CN107854367A - A kind of Essence for sensitive skin reparation - Google Patents
A kind of Essence for sensitive skin reparation Download PDFInfo
- Publication number
- CN107854367A CN107854367A CN201711369856.6A CN201711369856A CN107854367A CN 107854367 A CN107854367 A CN 107854367A CN 201711369856 A CN201711369856 A CN 201711369856A CN 107854367 A CN107854367 A CN 107854367A
- Authority
- CN
- China
- Prior art keywords
- skin
- essence
- weight
- parts
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000037307 sensitive skin Effects 0.000 title claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 50
- 239000000419 plant extract Substances 0.000 claims abstract description 43
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 33
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 26
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 26
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940106189 ceramide Drugs 0.000 claims abstract description 19
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 18
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 18
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 18
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000002537 cosmetic Substances 0.000 claims abstract description 14
- 208000003251 Pruritus Diseases 0.000 claims abstract description 13
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 10
- 206010015150 Erythema Diseases 0.000 claims abstract description 10
- 229960000458 allantoin Drugs 0.000 claims abstract description 10
- 230000008591 skin barrier function Effects 0.000 claims abstract description 10
- 108010020346 Polyglutamic Acid Proteins 0.000 claims abstract description 9
- 231100000321 erythema Toxicity 0.000 claims abstract description 9
- 229920002643 polyglutamic acid Polymers 0.000 claims abstract description 9
- 239000008280 blood Substances 0.000 claims abstract description 7
- 210000004369 blood Anatomy 0.000 claims abstract description 7
- 230000008439 repair process Effects 0.000 claims abstract description 7
- 230000003712 anti-aging effect Effects 0.000 claims abstract description 6
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 6
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 6
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 6
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 5
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 5
- 230000000172 allergic effect Effects 0.000 claims abstract description 5
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 5
- 208000010668 atopic eczema Diseases 0.000 claims abstract description 5
- 238000006243 chemical reaction Methods 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- 239000000284 extract Substances 0.000 claims description 35
- 239000002994 raw material Substances 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 13
- 240000005528 Arctium lappa Species 0.000 claims description 10
- 235000003130 Arctium lappa Nutrition 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000003921 oil Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 4
- 235000008078 Arctium minus Nutrition 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 208000009766 Blau syndrome Diseases 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 230000001815 facial effect Effects 0.000 claims description 2
- 239000004816 latex Substances 0.000 claims description 2
- 229920000126 latex Polymers 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 238000002390 rotary evaporation Methods 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 230000003266 anti-allergic effect Effects 0.000 abstract description 28
- 230000003020 moisturizing effect Effects 0.000 abstract description 26
- 241000196324 Embryophyta Species 0.000 abstract description 23
- 241000233866 Fungi Species 0.000 abstract description 19
- 235000001855 Portulaca oleracea Nutrition 0.000 abstract description 19
- 244000246386 Mentha pulegium Species 0.000 abstract description 17
- 235000016257 Mentha pulegium Nutrition 0.000 abstract description 17
- 235000004357 Mentha x piperita Nutrition 0.000 abstract description 17
- 235000001050 hortel pimenta Nutrition 0.000 abstract description 17
- 230000001151 other effect Effects 0.000 abstract description 5
- 244000234609 Portulaca oleracea Species 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 52
- 230000000694 effects Effects 0.000 description 23
- 241000219304 Portulacaceae Species 0.000 description 18
- 238000012360 testing method Methods 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 8
- 241000205585 Aquilegia canadensis Species 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 238000013329 compounding Methods 0.000 description 5
- 230000001139 anti-pruritic effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000010408 film Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 241000246044 Sophora flavescens Species 0.000 description 3
- 239000002390 adhesive tape Substances 0.000 description 3
- 239000003908 antipruritic agent Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000002085 irritant Substances 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 2
- 244000077995 Coix lacryma jobi Species 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 244000170916 Paeonia officinalis Species 0.000 description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 description 2
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 description 2
- 240000007509 Phytolacca dioica Species 0.000 description 2
- 208000002474 Tinea Diseases 0.000 description 2
- 241000893966 Trichophyton verrucosum Species 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000002804 anti-anaphylactic effect Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 101100248237 Arabidopsis thaliana RH34 gene Proteins 0.000 description 1
- 244000003416 Asparagus officinalis Species 0.000 description 1
- 235000005340 Asparagus officinalis Nutrition 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 244000025596 Cassia laevigata Species 0.000 description 1
- 235000006693 Cassia laevigata Nutrition 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 241000208690 Hamamelis Species 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 241001598107 Imperata Species 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 101100125689 Oryza sativa subsp. japonica EIF4A3B gene Proteins 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000001643 allantois Anatomy 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940055416 blueberry extract Drugs 0.000 description 1
- 235000019216 blueberry extract Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229940038487 grape extract Drugs 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229940064064 purslane extract Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 229940124513 senna glycoside Drugs 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000004347 surface barrier Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to daily cosmetics field, is related to a kind of plant extract composition and the Essence containing the plant extract composition.Described plant extract composition contains purslane, white fungus, peppermint, radix glycyrrhizae, and said composition has prominent moisturizing and antiallergic effect.Described Essence contains afore-mentioned plants extractive composition, ceramide, Sodium Hyaluronate, polyglutamic acid, trehalose, allantoin, the Essence has the reaction such as erythema, itch when alleviating skin allergic state, repair sensitive skin damaged skin barrier, dispel red blood silk, improve elasticity of skin, anti-aging, anti-oxidant and other effects.
Description
Technical field
The invention belongs to daily cosmetics field, is related to a kind of anti-with erythema, itch etc. when alleviating skin allergic state
Should, sensitive skin damaged skin barrier is repaired, dispels red blood silk, improves elasticity of skin, the essence of anti-aging, anti-oxidant and other effects
Magnificent liquid.
Background technology
Sensitiveness skin is the skin that a kind of height does not tolerate, and is easily produced by the excitation of various factors：It is subjective
Symptom：Shouting pain, burn, be tight, itch etc.；Its nbjective symptom：Slight erythema, telangiectasis, furfur, dry skin.
According to《Chinese sensitive specialist common recognition》Version in 2017, sensitiveness skin are in the incidence of Asia women
40%-55.98%.Although wherein Chinese women incidence is less than average level, also reach 36.1%, that is every three
In Chinese women, there is a sensitive flesh.
The characteristics of sensitive skin：Skin barrier destruction, epidermis is thin, congested, there is red blood silk；The hydration levels of cuticula are low,
Complete sebum film can not be formed, skin has easily dried scurf, and the autumn and winter, more so skin lacked gloss, low and deep；During seasonal law,
For example between autumn and winter, spring and summer, the unstable situation of skin aggravates；Easily receive ultraviolet, cold wind, high temperature, water quality, animal wool, essence,
The influence of pigment etc.；Using general class cosmetics, the easy allergy generation of skin is red, swollen, shouting pain, itch occurs.
It has been reported that a variety of natural plant extracts have antiallergic of releiving, histamine release is reduced, anti-inflammatory anti-irritant, is repaired
Sensitive skin damaged skin barrier, free radical and other effects is removed, and in cosmetics.As patent CN104940093A is disclosed
Using the cosmetics of kuh-seng water extract, the total water extract of alate senna leaf as antianaphylaxis components.Patent CN101810794A, which is disclosed, to be adopted
It is used to prepare cosmetics with natural extract oat, lalang grass rhizome, windproof and radix glycyrrhizae combination.Patent CN103520061A, which is disclosed, to be adopted
It is used to prepare shin moisturizer with compositions such as peony essential oil, peony seeds essential oil 1-3 parts, Paeonol, asparagus juices.
Even disclosed a variety of tool natural plant extracts have antiallergic effect, but single group in the prior art
Divide effect limited, so in the prior art typically effect can be strengthened in the form of compounding.However, different extracted form natural plant
When liquid compounds, when some components compound, the superposition of antiallergic effect can be brought；During some component compoundings, antiallergic effect can be brought
Antagonism, when some components compound, then it can bring the collaboration of antiallergic effect.
The content of the invention
It is an object of the invention to provide a kind of extracted form natural plant composition for collecting antiallergic and releiving with moistening effect one.
The present invention also aims to provide a kind of Essence for sensitive skin reparation, it, which has, repairs sensitive skin
Damaged skin barrier, dispel the effect of red blood silk.
It is anti-oxidant the present invention also aims to provide a kind of improvement elasticity of skin, improve the colour of skin, the elite of anti-aging
Liquid.
The present invention also aims to provide a kind of Essence without preservative.
The above-mentioned purpose of the present invention is realized by following technological means：
On the one hand, the invention provides a kind of extracted form natural plant composition, said composition to contain following parts by weight
Raw material：
As preferred embodiment, the extracted form natural plant composition contains the raw material of following parts by weight：
As preferred embodiment, the extracted form natural plant composition contains the raw material of following parts by weight：
On the other hand, present invention also offers the preparation method of above-mentioned extracted form natural plant composition, this method include with
Under in step：
S1：Each raw material is weighed by the parts by weight of above-mentioned natural plant extracts, is ground into powder；
S2：Powder is crossed into 50 mesh sieves, with discarding liquid after soaked in absolute ethyl alcohol 10-30 minutes；
S3:Decolourize；Preferably, it is repeated 3 times decolouring；
S4：According to material-water ratio 1：80-100 extracts 5-7h in 85-95 DEG C of water-bath, is persistently stirred in extraction process,
Mixing speed is 1000~2000rpm/S, then filtering and collecting filter liquid；Preferably, at least repeat extraction twice, merge filter
Liquid；
S5：The concentration of filtrate rotary evaporation removes most water, such as from about 85-95% water；Preferably, 90% is removed
Water；
90% water；
S6：Raw material water extract is obtained after vacuum freeze drying.
The extracted form natural plant composition (purslane, white fungus, peppermint, radix glycyrrhizae) of the present invention has antiallergic of releiving, reduction group
Amine discharges, anti-inflammatory anti-irritant, repairs sensitive skin damaged skin barrier, removes the multiple efficacies such as free radical.Although existing skill
In art, disclose and reported various plants extract and have the function that antiallergic is releived, still, be verified by experiments, different days
During right plant extracts compounding, its antiallergic of different combinations effect of releiving assumes a marked difference.Inventor has screened largely
The natural herb extract that the conventional antiallergic of clinic is releived, including：Purslane, white fungus, peppermint, radix glycyrrhizae, kuh-seng, folium artemisiae argyi, gold and silver
Flower, great burdock achene, ginseng, green tea, coix seed etc..In the natural herb extract that these conventional clinics are releived with antiallergic,
Find to inventor's unobviousness, when four kinds of purslane, white fungus, peppermint, radix glycyrrhizae component proportions together when, its alleviation is quick
Feel skin the fash such as scratchiness, regression erythema the effect of with other component proportions relatively have obvious otherness, show this four
Individual component combination, has very prominent antianaphylactic effect.
In addition, making us pleasantly surprised and it was unexpected that purslane, not only antiallergic effect of releiving is dashed forward for the combination of white fungus, peppermint, radix glycyrrhizae
Go out, its moistening effect also combines with other has significant difference.Such combine for preparing a cosmetics is that extremely have
Sharp and rare, because demand of the consumer to cosmetics at present is mainly moisturizing moisturizing, for sensitive flesh, with greater need for guarantor
Wet moisturizing.And the natural plant extracts of the present invention not only have prominent antiallergic effect of releiving, also there is prominent moisturizing work(
Effect.
On the other hand, present invention also offers above-mentioned extracted form natural plant composition to prepare the application of cosmetics.It is described
Cosmetics such as creams class, type of latex type, oils, toner class or facial mask class.
On the other hand, present invention also offers above-mentioned extracted form natural plant composition to prepare answering for external application antiallergy medicine
With.
On the other hand, the invention provides the Essence containing above-mentioned extracted form natural plant composition, it contains following heavy
Measure the component of number：
Described plant extract composition contains the raw material of following parts by weight：
As preferred embodiment, Essence of the invention, it contains the component of following parts by weight：
Described plant extract composition contains the raw material of following parts by weight：
Preferably, described Essence contains the component of following parts by weight：
Described plant extract composition contains the raw material of following parts by weight：
As preferred embodiment, in above-mentioned Essence, described ceramide in Cer EOS -6 one
Kind or several combinations.As preferred embodiment, described ceramide is selected from Cer EOS, Cer NP, nerve
The combination of acid amides 6；Further, described ceramide is selected from 0.5-5 part Cer EOSs, the Cer NP of 0.1-2 parts and
The combination of 0.1-0.5 part Cer APs.Ceramide, it is the repairing great master of keratoderma：Skin barrier is improved in maintenance；Increase
The bonding force of strong skin keratin confluent monolayer cells, improves and dries furfur；Calm anti-inflammatory, alleviate skin erythema, red blood silk；It is lasting for skin
Keep the skin wet；Form moisture film and pin deep layer moisture；Increase the thickness of epidermis, strengthen skin elasticity, delay skin aging；Repair
Fragile skin quality is damaged, after beauty invasive surgery, after laser operation.Cer EOS, sebum film is protected, lifts skin surface barrier function,
Reduce the loss of moisture；Cer NP, maintains skin water conservation degree, reconstituted cell adhesion, and rapid maintenance is dried and impaired flesh
Skin；Cer AP, cutin metabolism is helped, promote skin smooth, tender.The combination of these three ceramides possesses good water
Dissolubility and stability.
As preferred embodiment, in above-mentioned Essence, described Sodium Hyaluronate is selected from middle molecular weight hyaluronic acid
One or more combination in sodium, micromolecule hyaluronic acid sodium and small numerator sodium hyaluronate；The more preferably combination of three.Its
In, middle numerator sodium hyaluronate, which has, to compact and moisture-keeping efficacy, micromolecule hyaluronic acid sodium can be absorbed with rapid transdermal, supplements cutin
The moisture of layer, the absorption of small molecule, moisturizing moisturizing effect are stronger.Three, which cooperates, can significantly strengthen moisturizing and moisturizing
Effect.Further, the molecular weight of middle numerator sodium hyaluronate is 1000000~18000000Da, micromolecule hyaluronic acid sodium
Molecular weight be 400000~10000000Da, the molecular weight of small numerator sodium hyaluronate is 100000~4000000Da.More
Further, middle numerator sodium hyaluronate, the ratio of weight and number of micromolecule hyaluronic acid sodium and small numerator sodium hyaluronate are
1-3:1-3:1-3；It is preferred that 1:1:1.
In the Essence of the present invention, wherein polyglutamic acid has natural moisture preserving, improves skin-nourishing, adjusts skin elasticity,
Promote cell metabolism, and ultraviolet can be absorbed and alleviate detrimental effect of the solar radiation to skin；Trehalose energy moisturizing, antioxygen
Change, anti-aging, antiultraviolet sunburn and other effects.Allantoin can keep moisture of skin, maintain the physiological equilibrium of skin moisture, alleviate
Stimulation of the active matter to skin, and can gently handle skin keratin so that skin smooth and plump.
The Essence of the present invention passes through specific natural plants combined extracts and ceramide, Sodium Hyaluronate, poly- paddy
The compatibility of propylhomoserin, allantoin etc., can dramatically increase moisture of skin, and adjustment skin can be effectively increased skin in water and oil balance state
The elasticity of skin.In an embodiment of the present invention, Essence of the invention lifts up to about 5 times to moisture content of skin, and compares
Then no significant difference, the lifting to skin oil content are also higher than contrast groups for group (pure water group).
It is worth noting that, inventor has been surprisingly found that in R＆D process, when specific plant extracts and ceramide,
Sodium Hyaluronate, polyglutamic acid, allantoin, especially specified plant extract and the common compatibility of ceramide, Sodium Hyaluronate
When, the effect for antiallergic of being releived to skin, than alone plant extracts, or alone ceramide, Sodium Hyaluronate, polyglutamic acid,
The effect of allantoin will be stronger.However, at present in research, not yet it has been found that plant extract composition (purslane, white fungus,
Peppermint, radix glycyrrhizae) there is the effect of prominent antiallergic of releiving, inflammation-resisting itch-stopping, although they have antiallergic effect by independent report.
And antiallergic effect of releiving of the component compounding such as plant extract composition collaboration ceramide, Sodium Hyaluronate is better than plant extract
Thing is in itself.
Except said components, the present invention can also contain additive and/or other active materials, as long as do not influence the present invention
The property of Essence and the material of effect.
Described additive including but not limited to：Thickener, buffer, film forming agent, NMF, spices, pigment, anti-corrosion
Agent, penetration-assisting agent, solvent, emulsifying agent, cleaning agent, solubilizer, sun-screening agent, antioxidant or free radical scavenger, chelating agent etc..
Described active material including but not limited to：Shrubby sophora extract, Folium Artemisiae Argyi extract, Honegsukle flower P.E, great burdock achene
Extract, Gotu Kola P.E, hamamelis extract, marine algae extract, ginseng extract, green-tea extract, coix seed extraction
Thing, yeast extract, blueberry extract, extractive of perilla, gadol extract, Punica granatum L. extract, grape extract etc..
As a preferred embodiment, in the Essence of the present invention, also include in described plant extract composition
Shrubby sophora extract 1-5 parts.
As another preferred embodiment, in Essence of the invention, also wrapped in described plant extract composition
Include Folium Artemisiae Argyi extract 1-5 parts.
As another preferred embodiment, in Essence of the invention, also wrapped in described plant extract composition
Include Honegsukle flower P.E 1-3 parts.
As another preferred embodiment, in Essence of the invention, also wrapped in described plant extract composition
Include burdock extract 1-3 parts.
As preferred embodiment, in Essence of the invention, in described plant extract composition, including it is following
Raw material：Purslane 12.5-17.5 parts, white fungus 10-15 parts, radix glycyrrhizae 6-8 parts, peppermint 1-3 parts, shrubby sophora extract 1.5-3 parts, folium artemisiae argyi
Extract 1.5-3 parts, Honegsukle flower P.E 1-2 parts, burdock extract 1-2 parts.
On the other hand, present invention also offers a kind of method for preparing Essence, it is characterised in that comprises the steps of：
(1) deionized water is heated to 80-90 DEG C, sequentially adds Sodium Hyaluronate, polyglutamic acid, trehalose, allantoin,
Stirring and dissolving is complete, agitation revolution 3000-9000rpm.
(2) 50-60 DEG C to be cooled to, ceramide is added, stirring and dissolving is complete.
(3) wait to be cooled to 40 DEG C, add plant extract composition, stirring and dissolving is complete.
The Essence of the present invention can be used directly, can also steep face paper use.
The beneficial effect that the present invention obtains：
1) present invention is by the clinical conventional antiallergic herbaceous plant of screening, unexpectedly finds purslane, white fungus, thin
Lotus, the compatibility of radix glycyrrhizae can play good antiallergic anti-inflammatory effect.In numerous extracted form natural plant compositions, said composition warp
Scientific matching is crossed, modern extraction process, it shows significantly to repair sensitive skin impaired barrier, alleviates sensitive skin for each
Kind stimulates former caused stimulation and condition susceptible, and said composition is with prominent moisture-keeping function.
2) present invention is by natural plant extracts purslane, white fungus, peppermint, the radix glycyrrhizae of particular combination, with ceramide,
The compatibility of Sodium Hyaluronate, polyglutamic acid, allantoin etc., prepare erythema when one kind can alleviate skin allergic state, itch
Deng reaction, sensitive skin damaged skin barrier is repaired, dispels the Essence of red blood silk and other effects.The Essence is releived the work(of antiallergic
Effect is not to have benefited from one-component such as Purslane extract, but has benefited from the plant extract composition that selects of the present invention and a variety of
The compatibility of composition.
3) present inventors have unexpectedly found that, specific plant extracts and ceramide, Sodium Hyaluronate, polyglutamic acid, allantois
Element, during the common compatibility of especially specific plant extracts and ceramide, Sodium Hyaluronate, the work for antiallergic of being releived to skin
With the effect than alone plant extracts, or alone ceramide, Sodium Hyaluronate, polyglutamic acid, allantoin will be stronger.
4) Essence of the invention can significantly improve moisture content of skin, and after, moisture content of skin is improved to administration
About 5 times.
5) Essence of the invention also has, and improves elasticity of skin, improves the colour of skin, smooth skin quality, anti-aging, anti-oxidant
Deng the effect of.
6) Essence of the present invention does not stimulate gently：It contains substantial amounts of natural constituents, and remaining component does not also stimulate gently,
Without preservative, without essence.
Brief description of the drawings
Moisturizing rate-time graph in Fig. 1 embodiments 2.
Embodiment
Technical scheme is further illustrated below by way of specific embodiment, specific embodiment is not represented to this hair
The limitation of bright protection domain.Some nonessential modifications and adjustment that other people are made according to theory of the present invention still fall within this hair
Bright protection domain.
The extracted form natural plant composition of embodiment 1
The extracted form natural plant composition (parts by weight) of table 1
| Raw material | Combination 1 | Combination 2 | Combination 3 | Combination 4 | Combination 5 |
| Purslane | 10 | 15 | 20 | 12 | 16 |
| White fungus | 20 | 18 | 10 | 16 | 14 |
| Peppermint | 1 | 3 | 2 | 4 | 5 |
| Radix glycyrrhizae | 8 | 5 | 9 | 10 | 6 |
The preparation method of above-mentioned extracted form natural plant composition：
After weighing each raw material by the parts by weight of upper table 1, powder is ground into, crosses 50 mesh sieves.By the powder of sieving with anhydrous
Ethanol discards liquid after soaking 15 minutes, and is repeated 3 times and is decolourized.After decolouring, raw material is moved into large beaker respectively, according to material
Water is than 1：90 extract 6h (lasting stirring, revolution 1000-2000rpm/S) in 90 DEG C of water-bath, are collected after filtered through gauze
Filtrate, filter residue extract 2 times again in this way.Then all filtrates are transferred in round bottom beaker carried out with Rotary Evaporators it is dense
90% is removed after contracting.Raw material water extract is finally obtained after vacuum freeze drying.
The plant extract composition screening experiment of embodiment 2
1. experiment material
1.1 raw materials and reagent
Purslane, white fungus, peppermint, radix glycyrrhizae, kuh-seng, folium artemisiae argyi, honeysuckle, great burdock achene are purchased from the attached south of Nanfang Medical Univ
Square Chinese medicine pharmacy of hospital.Absolute ethyl alcohol, anhydrous calcium chloride, Ph test paper, equal Guangzhou Yue Can laboratory apparatus Co., Ltd；It is medical
Gas adhesive tape, the chain big pharmacy of health care hall.
1.2 instrument
Rotary Evaporators (RE5203 types, Shanghai Yarong Biochemical Instrument Plant), electric furnace, transformer, culture dish (please by 6cm, Guangzhou
Bright laboratory apparatus Limited Liability public affairs color), big small beaker, evaporating dish, drier, glass bar.
2. experimental method and experimental result
2.1 medicines extract the preparation of concentrate
According to orthogonal arrage (table 2 and table 3, as follows), the material powder of 50 mesh sieves will be crossed with after soaked in absolute ethyl alcohol 15 minutes
Discard, and be repeated 3 times and decolourized.After decolouring, raw material is moved into large beaker respectively, according to material-water ratio 1：90 in 90 DEG C of water-bath
6h (lasting stirring) is extracted in pot, through gauze filtering and collecting filter liquid, filter residue extracts 2 times again in this way.Then will be all
Filtrate is transferred to concentrated in round bottom beaker with Rotary Evaporators after remove most of water.Finally after vacuum freeze drying
Obtain raw material water extract.
Using deionized water as object of reference, pass through orthogonal experimental method, the moisturizing of the extraction concentrate to various drug ratios
Rate is measured, and is finally drawn moisturizing rate-time graph, is compared and draw optimum proportioning；
The measure of 2.2 moisturizing rates
20 a diameter of 6cm culture dish is taken, bottom is attached to breathable adhesive tape with the actual conditions of simulated skin, according to just
Table numbering is handed over, is divided into 10 groups, every group sets two parallel laboratory tests, and blank control group is set with distilled water.Precision weighing extract solution 3-
6g, it is uniformly coated on breathable adhesive tape, distilled water is directly poured into culture dish, is placed in a drier at room temperature, is done
Saturation CaCl is placed with dry device2Solution (RH 34%), culture dish lid is opened, covers drier, and start timing, every
1h, 1h, 1h, 3h, 6h, 12h, 12h measure the weight of culture dish, calculate its moisturizing rate, draw moisturizing rate-time graph, analysis
Show that optimal drug matches.Moisturizing rate calculation formula is as follows：
Moisturizing rate=Mt/M0× 100%
In formula Mt be place t hours after sample quality, g；Mo be place before sample quality, g.
The exploration orthogonal arrage of 2.3 medicine optimum proportionings
The empirical factor water-glass of table 2
The orthogonal array of table 3
The moisturizing rate of the 1st, 2,3,4,5,6,7,8,9 group and blank group is tested, every group sets a parallel group, draws moisturizing
Rate-time graph.
3. experimental result
The experimental result of 3.1 medicine optimum proportionings
It can be drawn by moisturizing rate-time graph (Fig. 1), in RH34% environment, the moisturizing rate of each experimental group is obvious
Higher than blank control group, wherein the 3rd group of moisturizing rate highest, the 7th group of moisturizing rate is minimum, the optimum proportioning of medicine is purslane,
White fungus, peppermint, radix glycyrrhizae, in 24 hours one day, its moisturizing rate is all remarkably higher than other combinations for the combination, in addition to the 7th group, remaining
Then moisturizing rate difference is little for group.
4. experiment conclusion
This experimental exploring purslane, white fungus, peppermint, the replenishing water and preserving moisture of this group of composition of radix glycyrrhizae, by L9 (33) just
Experiment is handed over to show that purslane, white fungus, peppermint, radix glycyrrhizae are optimum proportioning.
The plant composition anti-irritant of embodiment 3 is tested
1 testing data
1.1 general information observation groups totally 60, it is the aspiration that Nanfang Medical Univ (former No.1 Military Medical Univ.) recruits
Person, 6 groups are randomly divided into, every group of 10 people, 5 groups of data are statistically analyzed, and difference there are no significant meaning (P ＞ 0.05), are had
Comparativity.
1.2 inclusive criterias select 18 years old~30 years old crowd, male or female.
1.3 exclusion standards exclude chronic eczema, ringworm of the body；Gestation or women breast-feeding their children；It is associated with liver, angiocardiopathy
Person；Malignant tumor patient；Stop treatment during treatment or change medicine, method person；Curative effect or data can not be judged, and umbra does not ring
Curative effect judgement person.
2. the situation of packet, each test group, the parts by weight of its raw material are from left to right followed successively by 20 parts, 10 parts, 5 parts, 5
Part；Blank group is the deionized water of 40 parts by weight, and each group raw material see the table below 4.
Component used in each group of table 4
| Test group 1 | Purslane, white fungus, peppermint, radix glycyrrhizae |
| Test group 2 | Kuh-seng, folium artemisiae argyi, honeysuckle, great burdock achene |
| Test group 3 | Purslane, kuh-seng, honeysuckle, radix glycyrrhizae |
| Test group 4 | Kuh-seng, white fungus, peppermint, great burdock achene |
| Test group 5 | Purslane, white fungus, honeysuckle, great burdock achene |
| Blank group | Deionized water |
3. experimental method：Using 5% tartaric acid as stimulus, stimulate left forearm to bend side skin to erythema, then smear and contain
The Essence of 20% plant society extract of the present invention, disappear respectively in 6h, 12h, 24h, 48,72h observation erythemas, and
Itch alleviates degree.
4. experimental result is shown in Table 5
Situation, test group 1- are alleviated for the itch after artificial treatment and fash by different ratio observation of plant composition
5 groups of alleviations for itch relatively have significant difference (* * P ＜ 0.01, * P ＜ 0.05), the wherein difference of test group 1 with blank group
The opposite sex becomes apparent from (* * P ＜ 0.01)；The regression fash of test group 1 and 2 relatively has significant difference (* P ＜ 0.05) with blank group.Survey
Although that is more effective for deflorescence for examination group 1, its antipruritic effect is poor.
Although natural plant extracts such as purslane, white fungus, peppermint, radix glycyrrhizae, kuh-seng, folium artemisiae argyi, honeysuckle, great burdock achenes,
It can be used as antiallergy raw material through being reported in the prior art, and in order to strengthen antianaphylactic effect, frequently with a variety of natural plants
Thing extract compounds.Releived effect however, different plant extracts assembled scheme compoundings show different enhancing antiallergics
Ability, wherein, the plant extract composition of test group 1 of the invention, purslane, white fungus, peppermint, the combination synthesis of radix glycyrrhizae are stopped
Itch, the deflorescence time, and moistening effect, it is most preferably to combine.
54 groups of clinical rehabilitation situations of table compare h
Compared with control group, * * P ＜ 0.01, * P ＜ 0.05
The Essence of embodiment 4
The Essence of table 6 (parts by weight)
Continued 6 (parts by weight)
The preparation method of above-mentioned Essence：Deionized water is heated to 80-90 DEG C, sequentially adds Sodium Hyaluronate, poly- paddy
Propylhomoserin, trehalose, allantoin, stirring and dissolving is complete, agitation revolution 3000-9000rpm.50-60 DEG C to be cooled to, add god
It is complete through acid amides, stirring and dissolving.Wait to be cooled to 40 DEG C, add plant extracts, stirring and dissolving is complete.(said components are as combined
In be not not required to then add)
The clinical observation of the water of embodiment 5 oil, elastic force and anti-inflammatory anti-itch
1 clinical data
1.1 general information observation groups totally 150, it is the attached south doctor of Nanfang Medical Univ (former No.1 Military Medical Univ.)
The volunteer that institute's TCM surgery outpatient service in January, 2015~2017 year August is recruited.It is randomly divided into 6 groups, treatment group 1 totally 25, wherein
Man 10, female 15；It is 18~42 years old age, average 26.3 years old；Treatment group 2 totally 25, wherein man 14, female 11；Age 20
It is~45 years old, average 29.7 years old；Treatment group 3 totally 25, wherein man 14, female 11；It is 20~45 years old age, average 29.7 years old；Control
Treatment group 4 totally 25, wherein man 12, female 13；It is 18~43 years old age, average 27.3 years old；Treatment group 5 totally 25, wherein man 11
Example, female 114；It is 19~45 years old age, average 28.6 years old；Control group 25, wherein man 15, female 10,22~44 years old age,
Average age 30.9 years old.6 groups of data are statistically analyzed, and difference there are no significant meaning (P ＞ 0.05), have comparativity.
1.2 inclusive criterias select 18 years old~45 years old crowd, male or female.Made with sensitive skin or hypersensitivity status skin
To be preferred.
1.3 exclusion standards exclude chronic eczema, ringworm of the body；Gestation or women breast-feeding their children；It is associated with liver, angiocardiopathy
Person；Malignant tumor patient；Stop treatment during treatment or change medicine, method person；Curative effect or data can not be judged, and umbra does not ring
Curative effect judgement person.
2 treatment methods
2.1
The combination 7 in the embodiment of the present invention 4 is given by treatment group 1；
The combination 12 in the embodiment of the present invention 4 is given by treatment group 2；
The combination 15 in the embodiment of the present invention 4 is given by treatment group 3；
The combination 17 in the embodiment of the present invention 4 is given by treatment group 4；
The combination 18 in the embodiment of the present invention 4 is given by treatment group 5；
Control group external application deionized water；
Each 1ml, 2 times a day, external application.Result is observed after 4 weeks.
2.2 statistical method is examined using T.
3 efficacy analysis
3.1 tester：Skin water oil tester (Xing Lin Internet technologies Co., Ltd, the patent No.：CN:
205514533U)
3.2 method of testings it is all test constant temperature, constant humidity room in carry out, temperature (22 ± 1) DEG C, humidity (50 ±
5) %.The person of being observed before the treatment, treatment 4 weeks after, under quiescent condition, respectively detect forehead, cheek moisture of skin, oil and
Elastic force, each site tests 2 times, averages.During observation, all objects of observation are without using other increase moisture of skin
The product of oil content.
3.3 treatment results 1 are shown in Table 7.
Add plant extracts in Essence to improve significantly for the performance of Essence, except treatment group 5 and control group
Outside, treatment group 1-4 water, oil, elastic force before the treatment after variant (P<0.05), i.e., treatment group 1-4 water, oil, elastic force are being controlled
Increased after treatment.Especially prominent is treatment group 2, and moisture content of skin improves to before about treating 5 times and carried after treatment group 2 treats
Rise, especially have significant difference (P at the aspect that keeps the skin wet with treatment group 3<0.01), in addition, treatment group 2 is for elastic force and grease
Lifting, apparently higher than other treatment group, its good effect is not the effect of having benefited from single plant extracts yet, but
Have benefited from the compatibility of whole composition.Water, grease, the elastic force of control group compare indifference (P afterwards before the treatment>0.05).
The treatment group of table 7 and the pretherapy and post-treatment skin of face property situation of control group
Compared with control group, * * P ＜ 0.01, * P ＜ 0.05
3.4 treatment results 2 are shown in Table 8
1,2,4,5 antipruritic, deflorescence number of days for the treatment of group and control group comparing difference have significant (* * P ＜
0.01, * P ＜ 0.05), show that plant extracts of the addition with antiallergic effect in cosmetics, can assign cosmetics antiallergic work(
Effect.Wherein the antipruritic number of days for the treatment of group 2 and other treatment group and control group relatively have more obvious difference (* * P ＜ 0.01),
Meanwhile its deflorescence time and control group have significant difference, and treatment group 3 (being free of plant extracts) antipruritic and fash
Disappear with control group comparing difference without significant (P ＞ 0.05).6 groups are relatively shown in Table 8.
86 groups of clinical rehabilitation situations of table compare day
Compared with control group, * * P ＜ 0.01, * P ＜ 0.05
4 conclusions
By clinical observation, it was demonstrated that the Essence assembles ratio entirely, can not only strengthen the hydrauture of cuticula, adjustment skin is in water
Oily poised state, the elasticity of skin can be effectively increased；And the antiallergic that can releive, erythema, itch etc. are anti-when alleviating skin allergic state
Should, repair sensitive skin damaged skin barrier.
Claims (10)
- A kind of 1. plant extract composition, it is characterised in that the raw material containing following parts by weight：
- 2. composition as claimed in claim 1, it is characterised in that the raw material containing following parts by weight：Preferably, the raw material containing following parts by weight：
- 3. the preparation method of the composition described in claim 1 or 2, it is characterised in that comprise the steps of：S1：Each raw material is weighed by the parts by weight in claim 1 or 2, is ground into powder；S2：Powder is crossed into 50 mesh sieves, with discarding liquid after soaked in absolute ethyl alcohol 10-30 minutes；S3:Decolourize；Preferably, it is repeated 3 times decolouring；S4：According to material-water ratio 1：80-100 extracts 5-7h in 85-95 DEG C, is persistently stirred in extraction process, mixing speed 1000 ~2000rpm/S, then filtering and collecting filter liquid；Preferably, at least extraction is repeated twice, merging filtrate；S5：The concentration of filtrate rotary evaporation removes 85-95% water；Preferably, 90% water is removed；S6：Raw material water extract is obtained after vacuum freeze drying.
- 4. application of the composition of claim 1 or 2 in cosmetics or medicine are prepared；Preferably, described cosmetics are creams class, type of latex type, oils, toner class or facial mask class；Preferably, described medicine is external preparation for skin medicine.
- A kind of 5. Essence, it is characterised in that the component containing following parts by weight：Described plant extract composition contains the raw material of following parts by weight：
- 6. Essence as claimed in claim 5, it is characterised in that the component containing following parts by weight：Described plant extract composition contains the raw material of following parts by weight：Preferably, described Essence contains the component of following parts by weight：Described plant extract composition contains the raw material of following parts by weight：
- 7. the Essence as described in claim 5 or 6, it is characterised in that it is a kind of that described ceramide is selected from Cer EOS -6 Or several combinations；It is preferred that the combination of Cer EOS, Cer NP, Cer AP；It is highly preferred that described ceramide is selected from 0.5-5 part Cer EOSs, the Cer NP of 0.1-2 parts and 0.1-0.5 parts The combination of Cer AP.
- 8. the Essence as described in claim 5 or 6, it is characterised in that described Sodium Hyaluronate is selected from middle molecule hyalomitome One or more combination in sour sodium, micromolecule hyaluronic acid sodium and small numerator sodium hyaluronate；It is preferred that the combination of three；It is highly preferred that the parts by weight of middle numerator sodium hyaluronate, micromolecule hyaluronic acid sodium and small numerator sodium hyaluronate Than for 1-3:1-3:1-3；Ratio of weight and number even more preferably from three is 1:1:1；It is more preferred still that the molecular weight of middle numerator sodium hyaluronate is 1000000~18000000Da, micromolecule hyaluronic acid sodium Molecular weight be 400000~10000000Da, the molecular weight of small numerator sodium hyaluronate is 100000~4000000Da.
- 9. the Essence as described in claim 5 or 6, it is characterised in that described plant extract composition also carries including kuh-seng Take thing 1.5-3 parts, Folium Artemisiae Argyi extract 1.5-3 parts are a kind of or several in Honegsukle flower P.E 1-2 parts and burdock extract 1-2 parts Kind.Preferably, erythema, itch reaction, repair sensitive skin and are damaged skin when described Essence is used to alleviate skin allergic state Skin barrier, dispels red blood silk, improves elasticity of skin, anti-aging, anti-oxidant.
- A kind of 10. method for preparing Essence, it is characterised in that comprise the steps of：(1) deionized water is heated to 80-90 DEG C, sequentially adds Sodium Hyaluronate, polyglutamic acid, trehalose, allantoin, stirred Dissolving is complete, agitation revolution 3000-9000rpm；(2) 50-60 DEG C to be cooled to, ceramide is added, stirring and dissolving is complete；(3) 40-50 DEG C to be cooled to, plant extract composition is added, stirring and dissolving is complete.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711369856.6A CN107854367B (en) | 2017-12-19 | 2017-12-19 | Essence for repairing sensitive skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711369856.6A CN107854367B (en) | 2017-12-19 | 2017-12-19 | Essence for repairing sensitive skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107854367A true CN107854367A (en) | 2018-03-30 |
| CN107854367B CN107854367B (en) | 2020-11-10 |
Family
ID=61706469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711369856.6A Active CN107854367B (en) | 2017-12-19 | 2017-12-19 | Essence for repairing sensitive skin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107854367B (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007516A (en) * | 2016-12-30 | 2017-08-04 | 佛山市康伲爱伦生物技术有限公司 | A kind of antiallergic prescription containing plant extracts |
| CN108524381A (en) * | 2018-07-16 | 2018-09-14 | 广东卓明仕生物科技有限公司 | It is a kind of to be used to repair composition of skin barrier and its preparation method and application |
| CN109010169A (en) * | 2018-08-28 | 2018-12-18 | 安徽科技学院 | A kind of preparation method of chu chrysanthemum eye cream |
| CN109674679A (en) * | 2019-01-28 | 2019-04-26 | 贝德氏（上海）健康科技股份有限公司 | A kind of skin barrier maintenance biomembrane and preparation method thereof |
| CN109966218A (en) * | 2019-03-09 | 2019-07-05 | 邹红媚 | A kind of production technology for moving back red toner conducive to skin |
| CN110742834A (en) * | 2019-11-29 | 2020-02-04 | 西安博和医疗科技有限公司 | Skin repair composition and preparation method thereof |
| CN110974763A (en) * | 2019-12-31 | 2020-04-10 | 广州重生化妆品实业有限公司 | All-natural plant anti-allergy repair essence and preparation method thereof |
| CN111494299A (en) * | 2020-05-26 | 2020-08-07 | 佛山市谷邦生物科技有限公司 | Ceramide compound muscle-calming repair factor and emulsion thereof |
| CN111759759A (en) * | 2020-06-04 | 2020-10-13 | 山东哈工生物科技有限公司 | Anti-allergy soothing mask |
| CN112656731A (en) * | 2021-01-08 | 2021-04-16 | 珠海伊斯佳科技股份有限公司 | Composition with red-repairing effect and preparation method and application thereof |
| CN112691069A (en) * | 2021-01-22 | 2021-04-23 | 上海加新生物科技有限公司 | Plant composition with anti-allergy and relieving effects and preparation method and application thereof |
| CN112891271A (en) * | 2021-02-01 | 2021-06-04 | 广州君研生物科技有限公司 | Composition for sensitive muscle barrier repair and application of composition in skin care product |
| CN113069389A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Liquorice anti-allergy repair essence and preparation method thereof |
| CN113069387A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Anti-fatigue mask and preparation method thereof |
| CN113350232A (en) * | 2020-03-05 | 2021-09-07 | 株式会社现代百朗德 | Cosmetic composition for skin protection and irritation relief containing mixed extract of purslane, mugwort leaf and rhodiola rosea as active ingredient |
| CN113425638A (en) * | 2021-06-24 | 2021-09-24 | 广东丸美生物技术股份有限公司 | Method for customizing and repairing sensitive muscle |
| CN115804744A (en) * | 2022-12-27 | 2023-03-17 | 广州研智化妆品有限公司 | Essence capable of reducing skin pruritus and erythema |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120033377A (en) * | 2010-09-30 | 2012-04-09 | 이상수 | Method for producing functional cosmetic composition and the cosmetic |
| CN104490717A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Hyaluronic acid hydrating mask essence and preparation method thereof |
| CN105769654A (en) * | 2016-03-02 | 2016-07-20 | 名臣健康用品股份有限公司 | Anti-sensitivity skin-care composition and application thereof to cosmetics |
| CN105997793A (en) * | 2016-06-21 | 2016-10-12 | 张信环 | Mask and preparation method thereof |
| CN106074315A (en) * | 2016-08-24 | 2016-11-09 | 广东芭薇生物科技股份有限公司 | A kind of facial mask liquid with multiple skin-care effect and preparation method thereof |
| CN106333885A (en) * | 2016-08-25 | 2017-01-18 | 广州睿森生物科技有限公司 | Plant extract and eye essence liquid |
| CN106606452A (en) * | 2017-01-10 | 2017-05-03 | 广州源理生物科技有限公司 | Essence capable of adjusting moisture-oil balance and whitening skin |
-
2017
- 2017-12-19 CN CN201711369856.6A patent/CN107854367B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120033377A (en) * | 2010-09-30 | 2012-04-09 | 이상수 | Method for producing functional cosmetic composition and the cosmetic |
| CN104490717A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Hyaluronic acid hydrating mask essence and preparation method thereof |
| CN105769654A (en) * | 2016-03-02 | 2016-07-20 | 名臣健康用品股份有限公司 | Anti-sensitivity skin-care composition and application thereof to cosmetics |
| CN105997793A (en) * | 2016-06-21 | 2016-10-12 | 张信环 | Mask and preparation method thereof |
| CN106074315A (en) * | 2016-08-24 | 2016-11-09 | 广东芭薇生物科技股份有限公司 | A kind of facial mask liquid with multiple skin-care effect and preparation method thereof |
| CN106333885A (en) * | 2016-08-25 | 2017-01-18 | 广州睿森生物科技有限公司 | Plant extract and eye essence liquid |
| CN106606452A (en) * | 2017-01-10 | 2017-05-03 | 广州源理生物科技有限公司 | Essence capable of adjusting moisture-oil balance and whitening skin |
Non-Patent Citations (4)
| Title |
|---|
| 王久红等: "《皮肤病常用中药药理及临床》", 31 October 2017, 中国科学技术出版社 * |
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社出版 * |
| 陪冈: "《带着我去化妆台柜台》", 31 December 2009, 新世界出版社 * |
| 马振友等: "《皮肤美容化妆品制剂手册》", 31 March 2004, 中医古籍出版社 * |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107007516A (en) * | 2016-12-30 | 2017-08-04 | 佛山市康伲爱伦生物技术有限公司 | A kind of antiallergic prescription containing plant extracts |
| CN108524381A (en) * | 2018-07-16 | 2018-09-14 | 广东卓明仕生物科技有限公司 | It is a kind of to be used to repair composition of skin barrier and its preparation method and application |
| CN108524381B (en) * | 2018-07-16 | 2020-11-27 | 广东卓明仕生物科技有限公司 | Composition for repairing skin barrier and preparation method and application thereof |
| CN109010169A (en) * | 2018-08-28 | 2018-12-18 | 安徽科技学院 | A kind of preparation method of chu chrysanthemum eye cream |
| CN109674679A (en) * | 2019-01-28 | 2019-04-26 | 贝德氏（上海）健康科技股份有限公司 | A kind of skin barrier maintenance biomembrane and preparation method thereof |
| CN109966218A (en) * | 2019-03-09 | 2019-07-05 | 邹红媚 | A kind of production technology for moving back red toner conducive to skin |
| CN110742834A (en) * | 2019-11-29 | 2020-02-04 | 西安博和医疗科技有限公司 | Skin repair composition and preparation method thereof |
| CN110974763A (en) * | 2019-12-31 | 2020-04-10 | 广州重生化妆品实业有限公司 | All-natural plant anti-allergy repair essence and preparation method thereof |
| CN113069389A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Liquorice anti-allergy repair essence and preparation method thereof |
| CN113069387A (en) * | 2020-01-06 | 2021-07-06 | 广州樱奈儿化妆品有限公司 | Anti-fatigue mask and preparation method thereof |
| CN113350232A (en) * | 2020-03-05 | 2021-09-07 | 株式会社现代百朗德 | Cosmetic composition for skin protection and irritation relief containing mixed extract of purslane, mugwort leaf and rhodiola rosea as active ingredient |
| CN111494299A (en) * | 2020-05-26 | 2020-08-07 | 佛山市谷邦生物科技有限公司 | Ceramide compound muscle-calming repair factor and emulsion thereof |
| CN111759759A (en) * | 2020-06-04 | 2020-10-13 | 山东哈工生物科技有限公司 | Anti-allergy soothing mask |
| CN112656731A (en) * | 2021-01-08 | 2021-04-16 | 珠海伊斯佳科技股份有限公司 | Composition with red-repairing effect and preparation method and application thereof |
| CN112691069A (en) * | 2021-01-22 | 2021-04-23 | 上海加新生物科技有限公司 | Plant composition with anti-allergy and relieving effects and preparation method and application thereof |
| CN112691069B (en) * | 2021-01-22 | 2023-06-06 | 上海加新生物科技有限公司 | Plant composition with anti-allergy relieving effect and preparation method and application thereof |
| CN112891271A (en) * | 2021-02-01 | 2021-06-04 | 广州君研生物科技有限公司 | Composition for sensitive muscle barrier repair and application of composition in skin care product |
| CN113425638A (en) * | 2021-06-24 | 2021-09-24 | 广东丸美生物技术股份有限公司 | Method for customizing and repairing sensitive muscle |
| CN115804744A (en) * | 2022-12-27 | 2023-03-17 | 广州研智化妆品有限公司 | Essence capable of reducing skin pruritus and erythema |
| CN115804744B (en) * | 2022-12-27 | 2024-04-09 | 广州研智化妆品有限公司 | Essence capable of reducing skin itch and erythema |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107854367B (en) | 2020-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107854367A (en) | A kind of Essence for sensitive skin reparation | |
| CN111407719B (en) | Skin barrier repair compound, face cream and preparation method thereof | |
| CN112494406A (en) | Whitening and freckle-removing cosmetic and preparation method thereof | |
| CN108815081A (en) | A kind of sericin whitening moisturizing face masque liquid and preparation method thereof | |
| CN105726439B (en) | Golden cicada spends skin whitening, moisturizing medicine cosmetic and preparation method thereof | |
| CN108653129B (en) | Skin dressing containing natural plant anti-allergy composition | |
| CN110974758A (en) | Moisture mask and preparation method thereof | |
| CN108888562A (en) | A kind of eye mask and preparation method thereof | |
| CN115317429A (en) | Composition containing recombinant collagen and having repairing and relieving effects, eye cream containing composition, preparation method and application | |
| CN108670933B (en) | Skin care composition with moisturizing, whitening and anti-aging functions and application thereof | |
| CN108619083A (en) | A kind of medical reparation dressing of skin and preparation method thereof | |
| CN109568159A (en) | Cosmetic composition and its preparation method and application is repaired in a kind of whitening | |
| CN114099391A (en) | Cosmetic composition with whitening, moisturizing and antioxidant effects and preparation method thereof | |
| KR20100124132A (en) | Anti-wrinkle cosmetic composition containing oriental herb extract treated by enzyme and its extraction method | |
| CN104473798A (en) | Pseudo-ginseng skin toner and preparation method thereof | |
| CN115054566B (en) | Scalp aging resisting composition and preparation method thereof | |
| CN110559231A (en) | Whitening and freckle-removing essence and preparation method thereof | |
| CN108143652B (en) | Preparation method of composition with skin-care effect and preparation method of shower gel of composition | |
| CN110613663A (en) | Skin repairing composition, skin care product and preparation method thereof | |
| CN109692144A (en) | A kind of prunus glue surface film and preparation method thereof | |
| CN112370404B (en) | Moisturizing and whitening composition, and preparation method and application thereof | |
| CN114848569A (en) | Formula and preparation method of hair loss prevention and hair nourishing product | |
| CN104053425A (en) | Dermocosmetic compositions based on synergistic combination of colloidal silver and deoxyribonucleic acid | |
| CN102961275A (en) | Araliaceae Acanthopanax trifoliatus ethanol extract-containing skin cosmetic | |
| CN106420991A (en) | Skin care massage oil containing tea tree essential oil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240112 Address after: Room 3003, No. 13-1 Hai'an Road, Tianhe District, Guangzhou City, Guangdong Province, 510000 (Location: K) Patentee after: Glami (Guangzhou) Biotechnology Co.,Ltd. Address before: Room 1004, No. 140-148 Tiyu East Road, Tianhe District, Guangzhou City, Guangdong Province, 510000 Patentee before: GUANGZHOU YUANLI BIOTECHNOLOGY CO.,LTD. |
|
| TR01 | Transfer of patent right |