CN107281418B - Pharmaceutical composition and preparation method and application thereof - Google Patents
Pharmaceutical composition and preparation method and application thereof Download PDFInfo
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- CN107281418B CN107281418B CN201710476767.5A CN201710476767A CN107281418B CN 107281418 B CN107281418 B CN 107281418B CN 201710476767 A CN201710476767 A CN 201710476767A CN 107281418 B CN107281418 B CN 107281418B
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Abstract
The invention provides a pharmaceutical composition, which is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of gordon euryale seed, 0.5-1.5 parts of Chinese yam, 0.05-0.15 part of lotus seed, 0.1-1 part of lily, 0.5-1.5 parts of angelica dahurica, 0.5-1.5 parts of fingered citron, 0.1-1 part of perilla leaf, 0.1-1 part of mint, 0.05-0.15 part of fermented soybean, 0.5-1.5 parts of platycodon grandiflorum, 0.05-0.15 part of coix seed, 0.1-1.5 parts of Chinese date, 0.005-0.02 part of phaseolus calcaratus, 0.05-0.15 part of dried orange peel, 0.005-0.02 part of white hyacinth bean, 0.05-0.15 part of malt, 0.05-0.15 part of pummelo peel, 0.05-0.15 part of hawthorn and 0.05-0.15 part of peach seed. The invention also provides a preparation method and application of the composition. The composition of the invention has obvious effects of clinically relieving or treating the respiratory system diseases of children and protecting the spleen and stomach, and has good application prospect.
Description
Technical Field
The invention relates to a pharmaceutical composition, a preparation method and application thereof.
Background
With the development of social economy and the conception of prepotency, children's health is the focus of attention. Respiratory and digestive diseases are common morbidity trends in children. In addition, for children with weak spleen and stomach, respiratory tract infection usually causes digestive system problems directly, such as gastrointestinal type common cold in children. The nose is the first line of the respiratory tract, 1 item of epidemiological investigation on western regions shows that the incidence rate of allergic rhinitis accounts for more than 30 percent, and then retrospective analysis of national allergic rhinitis within 10 years shows that the incidence rate is in a stable state. Allergic rhinitis is an allergic disease caused by a sensitization source and caused by inflammatory factors released by an immune system, is closely related to infantile asthma, and is discovered in early researches that the incidence rate of the infantile asthma suffering from the allergic rhinitis is higher than that of other infants suffering from the allergic rhinitis. Furthermore, with the opening of the two-fetus policy and the development of medical technology, the number of cesarean section is increasing year by year, and 1 in the recent epidemiological investigation of the jinmei on allergic rhinitis and asthma of the cesarean section and children patients, the cesarean section is related to allergic rhinitis and asthma of children, and the children patients with family allergy history are more obvious. Children with respiratory diseases are large in number and are easily accompanied by digestive diseases.
With the development of social economy, the acceleration of urbanization and environmental pollution, allergic diseases of children tend to increase year by year, allergic rhinitis is manifested by a large amount of watery nasal discharge, sneezing and the like, and diseases such as chronic rhinosinusitis, nasal polyp and the like can be caused by delayed period. Influences intelligence development and physical development, children suffer from rhinitis for a long time, and respiratory obstruction can lead the brain to lack of oxygen to cause dizziness, lethargy, concentration failure, learning achievement reduction and the like, and has obvious influence on the brain of the children, including cognitive ability, memory and psychological activities. In addition, children can breathe with the mouth due to unsmooth expiration, and pharyngitis is caused by direct stimulation to the pharyngeal cavity, so that the lips of the children are thickened, teeth grow outwards, and face deformity is caused. While western medicine mainly treats allergic rhinitis of children with symptomatic treatment such as antihistamine, hormone, decongestant and the like, the long-term repeated use of the western medicine can cause adverse reactions such as nasal concha atrophy, nasal cavity dryness and the like. The traditional Chinese medicine has good treatment effect on allergic rhinitis and chronic rhinosinusitis and has no other side effect.
The traditional Chinese medicine of the constitution of children considers that the children are easy to be deficient and easy to be excessive, and easy to be cold and easy to be hot, and the children cannot express the disease, so that the pediatrics is called as the dumb department, the excessive syndrome of the disease occurs rapidly, and the deficient disease can be diagnosed only by carefully discovering that a doctor looks through the body, but cannot be treated rapidly. Therefore, the prevention of the disease before onset is more important in pediatrics than the treatment of the disease immediately. And the guidelines of western medicine on respiratory diseases such as allergic rhinitis and asthma are turned over to eliminate allergens, and the western medicine is mainly used for symptomatic treatment. And allergic diseases occur repeatedly, and are mostly taken for a long time, and children are difficult to take medicine, and atomization and the like are often not matched, so that effective treatment is difficult.
In the domestic market, products aiming at the weakness of the spleen and the stomach of children such as 'fat baby powder' and 'spleen-strengthening paste' exist, but the products only aim at children with the weakness of the spleen and the stomach, but cannot be used for children with the symptoms of the weakness of the spleen and the stomach, which are affected by respiratory diseases and lung qi weakness, and at present, products for performing long-term intervention on allergic rhinitis and chronic rhinosinusitis of children are lacked.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition capable of relieving or/and treating respiratory system diseases of children, giving consideration to spleen and stomach transportation and transformation, and treating the problems of lung qi obstruction, nasal obstruction and spleen and stomach weakness of children, and a preparation method and application thereof. The invention provides a pharmaceutical composition.
The invention provides a pharmaceutical composition, which is prepared from the following raw materials in parts by weight:
0.5-1.5 parts of gordon euryale seed, 0.5-1.5 parts of Chinese yam, 0.05-0.15 part of lotus seed, 0.1-1 part of lily, 0.5-1.5 parts of angelica dahurica, 0.5-1.5 parts of fingered citron, 0.1-1 part of perilla leaf, 0.1-1 part of mint, 0.05-0.15 part of fermented soybean, 0.5-1.5 parts of platycodon grandiflorum, 0.05-0.15 part of coix seed, 0.1-1.5 parts of Chinese date, 0.005-0.02 part of phaseolus calcaratus, 0.05-0.15 part of dried orange peel, 0.005-0.02 part of white hyacinth bean, 0.05-0.15 part of malt, 0.05-0.15 part of pummelo peel, 0.05-0.15 part of hawthorn and 0.05-0.15 part of peach seed.
The composite material is prepared from the following raw materials in parts by weight:
1 part of gordon euryale seed, 1 part of Chinese yam, 0.1 part of lotus seed, 0.5 part of lily, 0.5 part of angelica dahurica, 0.5 part of fingered citron, 0.5 part of perilla leaf, 0.2 part of mint, 0.1 part of fermented soybean, 1 part of platycodon grandiflorum, 0.1 part of coix seed, 0.1 part of Chinese date, 0.01 part of red bean, 0.1 part of dried orange peel, 0.01 part of white hyacinth bean, 0.1 part of malt, 0.1 part of pummelo peel, 0.1 part of hawthorn and 0.1 part of peach seed.
Wherein the yam is dioscorea opposita; the dried orange peel is fried dried orange peel; the malt is fried malt; the fructus crataegi is parched fructus crataegi.
Wherein, the oral preparation is prepared by taking crude medicinal powder of the raw materials, or water or organic solvent extract as an active ingredient, and adding acceptable auxiliary materials or auxiliary ingredients into the active ingredient to prepare a common oral preparation.
Wherein the oral preparation is paste, granules, powder, tablets, capsules and oral liquid.
The granule is prepared from the following raw and auxiliary materials in parts by weight:
1 part of gordon euryale seed, 1 part of common yam rhizome, 0.1 part of lotus seed, 0.5 part of lily, 0.5 part of angelica dahurica, 0.5 part of fingered citron, 0.5 part of perilla leaf, 0.2 part of mint, 0.1 part of fermented soybean, 1 part of platycodon root, 0.1 part of coix seed, 0.1 part of Chinese date, 0.01 part of red bean, 0.1 part of fried dried orange peel, 0.01 part of white hyacinth bean, 0.1 part of fried malt, 0.1 part of pummelo peel, 0.1 part of scorched hawthorn fruit, 0.1 part of peach kernel, 7 parts of cooked rice flour and 2 parts of white granulated sugar.
The invention also provides a preparation method of the composition, which is prepared by powdering the raw materials, or adding water or organic solvent for extraction, and adding acceptable auxiliary materials or auxiliary components.
Wherein, it includes the following steps:
a) mixing semen euryales, rhizoma Dioscoreae, semen Nelumbinis, Bulbus Lilii, radix Angelicae Dahuricae, fructus Citri Sarcodactylis, folium Perillae, herba Menthae, semen Sojae Preparatum, radix Platycodi, Coicis semen, fructus Jujubae, semen Phaseoli, parched pericarpium Citri Tangerinae, semen lablab album, fructus Hordei Germinatus preparata, exocarpium Citri Grandis, fructus crataegi preparata, and semen Persicae, pulverizing into powder, and sieving;
b) b, baking, powdering and sieving rice, and mixing with the raw materials sieved in the step a;
c) adding white sugar or other acceptable adjuvants or auxiliary components, and making into common preparation.
The invention also provides application of the composition in preparing a medicine for relieving or/and treating respiratory system diseases, digestive system diseases and lung-spleen deficiency of children.
The invention also provides application of the composition in preparing a medicine for relieving or/and treating infantile rhinitis, nasosinusitis, repeated upper respiratory tract infection, inappetence and night cry and night convulsion.
The children's viscera qi clearing-away medicine is pure yang body, easy to be deficient and easy to be excessive, easy to be cold and easy to be hot, the inherent kidney qi is insufficient, the lung defense is weakened, the acquired transportation and transformation are lost, the wind evil is externally infected, and the nasal orifice is obstructed. For improvement of nasal diseases of children, the traditional Chinese medicine composition starts from three aspects of lung, spleen and kidney, strengthens spleen, assists transportation and transformation, strengthens lung to resist exogenous pathogenic factors, and tonifies kidney and nourishes innate. The gorgon fruit is sweet and neutral in nature and enters spleen and kidney meridians in order to tonify spleen to check diarrhea, astringe kidney to arrest spontaneous emission. The theory of Su Wen and Ci Fang (Su Wen & Ci Fang) is: … is sweet and mild in flavor to make the spleen excess. Rhizoma dioscoreae is sweet and neutral, and the book 1 from Shen nong Ben Cao Jing means that it is a medicine for treating injury, tonifying deficiency and nourishing essence …, tonifying middle-jiao and energy, growing muscle, and hearing and improving eyesight after being taken for a long time, and is a product for tonifying spleen and stomach, and the two medicines are monarch medicines together, and the angelica dahurica is pungent in flavor and warm in property and relieves exterior syndrome, and is capable of freeing and dredging nasal orifices. The fingered citron is pungent in flavor and capable of promoting the circulation of qi and eliminating dampness, the mint is capable of inducing resuscitation and refreshing mind, the perilla leaf is capable of promoting the circulation of meridian and channels and supporting yang and regulating qi, and the aromatic qi-flowing, the lung-strengthening and the nasal orifice-benefiting are combined to be used as ministerial drugs. Von Shi jin Mao Mi Lu (book of Shang Shi brocade secret records) 5 Jie Geng enters lung and can ascend and descend. Therefore, the platycodon root is used as an adjuvant drug for treating earth-forming metal caused by dispersing lung qi, promoting water passage and carrying various drugs upward, and the platycodon root is used for treating the earth-forming metal and is used as an adjuvant drug for treating the weather in the tunnel without worry of stuffiness and stuffiness. Lotus seed meat is sweet, mild and astringent, good at tonifying spleen and stomach, relieving diarrhea with astringents, and hawthorn fruit and malt have the effects of promoting digestion and resolving food stagnation, and can strengthen spleen, stimulate appetite and promote appetite when used together. Dolichos lablab seed, semen lablab album, radix et rhizoma Nardostachyos, semen coicis, semen. The medicines are combined to achieve the effects of dredging orifices, promoting qi circulation, warming yang and lung, invigorating spleen, removing food retention, harmonizing stomach, eliminating dampness and tonifying kidney qi. Thereby treating both principal and secondary aspects of diseases and improving the nasal diseases of children.
The composition provided by the invention can simultaneously improve respiratory system diseases of children such as allergic rhinitis, chronic rhinosinusitis, nasal obstruction and the like, repeated cold, asthma and the like, takes the functions of spleen and stomach into consideration, treats the problems of obstruction of lung qi and weakness of spleen and stomach of children, recovers the functions of spleen and stomach, is also effective in treating night cry and night fright symptoms of infants, and fills the market blank. The invention is composed of medicinal and edible traditional Chinese medicinal materials, has obvious clinical application effect, no other additives, safety and reliability, can be taken for a long time, conforms to the traditional eating habits of children, has good taste and high child acceptance, and also has the advantages of simple production process, low cost, convenient carrying and the like.
Detailed Description
The following examples are further illustrative, but the present invention is not limited to these examples.
EXAMPLE 1 preparation of a composition according to the invention
The prescription content is as follows: 1g of gordon euryale seed, 1g of common yam rhizome, 0.1g of lotus seed, 0.5g of lily, 0.5g of angelica dahurica, 0.5g of fingered citron, 0.5g of perilla leaf, 0.2g of mint, 0.1g of fermented soybean, 1g of platycodon root, 0.1g of coix seed, 0.1g of Chinese date, 0.01g of small red bean, 0.1g of fried dried orange peel, 0.01g of white hyacinth bean, 0.1g of fried malt, 0.1g of pummelo peel, 0.1g of scorched hawthorn fruit and 0.1g of peach seed.
The process comprises the following steps:
1. weighing the medicinal materials according to the prescription, spreading in an oven, preheating the oven, baking at 120 deg.C for 30min, turning over for 1 time every 10min to ensure the medicinal materials are baked uniformly, and taking out after the medicinal materials are slightly brown on the surface.
2. Taking out the baked medicinal materials, airing to normal temperature, pulverizing, and sieving with a 100-mesh sieve.
3. Baking rice at low temperature, pulverizing, sieving with 100 mesh sieve, and mixing with the medicinal powder at a certain proportion (7 g).
4. Mixing the sieved medicinal powder and cooked rice flour, and oven drying at 60-65 deg.C to avoid agglomeration of the medicinal powder or cooked rice flour.
5. Adding auxiliary materials of white granulated sugar: grinding white sugar with a grinding machine, sieving with 100 mesh sieve, and adding into the powder and rice flour at a dose of 2 g/day.
Clinically: 1 time in 1 day, 15-30 g in 1 time, and is dissolved in boiling water to be blended into paste for taking. Can be taken for a long time, and the shortest treatment course is 15 days.
Example 2 preparation of a composition according to the invention
Prescription: 0.5g of gordon euryale seed, 0.5g of Chinese yam, 0.05g of lotus seed, 0.1g of lily, 0.5g of angelica dahurica, 0.5g of fingered citron, 0.1g of perilla leaf, 0.1g of mint, 0.05g of fermented soybean, 0.5g of platycodon root, 0.05g of coix seed, 0.1g of Chinese date, 0.005g of phaseolus calcaratus, 0.05g of dried orange peel, 0.005g of white hyacinth bean, 0.05g of malt, 0.05g of pummelo peel, 0.15g of hawthorn and 0.15g of peach seed.
The preparation process comprises the following steps: the preparation process is the same as that of example 1.
EXAMPLE 3 preparation of the composition of the invention
Prescription: 1.5g of gordon euryale seed, 1.5g of Chinese yam, 0.15g of lotus seed, 1g of lily, 1.5g of angelica dahurica, 1.5g of fingered citron, 1g of perilla leaf, 1g of mint, 0.15g of fermented soybean, 1.5g of platycodon grandiflorum, 0.15g of coix seed, 1.5g of Chinese date, 0.02g of phaseolus calcaratus, 0.15g of dried orange peel, 0.02g of white hyacinth bean, 0.15g of malt, 0.15g of pummelo peel, 0.05g of hawthorn and 0.05g of peach seed.
The preparation process comprises the following steps: the preparation process is the same as that of example 1.
EXAMPLE 4 preparation of the composition of the invention
Prescription: the same prescription as in example 1.
The preparation process comprises the following steps: weighing the raw materials according to the prescription, crushing, sieving, adding 7g of cooked rice flour and 2g of white granulated sugar, uniformly mixing, and subpackaging to obtain the traditional Chinese medicine.
The advantageous effects of the present invention are specifically described below by way of test examples.
Test example 1 clinical observations of the pharmaceutical composition of the present invention
1. General data
59 cases of the infants are all the pediatric outpatients and inpatients of subsidiary hospitals of Chengdu Chinese medicine university, and meet the diagnosis standard established in the national small respiratory tract conference in 1987.
Diagnostic criteria:
repeating upper respiratory tract infection every year for 7 times in 0-2 years old;
② repeatedly upper respiratory tract infection for 6 times per year in 3-5 years old;
③ repeated upper respiratory tract infection for 6-14 years old every 5 times a year.
The concept of repetitive upper respiratory tract infections: repeated upper respiratory tract infection is mostly caused by virus infection, is an inflammatory reaction of repeated attacks of the upper respiratory tract, and clinical symptoms mainly include repeated fever, rhinorrhea, jet printing, cough, red throat, tonsil swelling and the like.
29 control cases, 1 case of abscission. 13 men and 14 women; the age is 6 months to 10 years old, the average age is 4.8 years old, and the number of attacks per year is 5 to 13. The treatment group comprises 30 cases, 16 cases of men and 14 cases of women, the age is 7 months-10 years, the average age is 5.2 years, and the number of attacks per year is 6-13. The disease course of the two groups is 0.4-2 years. The difference between the two groups of children patients in terms of sex, age and disease course has no statistical significance (P is less than 0.05), and the children patients have comparability.
2. Method of treatment
Control group: the symptomatic treatment (such as defervescence treatment, cough relieving, phlegm reducing, fluid infusion and the like, and the antibiotic treatment can be given under the condition of bacterial infection.
The treatment group is administered 1 bag each time and 1 time each day with boiled water for 3 months continuously under conventional treatment.
3. Standard of therapeutic effect
The effect is shown: in the latter half year after the treatment course of 3 months, the attack times are reduced by more than 2/3 compared with before treatment, the symptoms are obviously relieved during attack, and the treatment course is obviously shortened.
The method has the following advantages: after the 3-month treatment course, the disease incidence frequency in the latter half year is reduced by more than 1/2, the symptoms are relieved during disease incidence, and the treatment course is shortened.
And (4) invalidation: the frequency of disease onset after treatment is reduced to 1/2, and the symptoms and the treatment course are not obviously improved.
The total effective rate is significant effect plus effective.
4. Results
TABLE 1 comparison of treatment results of the treated groups with the control group
As can be seen from Table 1, the total effective rate of the treatment group using the pharmaceutical composition of the invention to the children recurrent respiratory tract infection is as high as 86.7%, which is significantly better than 55.5% of the control group, and the pharmaceutical composition of the invention has excellent treatment effect on the children recurrent respiratory tract infection.
Test example 2 sensory evaluation of the pharmaceutical composition of the present invention
Firstly, the taste is compared by adding different sugar
The product is a children product, no additive is recommended, and the composition prepared in the embodiment 1 of the invention is powder, is not suitable for being flavored by maltose and honey, and is added and compared with different types of sugar. 2g of white sugar, 2g of brown sugar and 2g of rock candy are added into the prescription amount per day respectively for comparing the taste, and the results are shown in a table 2.
Table 2 mouthfeel of products with different sugar additions
Therefore, the taste of the composition is greatly influenced by adding different kinds of sugar, wherein when 2g of white sugar is used, the taste is burnt after being mixed with boiled water, the white sugar is dark brown paste, the taste is fine and smooth, the fragrance is natural, the sweetness is slightly bitter, the taste is similar to that of sesame paste, and the taste is good; when other saccharides are added, the taste is not good, for example, brown sugar is added, and the taste is bitter; when crystal sugar is added, the taste is slightly bitter and sticky.
Secondly, the mouthfeel of the white sugar added with different dosages is compared
The product is a children product, does not suggest to use additives, is added with white sugar for flavoring, and simultaneously optimizes the addition amount of the white sugar. The original bitterness and sweetness of the sugar were compared by adding 0.5g, 1g, 1.5g, 2g, 2.5g of white sugar to the recipe one day, respectively, and the results are shown in Table 3.
Table 3 mouthfeel of products with different amounts of white sugar added
Therefore, different amounts of the white sugar have influence on the mouthfeel of the composition, wherein when 2g of the white sugar is used, the bitter taste disappears, the sweetness is proper, and the mouthfeel is optimal.
Therefore, the composition has good mouthfeel and is suitable for children.
In conclusion, the composition has reasonable compatibility, can be used for relieving various symptoms caused by respiratory system diseases of children, has obvious curative effect on repeated respiratory tract infection of children and has high clinical cure rate; the composition has good safety, good taste and high pediatric acceptance, and provides a new medicine selection for clinic.
Claims (6)
1. A pharmaceutical composition for alleviating or/and treating infantile respiratory system diseases is characterized in that: the traditional Chinese medicine composition is prepared into a common oral preparation by using crude drug powder of gordon euryale seed, Chinese yam, lotus seed, lily, angelica dahurica, finger citron, perilla leaf, mint, fermented soybean, platycodon grandiflorum, coix seed, Chinese date, phaseolus calcaratus, dried orange peel, white hyacinth bean, malt, pummelo peel, hawthorn and peach seed, or water or organic solvent extract as an active ingredient, and adding acceptable auxiliary materials or auxiliary ingredients;
the auxiliary materials or auxiliary components are cooked rice flour and white granulated sugar;
the weight ratio of the raw materials to the auxiliary materials is as follows: 1 part of gordon euryale seed, 1 part of Chinese yam, 0.1 part of lotus seed, 0.5 part of lily, 0.5 part of angelica dahurica, 0.5 part of fingered citron, 0.5 part of perilla leaf, 0.2 part of mint, 0.1 part of fermented soybean, 1 part of platycodon grandiflorum, 0.1 part of coix seed, 0.1 part of Chinese date, 0.01 part of red bean, 0.1 part of dried orange peel, 0.01 part of white hyacinth bean, 0.1 part of malt, 0.1 part of pummelo peel, 0.1 part of hawthorn, 0.1 part of peach kernel, 7 parts of cooked rice flour and 2 parts of white granulated sugar;
the Chinese yam is common yam rhizome; the dried orange peel is fried dried orange peel; the malt is fried malt; the fructus crataegi is parched fructus crataegi.
2. The composition of claim 1, wherein: the oral preparation is paste, granules, powder, tablets, capsules and oral liquid.
3. A process for preparing a composition according to claim 1 or 2, characterized in that: the preparation method is characterized by pulverizing the raw materials into powder, or adding water or an organic solvent for extraction, and adding acceptable auxiliary materials or auxiliary components for preparation.
4. A process for preparing a composition according to claim 3, characterized in that: it comprises the following steps:
a) mixing semen euryales, rhizoma Dioscoreae, semen Nelumbinis, Bulbus Lilii, radix Angelicae Dahuricae, fructus Citri Sarcodactylis, folium Perillae, herba Menthae, semen Sojae Preparatum, radix Platycodi, Coicis semen, fructus Jujubae, semen Phaseoli, parched pericarpium Citri Tangerinae, semen lablab album, parched fructus Hordei Germinatus, exocarpium Citri Grandis, fructus crataegi preparata, and semen Persicae, pulverizing into powder, and sieving;
b) b, baking, powdering and sieving rice, and mixing with the raw materials sieved in the step a;
c) adding white sugar or other acceptable adjuvants or auxiliary components, and making into common preparation.
5. Use of a composition according to claim 1 or 2 for the preparation of a medicament for the alleviation or/and treatment of respiratory disorders, digestive disorders, lung-spleen deficiency in children.
6. Use of a composition according to claim 1 or 2 for the manufacture of a medicament for the alleviation or/and treatment of recurrent upper respiratory infections in children.
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| CN102416038A (en) * | 2011-12-09 | 2012-04-18 | 上海市中医医院 | Chinese medicinal composition for treating infantile recurrent respiratory tract infection |
| CN103120793A (en) * | 2013-01-09 | 2013-05-29 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for preventing and treating recurrent respiratory tract infection of children and application thereof |
| CN103830481A (en) * | 2014-03-26 | 2014-06-04 | 杨巧芝 | Medicine for treating recurrent respiratory tract infection of children |
| CN105853486A (en) * | 2016-04-11 | 2016-08-17 | 韩秀华 | Traditional Chinese medicine preparation for treating children recurrent respiratory infection and preparation method and application thereof |
| CN106267052A (en) * | 2015-06-03 | 2017-01-04 | 天津药物研究院有限公司 | A kind of medicine treating infantile acute upper respiratory infection and preparation method thereof |
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| CN1947782A (en) * | 2006-08-16 | 2007-04-18 | 湖南科威制药有限公司 | Infantile health-care capsule prepn. method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416038A (en) * | 2011-12-09 | 2012-04-18 | 上海市中医医院 | Chinese medicinal composition for treating infantile recurrent respiratory tract infection |
| CN103120793A (en) * | 2013-01-09 | 2013-05-29 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for preventing and treating recurrent respiratory tract infection of children and application thereof |
| CN103830481A (en) * | 2014-03-26 | 2014-06-04 | 杨巧芝 | Medicine for treating recurrent respiratory tract infection of children |
| CN106267052A (en) * | 2015-06-03 | 2017-01-04 | 天津药物研究院有限公司 | A kind of medicine treating infantile acute upper respiratory infection and preparation method thereof |
| CN105853486A (en) * | 2016-04-11 | 2016-08-17 | 韩秀华 | Traditional Chinese medicine preparation for treating children recurrent respiratory infection and preparation method and application thereof |
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