CN105343858A - Spleen strengthening meridian warming and activating patch for child and extraction and forming process thereof - Google Patents
Spleen strengthening meridian warming and activating patch for child and extraction and forming process thereof Download PDFInfo
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Abstract
The invention discloses a spleen strengthening warm and smooth patch for a child. The patch is prepared from the following raw materials in parts by weight: 3 parts of rhizoma atractylodis, 3 parts of largehead atractylodes rhizome, 3 parts of fructus amomi, 3 parts of rhizoma zingiberis, 3 parts of white cardamon fruit, 3 parts of fennel, 2 parts of cablin patchouli herb, 2 parts of herba eupatorii and 2 parts of folium artemisiae argyi; a finished product patch is prepared from the raw materials which are subjected to proportioning, stewing, extracting, concentrating, paste making and coating, and is used for treating weakness of the spleen and the stomach and the symptoms caused thereby. The spleen strengthening warm and smooth patch has the functions of strengthening the spleen, removing dampness, checking diarrhea, and harmonizing the spleen and the stomach; due to the fact that the medicines of the patch do not pass through the stomach and the small intestine, the influence and destructive effect of acid, alkali and digestive enzyme on the medicines are avoided, the stimulation of the medicines on the digestive tract is avoided, the metabolic burden of the medicines on the liver and the kidneys is avoided, the bioavailability of the medicines is greatly improved, and the patch is a novel medicine for treating child splenasthenic diarrhea; the patch only needs to be pasted at the navel of the sick child; the symptoms are improved one day after the patch is applied; the child is recovered after being treated for three days; no suffering, and no toxic and side effects are generated; the treatment effect is significant.
Description
Technical field
The present invention relates to field of medicaments, specifically a kind of infant spleen-tonifying temperature is logical pastes and extracts excipient technique.
Background technology
Children's is in growth and development stage, and spleen and stomach function is also unsound, if diet does not add restraining, and hungry one, full one, be late for having a meal, or snacks are too many, all can affect spleen and stomach function, cause dysfunction of spleen and stomach, the diseases such as weakness of the spleen and stomach, with the passing of time then " emaciation and sallow complexion "; The disease of the more common weakness of the spleen and stomach of Pediatric Clinic is virgin, jaundice as sparse in hair, Sleep hyperhidrosis, athletic meeting are easily perspired, colour of skin jaundice, color of the lip are pale, become thin or excessivelys fat, rather doss, anorexia, diarrhoea constipation, brothers' heart are hot, cold cough etc., the traditional Chinese medical science thinks that The spleen has the function to transport and transform nutrients, stomach receiving food and drink and becoming thoroughly decomposed, weakness of the spleen and stomach is deficient qi and blood then, resistance declines, and various virus is easily invasion just; After children's is ill, the head of a family is very worried, just takes high amount of drug in a short period of time, especially some antiinflammatory, analgesic Western medicine, as aspirin, acetaminophen, indometacin, erythromycin etc., these medicines all have stimulation to gastrointestinal tract, and cause nausea, the disease such as vomiting, like this, cure though sick, but leave the future trouble of stomach damaged, go down then to affect digesting and assimilating of food for a long time, cause malnutrition; Because the spleen and stomach in children function does not also perfect, even if Chinese medicine decoction side effect is little, still can cause burden to children's's the intestines and stomach, for these reasons, need research and develop a kind of newly without the need to the oral medicine in order to regulate the spleen and stomach in children, to meet user demand.
Summary of the invention
The object of the present invention is to provide the logical subsides of a kind of infant spleen-tonifying temperature that is safe and efficient, easy to use, that have no side effect and extract excipient technique, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of infant spleen-tonifying temperature is logical pastes, and is prepared from by the raw material of following weight portion:
As the further scheme of the present invention: described infant spleen-tonifying temperature is logical pastes, and is prepared from by the raw material of following weight portion:
As the present invention's further scheme: the logical extraction excipient technique of pasting of described infant spleen-tonifying temperature, comprises the following steps:
1) weighing batching: the medicinal raw material taking ten times amount according to formula, cleaning, decontamination, dry for subsequent use;
2) steaming and decocting: the water medicinal raw material in step 1 being added six times of weight, soaks 30min, distilling with water 7h, filters, obtains volatile oil and residue;
3) extract: the water extraction twice residue in step 2 being added six times amount, merge extractive liquid, after extracting liquid filtering, after concentrated, pulverizing, drying and screening, obtain dry extract powder;
4) preparation of A phase: 4g gelatin is evenly sprinkled in 61g purified water, molten in 45 DEG C of Water Unders, swelling 1-1.5h, to complete swelling, adds 2g polyethylene and gives a tongue-lashing pyrrolidone K-30, be swelled into homogeneous liquid, obtain A phase for subsequent use;
5) preparation of B phase: 5g sodium polyacrylate, 2g dry extract, 2g azone are dispersed in 24g glycerol successively, are stirred into homogeneous suspension, obtain B phase for subsequent use;
6) preparation of mastic: B phase prepared by A phase step 4 prepared and step 5, stir with the mixing limit, speed limit of 80-120r/min, the volatile oil simultaneously taking preparation in 0.47g step 2 adds B phase, stir 20min, refining and temperature are 45 DEG C, obtain pitchy, mastic that homogeneous, viscosity is suitable for;
7) be coated with: mastic step 6 prepared is coated on non-woven fabrics while hot, and coating thickness is 2-3mm, hangs and spends the night, sizing, lid protecting film, die-cutly obtain finished product.
As the present invention's further scheme: in described step 6, best mixing speed is 100r/min.
As the present invention's further scheme: described infant spleen-tonifying temperature is logical pastes, and be used for the treatment of infantile spleen deficiency weakness, every day respectively once, is affixed on infant umbilicus place sooner or later.
In the present invention, the pharmacological action of each raw material is:
1. Rhizoma Atractylodis: the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodeslancea (Thunb.) DC. or Atractylis chinensis Atractylodeschinensis (DC.) Koidz.; Spring, Qiu Erji excavate, and removing silt, dries, pluck fibrous root; Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, Liver Channel; Drying damp and strengthening spleen, expelling wind and cold, improving eyesight; For retention of dampness in middle-JIAO, distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity are preesed, rheumatic arthralgia, anemofrigid cold, nyctalopia, eyes dusk are puckery;
2. the Rhizoma Atractylodis Macrocephalae: Classification system Atractylodesmacrocephala; Another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc., belong to Compositae, [WTBX herbaceos perennial, the nice and cool weather of happiness, be used as medicine, have multinomial medicinal function with rhizome; " medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, antiabortive." bitter in the mouth, sweet, warm in nature; Return spleen, stomach warp; Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive; Have loose bowels for insufficiency of the spleen lack of appetite, abdominal distention, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement;
3. Fructus Amomi: be the dry mature fruit of zingiberaceous plant Fructus Amomi AmomumvillosumLour., green shell sand AmomumvillosumLour.var.xanthioidesT.L.WuetSenjen or SEMEN AMOMI LONGILIGULA AmomumlongiligulareT.L.Wu, gather when summer, autumn two season fruit maturation, dry or cold drying; Acrid in the mouth, property wets; Return spleen, stomach, kidney channel; Removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive; , Deficiency and coldness of spleen and stomach not hungry for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass, vomiting are had loose bowels, pregnancy reactions, frequent fetal movement;
4. Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiberoj-jicinaleRosc., winter excavates, removing fibrous root and silt, dries or cold drying, takes advantage of fresh slices and to dry or cold drying person is called " dried ginger slice "; Acrid in the mouth, hot in nature; Return spleen, kidney, stomach, the heart, lung meridian; Warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, warming the lung to resolve fluid-retention; For coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, cold fluid-retention breath with cough;
5. Fructus Amomi Rotundus: be the dry mature fruit of zingiberaceous plant Fructus Amomi Rotundus AmomumkravanhPierreexGagnep. or amomum compactum Soland ex Maton AmomumcompactumSolandexMaton; Acrid in the mouth, warm in nature; Return lung, spleen, stomach warp; Removing dampness disappears painful abdominal mass, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving; For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation uncomfortable in chest do not disappear;
6. Fructus Foeniculi: be the dry mature fruit of samphire Fructus Foeniculi FoeniculumvuLgareMill., autumn taps plant when fruit is first ripe, dries, lays fruit, removing impurity; Acrid in the mouth, warm in nature; Return liver,kidney,spleen, stomach warp; Dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach; For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting;
7. Herba Pogostemonis: be the dry aerial parts of labiate Herba Pogostemonis Pogostemoncablin (Blanco) Benth., tap when branch and leaf are luxuriant, Exposure to Sunlight is vexed for night, repeatedly to dry; Acrid in the mouth, slightly warm in nature; Return spleen, stomach, lung meridian; Eliminating turbid pathogen with aromatics and middle preventing or arresting vomiting, deliver expelling summer-heat; For turbid damp obstructing in middle-JIAO, the vomiting of gastral cavity painful abdominal mass, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chest relax, cold-damp close summer-heat, stomachache vomit and diarrhoea, nasosinusitis headache;
8. Herba Eupatorii: be the dry aerial parts of feverfew Herba Eupatorii EupatoriumfortuneiTurcz., summer, Qiu Erji tap at twice, removing impurity, dries; Acrid in the mouth, property are flat; Return spleen, stomach, lung meridian; Removing dampness by means of aromatics, appetizing of being amusing, deliver expelling summer-heat; For sweet in turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, mouth greasy, halitosis, sialism, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly not relax;
9. Folium Artemisiae Argyi: be the dried leaves of feverfew Chinese mugwort ArtemisiaargyiLevl.etVant..Pluck when summer, flower was not opened, removing impurity, dries; Acrid in the mouth, hardship, warm in nature; Return liver,spleen,kidney warp; Warming the meridian for stopping bleeding, dispersing cold for relieving pain, external removing dampness to relieve itching; , external treatment skin pruritus, vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding infertile for haematemesis, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb, hemorrhage for deficient cold type; " Handbook of Prescriptions for Emergencies " is recorded: with three liters, dry moxa leaf, water is a pipeful of, and boil one liter, decoction being taken at a draught gets antiperspirant, is used for the treatment of typhoid fever seasonal epidemic pathogens, and epidemic febrile disease is had a headache, high fever full and forceful pulse.
Compared with prior art, the invention has the beneficial effects as follows: in the present invention, several Chinese medicine composition is prepared according to method of the present invention after quantitative compatibility of the present invention, make to there occurs obvious synergistic function between each raw material the effective elements of the medicine, selected medical material compatibility is suitable, and meet Chinese medicine and pharmacy and modern medicine theory, raw material is easy to get, preparation method is simple, low price, determined curative effect, plays the effect of invigorating spleen to remove dampness antidiarrheal, the spleen and stomach regulating; Because medicine of the present invention is without harmonization of the stomach small intestinal, avoid acid, alkali, digestive enzyme to the impact of medicine and destruction, avoid medicine to gastral stimulation, avoid medicine to bear the metabolism of liver, kidney, the bioavailability of medicine improves greatly, is a kind of newtype drug that treatment infantile spleen deficiency is had loose bowels; This medicine only need be affixed on infant umbilicus place, and general medication one day symptom is improved, and treats recovery from illness in three days, no pain, has no side effect, evident in efficacy, avoids the situation of children medicament feeding difficulty.
Accompanying drawing explanation
Fig. 1 is process chart of the present invention.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
A kind of infant spleen-tonifying temperature is logical pastes, and is prepared from by the raw material of following weight portion:
Embodiment 2
A kind of infant spleen-tonifying temperature is logical pastes, and is prepared from by the raw material of following weight portion:
Embodiment 3
A kind of infant spleen-tonifying temperature is logical pastes, and is prepared from by the raw material of following weight portion:
Refer to Fig. 1, the logical extraction excipient technique of pasting of the infant spleen-tonifying temperature described in embodiment 1-3, comprises the following steps:
1) weighing batching: the medicinal raw material taking ten times amount according to formula, cleaning, decontamination, dry for subsequent use;
2) steaming and decocting: the water medicinal raw material in step 1 being added six times of weight, soaks 30min, distilling with water 7h, filters, obtains volatile oil and residue;
3) extract: the water extraction twice residue in step 2 being added six times amount, merge extractive liquid, after extracting liquid filtering, after concentrated, pulverizing, drying and screening, obtain dry extract powder;
4) preparation of A phase: 4g gelatin is evenly sprinkled in 61g purified water, molten in 45 DEG C of Water Unders, swelling 1-1.5h, to complete swelling, adds 2g polyethylene and gives a tongue-lashing pyrrolidone K-30, be swelled into homogeneous liquid, obtain A phase for subsequent use;
5) preparation of B phase: 5g sodium polyacrylate, 2g dry extract, 2g azone are dispersed in 24g glycerol successively, are stirred into homogeneous suspension, obtain B phase for subsequent use;
6) preparation of mastic: B phase prepared by A phase step 4 prepared and step 5, stir with the mixing limit, speed limit of 100r/min, the volatile oil simultaneously taking preparation in 0.47g step 2 adds B phase, stirs 20min, refining and temperature are 45 DEG C, obtain pitchy, mastic that homogeneous, viscosity is suitable for;
7) be coated with: mastic step 6 prepared is coated on non-woven fabrics while hot, and coating thickness is 2-3mm, hangs and spends the night, sizing, lid protecting film, die-cutly obtain finished product.
Below using the formula of embodiment 3 as test medication, in conjunction with clinical case, the logical drug effect of pasting of infant spleen-tonifying temperature of the present invention is described further.
Clinical trial:
1. diagnostic criteria: diagnostic criteria is formulated with reference to " Chinese medical disease Standardization of diagnosis and curative effect " (ZY/T001.1-001.9-94, Chinese medical disease Standardization of diagnosis and curative effect [S] .); Clinically have cough paroxysm, cough round the clock, night for very, the few or abundant expectoration of sound of cough being low and weak, expectorant, color white matter thickness lusterless complexion or few China, diarrhoea and defecate rare soft, the bodily form is partially thin, be off one's feed.
2. subjects: choose meet above-mentioned diagnostic criteria infant 300 example, wherein men and women half and half, the age be 3-12 year, be divided into three groups, be respectively Western medicine group A group, extract oral medicament group B group and patch group C group of the present invention, often organize 100 examples, every day is administered twice sooner or later, within 3-5 days, is a course for the treatment of.
3. curative effect judging standard:
Recovery from illness: symptom all disappears, main physical and chemical index detects normal;
Effective: symptomatology is eliminated or cardinal symptom is eliminated; Main physical and chemical index detects normal;
Effective: cardinal symptom disappears substantially, main physical and chemical index detects and makes moderate progress;
Invalid: main physical and chemical index is front unchanged with treatment.
4. result of the test:
Table 1 clinical test results
(1) Western medicine group A group healing 54 example, effective 32 examples, effective 8 examples, invalid 6 examples, total effective rate 94%, untoward reaction example 4 example, follows the trail of after half a year and pays a return visit, recurrence example 9 example;
(2) extract oral medicament group B group healing 64 example, effective 22 examples, effective 10 examples, invalid 4 examples, total effective rate 96%, untoward reaction example 1 example, follows the trail of after half a year and pays a return visit, recurrence example 4 example;
(3) infant spleen-tonifying temperature logical patch group C group healing 93 example, effective 4 examples, effective 2 examples, invalid 1 example, total effective rate 99%, the example that has no adverse reaction and recurrence example.
As can be seen from the above table, infant spleen-tonifying temperature of the present invention leads to the Western medicine group and extract oral medicament group of pasting relative to prior art, the curative effect of the spleen and stomach in children weakness is significantly improved, and without any untoward reaction and recurrent cases, there is the beneficial effect that curative effect is high, side effect is little, focus can be eradicated, thorough treatment.
5. model case citing:
1) Wang, man, 9 months, loose stool, rush down after common food, every day defecates 7-8 time, color is light, shallow complexion, tired, pale tongue with white fur, recurrent exerbation more than 10 sky, is diagnosed as diarrhea due to hypofunction of the spleen, be affixed on infant umbilicus place with the logical subsides of infant spleen-tonifying temperature of the present invention, morning and evening every day is each once, medication three days, stool is normal, and appetite is good, and symptom is fully recovered.
2) thank certain, female, 4 years old, long-term inappetence, anorexia, monophagia, become thin, and stool is hospitalized for treatment after one week in the pasty state, does not take effect with western medicines in treatment, and the medicine 1 day of losing money in a business is just normal.
3) Zhang, man, 8 years old, because coldrex takes western medicine 10 days before half a year, there is anorexia, feel sick in cold symptoms after eliminating, and then develop in stool and accompany non-slaking residue, spirit is poor, after taking JIANWEI XIAOSHI PIAN, heavy time light during the state of an illness, be not clearly better always, have a medical check-up: emaciated physique, shallow complexion, spirit is poor, slightly move i.e. perspiration, thin white fur of tongue, arteries and veins are unable; Be diagnosed as: anorexia, insufficiency of the spleen mistake fortune, indigestion, disorder of stomach-QI, poor appetite; After docile two course for the treatment of, appetite obviously increases, and dietary amount obviously increases, and nausea disappears, and the mental status is greatly improved, and does not have indigested residue in stool, spontaneous perspiration transference cure.
4) Cui, female, 2 years old half, anorexia half a year, inappetence, body is thin, the few China of shallow complexion, large dry stool, accompany non-slaking residue in stool, night, dormancy was ground one's teeth in sleep, and easily wet the bed, had a medical check-up: emaciated physique, shallow complexion, spirit is poor, enlarged tongue is light red, white and thin fur is greasy, weak pulse; Be diagnosed as anorexia, deficiency of body fluid, insufficiency of the spleen mistake fortune, indigestion, disorder of stomach-QI; After docile 1 course for the treatment of, appetite obviously increases, and dietary amount obviously increases, and all diseases disappear.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. the logical subsides of infant spleen-tonifying temperature, is characterized in that, be prepared from by the raw material of following weight portion:
2. infant spleen-tonifying temperature according to claim 1 is logical pastes, and it is characterized in that, is prepared from by the raw material of following weight portion:
3. the logical extraction excipient technique of pasting of the infant spleen-tonifying temperature as described in as arbitrary in claim 1-2, is characterized in that, comprise the following steps:
1) weighing batching: the medicinal raw material taking ten times amount according to formula, cleaning, decontamination, dry for subsequent use;
2) steaming and decocting: the water medicinal raw material in step 1 being added six times of weight, soaks 30min, distilling with water 7h, filters, obtains volatile oil and residue;
3) extract: the water extraction twice residue in step 2 being added six times amount, merge extractive liquid, after extracting liquid filtering, after concentrated, pulverizing, drying and screening, obtain dry extract powder;
4) preparation of A phase: 4g gelatin is evenly sprinkled in 61g purified water, molten in 45 DEG C of Water Unders, swelling 1-1.5h, to complete swelling, adds 2g polyethylene and gives a tongue-lashing pyrrolidone K-30, be swelled into homogeneous liquid, obtain A phase for subsequent use;
5) preparation of B phase: 5g sodium polyacrylate, 2g dry extract, 2g azone are dispersed in 24g glycerol successively, are stirred into homogeneous suspension, obtain B phase for subsequent use;
6) preparation of mastic: B phase prepared by A phase step 4 prepared and step 5, stir with the mixing limit, speed limit of 80-120r/min, the volatile oil simultaneously taking preparation in 0.47g step 2 adds B phase, stir 20min, refining and temperature are 45 DEG C, obtain pitchy, mastic that homogeneous, viscosity is suitable for;
7) be coated with: mastic step 6 prepared is coated on non-woven fabrics while hot, and coating thickness is 2-3mm, hangs and spends the night, sizing, lid protecting film, die-cutly obtain finished product.
4. the logical extraction excipient technique of pasting of infant spleen-tonifying temperature according to claim 3, it is characterized in that, in described step 6, best mixing speed is 100r/min.
5. the infant spleen-tonifying temperature according to claim 1-2 is logical pastes, and it is characterized in that, be used for the treatment of infantile spleen deficiency weakness, every day respectively once, is affixed on infant umbilicus place sooner or later.
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Application publication date: 20160224 |