times of water, soaking for 8-12 hr, filtering, collecting filtrate, distilling the filtrate for 2-4 hr, and collecting distillate to obtain radix Rhodiolae extract.
4. The essence for whitening and removing freckles according to claim 1, wherein the extract of Cornus officinalis is prepared by the following steps: pulverizing dried Corni fructus, sieving with 20 mesh sieve, extracting with 6-9 times of water under reflux for 2 times (each time for 2 hr), filtering, mixing filtrates, standing for 4-6 hr, collecting supernatant, and concentrating to obtain extract.
5. the essence for whitening and removing freckles according to claim 1, wherein the erigeron breviscapus extract is prepared by the following steps: adding 95v/v% ethanol into herba Erigerontis at material liquid mass ratio of 1: 4-10, stirring for 20-40min to swell, adding 95v/v% ethanol at material liquid mass ratio of 1: 4-10, soaking for 20-26h, percolating, collecting filtrate, and concentrating the filtrate into extract to obtain herba Erigerontis extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910895714.6A CN110559231A (en) | 2019-09-21 | 2019-09-21 | Whitening and freckle-removing essence and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910895714.6A CN110559231A (en) | 2019-09-21 | 2019-09-21 | Whitening and freckle-removing essence and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110559231A true CN110559231A (en) | 2019-12-13 |
Family
ID=68781711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910895714.6A Pending CN110559231A (en) | 2019-09-21 | 2019-09-21 | Whitening and freckle-removing essence and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110559231A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110183309A (en) * | 2019-07-02 | 2019-08-30 | 黑龙江康源生物科技有限公司 | A kind of method and bateriostatics for extracting bateriostatics from industrial hemp root |
| CN111494466A (en) * | 2020-01-14 | 2020-08-07 | 四川大学华西医院 | A topical composition containing Cannabis sativa extract and its application |
-
2019
- 2019-09-21 CN CN201910895714.6A patent/CN110559231A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110183309A (en) * | 2019-07-02 | 2019-08-30 | 黑龙江康源生物科技有限公司 | A kind of method and bateriostatics for extracting bateriostatics from industrial hemp root |
| CN111494466A (en) * | 2020-01-14 | 2020-08-07 | 四川大学华西医院 | A topical composition containing Cannabis sativa extract and its application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107854367B (en) | Essence for repairing sensitive skin | |
| CN110090191B (en) | After-sun repair composition and cosmetic thereof | |
| CN109662928A (en) | A kind of skin care compositions and its application and preparation method with sun-proof reparation effect | |
| KR20080002279A (en) | Lip cosmetic composition for atopy skin | |
| CN109662904A (en) | It is a kind of to have effects that the skin care compositions of whitening antioxidation and its application and preparation method | |
| KR102292975B1 (en) | Cosmetic materials composition for skin anti-wrinkling and skin-soothing, Cosmetic materials using the same and Manufacturing method thereof | |
| KR102326796B1 (en) | Cosmetic materials composition for skin anti-oxidant and skin-soothing, Cosmetic materials using the same and Manufacturing method thereof | |
| KR101829892B1 (en) | A cosmetic composition comprising fraxinus rhynchophylla extract and calystegia soldanella extract | |
| CN104274357B (en) | A kind of scalp care compositions containing plant tincture and preparation method thereof | |
| KR102004366B1 (en) | A cosmetic composition comprising centipeda minima extract | |
| CN113350247A (en) | Preparation method and application of hair-care plant compound | |
| CN110559231A (en) | Whitening and freckle-removing essence and preparation method thereof | |
| KR100712249B1 (en) | Oily to acne skin cosmetics composite containing oriental herb extract and manufacturing method thereof | |
| CN104814916A (en) | Moisturizing essence and preparing method thereof | |
| CN109528606B (en) | Lamellar liquid crystal cosmetic containing compound plant composition of radix trichosanthis and preparation method thereof | |
| KR20110128384A (en) | The composition material and the manufacturing process for skin-wrinkle, moisture and skin-lightening uses by midam-kyungokko | |
| KR101459742B1 (en) | Cosmetic composition for improving acne containing extracts of natural substance | |
| CN109568230A (en) | A kind of Chinese medicine cosmetic of the anti-aging of moisturizing whitening | |
| CN110141542B (en) | Allergy-relieving agent containing radix pseudostellariae and preparation method thereof | |
| KR101998685B1 (en) | A cosmetic composition comprising arenaria serpyllifolia extract | |
| KR101214344B1 (en) | Cosmetics composition containing fermented rice bran and licorice extract | |
| KR101985660B1 (en) | Cosmetic composition for treating acne containing mixed herbal extracts fermented with Nuruk | |
| CN104825352A (en) | Sunscreen anti-allergy essence and preparation method thereof | |
| CN104758239A (en) | Anti-wrinkle essence and preparation method | |
| KR102642998B1 (en) | Female breast expansion cosmetic materials comprising arginine, Female breast expansion cosmetics containing the same and Manufacturing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20191213 |