CN112691069B

CN112691069B - Plant composition with anti-allergy relieving effect and preparation method and application thereof

Info

Publication number: CN112691069B
Application number: CN202110088829.1A
Authority: CN
Inventors: 赵鑫; 刘�英; 蔡建平
Original assignee: Shanghai Jiaxin Biotechnology Co ltd
Current assignee: Shanghai Jiaxin Biotechnology Co ltd
Priority date: 2021-01-22
Filing date: 2021-01-22
Publication date: 2023-06-06
Anticipated expiration: 2041-01-22
Also published as: CN112691069A

Abstract

The application relates to the field of cosmetics, and particularly discloses a plant composition with an anti-allergy relieving effect and a preparation method and application thereof. The plant composition with the antiallergic and soothing effects comprises the following raw materials in parts by weight: 10-30 parts of gentian, 5-10 parts of rosemary, 15-25 parts of mint, 25-40 parts of betaine, 12-24 parts of spiraea, 20-35 parts of stephania tetrandra, 20-30 parts of scutellaria baicalensis, 10-20 parts of caffeine and 20-40 parts of plant microcapsules; the preparation method comprises the following steps: s1, extracting gentian, stephania tetrandra and scutellaria baicalensis with water to obtain an aqueous extract; s2, extracting rosemary, mint and spiraea with ethanol to obtain an ethanol extract; s3, mixing betaine, plant microcapsules, caffeine, an aqueous extract and an alcohol extract. The plant composition with the anti-allergic and soothing effects can be used for cosmetics, and has the advantages of lasting itching relieving effect, rapid itching relieving and melanin accumulation prevention caused by allergy.

Description

Plant composition with anti-allergy relieving effect and preparation method and application thereof

Technical Field

The application relates to the technical field of cosmetics, in particular to a plant composition with anti-allergy relieving effect, and a preparation method and application thereof.

Background

Along with the deterioration of environmental quality, the increase of working pressure and the abuse of hormones on the skin surface caused by excessive pursuit of rapid efficacy by some consumers or manufacturers, the tolerance of the skin to external stimulus is gradually deteriorated, skin allergy phenomenon is more and more frequent, common skin allergy symptoms include tight skin, redness, itching, burning or peeling, and the like, and frequent skin allergy phenomenon brings great trouble to allergic skin crowds, so that cosmetics with anti-inflammatory, anti-allergic and soothing effects, which are developed for allergic skin crowds, are gradually paid attention to and favored by consumers.

With the popularity of plant skin care concepts, cosmetics added with natural plant components are favored by consumers, and natural plant products have small toxic and side effects, generally do not generate drug dependence and are easy to accept by consumers. However, the natural plant components have slow drug effects, and if itching caused by skin allergy cannot be relieved in time, the skin can be caused to be scratched continuously by allergic people, so that symptoms such as edema, hemorrhage, ulcer and the like are caused on the skin.

In the prior art, application number CN201910792058.7 discloses an antiallergic and antipruritic pharmaceutical composition based on natural plant extracts, which is mainly prepared from the following raw materials in parts by weight: 1-2 parts of sodium chloride, 0.3-0.5 part of biotin, 1-2 parts of potassium chloride, 5-8 parts of glycerol, 0.2-0.4 part of urea, 0.1-0.2 part of sodium linoleate, 0.7-1 part of lysine, 0.8-1.2 parts of phenylalanine, 2-5 parts of lactic acid, 65-80 parts of water and 0.4-0.6 part of jackfruit plant extract.

The existing pharmaceutical composition is safe and non-irritating, can rapidly relieve itching and eliminate inflammation, helps the skin to recover health, and is beneficial to patients to get rid of sensitive skin.

In view of the above-mentioned related art, the inventors believe that although natural plant components can rapidly relieve itching, the itching relieving effect is maintained for a short period of time, and it is necessary to administer the drug repeatedly locally, and the long-acting itching relieving effect is poor.

Disclosure of Invention

In order to prolong the maintenance time of the itching relieving effect and achieve the purpose of long-acting itching relieving, the application provides a plant composition with the anti-allergic and soothing effects, and a preparation method and application thereof.

In a first aspect, the present application provides a plant composition with anti-allergic and soothing effects, which adopts the following technical scheme:

a plant composition with anti-allergy relieving effect comprises the following raw materials in parts by weight: 10-30 parts of gentian, 5-10 parts of rosemary, 15-25 parts of mint, 25-40 parts of betaine, 12-24 parts of spiraea, 20-35 parts of stephania tetrandra, 20-30 parts of scutellaria baicalensis, 10-20 parts of caffeine and 20-40 parts of plant microcapsules;

the plant microcapsule comprises a core material and a wall material in a mass ratio of 1:2-5;

the wall material comprises the following components in parts by weight: 2.5-3.5 parts of tremella extract, 1.2-1.8 parts of hydrolyzed eggshell membrane powder, 0.7-1.4 parts of ginger, 0.4-1 part of cactus and 1.5-2 parts of fish skin gelatin;

The core material comprises the following components in parts by weight: 0.5-0.9 part of nicotinamide, 1.1-2.4 parts of sage herb, 1.2-1.8 parts of portulaca oleracea and 0.4-0.8 part of giant knotweed.

By adopting the technical scheme, as the plant microcapsule, the gentian, the betaine and other components are adopted to prepare the plant composition, the wall material of the plant microcapsule has high biocompatibility with the skin of the face of a human body, so that the accumulation of the medicine on the local part of the skin can be increased, the sustained release effect is achieved, the effect time is prolonged, and the use times are reduced; the gentiopicroside as the effective component in the gentian has excellent anti-irritation property, has the effects of relieving itching, detumescence, removing red, resisting inflammation and resisting bacteria, the stephania tetrandra has the effects of dispelling wind and removing dampness, clearing heat and detoxicating and relieving itching, the gentian and the stephania tetrandra are matched for use, the itching relieving speed can be accelerated, the itching relieving time can be prolonged, the aim of long-acting itching relieving is achieved, the betaine has the effects of resisting sensitization and relieving, and reducing skin irritation, the performance of an active agent in cosmetics on skin can be obviously reduced, the betaine is also a natural moisturizing factor, has the effects of naturally moisturizing and locking moisture, and the betaine and the stephania are matched, so that the allergy resistance can be relieved, and the skin itching caused by dryness can be reduced; rosemary has spectral antibacterial effect, has mint flavor faint scent, spiraea can promote organisms to secrete antibacterial peptide, strengthen self defensive power of skin, achieve the effects of sterilizing and relieving itching, spiraea can calm skin, astringe pores, reduce irritation and the like, scutellaria baicalensis has the effects of clearing heat and relieving itching, caffeine has antibacterial effect, and the synergistic cooperation of multiple components achieves the purposes of high itching relieving speed, long duration of itching relieving effect and good itching relieving effect.

The raw materials such as tremella extract and hydrolyzed eggshell membrane powder are used for preparing a wall material of the plant microcapsule, sage, portulaca oleracea and the like are used for preparing a core material of the plant microcapsule, and as ginger and cactus are added into the wall material, after the plant microcapsule contacts facial skin, the ginger and the cactus can immediately play roles in relieving, moistening and relieving itching on allergic skin, so that the itching relieving effect time is quick, the tremella extract contains organic fibers with stronger skin affinity and good biocompatibility, the protein content in the hydrolyzed eggshell membrane powder is up to more than 80%, most of the tremella extract is keratin and collagen which are similar to the protein property of human skin, metabolism can be effectively promoted, skin elasticity is recovered, the fishskin gelatin has excellent film forming effect, the film forming effect of the tremella extract and hydrolyzed eggshell membrane powder can be increased, the core material is coated, each component in the wall material can effectively transfer the effective components in the ginger and the cactus to permeate into the dermis, the effective components are prevented from evaporating and losing, the effective components entering the skin can be prevented from evaporating and losing, and the action time of the effective components entering the skin can be further moistened and nourished; the purslane in the core material has the effects of inhibiting the activity of hyaluronidase, reducing the secretion of inflammatory factors interleukin, resisting allergy, relieving facial red blood streak and the like, can inhibit skin itch, the sage has the effects of promoting cell regeneration and repairing skin, inhibiting bacteria and relieving itching, the two are matched for use, the long-acting antibacterial and antipruritic effect can be achieved, the nicotinamide can rapidly relieve itching, moisten and moisturize, the giant knotweed has the effects of clearing heat and relieving itching, the two are matched, the antipruritic effect can be effectively prolonged, and in addition, the carnosol and rosemary in the sage are matched for use, the antibacterial activity of various bacteria such as staphylococcus aureus, escherichia coli and the like is further improved, so that the antipruritic effect is further enhanced.

Preferably, the preparation method of the plant microcapsule comprises the following steps: pulverizing rhizoma Polygoni Cuspidati, and sieving to obtain rhizoma Polygoni Cuspidati fine powder; cleaning herba Portulacae and herba Salvia officinalis, drying, pulverizing, and sieving; cleaning radix et caulis Opuntiae Dillenii and rhizoma Zingiberis recens, and pulverizing; melting fish skin gelatin at 27-30deg.C;

mixing radix et caulis Opuntiae Dillenii and rhizoma Zingiberis recens, adding fish skin gelatin, mixing, introducing supercritical carbon dioxide for extraction at a flow rate of 20-25L/h under 15-20MPa and at 30-35deg.C for 2-2.5 hr, vacuum separating to obtain first mixed extractive solution, adding Tremella extractive solution and hydrolyzed eggshell membrane powder, and mixing to obtain wall material;

mixing herba Portulacae, herba Salvia officinalis and rhizoma Polygoni Cuspidati, extracting with supercritical carbon dioxide under 20-30MPa at 55-65deg.C at 20-30L/h, vacuum separating to obtain core material solution, and concentrating under reduced pressure to relative density of 1.1-1.2 to obtain core material;

introducing supercritical carbon dioxide into the wall material, spraying the wall material on the core material, wherein the spraying pressure is 7-10MPa, the spraying temperature is 40-60 ℃, and the mass ratio of the supercritical carbon dioxide to the wall material is 1:0.05-0.2.

By adopting the technical scheme, the cactus and the ginger are extracted by using the supercritical carbon dioxide, the extraction amount of the effective components is high, living bacteria can be killed by high pressure, unstable components in the ginger are prevented from being decomposed in the separation process, purslane, sage and polygonum cuspidatum are extracted by using the supercritical carbon dioxide, and no solvent is used during the supercritical carbon dioxide extraction, so that the extract is a natural active component and has higher stability; finally, the core material and the wall material are coated under supercritical carbon dioxide, so that the liquid drop atomization is finer, the particle size distribution range is narrower, and the coating of the nanoscale core material is easier to realize.

Preferably, when the first mixed extract is mixed with the tremella extract and the hydrolyzed eggshell membrane powder, auxiliary materials with the dosage of 20-30% of the tremella extract are added, wherein the auxiliary materials comprise woodchuck oil and chamomile extract with the mass ratio of 1:0.5-0.8.

By adopting the technical scheme, the chamomile extract contains volatile oil, flavonoid mixture, amino acid, chlorogenic acid, trace elements and the like, has the effects of resisting bacteria, relieving itching and resisting oxidization, has a very strong percutaneous permeation promotion effect, the woodchuck oil is also called snow pig oil, is animal fatty oil, has the effects of inhibiting bacteria, relieving itching and moistening skin, and can quickly permeate high permeability factors in the snow pig oil to the surface layer, so that deep bacteria are effectively inhibited.

Preferably, the preparation method of the tremella extract is as follows: pulverizing Tremella, adding onion juice and zymophyte, mixing, fermenting at 35-45deg.C for 24-72 hr, centrifuging the fermentation liquid, collecting supernatant, and inactivating at high temperature to obtain Tremella extractive solution, wherein the mass ratio of onion juice, zymophyte and Tremella is 0.3-0.5:0.01-0.02:1.

By adopting the technical scheme, onion juice is added when tremella is fermented, and after the onion juice is fermented, the viscosity is increased, so that the adhesion time of tremella extract and facial skin is increased, the medicine maintenance time is prolonged, and the antipruritic effective time is prolonged; the onion juice can decompose melanin, remove freckle and moisturize, so that the whitening and melanin accumulation inhibiting effects of the tremella extract are further improved.

Preferably, the fermentation bacteria are acetobacter xylinum and lactobacillus casei with a mass ratio of 1:0.2-0.5.

By adopting the technical scheme, the tremella and onion juice is fermented by using acetobacter xylinum and lactobacillus casei, so that the tremella can secrete biological natural fibers, and the skin is moistened deeply.

In a second aspect, the present application provides a method for preparing a plant composition with anti-allergic and soothing effects, which adopts the following technical scheme:

A preparation method of a plant composition with anti-allergy relieving effect comprises the following steps:

s1, crushing gentian, stephania tetrandra and scutellaria baicalensis, adding water 2-3 times of the total weight of the medicinal materials and cellulase 0.01-0.02 times of the total weight of the medicinal materials, soaking, decocting for 1-3 times, each time for 1-3 hours, filtering, combining the filtrates, retaining filter residues, and concentrating the filtrate under reduced pressure to obtain an aqueous extract;

s2, crushing rosemary, peppermint and meadowsweet, adding filter residue reserved in the step S1, adding ethanol, extracting for 20-30min under the conditions of 400-600W of microwave power and 60-70 ℃, filtering, and concentrating under reduced pressure to obtain alcohol extract;

s3, mixing betaine, plant microcapsules, caffeine, water extract and alcohol extract to prepare the plant composition with the anti-allergy and relieving effects.

By adopting the technical scheme, as the gentian, the stephania tetrandra and the baikal skullcap root have harder textures, the effective components are extracted in a decoction way, the extraction rate is high, the rosemary, the peppermint and the spiraea are extracted by using ethanol under the microwave condition, the dissolution of the effective components can be quickened, and finally the water extract, the ethanol extract, the betaine, the plant microcapsule and the caffeine are mixed, so that the prepared plant composition has better antipruritic effect, has high antipruritic speed and long antipruritic time.

In a third aspect, the present application provides an application of a plant composition with anti-allergic and soothing effects, which adopts the following technical scheme:

use of a herbal composition with antiallergic and soothing effects in the preparation of cosmetics.

By adopting the technical scheme, the plant composition with the anti-allergic and soothing effects is applied to cosmetics, can effectively relieve, repair or treat skin sensitive itch or inhibit bacteria and fungi on the surface of the skin, has good itching relieving effect and has long-acting itching relieving effect.

Preferably, the cosmetic is a repair cream, and the repair cream comprises the following raw materials in percentage by weight: phase A: 3-4% of cetostearyl alcohol, 5.5-6.5% of glycerol stearate, 1-1.5% of stearic acid, 5-6% of caprylic triglyceride, 1.5-2% of mineral oil, 2-3% of isopropyl palmitate and 2-3% of polydimethylsiloxane; and B phase: 2-3% of EDTA disodium, 4.5-5.5% of glycerol, 0.1-0.3% of p-hydroxyacetophenone and the balance of water; and C phase: 5-10% of whitening agent, 1.5-2% of 1, 2-hexanediol and 5-10% of plant composition with antiallergic and soothing effects.

By adopting the technical scheme, when the allergy symptoms repeatedly occur, various complex chemical reactions in the substrate cause excessive local accumulation of melanocytes to cause melanin pigmentation, so that local dark complexion and uneven complexion are caused, and the phenomenon of uneven complexion caused by allergy can be improved by adding the whitening agent into the repairing cream.

Preferably, the whitening agent is prepared from the following components in parts by weight: 2.3-5 parts of lemon peel extract, 1.2-2 parts of silk protein powder and 1-2 parts of seaweed particles.

By adopting the technical scheme, the lemon peel extract contains more vitamin C, can directly permeate into melanocytes, and is combined with PPAR peroxidase activated proliferation receptors floating in cell nuclei, so that new tyrosinase is prevented from being generated, subcutaneous activity is stimulated, vitamin C can be slowly fed into fibroblasts of skin to synthesize collagen, skin tenderness is improved, the lemon peel extract is combined with seaweed particles, the lemon peel extract has the effects of moisturizing, moistening and whitening, skin is moistened Bai Rounen, silk condensed amino acid in silk protein powder can effectively inhibit melanin generation in skin, the effect of whitening skin is achieved, and the silk protein powder, the lemon peel extract and seaweed particles are matched for use, so that the problems of skin melanin deposition and dark skin color can be effectively improved.

Preferably, the preparation method of the repair cream comprises the following steps: mixing the B phase raw materials, stirring and heating to 80-85 ℃, homogenizing, preserving heat for 8-12min, mixing the A phase raw materials, stirring and heating to 75-80 ℃, dispersing uniformly, mixing the A phase raw materials and the B phase raw materials, stirring and homogenizing, preserving heat for 8-10min, cooling to 55-60 ℃, adding the mixed C phase raw materials, stirring and homogenizing, preserving heat for 3-7min, cooling to 40 ℃, adjusting the pH value to 5.5-6.5, filtering, discharging, and obtaining the repair cream.

By adopting the technical scheme, after the A phase raw material and the B phase raw material are respectively and uniformly mixed, the A phase raw material and the B phase raw material are mixed and uniformly mixed with the C phase, and the prepared repair cream has the advantages of quick itching relieving effect, long itching relieving effect duration, melanin accumulation inhibition, whitening and skin tendering.

In summary, the present application has the following beneficial effects:

1. as the gentian, the stephania tetrandra, the betaine, the plant microcapsule and other components are adopted to prepare the plant composition with the antiallergic and soothing functions, the gentian, the rosemary and the baical skullcap root have the effects of resisting irritation, relieving itching, diminishing inflammation and resisting bacteria, the betaine and the caffeine can resist bacteria and resist irritation, the antipruritic effect can be effectively increased by the cooperation of various components, the antipruritic speed can be accelerated, the antipruritic effective time can be prolonged, the plant microcapsule uses tremella extract, hydrolyzed eggshell membrane powder and other substances with good skin affinity and strong biocompatibility as wall materials and can be more effectively contacted with the skin surface, so that the permeation of an internal core material is accelerated, and giant knotweed, sage herb, purslane and nicotinamide in the core material are released in the gradual absorption of the wall materials, so that the long-acting antipruritic effect is achieved.

2. The preferred sage that adopts in this application is mutually supported in rosemary and the core, because the rosemary has spectral antibacterial effect, can strengthen skin's self defensive power, reaches disinfect, antipruritic, anti-allergic effect, and the sage can promote cell regeneration, restores skin, and the two cooperation can effectively kill multiple bacterium, reaches the effect of quick antipruritic.

3. In the application, supercritical carbon dioxide is preferably used for extracting the wall material and the effective components in the core material, so that unstable components can be prevented from being decomposed in the separation process, any solvent is not introduced, the skin is prevented from being stimulated by solvent residues, the core material and the wall material are mixed to form the plant microcapsule by using the supercritical carbon dioxide, the wall material and the core material can be atomized more finely, the particle size distribution range of the plant microcapsule is narrower, and the coating is more uniform.

4. The chamomile extract and woodchuck oil are added in the coating process of the wall material and the core material, so that the percutaneous penetration effect of the wall material can be effectively enhanced, the itching relieving speed of the plant microcapsule is accelerated, and the melanin synthesis inhibiting, whitening and freckle removing effects of the plant composition are enhanced.

5. When the plant composition is prepared into the repairing cream, the whitening agent prepared from lemon peel extract, seaweed particles and fibroin powder is added, so that melanin synthesis can be effectively inhibited, and uneven skin color caused by local melanin deposition caused by allergy can be prevented.

Detailed Description

Preparation example 1 of hydrolyzed eggshell membrane powder

Preparation example 1: crushing 10kg eggshell, adding 240L of water with concentration, adding 24L of 36% acetic acid, preserving heat at 45 ℃ for 1.5 hours, standing for 24 hours at normal temperature, filtering, washing with water, drying at 60 ℃ for 1.5 hours, chopping, adding 10L of 20% sulfuric acid, heating to 80 ℃ for reflux extraction for 5 hours, adding 3kg of calcium carbonate, filtering, spray drying, crushing to 1um, and obtaining the hydrolyzed eggshell membrane.

Preparation examples 1-4 of Tremella extract

Acetobacter xylinum in preparation examples 1-4 was selected from Shanghai research and development industries, inc., with the product number YS-J0512; the Lactobacillus casei is selected from Shaanxi Guanzhong biotechnology Co Ltd, and the model is GC-010401; the onion juice is selected from Hirudo Highway food ingredient Co., ltd, and has BRIX70.

Preparation example 1: pulverizing Tremella, adding Bulbus Allii Cepae juice and zymophyte, mixing, fermenting at 35deg.C for 72 hr, centrifuging the fermentation broth at 8000r/min, collecting supernatant, and inactivating at high temperature to obtain Tremella extract with mass ratio of Bulbus Allii Cepae juice, zymophyte and Tremella of 0.3:0.01:1, and zymophyte of 1:0.2 including Acetobacter xylinum and Lactobacillus casei at 120deg.C for 25min, wherein the concentrations of Acetobacter xylinum and Lactobacillus casei are 1.0X10:1 ⁶ CFU/mL。

Preparation example 2: pulverizing Tremella, adding onion juice and zymophyte, mixing, fermenting at 40deg.C for 36 hr, centrifuging the fermentation broth at 9000r/min, collecting supernatant, and inactivating at high temperature to obtain Tremella extract, wherein the mass ratio of onion juice, zymophyte and Tremella is 0.4:0.01:1, the mass ratio of the zymophyte is 1:0.3, and the mass ratio of Acetobacter xylinum and Lactobacillus casei is 122 deg.C, and the inactivation time is 22min The concentration of the bacillus was 1.0X10 ⁷ CFU/mL。

Preparation example 3: pulverizing Tremella, adding Bulbus Allii Cepae juice and zymophyte, mixing, fermenting at 45deg.C for 24 hr, centrifuging the fermentation broth at 10000r/min, collecting supernatant, and inactivating at high temperature to obtain Tremella extract, wherein the mass ratio of Bulbus Allii Cepae juice, zymophyte and Tremella is 0.5:0.02:1, the mass ratio of the zymophyte is 1:0.5, and the concentration of Acetobacter xylinum and Lactobacillus casei is 1.0X10.after fermenting at 125deg.C for 20min ⁶ CFU/mL。

Preparation example 4: the difference from preparation example 1 is that no onion juice was added.

Preparation examples 1 to 10 of plant microcapsules

The fishskin gelatin in preparation examples 1-10 is selected from Guangzhou City-high trade company, with the product number of 002; the woodchuck oil is selected from special Tibetan medicinal materials store with the commodity number of 0127; the flos Matricariae Chamomillae extract is selected from the company of biological technology of the company of the West Anwans, and has a product number of 02.

Preparation example 1: (1) Pulverizing 0.4kg of rhizoma Polygoni Cuspidati, and sieving to obtain rhizoma Polygoni Cuspidati fine powder; cleaning and drying 1.2kg of purslane and 1.1kg of sage, pulverizing, and sieving for use; cleaning 0.4kg of cactus and 0.7kg of ginger, and crushing for later use; melting fish skin gelatin at 27deg.C;

(2) Mixing radix et caulis Opuntiae Dillenii and rhizoma Zingiberis recens, adding 1.5kg of fishskin gelatin, mixing, extracting with supercritical carbon dioxide with flow rate of 20L/h and extraction pressure of 15MPa and extraction temperature of 30deg.C for 2.5h, separating under reduced pressure to obtain first mixed extractive solution, adding 2.5kg of Tremella extractive solution and 1.2kg of hydrolyzed eggshell membrane powder into the first mixed extractive solution, mixing to obtain wall material, wherein Tremella extractive solution is selected from Mains biological technology (Guangzhou) limited company, product number is 201916, and hydrolyzed eggshell membrane powder is selected from hydrolyzed eggshell membrane powder preparation example 1;

(3) Mixing herba Portulacae, herba Salvia officinalis and rhizoma Polygoni Cuspidati, extracting with supercritical carbon dioxide under 20MPa at 55deg.C at 20L/h, vacuum separating to obtain core material solution, and concentrating under reduced pressure to relative density of 1.1 to obtain core material;

(4) Introducing supercritical carbon dioxide into the wall material, and spraying the wall material on the core material to obtain the plant microcapsule, wherein the spraying pressure is 7MPa, the spraying temperature is 60 ℃, and the mass ratio of the supercritical carbon dioxide to the wall material is 1:0.05.

Preparation example 2: the difference from preparation example 1 is that the tremella extract is selected from preparation example 1.

Preparation example 3: (1) Pulverizing 0.6kg of rhizoma Polygoni Cuspidati, and sieving to obtain rhizoma Polygoni Cuspidati fine powder; cleaning and drying 1.5kg of purslane and 1.7kg of sage, pulverizing, and sieving for use; cleaning 0.7kg of cactus and 1kg of ginger, and crushing for later use; melting fish skin gelatin at 28deg.C;

(2) Mixing cactus and ginger, adding 1.8kg of fishskin gelatin, uniformly mixing, introducing supercritical carbon dioxide for extraction, wherein the flow rate of the supercritical carbon dioxide is 23L/h, the extraction pressure is 18MPa, the extraction temperature is 33 ℃, the extraction time is 2.3h, and the decompression separation is carried out to obtain a first mixed extract, adding 3kg of tremella extract and 1.5kg of hydrolyzed eggshell membrane powder into the first mixed extract, uniformly mixing to obtain a wall material, wherein the tremella extract is selected from preparation example 2 of tremella extract, and the hydrolyzed eggshell membrane powder is selected from preparation example 1 of hydrolyzed eggshell membrane powder;

(3) Mixing herba Portulacae, herba Salvia officinalis and rhizoma Polygoni Cuspidati, extracting with supercritical carbon dioxide under 28MPa at 60deg.C at 25L/h, vacuum separating to obtain core material solution, and concentrating under reduced pressure to relative density of 1.2 to obtain core material;

(4) Introducing supercritical carbon dioxide into the wall material, and spraying the wall material on the core material to obtain the plant microcapsule, wherein the spraying pressure is 9MPa, the spraying temperature is 50 ℃, and the mass ratio of the supercritical carbon dioxide to the wall material is 1:0.1.

Preparation example 4: (1) Pulverizing 0.8kg of rhizoma Polygoni Cuspidati, and sieving to obtain rhizoma Polygoni Cuspidati fine powder; cleaning 1.8kg of purslane and 2.4kg of sage, drying, pulverizing, and sieving for use; cleaning 1kg of cactus and 1.4kg of ginger, and crushing for later use; melting fish skin gelatin at 30deg.C;

(2) Mixing radix et caulis Opuntiae Dillenii and rhizoma Zingiberis recens, adding 2kg of fishskin gelatin, mixing, extracting with supercritical carbon dioxide with flow rate of 25L/h and extraction pressure of 20MPa and extraction temperature of 35deg.C for 2h, separating under reduced pressure to obtain first mixed extractive solution, adding 3.5kg of Tremella extractive solution and 1.8kg of hydrolyzed eggshell membrane powder into the first mixed extractive solution, mixing to obtain wall material, wherein Tremella extractive solution is selected from preparation example 3 of Tremella extractive solution, and hydrolyzed eggshell membrane powder is selected from preparation example 1 of hydrolyzed eggshell membrane powder;

(3) Mixing herba Portulacae, herba Salvia officinalis and rhizoma Polygoni Cuspidati, extracting with supercritical carbon dioxide under 30MPa at 65deg.C with carbon dioxide flow rate of 30L/h, vacuum separating to obtain core material solution, and concentrating under reduced pressure to relative density of 1.2 to obtain core material;

(4) Introducing supercritical carbon dioxide into the wall material, and spraying the wall material on the core material to obtain the plant microcapsule, wherein the spraying pressure is 10MPa, the spraying temperature is 60 ℃, and the mass ratio of the supercritical carbon dioxide to the wall material is 1:0.2.

Preparation example 5: the difference from preparation example 2 is that the tremella extract is selected from preparation example 4 of tremella extract.

Preparation example 6: the difference from preparation example 2 is that the core material and the wall material are mixed for 1 hour at 60 ℃ in the step (4) to obtain the plant microcapsule.

Preparation example 7: the difference from preparation example 2 is that when the first mixed extract in step (1) is mixed with the tremella extract and the hydrolyzed eggshell membrane powder, auxiliary materials with the dosage of 20% of the tremella extract are added, and the auxiliary materials comprise woodchuck oil and chamomile extract with the mass ratio of 1:0.5.

Preparation example 8: the difference from preparation example 2 is that, when the first mixed extract in step (1) is mixed with the tremella extract and the hydrolyzed eggshell membrane powder, auxiliary materials with the dosage of 30% of that of the tremella extract are added, and the auxiliary materials comprise woodchuck oil and chamomile extract with the mass ratio of 1:0.8.

Preparation example 9: the difference from preparation example 2 is that, after mixing the cactus and ginger in step (2), fishskin gelatin is added, ethanol 3 times of the total weight of the raw materials is used for extraction for 2 hours at 65 ℃, and the extract is filtered to be used as a first mixed extract.

Preparation example 10: the difference from preparation example 2 is that the purslane, the sage and the giant knotweed in the step (3) are extracted by ethanol, the amount of the ethanol is 3 times of the total weight of the purslane, the sage and the giant knotweed, the extraction stability is 65 ℃, the extraction time is 2 hours, and the advance solution is concentrated to 1.1 to be used as a core material.

Examples

Caffeine in the following examples was selected from Yunnan YueChi food Co., ltd, product number 6901; betaine is selected from Shaanxi He biological engineering Co., ltd, with the product number of 1106-1; the cellulase is selected from Hubei Furun food materials Co.

Example 1: the plant composition with the antiallergic and soothing effects is prepared by the following steps:

s1, crushing gentian, stephania tetrandra and scutellaria baicalensis, adding water 2 times of the total weight of the medicinal materials and cellulase 0.01 times of the total weight of the medicinal materials, soaking, decocting for 1 time and 3 hours each time, filtering, combining the filtrates, retaining filter residues, concentrating the filtrate under reduced pressure to obtain an aqueous extract, wherein the enzyme activity of the cellulase is 2 ten thousand u/g;

s2, crushing rosemary, peppermint and meadowsweet, adding the filter residue reserved in the step S1, adding ethanol, extracting for 30min under the conditions of 400W of microwave power and 60 ℃, filtering, and concentrating under reduced pressure to obtain ethanol extract;

s3, mixing betaine, plant microcapsules, caffeine, water extract and alcohol extract to prepare the plant composition with the anti-allergy and relieving effects, wherein the plant microcapsules are prepared from preparation 2 of the plant microcapsules.

TABLE 1 raw material amounts of plant compositions having antiallergic and soothing effects in examples 1 to 4

Examples 2 to 4: a herbal composition with antiallergic and soothing effects differs from example 1 in that the amounts of the raw materials are shown in Table 1.

Example 5: the plant composition with the antiallergic and soothing effects is prepared by the following steps:

S1, crushing gentian, stephania tetrandra and scutellaria baicalensis, adding water which is 3 times of the total weight of the medicinal materials and cellulase which is 0.02 times of the total weight of the medicinal materials, soaking, decocting for 2 times and 2 hours each time, filtering, combining the filtrates, retaining filter residues, and concentrating the filtrate under reduced pressure to obtain an aqueous extract;

s2, crushing rosemary, peppermint and meadowsweet, adding the filter residue reserved in the step S1, adding ethanol, extracting for 25min under the conditions of 500W of microwave power and 65 ℃, filtering, and concentrating under reduced pressure to obtain alcohol extract;

Example 6: the plant composition with the antiallergic and soothing effects is prepared by the following steps:

s1, crushing gentian, stephania tetrandra and scutellaria baicalensis, adding water which is 3 times of the total weight of the medicinal materials and cellulase which is 0.01 times of the total weight of the medicinal materials, soaking, decocting for 3 times, 1 hour each time, filtering, combining the filtrates, retaining filter residues, and concentrating the filtrate under reduced pressure to obtain an aqueous extract;

s2, crushing rosemary, peppermint and meadowsweet, adding the filter residue reserved in the step S1, adding ethanol, extracting for 20min under the condition of 600W of microwave power and 70 ℃, filtering, and concentrating under reduced pressure to obtain alcohol extract;

Example 7: a plant composition having antiallergic and soothing effects is different from example 1 in that a plant microcapsule is prepared from preparation example 3 of a plant microcapsule.

Example 8: a plant composition having antiallergic and soothing effects is different from example 1 in that a plant microcapsule is prepared from preparation example 1 of a plant microcapsule.

Example 9: a plant composition having antiallergic and soothing effects is different from example 1 in that a plant microcapsule is prepared from preparation example 4 of a plant microcapsule.

Example 10: a plant composition having antiallergic and soothing effects is different from example 1 in that a plant microcapsule is prepared from preparation example 5 of a plant microcapsule.

Example 11: a plant composition having antiallergic and soothing effects is different from example 1 in that the plant microcapsule is prepared from preparation example 6 of plant microcapsule.

Example 12: a plant composition having antiallergic and soothing effects is different from example 1 in that the plant microcapsule is prepared from preparation example 7 of the plant microcapsule.

Example 13: a plant composition having antiallergic and soothing effects is different from example 1 in that a plant microcapsule is prepared from preparation example 8 of a plant microcapsule.

Example 14: a plant composition having antiallergic and soothing effects is different from example 1 in that the plant microcapsule is prepared from preparation example 9 of plant microcapsule.

Example 15: a plant composition having antiallergic and soothing effects is different from example 1 in that a plant microcapsule is prepared from preparation example 10 of a plant microcapsule.

Comparative example

Comparative example 1: a plant composition with antiallergic and soothing effects differs from example 1 in that no plant microcapsule is added.

Comparative example 2: a plant composition with antiallergic and soothing effects is different from example 1 in that tremella extract is not added to the wall material.

Comparative example 3: a plant composition with antiallergic and soothing effects is different from example 1 in that no hydrolyzed eggshell membrane powder is added to the wall material.

Comparative example 4: a plant composition with antiallergic and soothing effects is different from example 1 in that no fishskin gelatin is added to the wall material.

Comparative example 5: a plant composition with antiallergic and soothing effects is different from example 1 in that ginger and cactus are not added to the wall material.

Comparative example 6: a herbal composition with antiallergic and soothing effects differs from example 1 in that no sage or purslane is added to the core material.

Comparative example 7: a plant composition with antiallergic and soothing effects is different from example 1 in that nicotinamide and rhizoma Polygoni Cuspidati are not added into the core material.

Comparative example 8: a herbal composition with antiallergic and soothing effects differs from example 1 in that radix Stephaniae Tetrandrae and radix Gentianae are not added.

Comparative example 9: a plant composition with antiallergic and soothing effects differs from that of example 1 in that betaine and radix Stephaniae Tetrandrae are not added.

Comparative example 10: an antiallergic and antipruritic pharmaceutical composition based on natural plant extract is prepared from the following raw materials: 10g of sodium chloride, 3g of biotin, 10g of potassium chloride, 50g of glycerol, 2g of urea, 1g of sodium linoleate, 7g of lysine, 8g of phenylalanine, 20g of lactic acid, 650g of water and 4g of jackfruit plant extract; the preparation method of the antiallergic and antipruritic pharmaceutical composition comprises the following steps: s1, weighing the raw materials according to the mass, dividing the level into two parts, heating 325g of water to 65 ℃, adding biotin, lysine and phenylalanine, and stirring until the biotin, the lysine and the phenylalanine are completely dissolved to obtain solution A; s2, adding urea, sodium linoleate and the jackfruit plant extract into 325g of water, and stirring for dissolution to obtain solution B; s3, mixing the solution A and the solution B, continuously stirring in the mixing process, and uniformly stirring to obtain solution C; s4, heating the solution C to 45 ℃, dropwise adding glycerol and lactic acid into the solution C, and stirring the solution C simultaneously to obtain solution D after uniform stirring; s5, adding sodium chloride and potassium chloride into the solution D, and stirring until the sodium chloride and the potassium chloride are completely dissolved, thus obtaining the aqueous emulsion.

Application example

The cetostearyl alcohol of application examples 1-10 is selected from the group consisting of Bo chemical Co., ltd., model 1518; the glyceryl stearate is selected from Guangdong Haohuang trade company, model SE; stearic acid is selected from Changzhou blue advanced Material science and technology Co., ltd, model 1860; the mineral oil is selected from oil products of Hexent oil products of Suzhou, model number is HS-021; the polydimethylsiloxane is selected from Guangdong high technology Co., ltd, and the model is KSG-210; the glycerol is selected from Guangzhou Heng chemical Co., ltd, and the model is 02G31128; disodium EDTA is selected from Suzhou blue chemical engineering Co., ltd, model number 002; the caprylic triglyceride is selected from Hengzhou Rong Ao chemical new materials, and is RA-111; the caprylic triglyceride is selected from Bisheng trade company, guangzhou, model number DUB928; the seaweed granule is selected from Guangzhou Zhen Cui Biotechnology Co., ltd, and the model is OEM; the fibroin powder is selected from Siamijia and biotechnology limited company, and the model is JH; the lemon peel extract is selected from North Biotechnology Co., ltd.

The plant composition with antiallergic and soothing functions prepared in example 1 is used for preparing a repair cream, the raw material consumption of the repair cream is shown in table 2, and the preparation method of the repair cream in application example 1 is as follows:

Mixing the B phase raw materials, stirring and heating to 80 ℃, homogenizing, preserving heat for 8min, mixing the A phase raw materials, stirring and heating to 75 ℃, dispersing uniformly, mixing the A phase raw materials and the B phase raw materials, stirring and homogenizing, preserving heat for 8min, cooling to 55 ℃, adding the mixed C phase raw materials, stirring and homogenizing, preserving heat for 3min, cooling to 40 ℃, adjusting the pH value to 5.5, filtering, discharging, and preparing the repairing cream, wherein the whitening agent is prepared by mixing 2.3kg of lemon peel extract, 1.2kg of silk protein powder and 1kg of seaweed particles, and the particle size of the seaweed particles is 10um.

TABLE 2 raw material usage of repair cream in application example

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Application example 2: the difference from application example 1 is that the raw material amounts are shown in table 2, and the preparation method of the application example repair cream is as follows: mixing the B phase raw materials, stirring and heating to 80 ℃, homogenizing, preserving heat for 8min, mixing the A phase raw materials, stirring and heating to 75 ℃, dispersing uniformly, mixing the A phase raw materials and the B phase raw materials, stirring and homogenizing, preserving heat for 8min, cooling to 55 ℃, adding the mixed C phase raw materials, stirring and homogenizing, preserving heat for 3min, cooling to 40 ℃, regulating the pH value to 5.5, filtering, discharging, and preparing the repairing cream, wherein the whitening agent is prepared by mixing 3.8kg of lemon peel extract, 1.6kg of silk protein powder and 1.5kg of seaweed particles.

Application example 3: the difference from application example 1 is that the raw material amounts are shown in table 2, and the preparation method of the application example repair cream is as follows: mixing the B phase raw materials, stirring and heating to 85 ℃, homogenizing, preserving heat for 12min, mixing the A phase raw materials, stirring and heating to 80 ℃, dispersing uniformly, mixing the A phase raw materials and the B phase raw materials, stirring and homogenizing, preserving heat for 10min, cooling to 60 ℃, adding the mixed C phase raw materials, stirring and homogenizing, preserving heat for 7min, cooling to 40 ℃, regulating the pH value to 6.5, filtering, discharging, and preparing the repairing cream, wherein the whitening agent is prepared by mixing 5kg of lemon peel extract, 2kg of silk protein powder and 2kg of seaweed particles.

Application example 4: the difference from application example 1 is that the plant composition having antiallergic and soothing effects was prepared from example 12.

Application example 5: the difference from application example 1 is that the lemon peel extract was not added to the whitening agent.

Application example 6: the difference from application example 1 is that no seaweed particles were added to the whitening agent.

Application example 7: the difference from application example 1 is that silk fibroin powder was not added to the whitening agent.

Application example 8: the difference from application example 1 is that the lemon peel extract and the seaweed particles were not added to the whitening agent.

Application example 9: the difference from application example 1 is that silk fibroin powder and lemon peel extract are not added to the whitening agent.

Application example 10: the difference from application example 1 is that silk fibroin powder and seaweed particles were not added to the whitening agent.

Performance test

1. Long-acting antipruritic effect detection of plant composition with antiallergic and soothing effects

The plant compositions with antiallergic and soothing effects prepared in each example and each comparative example were tested according to the following method, and the test results are recorded in table 3:

1. antipruritic effect: 230 healthy mice with the weight of 20g are randomly divided into 23 groups, each group is divided into half, the back hair of the mice is removed by 1% sodium sulfide, the area of dehairing skin area is 1.5cm multiplied by 1.5cm, and the mice are used for experiments after 2 days; the 22 groups of animal back dehairing areas in the experiment correspond to the plant compositions prepared in the examples 1-16 and the comparative examples 1-6, the 23 group is used as a control group, distilled water is smeared, the smearing amount is 1mL/kg, once daily, after continuous smearing for 5 days, dextran is injected into the tail of the mouse for 30min after last smearing, the front paw scratching head, the rear scratch trunk and the mouth biting all parts of the whole body of the mouse are used as pruritus indexes, and the pruritus frequency of the mouse is recorded within 30 min.

2. Antipruritic onset time and antipruritic duration time: taking 230 white guinea pigs with a weight of 300g, dehairing right hind feet by using a dehairing agent, then dividing the right hind feet into 23 groups at random, lightly rubbing the right hind feet dehairing skin of the guinea pigs with fine sand paper to make the right hind feet dehairing skin of the guinea pigs reddish, but not bleeding, correspondingly smearing the plant compositions prepared in examples 1-16 and comparative examples 1-6 on the guinea pigs in groups 1-22, smearing triamcinolone acetonide urea acetate ointment on groups 23, smearing 1mL/kg on each group, smearing 0.2mL of the plant composition on dehairing areas after the itching reaction of the guinea pigs, and recording the time from smearing the plant composition to stopping licking the wound parts of the right hind feet, wherein the time is the anti-allergic itching relieving time of the plant composition; the duration of itching was recorded from the time the guinea pig was antipruritic to the time the guinea pig repeatedly licked the right hindfoot wound face again.

Table 3 antipruritic effect of plant compositions

As can be seen from the data in examples 1-7 and Table 3, the plant composition has good antipruritic effect, the antipruritic effect time is 1.5-1.7min, the effect time is fast, the antipruritic duration time is 4.5-4.6h, and the long-acting antipruritic effect is achieved.

In example 8, the plant microcapsule prepared in example 1 was prepared by using plant microcapsules, and since the raw materials of the plant microcapsule are commercial tremella extract, compared with examples 1 to 7, the plant composition has slow effect of relieving itching, short duration of effect of relieving itching and poor effect of relieving itching.

The test performance of the plant microcapsules prepared in example 4 was not very different from that of examples 1 to 7.

The white fungus advanced liquor prepared by the plant microcapsule in the embodiment 10 is fermented without onion juice, and the detection result shows that the itching-relieving duration time is obviously shorter than that of the embodiment 1-7, and the itching-relieving effect time is slower, which shows that after the onion juice and the white fungus are mixed and fermented, the itching-relieving duration time and the itching-relieving effect speed of the plant composition can be effectively improved.

Example 11 since the plant microcapsule is formed by simply mixing the wall material and the core material when preparing the plant microcapsule, the wall material is difficult to fully wrap the core material, so that the slow release effect is poor, the itching relieving effect time of the plant composition is accelerated, but the itching relieving duration time is shortened.

In examples 12 and 13, when plant microcapsules are prepared, marmot oil and chamomile extract are added, the itching relieving time is accelerated to 1.2-1.3min, and compared with examples 1-7, the itching relieving time is obviously accelerated, and the itching relieving duration is prolonged, so that the marmot oil and chamomile extract can effectively improve the itching relieving effect time and the itching relieving duration effect of the plant composition.

In the embodiment 14, the plant microcapsule is prepared by extracting cactus, ginger and fishskin gelatin with ethanol, so that the effective components in the wall material are few, the onset time is long, and the itching relieving duration time is short; example 15 since purslane, sage and polygonum cuspidatum were extracted with ethanol in the preparation of plant microcapsules, the content of active ingredients was low due to low extraction rate of active ingredients by ethanol extraction, and the duration of itching relieving of the plant microcapsules was shortened.

Comparative example 1 the plant composition prepared in comparative example 1 has a shorter duration of the antipruritic effect and a slower antipruritic effect onset time and a poorer antipruritic effect than those of examples 1 to 7 because no plant microcapsule is added.

In the comparative example 2, the tremella extract is not added in the wall material, in the comparative example 3, the hydrolyzed eggshell membrane powder is not added in the wall material, in the comparative example 4, the fishskin gelatin is not added in the wall material, and the plant compositions prepared in the comparative examples 2-4 have quick effect on relieving itching, but have poor long-acting effect on relieving itching, and the long-acting effect on relieving itching is reduced compared with the examples 1-7.

In comparative example 5, ginger and cactus were not added to the wall material, and when the plant composition was in contact with the skin, the itching relieving component of the wall material was reduced, resulting in an increase in the time of the itching relieving effect and a deterioration in the itching relieving effect.

Comparative example 6 because no sage and purslane were added to the wall material, and comparative example 7 because no nicotinamide and giant knotweed were added to the core material, the antipruritic effect of the core material was reduced after the wall material was dissolved, so that the antipruritic effective time of the plant composition was shortened.

Comparative example 8 since no stephania tetrandra and gentian were added to the plant composition and no betaine and stephania tetrandra were added to the plant composition and comparative example 9, it was found from the results of the examination that the plant compositions prepared in comparative examples 8 to 9 had prolonged antipruritic effect and deteriorated long-acting antipruritic effect.

Comparative example 10 is a natural plant extract prepared in the prior art, and although the itching relieving speed is high and the itching relieving effect is good, the itching relieving effect lasts for a short time.

2. Detection of melanin precipitation-inhibiting Effect of repair cream in application examples 1 to 9

90 subjects with sensitive skin aged 22-54 years are selected, randomly divided into 9 groups, 10 persons are selected in each group, the ITA degree value of the faces of the subjects is 28-43 degrees, the subjects in the 9 groups are correspondingly coated with the repair cream prepared in application examples 1-9, the repair cream is coated on the faces after cleaning the faces every day, each time is 1 time in the morning and at the evening, and the detection is carried out on the subjects in the first 1 day and 4 weeks and 8 weeks after use:

1. Skin melanin content was measured using a MEXAMETER MX18 skin pigmentation meter, and the higher the absolute value of the melanin reduction rate = (pre-use melanin content-post-use melanin content)/pre-use melanin content×100%, the more remarkable the whitening effect was; continuously testing for 3 times, taking an average value, and recording the detection result in table 4;

2. the skin color was measured using Colorimeter CL400, the change in skin color ita° value before and after use was detected, the change rate of skin color ita° value= (pre-use skin color ita° value-post-use skin color ita° value)/pre-use skin color ita° value×100%, the higher the change rate of ita° value, the more remarkable the lightening and whitening effect was, the 3 times of continuous test were taken, the average value was taken, and the detection results were recorded in table 4.

Table 4 detection of Performance of the repair cream prepared in application examples 1 to 9

As can be seen from the data in application examples 1 to 4 and Table 4, after the use of the restoration cream prepared in examples 1 to 3, the melanin content was significantly reduced after 4 weeks and 8 weeks compared with that before the use, and the change rate of ITA degree value was large, and the restoration cream of application example 4 using the plant composition prepared in example 12 was better in melanin inhibiting effect and whitening effect than application examples 1 to 3, indicating that the plant microcapsules added with the woodchuck oil and the chamomile extract can further improve the whitening and skin-brightening effects of the restoration cream.

In application example 5, the skin whitening agent is prepared without lemon peel, and the effect of the restoration cream of application example 5 on inhibiting melanin and brightening skin is not as good as that of application examples 1-3.

The seaweed particles are not added in application example 6, the silk protein powder is prepared in application example 7, the effect of inhibiting melanin of the repair cream prepared in application examples 6-7 is reduced compared with that of application examples 1-3, the ITA degree value change before and after use is small, the seaweed particles and the silk protein powder are not added in application example 10 at the same time to prepare the whitening agent, and the effects of the repair cream prepared in application examples 6-7, 10 and 1-3 are compared, so that the seaweed particles and the silk protein have better synergistic effects, can act together, and the effects of inhibiting melanin synthesis, improving skin color and moisturizing and whitening of the repair cream are improved.

In application example 8, lemon peel and seaweed particles are not added at the same time, in application example 9, silk protein powder and lemon peel are not added at the same time, and comparison of detection results of application example 5, application example 6 and application example 8 shows that the lemon peel and seaweed particles have stronger synergistic effects, and can effectively increase the effects of whitening, brightening skin and inhibiting melanin synthesis of the repair cream; as can be seen from comparison of the detection results of application examples 5, 7 and 9, the silk protein powder and the seaweed particles have a strong synergistic effect, and can increase the effects of the repair cream on inhibiting melanin synthesis and brightening skin.

The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.

Claims

1. The plant composition with the anti-allergy relieving effect is characterized by comprising the following raw materials in parts by weight: 10 parts of gentian, 5 parts of rosemary, 15 parts of mint, 25 parts of betaine, 12 parts of spiraea, 20 parts of stephania tetrandra, 20 parts of scutellaria baicalensis, 10 parts of caffeine and 20 parts of plant microcapsules;

the preparation method of the plant microcapsule comprises the following steps:

pulverizing 0.4kg of rhizoma Polygoni Cuspidati, and sieving to obtain rhizoma Polygoni Cuspidati fine powder; cleaning and drying 1.2kg of purslane and 1.1kg of sage, pulverizing, and sieving for use; cleaning 0.4kg of cactus and 0.7kg of ginger, and crushing for later use; melting fish skin gelatin at 27deg.C;

mixing cactus and ginger, adding 1.5kg of fishskin gelatin, uniformly mixing, introducing supercritical carbon dioxide for extraction, wherein the flow rate of the supercritical carbon dioxide is 20L/h, the extraction pressure is 15MPa, the extraction temperature is 30 ℃, the extraction time is 2.5h, and the decompression separation is carried out to obtain a first mixed extract, adding 2.5kg of tremella extract, 1.2kg of hydrolyzed eggshell membrane powder and 0.75kg of auxiliary materials into the first mixed extract, and uniformly mixing the auxiliary materials by adopting woodchuck oil and chamomile extract with the mass ratio of 1:0.8 to obtain a wall material;

Mixing herba Portulacae, herba Salvia officinalis and rhizoma Polygoni Cuspidati, extracting with supercritical carbon dioxide under 20MPa at 55deg.C at 20L/h, vacuum separating to obtain core material solution, and concentrating under reduced pressure to relative density of 1.1 to obtain core material;

introducing supercritical carbon dioxide into the wall material, spraying the wall material on the core material, wherein the spraying pressure is 7MPa, the spraying temperature is 60 ℃, and the mass ratio of the supercritical carbon dioxide to the wall material is 1:0.05;

the preparation method of the tremella extract comprises the following steps: pulverizing Tremella, adding onion juice and zymophyte, mixing, fermenting at 35deg.C for 72 hr, centrifuging the fermentation liquid, collecting supernatant, and inactivating at high temperature to obtain Tremella extractive solution with the mass ratio of onion juice, zymophyte and Tremella of 0.3:0.01:1; the fermentation bacteria are acetobacter xylinum and lactobacillus casei with the mass ratio of 1:0.2, the high-temperature inactivation temperature is 120 ℃, the inactivation time is 25min, and the concentration of acetobacter xylinum and lactobacillus casei is 1.0x10 ⁶ CFU/mL；

The hydrolyzed eggshell membrane powder is prepared by the following steps: crushing 10kg of eggshells, adding 240L of water with concentration, adding 24L of 36% acetic acid, preserving heat at 45 ℃ for 1.5 hours, standing for 24 hours at normal temperature, filtering, washing with water, drying at 60 ℃ for 1.5 hours, chopping, adding 10L of 20% sulfuric acid, heating to 80 ℃ for reflux extraction for 5 hours, adding 3kg of calcium carbonate, filtering, spray drying, crushing to 1um, and obtaining hydrolyzed eggshell membranes;

The preparation method of the plant composition with the anti-allergy relieving effect comprises the following steps:

s1, crushing 10kg of gentian, 20kg of stephania tetrandra and 20kg of radix scutellariae, adding water 2 times of the total weight of the medicinal materials and cellulase 0.01 times of the total weight of the medicinal materials, soaking, decocting for 1 time and 3 hours each time, filtering, combining the filtrates, retaining filter residues, concentrating the filtrate under reduced pressure to obtain an aqueous extract, wherein the enzyme activity of the cellulase is 2 ten thousand u/g;

2. Use of a phytochemical composition with anti-allergic and soothing effects according to claim 1 in the preparation of cosmetics.

3. The use of a plant composition with antiallergic soothing effect according to claim 2, characterized in that said cosmetic is a repair cream comprising the following raw materials in weight percentage: phase A: 3-4% of cetostearyl alcohol, 5.5-6.5% of glycerol stearate, 1-1.5% of stearic acid, 5-6% of caprylic triglyceride, 1.5-2% of mineral oil, 2-3% of isopropyl palmitate and 2-3% of polydimethylsiloxane; and B phase: 2-3% of EDTA disodium, 4.5-5.5% of glycerol, 0.1-0.3% of p-hydroxyacetophenone and the balance of water; and C phase: 5-10% of whitening agent, 1.5-2% of 1, 2-hexanediol and 5-10% of plant composition with anti-allergy and relieving effects; the whitening agent is prepared from the following components in parts by weight: 2.3-5 parts of lemon peel extract, 1.2-2 parts of silk protein powder and 1-2 parts of seaweed particles.

4. The use of a plant composition with antiallergic soothing effect according to claim 3, characterized in that the preparation method of the repair cream is as follows: mixing the B phase raw materials, stirring and heating to 80-85 ℃, homogenizing, preserving heat for 8-12min, mixing the A phase raw materials, stirring and heating to 75-80 ℃, dispersing uniformly, mixing the A phase raw materials and the B phase raw materials, stirring and homogenizing, preserving heat for 8-10min, cooling to 55-60 ℃, adding the mixed C phase raw materials, stirring and homogenizing, preserving heat for 3-7min, cooling to 40 ℃, adjusting the pH value to 5.5-6.5, filtering, discharging, and obtaining the repair cream.