CN107432472B - Composition for treating diarrhea and application thereof - Google Patents
Composition for treating diarrhea and application thereof Download PDFInfo
- Publication number
- CN107432472B CN107432472B CN201710743148.8A CN201710743148A CN107432472B CN 107432472 B CN107432472 B CN 107432472B CN 201710743148 A CN201710743148 A CN 201710743148A CN 107432472 B CN107432472 B CN 107432472B
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- parts
- powder
- diarrhea
- seed
- composition
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Abstract
The invention relates to functional food or health food, and particularly discloses a composition for treating diarrhea and application thereof. The composition comprises the following components in parts by weight: 5-20 parts of ginseng, 5-20 parts of gordon euryale seed, 5-15 parts of poria cocos, 20-30 parts of Chinese yam, 5-10 parts of white hyacinth bean, 5-10 parts of fried lotus seed, 10-20 parts of coix seed, 5-10 parts of fructus amomi, 5-10 parts of platycodon grandiflorum and 5-10 parts of liquorice. The components are matched and used together, the effect of treating diarrhea is achieved by adjusting gastrointestinal functions, tonifying spleen and nourishing stomach, and dehumidifying and checking diarrhea, and the health food is suitable for people with diarrhea problems caused by irregular diet, fast eating and insanitary eating. The granule provided by the invention is convenient to carry, quick to take, moderate in taste and special in fragrance. Compared with the conventional medicaments for treating diarrhea, the composition has the characteristics of short administration period, good curative effect, no side effect and the like when being applied to treating the diarrhea diseases.
Description
Technical Field
The invention relates to a functional food or a health-care food, in particular to a composition for treating diarrhea and application thereof.
Background
Diarrhea is commonly called as diarrhea, and means that the frequency of defecation obviously exceeds the frequency of ordinary habit, the feces is thin, and the moisture is increased. The pathogenesis of diarrhea is relatively complex, and the traditional Chinese medicine theory considers that the main reason of diarrhea is that the spleen fails to transport and the stomach fails to disperse and leads to food stagnation due to the internal injury of the spleen and the stomach caused by the pathogenic dampness-heat. With the acceleration of the life rhythm of modern people, a series of problems of spleen and stomach disorder, dyspepsia, gastroenteritis, diarrhea and the like caused by irregular diet, fast meal and insanitation of foreign food become more and more serious. Western medicine usually adopts ofloxacin, norfloxacin and other antibiotic drugs to treat diarrhea, but with the abuse of antibiotics, the problems of drug resistance and the like are generated, so that the traditional Chinese medicine is not only ineffective, but also has a plurality of side effects. Besides the toxic and side effects of antibiotics, the micro-ecological balance in vivo can be destroyed, flora disturbance is caused, and diarrhea is delayed and not healed or secondary double infection is caused. Compared with the western medicine, the Chinese herbal medicine treatment has the advantages of integral regulation and dialectical treatment, and has no toxic or side effect, and is safer and more effective.
Ginseng is sweet and slightly bitter in taste, warm and mild in nature. It enters spleen, lung and heart meridians. Has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing. Gorgon fruit is sweet, astringent and neutral. It enters spleen and kidney meridians. Has effects in invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, eliminating dampness, and stopping leukorrhagia. Poria cocos, sweet, bland and neutral. It enters heart, lung, spleen and kidney meridians. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. It is commonly indicated for edema, oliguria, dizziness and palpitation due to phlegm-fluid retention, spleen deficiency, poor appetite, loose stool, diarrhea, restlessness, palpitation, insomnia. Yam is sweet and neutral. It enters spleen, lung and kidney meridians. Has effects in invigorating spleen, nourishing stomach, promoting salivation, tonifying lung, and tonifying kidney. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat. Bai Dou is sweet and warm. It enters spleen and stomach meridians. Can be used for treating weakness of spleen and stomach, anorexia, diarrhea, leukorrhagia, summer heat, dampness, vomiting and diarrhea, chest distress, and abdominal distention. Stir-baked Bai Dou is indicated for diarrhea due to spleen deficiency because it can invigorate spleen and resolve dampness. The compatibility of the traditional Chinese medicines such as the fried lotus seed, the coix seed, the villous amomum fruit, the platycodon root, the liquoric root and the like has the effects of regulating the gastrointestinal function, tonifying the spleen and nourishing the stomach, and removing dampness and stopping diarrhea.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide a composition for treating diarrhea and application thereof.
In order to realize the purpose of the invention, the technical scheme of the invention is as follows:
the invention firstly provides a composition for treating diarrhea, which comprises the following components in parts by weight: 5-20 parts of ginseng, 5-20 parts of gordon euryale seed, 5-15 parts of poria cocos, 20-30 parts of Chinese yam, 5-10 parts of white hyacinth bean, 5-10 parts of fried lotus seed, 10-20 parts of coix seed, 5-10 parts of fructus amomi, 5-10 parts of platycodon grandiflorum and 5-10 parts of liquorice.
Preferably, the composition comprises the following components in parts by weight: 5-15 parts of ginseng, 5-15 parts of gordon euryale seed, 5-10 parts of poria cocos, 20-25 parts of Chinese yam, 5-8 parts of white hyacinth bean, 5-9 parts of fried lotus seed, 10-15 parts of coix seed, 5-7 parts of fructus amomi, 5-8 parts of platycodon grandiflorum and 5-8 parts of liquorice.
More preferably, the composition comprises the following components in parts by weight: 15 parts of ginseng, 15 parts of gordon euryale seed, 12 parts of poria cocos, 23 parts of Chinese yam, 7 parts of white hyacinth bean, 9 parts of fried lotus seed, 15 parts of coix seed, 6 parts of fructus amomi, 7 parts of platycodon grandiflorum and 6 parts of liquorice.
In the above composition:
the weight parts can be the weight units known in the medical field such as mu g, mg, g, kg, and the like, and can also be multiples thereof such as 1/10, 1/100, 10, 100, and the like.
The invention also provides application of the composition in preparing functional food or health-care food for treating diarrhea.
The functional food or health food can be made into conventional dosage forms in the fields of medicine and health, such as granule, tablet, capsule, soft extract, beverage, etc.
Optionally/preferably, the dosage form is a granule, and comprises the following components in parts by weight: 5-20 parts of ginseng, 5-20 parts of gordon euryale seed, 5-15 parts of poria cocos, 20-30 parts of Chinese yam, 5-10 parts of white hyacinth bean, 5-10 parts of fried lotus seed, 10-20 parts of coix seed, 5-10 parts of fructus amomi, 5-10 parts of platycodon grandiflorum, 5-10 parts of liquorice, 50-100 parts of prebiotics and 2-10% of binder (the dosage is 2-10% of the total weight of other components).
Preferably, the granules comprise the following components in parts by weight: 5-15 parts of ginseng, 5-15 parts of gordon euryale seed, 5-10 parts of poria cocos, 20-25 parts of Chinese yam, 5-8 parts of white hyacinth bean, 5-9 parts of fried lotus seed, 10-15 parts of coix seed, 5-7 parts of fructus amomi, 5-8 parts of platycodon grandiflorum, 5-8 parts of liquorice, 50-80 parts of prebiotics and 2-8% of binder (the dosage is 2-8% of the total weight of other components).
More preferably, the granules comprise the following components in parts by weight: 15 parts of ginseng, 15 parts of gordon euryale seed, 12 parts of poria cocos, 23 parts of Chinese yam, 7 parts of white hyacinth bean, 9 parts of fried lotus seed, 15 parts of coix seed, 6 parts of fructus amomi, 7 parts of platycodon grandiflorum, 6 parts of liquorice, 60 parts of prebiotics and 5% of binder (the dosage is 5% of the total weight of other components).
Wherein the prebiotics are isomaltooligosaccharide, fructo-oligosaccharide or xylo-oligosaccharide. In a specific embodiment of the present invention, the prebiotic is isomaltooligosaccharide, which is available from tianjin yibeiyuan natural products technology ltd, and has an isomaltooligosaccharide content of more than 80%.
Wherein the binder is 80% (volume fraction) alcohol.
The invention further provides a preparation method of the granules, which comprises the following steps:
1) sieving isomaltooligosaccharide, selecting fine powder of 60 meshes, weighing Ginseng radix powder, semen euryales powder, Poria powder, rhizoma Dioscoreae powder, semen lablab album powder, semen Nelumbinis powder, Coicis semen powder, fructus Amomi powder, radix Platycodi powder, Glycyrrhrizae radix powder, and isomaltooligosaccharide powder according to a certain ratio, and mixing;
2) adding 80% alcohol as binder into the mixed fine powder, making into 60 mesh granule, drying at 50 deg.C for 60 min, and packaging.
Alternatively, the dosage form may be a granule. In preparation, an extract of the composition may optionally be used. The ginseng, the gordon euryale seed, the poria cocos, the Chinese yam, the white hyacinth bean, the fried lotus seed, the coix seed, the fructus amomi, the platycodon grandiflorum and the liquorice can be prepared into extracts by a conventional method in the prior art and can also be purchased from the market.
The raw materials or reagents involved in the invention are all common commercial products, and the operations involved are all routine operations in the field unless otherwise specified.
The above-described preferred conditions may be combined with each other to obtain a specific embodiment, in accordance with common knowledge in the art.
The invention has the beneficial effects that:
1. the health food takes ginseng, gordon euryale seed, poria cocos, Chinese yam, white hyacinth bean, fried lotus seed, coix seed, fructus amomi, platycodon grandiflorum and liquorice as main raw materials, various components are reasonably combined and matched for use, the effect of treating diarrhea is achieved by adjusting gastrointestinal functions, tonifying spleen and nourishing stomach, and dehumidifying and checking diarrhea, and the health food is suitable for people who have diarrhea problems caused by irregular diet, fast food intake and insanitary eating.
2. The granule provided by the invention is convenient to carry, quick to take, moderate in taste and special in fragrance.
3. Experiments show that the diarrhea condition of volunteers taking the composition and the granules provided by the invention is obviously improved.
Compared with the conventional medicaments for treating diarrhea, the composition has the characteristics of short administration period, good curative effect, no side effect and the like when being applied to treating the diarrhea diseases.
Detailed Description
Preferred embodiments of the present invention will be described in detail with reference to the following examples. It is to be understood that the following examples are given for illustrative purposes only and are not intended to limit the scope of the present invention. Various modifications and alterations of this invention will become apparent to those skilled in the art without departing from the spirit and scope of this invention.
Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.
In the preparation process of the granules, the used means are all conventional technical means in the field if no special description is given.
The ginseng is raw ginseng powder which is planted for less than 5 years and is purchased from Tianjin Yibeiyuan natural product technology limited company;
the gorgon euryale seed extract is 10: 1 proportion of extract, purchased from Tianjin Yibeiyuan Natural products technology Limited;
the poria extract contains 30-50% of pachymaran and 0.5-2% of triterpenic acid, and is purchased from Tianjin Yibeiyuan natural product technology limited company;
the yam extract contains diosgenin 5-20%, and is purchased from Tianjin Yibeiyuan natural product technology limited company;
the white hyacinth bean extract is 10: 1 proportion of extract, purchased from Tianjin Yibeiyuan Natural products technology Limited;
the fried lotus seed extract is 10: 1 proportion of extract, purchased from Tianjin Yibeiyuan Natural products technology Limited;
the coix seed extract is 10: 1 proportion of extract, purchased from Tianjin Yibeiyuan Natural products technology Limited;
the fructus amomi extract is 10: 1 proportion of extract, purchased from Tianjin Yibeiyuan Natural products technology Limited;
the platycodon extract is 10: 1 proportion of extract, purchased from Tianjin Yibeiyuan Natural products technology Limited;
the glycyrrhiza extract contains 2-5% glycyrrhizic acid and 2-5% flavone, and is purchased from Tianjin Yibeiyuan natural product technology limited company;
the content of the isomaltooligosaccharide is more than 80 percent and is purchased from Tianjin Yibeiyuan natural product technology Limited company.
Example 1
Weighing 15 parts of dried ginseng powder, 15 parts of gordon euryale seed powder, 12 parts of poria cocos powder, 23 parts of yam powder, 7 parts of white hyacinth bean powder, 9 parts of fried lotus seed powder, 15 parts of coix seed powder, 6 parts of fructus amomi powder, 7 parts of platycodon grandiflorum powder, 6 parts of licorice powder, 60 parts of isomaltose hypgather powder and 0.2% of sucralose according to weight, mixing uniformly, and spraying 5% of a binder. Making into 60 mesh granule, drying at 50 deg.C for 60 min, and packaging.
Example 2
Respectively weighing 10 parts of dried ginseng powder, 10 parts of gordon euryale seed, 10 parts of poria cocos, 30 parts of Chinese yam, 5 parts of white hyacinth bean, 7 parts of fried lotus seed, 13 parts of bran-fried coix seed, 8 parts of fructus amomi, 7 parts of platycodon grandiflorum, 10 parts of liquorice and 60 parts of isomaltooligosaccharide powder according to weight, uniformly mixing, and spraying 5% of a binder. 0.2 percent of sucralose, preparing into 60-mesh granules, drying at the temperature of 50 ℃ for 60 minutes, and subpackaging.
Example 3
Respectively weighing 5 parts of dried ginseng powder, 5 parts of gordon euryale seed, 5 parts of poria cocos, 20 parts of Chinese yam, 5 parts of white hyacinth bean, 10 parts of fried lotus seed, 20 parts of bran-fried coix seed, 10 parts of fructus amomi, 15 parts of platycodon grandiflorum, 10 parts of liquorice, 60 parts of isomaltooligosaccharide powder and 0.2% of sucralose by weight, uniformly mixing, and spraying 5% of a binder. Making into 60 mesh granule, drying at 50 deg.C for 60 min, and packaging.
Example 4
Respectively weighing 7 parts of dried ginseng powder, 7 parts of gordon euryale seed, 13 parts of poria cocos, 25 parts of Chinese yam, 5 parts of white hyacinth bean, 9 parts of fried lotus seed, 10 parts of bran-fried coix seed, 9 parts of fructus amomi, 14 parts of platycodon grandiflorum, 8 parts of liquorice, 60 parts of isomaltooligosaccharide powder and 0.2% of sucralose by weight, uniformly mixing, and spraying 5% of a binder. Making into 60 mesh granule, drying at 50 deg.C for 60 min, and packaging.
Example 5
Weighing 15 parts of dried ginseng powder, 15 parts of gordon euryale seed extract, 12 parts of poria cocos extract, 23 parts of Chinese yam extract, 7 parts of white hyacinth bean extract, 9 parts of fried lotus seed extract, 15 parts of coix seed extract, 6 parts of fructus amomi extract, 7 parts of platycodon grandiflorum extract, 6 parts of liquorice extract, 60 parts of isomalto-oligosaccharide powder, 20 parts of microcrystalline cellulose, 5 parts of carboxymethyl starch and 1 part of magnesium stearate according to weight, mixing uniformly, and directly performing powder tabletting.
Experimental example 1
Experiments for proving that the composition has the function of treating diarrhea
1. Selecting a crowd: selecting 25-45-year-old diarrhea patients, and selecting 60 men and women.
2. Grouping experiments: 120 volunteers were divided into 6 groups on average, and the 6 groups of volunteers were administered with the compositions of examples 1-4 and the drugs of comparative examples 1, 2, respectively. Comparative example 1 Benzylpiperidine (for acute and chronic functional diarrhea) was administered 1 tablet at a time 3 times a day according to the instructions. Comparative example 2 norfloxacin (for treating diarrhea caused by bacterial infection) was administered 4 capsules at a time 2 times a day according to the instructions.
3. The experimental method comprises the following steps: the volunteers of examples 1-4 were dosed once a day after 3 meals, with 5g of warm water each time for 7 days. The volunteers taking comparative examples 1 and 2 were taken according to the instructions for 7 days.
4. The results of the experiment are shown in the following table:
| complete cure example | Significant example of cure | Basic example of invalidation | |
| Example 1 | 16 | 2 | 2 |
| Example 2 | 14 | 3 | 3 |
| Example 3 | 11 | 6 | 3 |
| Example 4 | 13 | 3 | 4 |
| Comparative example 1 | 9 | 6 | 5 |
| Comparative example 2 | 7 | 7 | 6 |
As can be seen from the healing results in the tables, the examples 1 to 4 of the present invention are significantly superior in the therapeutic effect for treating diarrhea to the comparative examples 1 and 2. The composition of the invention has the function of treating diarrhea and has obvious effect on acute and chronic functional diarrhea and diarrhea caused by bacterial infection. The patients taking the medicines of the examples 1 to 4 do not have the side effects of abdominal discomfort, nausea, vomiting, dizziness, somnolence and the like of the patients of the comparative examples 1 and 2. The composition of the invention is safe and effective and has no side effect.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (2)
1. The pharmaceutical preparation for treating diarrhea is characterized in that the preparation is granules, raw materials of the granules comprise a composition for treating diarrhea, and the composition comprises the following components in parts by weight: 15 parts of ginseng, 15 parts of gordon euryale seed, 12 parts of poria cocos, 23 parts of Chinese yam, 7 parts of white hyacinth bean, 9 parts of fried lotus seed, 15 parts of coix seed, 6 parts of fructus amomi, 7 parts of platycodon grandiflorum and 6 parts of liquorice;
the raw materials of the granule also comprise 60 parts of prebiotics and a binder with the weight of 5 percent of the total weight of the components.
2. The formulation according to claim 1, characterized in that it is prepared by a process comprising the following steps:
1) sieving prebiotics, selecting fine powder of isomaltooligosaccharide under 60 mesh, weighing Ginseng radix powder, semen euryales powder, Poria powder, rhizoma Dioscoreae powder, semen lablab album powder, semen Nelumbinis powder, Coicis semen powder, fructus Amomi powder, radix Platycodi powder, Glycyrrhrizae radix powder, isomaltooligosaccharide fine powder according to proportion, and mixing well;
2) adding binder into the mixed fine powder, making into 60 mesh granules, drying at 50 deg.C for 60 min, and packaging.
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| CN110326777A (en) * | 2019-06-26 | 2019-10-15 | 洛阳深山生物科技有限公司 | With invigorate the spleen and benefit qi, the konjaku of coordinating intestines and stomach function generation meal congee and preparation method thereof |
| CN113068833A (en) * | 2021-03-10 | 2021-07-06 | 苏州雷允上健康养生有限公司 | Health food with functions of tonifying spleen, eliminating dampness and regulating gastrointestinal tract and preparation method and application thereof |
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