CN103120793A - Traditional Chinese medicine composition for preventing and treating recurrent respiratory tract infection of children and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating recurrent respiratory tract infection of children and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating recurrent respiratory tract infection of children and application thereof. The composition comprises the following material medicines in parts by weight: 18-25 parts of white mustard seed, 40-60 parts of ginger, 18-25 parts of rhizoma corydalis, 1-3 parts of manchurian wildginger, 1-3 parts of euphorbia kansui root and 0.2-0.8 parts of borneol. Clinical tests prove that through applying the ointment of the traditional Chinese medicine composition provided by the invention to acupoints, the traditional Chinese medicine composition can be used for warming meridians, dispelling cold and eliminate phlegm, supporting the healthy energy and conditioning the viscera functions, and can be used for effectively reducing the time of the recurrent respiratory tract infection of children and the degree of the recurrent respiratory tract infection, thus being an effective method for preventing and treating the recurrent respiratory tract infection of children.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly Chinese medicine composition and the application thereof of a kind of prevention and treatment infantile respiratory tract infection repeatedly.
Background technology
Infantile respiratory tract infection repeatedly (RRTI) refers to that in the unit interval, upper lower respiratory infection shows effect repeatedly, surpasses a kind of clinical syndrome of stipulated number, and sickness rate is about 17.8% in recent years, belongs to " weakness type cold ", " deficiency syndrome " category in the traditional Chinese medical science.Its pathogeny still imperfectly understands, and majority think the immunologic hypofunction with congenital factors or body, and the shortage of trace element and vitamin is relevant, and immune factor lapses at disease progression and presents regular the variation in process.The traditional Chinese medical science thinks, the reason that forms primary disease mainly is the positive QI-insufficiency of children's, especially take lung, spleen, the dirty insufficiency of function of kidney three as main, say as Jiang Yuren professor institute, recurrent respiratory tract infection why, crucial " not heresy many and weakened body resistance ".Therefore adjust lung, spleen, the dirty function of kidney three, strengthening the body resistance is crucial for treatment.
Point application therapy is according to the traditional Chinese medical science " inner disease outer treat ", " midnight-noon and ebb-flow doctrine ", " correspondence between man and universe " theory, academic thought in conjunction with Huangdi's Internal Classics taking good care of YANG in spring and summer, taking good care of YIN in autumn and winter, dog days, a kind of traditional treatment means for the treatment of and preventing lung pattern disease with the external application of Chinese medicine specific acupuncture point when three nine-day periods after the winter solstice in midwinter have in full summer embodied the scientific idea of traditional Chinese medical science preventive treatment of disease." the large opinion of Plain Questions regulating life activities according to natural changes in four seasons " said: " sage's preventing diseases instead for the treatment of diseases hereat; do not control and disorderly control disorderly, this meaning is also ", so preventive treatment of disease is one of content of showing unique characteristics of Chinese medicine, be the basis of prevention with Chinese medicine medical science, and the sick protection in winter for the treatment of winter disease in summer, summer is the typical method of preventive treatment of disease.The acupuncture point note apply get annual just, in, treat the first day of the last period of the hot season, during dog days, sunlight is contained most, temperature is the highest, body space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation, Dog-day paste can up time be made use of momentum, the picked-up yang-energy, therefore strengthening the body resistance, can actively prevent and treat the cold syndrome in winter.Get annual one, two, three nine-day periods after the winter solstice and treat, adjustable moving body yang-energy is inspired healthy energy, unimpeded QI and blood, disease preventing and treating summer repeatedly.
Recurrent respiratory tract infection (recurrent respiratory tract infection, RRTI) is common disease in children, frequently-occurring disease, account for＜6 years old child 10%, especially be common in the child below 3 years old.Main manifestations is that repeatedly to occur upper and lower respiratory tract infection number of times in 1 year frequent, has surpassed normal range, has a strong impact on the physical and mental health of infant.It is a kind of outer treating method that tcm characteristic is arranged that the acupuncture point note applies, send out catching cold winter and summer the easy disease of outbreak repeatedly, respectively in dog days, the coldest days of winter, use the treatment means of the traditional Chinese medical science to treat, to reach strengthening the body resistance, reduce the purpose of morbidity, embodied traditional " preventive treatment of disease " thought of the traditional Chinese medical science.
Summary of the invention
The object of the invention is to provide Chinese medicine composition and the application thereof of a kind of prevention and treatment infantile respiratory tract infection repeatedly.
The present invention seeks to be achieved through the following technical solutions.
The crude drug of Chinese medicine composition of the present invention consists of:
Semen Sinapis Albae 18～25 weight portions, Rhizoma Zingiberis Recens 40～60 weight portions, Rhizoma Corydalis 18～25 weight portions, Herba Asari 1～3 weight portion, Radix Kansui 1～3 weight portion, Borneolum Syntheticum 0.2～0.8 weight portion.
The crude drug composition of Chinese medicine composition of the present invention is preferably:
Semen Sinapis Albae 22.5 weight portions, Rhizoma Zingiberis Recens 50 weight portions, Rhizoma Corydalis 22.5 weight portions, Herba Asari 2.1 weight portions, Radix Kansui 2.3 weight portions, Borneolum Syntheticum 0.5 weight portion.
The crude drug composition of Chinese medicine composition of the present invention is preferably:
Semen Sinapis Albae 20 weight portions, Rhizoma Zingiberis Recens 55 weight portions, Rhizoma Corydalis 20 weight portions, Herba Asari 2.5 weight portions, Radix Kansui 2 weight portions, Borneolum Syntheticum 0.7 weight portion.
The crude drug composition of Chinese medicine composition of the present invention is preferably:
Semen Sinapis Albae 24 weight portions, Rhizoma Zingiberis Recens 45 weight portions, Rhizoma Corydalis 24 weight portions, Herba Asari 1.7 weight portions, Radix Kansui 2.6 weight portions, Borneolum Syntheticum 0.3 weight portion.
Get traditional Chinese medicinal composition raw materials of the present invention, according to common process, add conventional adjuvant, can be prepared into clinical acceptable exterior-applied formulation, as ointment, spray, emplastrum, cataplasma, liniment etc.
Chinese medicine composition preferred dosage form of the present invention is ointment.
The preparation method of Chinese medicine composition ointment of the present invention (being named as in the present invention Semen Sinapis cough with asthma ointment) is:
Above Six-element is got Rhizoma Zingiberis Recens and is cleaned, and mashes, and adds water, and the squeezing extracting juice adds water and makes total amount become 500 parts by volume, adds carboxymethylstach sodium 10 weight portions, and heating makes dissolving, adds 5 weight portion polyoxyethylene sorbitan monoleates, makes emulsion standby; Semen Sinapis Albae, Rhizoma Corydalis, Herba Asari, Radix Kansui four flavors are ground into fine powder, and the Borneolum Syntheticum porphyrize is crossed 100 mesh sieves, with above-mentioned fine powder facing-up mixing, adds in emulsion to stir evenly, and grinds with colloid mill, makes altogether 1000 weight portion ointment, packing and get final product.
Wherein the Semen Sinapis Albae oiliness is large, is difficult for pulverizing and sieving, and needs parch in advance, take not burnt burnt for after degree, independent powder become coarse powder, then mixes with other medical material fine powder, pulverizes and sieves.
The unit corresponding relation of described weight portion/parts by volume is g/ ml.
The logical cold coagulation of Semen Sinapis Albae in Chinese medicine composition of the present invention, warming the lung for resolving phlegm, the hot temperature of Herba Asari is walked to alter, can eliminating phlegm promoting the circulation of QI eliminating stagnation, Radix Kansui eliminates the phlegm by drink, and all medicines match, can depressed lung-energy dispersing, the promoting the circulation of QI that eliminates the phlegm, cold expelling be by drink, again can the QI invigorating righting, treating both the principal and secondary aspects of a disease.Modern pharmacology proves, this medical instrument has good antiinflammatory, antiviral effect.Point application can improve the functional activity of body tissue, improves body constitution, strengthens immunologic function, improves the function of hypo_pit_adr cortex, and the treatment recurrent respiratory tract infection is had good efficacy.The acupuncture point note applies on the one hand by summer YANG QI tending to rise in nature, human body vigorous trend thereupon, and solidifying cold air-capacitor is easily discongested; Can lay in yang-energy for the autumn and winter again on the other hand, to dispel the heresy of haze, prevent disease is shown effect summer, thereby reaches the purpose of strengthening the body resistance.
The present invention finds by research, the point application of Semen Sinapis cough with asthma ointment can temperature three-way meridian, cold expelling eliminates the phlegm, strengthening the body resistance, adjust internal organs, effectively reduced the number of times of infant recurrent respiratory tract infection, and the degree of recurrent respiratory tract infection, compare that all there were significant differences (P＜0.05) before treatment with after treatment, obtained clinical efficacy preferably.This method is simple to operate, and infant is easy to accept, and compliance is good, has reduced the defective of extract oral bitter in the mouth, is one of effective ways for the treatment of infantile respiratory tract infection repeatedly.
Following experimental example and embodiment are used for further illustrating but being not limited to the present invention.
Experimental example: use Semen Sinapis cough with asthma ointment point-application to prevent and treat the infantile respiratory tract infection repeatedly clinical trial
One, clinical data
1. physical data
All patients are all from 2008-2010 Beijing University of Traditional Chinese Medicine Subsidiary Dongfang Hospital Pediatric Clinic, 2 ~ 12 years old age, infant 242 examples in 2008 wherein, male 116 examples, female's 130 examples, 4.25 ± 1.3 years old mean age; Infant 219 examples in 2009, male 123 examples, female's 96 examples, mean age 3.89 ± 1.62.187 examples in 2010, male 96 examples, female's 91 examples, mean age 4.24 ± 1.61.
2. diagnostic criteria
2.1 Western medicine diagnose standard: the diagnostic criteria of the recurrent respiratory tract infection that reference national infantile respiratory disease academic conference in 1987 is formulated: 0 ~ 2 years old age, annual 7 times of upper respiratory tract infection, annual 3 times of lower respiratory infection; 3 ~ 6 years old age, annual 6 times of upper respiratory tract infection, annual 2 times of lower respiratory infection; 6 ~ 12 years old age, annual 5 times of upper respiratory tract infection, (the 2nd distance of upper respiratory tract infection the 1st time is more than at least 7 d for annual 2 times of lower respiratory infection, if the respiratory tract infection number of times is inadequate, can add the lower respiratory infection number of times, otherwise not become, need to observe 1 year).
2.2 tcm diagnosis standard:
Be divided into three kinds of pattern of syndrome with reference to " Pediatrics of Chinese Medicine ": battalion defends and becomes estranged, deficiency of both lung and spleen, the weak bone of suffering from a deficiency of the kidney.
3. inclusive criteria
Select the age at 2 ~ 16 years old, be in the remission phase during treatment, do not use the infant of Chinese and western medicine immunomodulator in nearly 3 months.
4. exclusion standard
Suffer from the febris acuta disease during getting rid for the treatment of, just accepting 17-hydroxy-11-dehydrocorticosterone or other immunosuppressant treatment, with the heart, liver, kidney and hemopoietic system primary disease, PID, tuberculosis in children, respiratory tract, heart malformations person, psychosis infant and severe allergy gonosome matter and to known drug or component allergy sufferers stick position skin injury person.
Two, method
1. Therapeutic Method
Ointment forms: Semen Sinapis cough with asthma ointment (provided by the east Preparation Room in Hospital, be prepared from by embodiment 1 method) authentication code: capital medicine word Z20070006 processed.Make approximately 1.5 cm * 1.5 cm, the medicine cake of thick 0.5 cm is standby.
Stick the position: bilateral big vertebra, fei shu, region below the heart six acupuncture points.
Paste the medicine time: during 2008,2009,2010 " dog days " reach " three nine-day periods after the winter solstice ".Sticked in the 1st, 2,3 day in every " volt " and every " nine ".Each 2～4 hours.If skin rubefaction after pasting, local herpes, scorching hot, the symptom such as very itch should in time be taken off.
Applying method: stick the position routine disinfection, the medicine cake is affixed on the acupuncture point, with the desensitization immobilization with adhesive tape.
Points for attention after pasting: fasting is pungent, raw and cold, the delicious food savoury.Prohibit and to blow air-conditioning, take a cold bath etc.
2. observation index and method
Respectively carry out Effect of follow-up visit by telephone 3 times after annual summer, winter stick, estimate sticking rear 1 year internal respiration road infection number of times, attack degree, curative effect of disease, pattern of syndrome curative effect, Proportion.
3. curative effect judging standard
Draft according to the relevant criterion that national infantile respiratory disease academic conference is formulated.Produce effects: finish the course for the treatment of in 1 year, before attack times is treated, (compared with the same period of last year, lower same) reduces more than 2/3, and disease time obviously shortens; Effectively: finish the course for the treatment of in 1 year, attack times is treated front minimizing more than 1/ 2, and disease time shortens; Invalid: after treatment, attack times reduces less than 1/ 2, and disease time is without obvious shortening.
The judgement of attack degree is judged according to the variable dictionary of seminar, is divided into 1～5 minute: 1 minute-obviously alleviate; 2 minutes-alleviate to some extent; 3 minutes-change not obvious; 4 minutes-increase to some extent; 5 minutes-obviously increase.
4. statistical method
Adopt the SPSS17.0 software kit to carry out statistical analysis, the measurement data own control adopts the t check, relatively uses variance analysis between group, the enumeration data X 2 test.
Three. result
1. curative effect of disease relatively
Observed case 242 examples in 2008, total effective rate was observed case 219 examples in 94.2%, 2009 year, and total effective rate was observed case 187 examples, total effective rate 94.3% in 92.7%, 2010 year.The curative effect in three years is identical, without significant difference (P〉0.05).
Table 1 children with repeated respiratory tract infections disease Clinical efficacy comparison [example (%)]
2. the morbidity number of times relatively
Before and after each annual note applies, the infant number of times of on average falling ill is per month carried out follow-up investigation, find treatment after the recurrent respiratory tract infection number of times reduce, difference has statistical significance (P＜0.05).
Table 2 children with repeated respiratory tract infections treatment forward backward averaging fall ill per month number of times relatively (inferior,
)
Annotate * P＜0.05
3. attack degree relatively
The attack degree of infant recurrent respiratory tract infection compares before and after each year note being applied, and finds that the rear attack degree for the treatment of all is improved, and difference has statistical significance (P＜0.05).
Attack degree comparison before and after the treatment of table 3 children with repeated respiratory tract infections (minute,
)
Annotate * P＜0.05
4. the pattern of syndrome curative effect relatively
Each annual note applies the infant TCM Syndrome Type and relatively finds, asthenia of pulmonosplenic qi type infant is maximum, and curative effect is best, and there were significant differences (P＜0.05) for the effective percentage of asthenia of pulmonosplenic qi type and disharmony of nutrient QI with defensive QI, the weak bone type of suffering from a deficiency of the kidney.
Table 4 children with repeated respiratory tract infections TCM Syndrome Type Clinical efficacy comparison [example (%)]
Annotate * P＜0.05
5. Proportion relatively
For the 125 routine infants of adhering to treating fully in 3 years, the comparison of Proportion before and after treating, after finding that treatment finishes, the ratio of upper respiratory tract infection increases relatively, and the sickness rate of tracheitis, pneumonia is on a declining curve, and utmost point significant difference (P＜0.01) is relatively arranged before and after treatment.
Before and after table 5 treatment, Proportion compares (%)
Following embodiment all can realize the described effect of above-mentioned experimental example.
Embodiment 1: ointment of the present invention (Semen Sinapis cough with asthma ointment)
1. crude drug forms:
Semen Sinapis Albae 22.5g, Rhizoma Zingiberis Recens 50g, Rhizoma Corydalis 22.5g, Herba Asari 2.1g, Radix Kansui 2.3g, Borneolum Syntheticum 0.5g.
2. preparation method:
Above Six-element is got Rhizoma Zingiberis Recens and is cleaned, and mashes, and adds water appropriate, and the squeezing extracting juice adds water and makes total amount become 500ml, adds carboxymethylstach sodium 10g, and heating makes dissolving, adds the 5g polyoxyethylene sorbitan monoleate, makes emulsion standby; Semen Sinapis Albae, Rhizoma Corydalis, Herba Asari, Radix Kansui four flavors are ground into fine powder, and the Borneolum Syntheticum porphyrize is crossed 100 mesh sieves, with above-mentioned fine powder facing-up mixing, adds in emulsion to stir evenly, and grinds with colloid mill, makes altogether 1000g ointment, packing and get final product.Wherein the Semen Sinapis Albae oiliness is large, is difficult for pulverizing and sieving, and needs parch in advance, take not burnt burnt for after degree, independent powder become coarse powder, then mixes with other medical material fine powder, pulverizes and sieves.
3. function cures mainly:
The lung qi dispersing cough-relieving, resolving phlegm and relieving asthma.Be used for the treatment of infantile respiratory tract infection repeatedly.
4. usage and dosage:
External sticks bilateral fei shu, region below the heart, DINGCHUAN acupoint, and the cough with asthma severe one can add with Danzhong or TIANTU acupoint.Every day 1 time, paste in each every cave 1, and each 2～4 hours, continuous 3 days.
Embodiment 2: ointment of the present invention
Semen Sinapis Albae 20 g, Rhizoma Zingiberis Recens 55g, Rhizoma Corydalis 20g, Herba Asari 2.5g, Radix Kansui 2g, Borneolum Syntheticum 0.7g.
According to common process, add conventional adjuvant, be prepared into ointment.
Embodiment 3: spray of the present invention
Semen Sinapis Albae 24g, Rhizoma Zingiberis Recens 45g, Rhizoma Corydalis 24g, Herba Asari 1.7g, Radix Kansui 2.6g, Borneolum Syntheticum 0.3g.
According to common process, add conventional adjuvant, be prepared into spray.
Embodiment 4: emplastrum of the present invention
Semen Sinapis Albae 22.5 g, Rhizoma Zingiberis Recens 50 g, Rhizoma Corydalis 22.5 g, Herba Asari 2.1 g, Radix Kansui 2.3 g, Borneolum Syntheticum 0.5 g.
According to common process, add conventional adjuvant, the preparation emplastrum.
Embodiment 5: cataplasma of the present invention
Semen Sinapis Albae 22.5 g, Rhizoma Zingiberis Recens 50 g, Rhizoma Corydalis 22.5 g, Herba Asari 2.1 g, Radix Kansui 2.3 g, Borneolum Syntheticum 0.5 g.
According to common process, add conventional adjuvant, the preparation cataplasma.
Embodiment 6: liniment of the present invention
Semen Sinapis Albae 22.5 g, Rhizoma Zingiberis Recens 50 g, Rhizoma Corydalis 22.5 g, Herba Asari 2.1 g, Radix Kansui 2.3 g, Borneolum Syntheticum 0.5 g.
According to common process, add conventional adjuvant, the preparation liniment.
Claims (9)
- One kind the prevention or the treatment infantile respiratory tract infection repeatedly Chinese medicine composition, it is characterized in that the crude drug of said composition consists of:Semen Sinapis Albae 18-25 weight portion, Rhizoma Zingiberis Recens 40-60 weight portion, Rhizoma Corydalis 18-25 weight portion, Herba Asari 1-3 weight portion, Radix Kansui 1-3 weight portion, Borneolum Syntheticum 0.2-0.8 weight portion.
- 2. Chinese medicine composition as claimed in claim 1 is characterized in that the crude drug of said composition consists of:Semen Sinapis Albae 22.5 weight portions, Rhizoma Zingiberis Recens 50 weight portions, Rhizoma Corydalis 22.5 weight portions, Herba Asari 2.1 weight portions, Radix Kansui 2.3 weight portions, Borneolum Syntheticum 0.5 weight portion.
- 3. Chinese medicine composition as claimed in claim 1 is characterized in that the crude drug of said composition consists of:Semen Sinapis Albae 20 weight portions, Rhizoma Zingiberis Recens 55 weight portions, Rhizoma Corydalis 20 weight portions, Herba Asari 2.5 weight portions, Radix Kansui 2 weight portions, Borneolum Syntheticum 0.7 weight portion.
- 4. Chinese medicine composition as claimed in claim 1 is characterized in that the crude drug of said composition consists of:Semen Sinapis Albae 24 weight portions, Rhizoma Zingiberis Recens 45 weight portions, Rhizoma Corydalis 24 weight portions, Herba Asari 1.7 weight portions, Radix Kansui 2.6 weight portions, Borneolum Syntheticum 0.3 weight portion.
- 5. any one Chinese medicine composition as described in claim 1-4, is characterized in that getting crude drug, according to common process, adds conventional adjuvant, is prepared into exterior-applied formulation: ointment, spray, emplastrum, cataplasma or liniment.
- 6. Chinese medicine composition as claimed in claim 5, is characterized in that described dosage form is ointment.
- 7. the preparation method of Chinese medicine composition ointment as claimed in claim 6, its feature in the method is:Above Six-element is got Rhizoma Zingiberis Recens and is cleaned, and mashes, and adds water, and the squeezing extracting juice adds water and makes total amount become 500 parts by volume, adds carboxymethylstach sodium 10 weight portions, and heating makes dissolving, adds 5 weight portion polyoxyethylene sorbitan monoleates, makes emulsion standby; Semen Sinapis Albae, Rhizoma Corydalis, Herba Asari, Radix Kansui four flavors are ground into fine powder, and the Borneolum Syntheticum porphyrize is crossed 100 mesh sieves, with above-mentioned fine powder facing-up mixing, adds in emulsion to stir evenly, and grinds with colloid mill, makes altogether 1000 weight portion ointment, packing and get final product.
- 8. preparation method as claimed in claim 7, its feature needs parch in advance in Semen Sinapis Albae, take not burnt burnt for after degree, independent powder become coarse powder, then mixes with other medical material fine powder, pulverizes and sieves.
- 9. the application of described any one Chinese medicine composition of claim 1-4 in the medicine of preparation prevention or treatment infantile respiratory tract infection repeatedly.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434546A (en) * | 2016-01-13 | 2016-03-30 | 牛坤汀 | Traditional Chinese medicine composition for treating wind-cold type upper respiratory infection |
| CN106267064A (en) * | 2016-08-03 | 2017-01-04 | 刘鹏 | A kind of Medicinal Vesiculation Therapy point-application ointment machin application process |
| CN107281418A (en) * | 2017-06-21 | 2017-10-24 | 成都中医药大学 | A kind of food, functional food or pharmaceutical composition and its production and use |
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| CN101810844A (en) * | 2010-04-23 | 2010-08-25 | 浙江省中医院 | External plaster for preventing disease and manufacturing method thereof |
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- 2013-01-09 CN CN2013100063468A patent/CN103120793A/en active Pending
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| CN101810844A (en) * | 2010-04-23 | 2010-08-25 | 浙江省中医院 | External plaster for preventing disease and manufacturing method thereof |
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| 李瑛等: "芥子咳喘膏穴位贴敷治疗小儿急性支气管炎的疗效", 《第四军医大学学报》, vol. 30, no. 2, 31 December 2009 (2009-12-31), pages 169 - 171 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434546A (en) * | 2016-01-13 | 2016-03-30 | 牛坤汀 | Traditional Chinese medicine composition for treating wind-cold type upper respiratory infection |
| CN106267064A (en) * | 2016-08-03 | 2017-01-04 | 刘鹏 | A kind of Medicinal Vesiculation Therapy point-application ointment machin application process |
| CN107281418A (en) * | 2017-06-21 | 2017-10-24 | 成都中医药大学 | A kind of food, functional food or pharmaceutical composition and its production and use |
| CN107281418B (en) * | 2017-06-21 | 2021-01-15 | 成都中医药大学 | Pharmaceutical composition and preparation method and application thereof |
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Application publication date: 20130529 |