CN105853486A - Traditional Chinese medicine preparation for treating children recurrent respiratory infection and preparation method and application thereof - Google Patents
Traditional Chinese medicine preparation for treating children recurrent respiratory infection and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating children recurrent respiratory infection and a preparation method and application thereof. The traditional Chinese medicine preparation is prepared from, by weight, 3-8 parts of hypodematium crenatum, 12-16 parts of fructus quisqualis, 2-7 parts of herb of balanophora polyandra Griff. and 15-22 parts of fructus xanthii. The preparation method comprises the steps that hypodematium crenatum and herb of balanophora polyandra Griff. are taken to be crushed and subjected to ultrasonic treatment by adding absolute ethyl alcohol, and filtering is conducted to obtain filtrate; fructus quisqualis and fructus xanthii are taken to be crushed, and microwave extraction is conducted by adding absolute ethyl alcohol to prepare an extracting solution; the filtrate and the extraction solution are mixed, subjected to ultrasonic treatment, concentrated, eluted, subjected to reduced-pressure ethyl alcohol recycling, concentrated and dried to obtain an extract, and the extract is prepared into the traditional Chinese medicine preparation by adding auxiliary materials acceptable in the medical science. According to the traditional Chinese medicine preparation, the treatment effect on children recurrent respiratory infection is significant under the combined action of all the components, the effect is rapidly achieved, no toxic or side effect is generated, the children recurrent respiratory infection does not relapse after being cured, and the immunity can be effectively improved. The traditional Chinese medicine preparation is reasonable in component, simple in process, easy to operate, low in cost and capable of being widely suitable for treatment on respiratory tract infection.
Description
Technical field
The present invention relates to drug world, specifically Chinese medicine preparation treating infantile respiratory tract infection repeatedly and preparation method thereof and should
With.
Background technology
RRTI (RRTI) is Pediatric Clinic common disease, and the incidence of disease reaches about 20%.Refer to upper respiratory tract sense in 1a
Dye or ALRI number of times are frequent, have exceeded a range of respiratory tract infection, are called for short Chinese medicinel.Recurrent respiratory tract sense
Dye (RRTI) is common disease in children, and the incidence of disease reaches about 20%, most common with 2～6 years old.The children's suffering from RRTI is called for short multiple
Sense youngster, had the upper ALRI of more than 7～10 times in 1 year.It mostly is congenital factor or body's immunity is low
Or trace element and hypovitaminosis, or feeding patterns is improper, and the many factors such as heredity, nursing, living environment is comprehensive
The result of effect, if malpractice can cause the diseases such as asthma, myocarditis, ephritis, has a strong impact on children's upgrowth and development and health
Health, for one of important subject in pediatrics.
Current treatment methods typically uses antibiotherapy, the most simply drop, the most not only damages human body,
Strengthen treatment cost, double again when future infection is had a fever to use antibiotic, vicious circle, cause immunity to lack, treatment
Effect also tends to unsatisfactory.The modern medicine treatment to susceptible youngster, how from zinc supplementation, replenish the calcium, replenishing vitamins, third
Planting globulin, thymic peptide, transfer factor etc., to improve infant immunity.But indivedual lacking of property of physique are treated, effect
The most not ideal enough.With susceptible side's prophylactic treatment RRTI, it is to avoid the toxic and side effect that long-term taking Western medicine causes.
Summary of the invention
It is an object of the invention to provide evident in efficacy, instant effect, have no side effect, the treatment children's of non-relapse after healing anti-
Chinese medicine preparation of multiple respiratory tract infection and its preparation method and application, with the problem solving to propose in above-mentioned background technology.
For achieving the above object, the present invention provides following technical scheme:
The Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly, is made up of according to the raw material of weight portion following: swollen foot fern 3-8 part,
Fruit of Rangoon creeper's 12-16 part, exceedingly high candle 2-7 part, achene of Siberian cocklebur 15-22 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly, by following according to weight
The raw material composition of amount part: swollen foot fern 4-7 part, fruit of Rangoon creeper's 13-15 part, exceedingly high candle 3-6 part, achene of Siberian cocklebur 17-20 part.
As the further scheme of the present invention: the Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly, by following according to weight
The raw material composition of amount part: swollen foot fern 5 parts, the fruit of Rangoon creeper 14 parts, 5 parts of exceedingly high candle, the achene of Siberian cocklebur 18 parts.
The preparation method of the Chinese medicine preparation of described treatment infantile respiratory tract infection repeatedly, comprises the steps of:
1) weigh swollen foot fern and exceedingly high candle, insert in pulverizer and pulverize, obtain mixture A, be 1: 7 according to solid-liquid ratio,
Adding absolute ethyl alcohol, ultrasonically treated 70-90min in mixture A, wherein ultrasonic power is 800-900W, filters,
To filtrate；
2) take the fruit of Rangoon creeper, the achene of Siberian cocklebur, pulverize, obtain mixture B, be 1: 7 according to solid-liquid ratio, add in mixture B
Entering absolute ethyl alcohol, put in microwave extracting apparatus and carry out microwave abstracting, extraction power is 700-800W, extracts 3 times, every time
2-3 minute, combination system obtained extract；
3) filtrate being merged with extract, then carry out ultrasonically treated, ultrasonic power is 800-900W, and ultrasonic time is
30-40min, is concentrated into the 30-40% of original volume, is added on large pore resin absorption column, 50% ethanol elution, collects eluent,
Decompression recycling ethanol, is concentrated and dried, and obtains extract, adds medically acceptable auxiliary material and makes Chinese medicine preparation.
The application in preparation treatment infantile respiratory tract infection repeatedly medicine of the described Chinese medicine preparation.
Swollen foot fern expelling wind and removing dampness, hemostasis, removing toxic substances in the present invention.For rheumatic arthritis；Sore, traumatism and bleeding are controlled in external application.
Fruit of Rangoon creeper's killing insect and eliminating accumulation.Cure mainly roundworm disease, enterobiasis, abdominal pain due to enterositosis, infantile malnutrition.
Exceedingly high candle is clearing heat and detoxicating；Nourishing yin and nourishing blood；Hemostasis.Cure mainly gonorrhoea；Syphilis；The deficiency of blood；Hemorrhage.
Achene of Siberian cocklebur expelling cold, eliminating, clearing the nasal passage, wines used as antirheumatic, pain relieving.Cure mainly anemofrigid cold, nasosinusitis, arthralgia due to wind-dampness, rubella scabies
The card such as itch.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention is under the common effect of each component, evident in efficacy for infantile respiratory tract infection repeatedly, instant effect, nontoxic pair
Effect, non-relapse after healing, can be effectively improved immunity, and instant component is reasonable, technique operation simple, easy, cost
Low, it is widely portable to the treatment of respiratory tract infection.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, aobvious
So, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, the Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly, by the following raw material group according to weight portion
Become: swollen foot fern 3 parts, the fruit of Rangoon creeper 12 parts, 2 parts of exceedingly high candle, the achene of Siberian cocklebur 15 parts.
Weigh swollen foot fern and exceedingly high candle, insert in pulverizer and pulverize, obtain mixture A, be 1: 7 according to solid-liquid ratio, to
Adding absolute ethyl alcohol in mixture A, solid-liquid ratio unit is g/ml, ultrasonically treated 70min, and wherein ultrasonic power is 800W,
Filter, obtain filtrate.Take the fruit of Rangoon creeper, the achene of Siberian cocklebur, pulverize, obtain mixture B, be 1: 7 according to solid-liquid ratio, to mixing
Adding absolute ethyl alcohol in thing B, solid-liquid ratio unit is g/ml, puts into and carries out microwave abstracting in microwave extracting apparatus, extracts power
For 700W, extracting 3 times, each 2 minutes, combination system obtained extract.Filtrate is merged with extract, then carries out ultrasonic place
Reason, ultrasonic power is 800W, and ultrasonic time is 30min, is concentrated into the 30% of original volume, is added on large pore resin absorption column,
50% ethanol elution, collects eluent, decompression recycling ethanol, is concentrated and dried, obtains extract, add medically acceptable
Chinese medicine preparation made by auxiliary material.
Embodiment 2
In the embodiment of the present invention, the Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly, by the following raw material group according to weight portion
Become: swollen foot fern 8 parts, the fruit of Rangoon creeper 16 parts, 7 parts of exceedingly high candle, the achene of Siberian cocklebur 22 parts.
Weigh swollen foot fern and exceedingly high candle, insert in pulverizer and pulverize, obtain mixture A, be 1: 7 according to solid-liquid ratio, to
Adding absolute ethyl alcohol, ultrasonically treated 90min in mixture A, wherein ultrasonic power is 900W, filters, obtains filtrate.Take
The fruit of Rangoon creeper, the achene of Siberian cocklebur, pulverize, obtain mixture B, be 1: 7 according to solid-liquid ratio, adds absolute ethyl alcohol in mixture B,
Putting in microwave extracting apparatus and carry out microwave abstracting, extraction power is 800W, extracts 3 times, and each 3 minutes, combination system obtained
Extract.Filtrate being merged with extract, then carry out ultrasonically treated, ultrasonic power is 900W, and ultrasonic time is 40min,
It is concentrated into the 40% of original volume, is added on large pore resin absorption column, 50% ethanol elution, collect eluent, recovered under reduced pressure second
Alcohol, is concentrated and dried, and obtains extract, adds medically acceptable auxiliary material and makes Chinese medicine preparation.
Embodiment 3
In the embodiment of the present invention, the Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly, by the following raw material group according to weight portion
Become: swollen foot fern 4 parts, the fruit of Rangoon creeper 13 parts, 3 parts of exceedingly high candle, the achene of Siberian cocklebur 17 parts.
Weigh swollen foot fern and exceedingly high candle, insert in pulverizer and pulverize, obtain mixture A, be 1: 7 according to solid-liquid ratio, to
Adding absolute ethyl alcohol, ultrasonically treated 80min in mixture A, wherein ultrasonic power is 900W, filters, obtains filtrate.Take
The fruit of Rangoon creeper, the achene of Siberian cocklebur, pulverize, obtain mixture B, be 1: 7 according to solid-liquid ratio, adds absolute ethyl alcohol in mixture B,
Putting in microwave extracting apparatus and carry out microwave abstracting, extraction power is 700W, extracts 3 times, and each 3 minutes, combination system obtained
Extract.Filtrate being merged with extract, then carry out ultrasonically treated, ultrasonic power is 900W, and ultrasonic time is 35min,
It is concentrated into the 35% of original volume, is added on large pore resin absorption column, 50% ethanol elution, collect eluent, recovered under reduced pressure second
Alcohol, is concentrated and dried, and obtains extract, adds medically acceptable auxiliary material and makes Chinese medicine preparation.
Embodiment 4
In the embodiment of the present invention, the Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly, by the following raw material group according to weight portion
Become: swollen foot fern 7 parts, the fruit of Rangoon creeper 15 parts, 6 parts of exceedingly high candle, the achene of Siberian cocklebur 20 parts.
Preparation process is consistent with embodiment 3.
Embodiment 5
In the embodiment of the present invention, the Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly, by the following raw material group according to weight portion
Become: swollen foot fern 5 parts, the fruit of Rangoon creeper 14 parts, 5 parts of exceedingly high candle, the achene of Siberian cocklebur 18 parts.
Preparation process is consistent with embodiment 3.
Comparative example 1
In addition to not containing swollen foot fern, its formula and preparation process are consistent with embodiment 5.
Comparative example 2
Containing only swollen foot fern, its preparation process is consistent with embodiment 5.
Comparative example 3
Fill a prescription consistent with embodiment 5, prepare according to " Antifebrile oral liquor " of Publication No. CN1049144 upper described method.
Embodiment 6 pharmacological toxicity is tested
1, acute toxicity test
Application mouse carries out acute toxicity testing and shows: the Chinese medicine preparation of the Mouse oral gavage embodiment of the present invention 5, at 346.2g
Under crude drug/kg dosage, after administration, mouse occurs that light activity reduces, and within about 1 hour, recovers normal, Continuous Observation 7 after administration
My god, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, test result indicate that:
The maximum dosage-feeding of the Chinese medicine preparation of the Mouse oral gavage embodiment of the present invention 5 is 346.2g crude drug/kg/d (LD50 ＞
346.2g crude drug/kg).The Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d；By batheroom scale, little
Dosis tolerata is clinical patient 3462 times of the Chinese medicine preparation of the mouse gavage present invention.Point out this medicine acute toxicity low, clinical use
Medicine safety.
2, long term toxicity test
Select SD rat, give the Chinese medicine system of the embodiment of the present invention 5 of variable concentrations (18.0,6.0,2.0g crude drug/kg)
Agent, every day gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 animal (male and female half and half), remaining
1/2 animal lives after continuing to observe 2 weeks and kills.The outward appearance of animal, general behavior, food ration, changes of weight is observed during test,
It is administered latter 90 days and drug withdrawal carries out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood for 2 weeks
Biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient,
The index checkings such as Histopathology.Result of the test shows: the Chinese medicine preparation of the present invention is general at high, medium and low dosage treated animal
In good condition, outward appearance sign, behavioral activity, food-intake and body weight increase change the most without exception；Three dosage groups and control group
Hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range (NR), group without significant difference；Respectively organize main organs
Histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively
The 180 of clinical medicine dose, 60,20 times, according to the Chinese medicine preparation of the result of the test present invention at high, medium and low three dosage
(18.0,6.0,2.0g crude drug/kg) are administered and have no significant effect rat for continuous 90 days, without clear and definite toxicity target organ and quick
Sense index, convalescence observation also has no retardance toxic reaction, the dosage safety of the Chinese medicine preparation clinical practice of the prompting present invention
Property is higher.
3, select SD rat, give the Chinese medicine of the embodiment of the present invention 5 of variable concentrations (18.0,6.0,2.0g crude drug/kg)
Preparation, every day gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 animal (male and female half and half), its
1/2 animal of Yuing lives after continuing to observe 2 weeks and kills.The outward appearance of animal, general behavior, food ration, body weight change is observed during test
Change, be administered latter 90 days and drug withdrawal carries out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) for 2 weeks
Biochemical, dirty with blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine
The index checkings such as device coefficient, Histopathology.Result of the test shows: the Chinese medicine preparation of the present invention is in high, medium and low dosage group
Animal general state is good, and outward appearance sign, behavioral activity, food-intake and body weight increase change the most without exception；Three dosage groups
And control group hematological examination, blood biochemical analysis, urine biochemical analysis all between normal range (NR), group without significant difference；Each group
Main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test medicament
Amount is respectively the 180 of clinical medicine dose, 60,20 times, according to the Chinese medicine preparation of the result of the test present invention high, medium and low
Three dosage (18.0,6.0,2.0g crude drug/kg) is administered and has no significant effect rat, without clear and definite toxicity target for continuous 90 days
Organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, the Chinese medicine preparation clinical practice of the prompting present invention
Dose safety is higher.
Embodiment 7 pharmacological effect is tested:
The experimental study of antipyretic effect of the present invention
(1), experiment material:
1, animal: health large ear rabbit, body weight (2.4 ± 0.3) kg, male and female have concurrently.Shandong agricultural college provides.
2, medicine: medicine A: (it is real that A1 group to A5 group is respectively the present invention to the Chinese medicine preparation prepared according to the method for the present invention
Execute example 1～the Chinese medicine preparation of embodiment 5 preparation).
Medicine B: comparative example 1.
Medicine C: comparative example 2.
Medicine D: comparative example 3.
3, instrument: computer numeral clinical thermometer.
(2), experimental technique: taking health large ear rabbit 30,3d before experiment, is 55 in room temperature 22-25 DEG C, humidity
%-65%, surveyed animal anus temperature 1 time totally 4 times at interval of 1 hour under ventilated environment, makes animal adapt to, and Thermal preference ripple
Dynamic scope animal in the range of 0.4 DEG C is standby.During experiment, animal is randomly divided into 5 groups by body weight size, respectively physiology
Salt solution group, A group, B group, C group, D group.Survey rabbit anus temperature 1 time every 30min computer digital clinical thermometer, survey 3 times altogether,
Asking for its mean value is this animal basal body temperature.It is administered rabbit ear edge intravenous injection inactivation EHEC pyrogenicity by 1ml/kg,
And before pyrogenicity 30 minutes gastric infusions at twice after 30min and pyrogenicity.After pyrogenicity 30,60,120,240 and 360min
Surveying rabbit anus temperature 5 times respectively, calculate anus temperature and the difference of basal body temperature after each group of rabbit day part treatment, take statistics processes.
(3), experimental result: the results detailed in Table 1.
Different periods Temperature changing situation after the treatment of table 1 each treated animal
(4), conclusion: as it can be seen from table 1 result shows that A group has, to EHEC pyrogenicity rabbit, work of substantially bringing down a fever
With, its effect of bringing down a fever is better than B group, C group and D group, and antipyretic effect relatively B group and C group are persistently.
Embodiment 8 clinical testing
Children's's its clinical manifestation of upper sense is: has some inkling of a cold, or delays a few days, and slight chill stream is lossless, or sweating is impermeable,
Neck body is scorching hot, hands and feet coolness, sleepy or dysphoria, and lip is red, and dry thinks drink, thin white fur of tongue or micro-Huang, floating and tense pulse
Number, line red tape is purple.
1, clinical data
With reference to the diagnostic criteria of RRTI, by 450 example RRTI (RRI) infants by the time of examining
Order is randomly divided into 9 groups, often organizes 50 examples.Each group is compared at the aspect such as age, sex, no significant difference.
2, methods for the treatment of
Infection of the upper respiratory tract medication 7 days.Treat 1 group of preparation taking embodiment 1.Treat 2 groups of systems taking embodiment 2
Agent.Treat 3 groups of preparations taking embodiment 3.Treat 4 groups of preparations taking embodiment 4.Treat 5 groups and take embodiment
The preparation of 5.Compareing 1 group is blank group, only takes physiological saline.Compare 2 groups of preparations taking comparative example 1.Comparison 3
Group takes the preparation of comparative example 2.Compare 4 groups of preparations taking comparative example 3.
3, criterion of therapeutical effect and treatment results
Effective: drug withdrawal does not occurs respiratory tract infection or only respiratory tract infection 1 time June；
Effective: respiratory tract infection number of times reduces or do not reduces, but infection symptoms is light earlier above every time, and the course of disease shortens；
Invalid: respiratory tract infection number of times is relatively treated front unchanged.
2 groups of comparitive study for the treatment of results, are shown in Table 2.Result shows, the present invention is evident in efficacy, and respiratory tract infection disease improves feelings
Condition is all good compared with control group, treats 5 groups and compares with compareing 2-3 group, illustrates that the present invention is to act as under the common effect of each component
?.Treat 5 groups and compare with compareing 4 groups, illustrate that the preparation method of the present invention is preferable.Therefore, instant component is reasonable,
Technique is advanced, is applicable to the treatment of respiratory tract infection.
Table 2
P ＜ 0.01 is compared with control group.
Meanwhile, to treat the patient of 5 groups before the treatment after all look into venous blood IgA, IgG, IgM and t lymphocyte subset group (CD3+,
CD4+ and CD8+).Before and after treatment, the change of immune indexes is shown in Table 3.
Before and after table 3 treatment, immune indexes change is compared
| Immune indexes | Before treatment | After treatment |
| IgG(g/L) | 6.10±0.13 | 7.92±0.15 |
| IgA(g/L) | 5.14±0.45 | 9.93±0.24 |
| IgM(g/L) | 0.96±0.12 | 1.34±0.25 |
| CD3+ (%) | 40.0±1.5 | 57.5±1.2 |
| CD4+ (%) | 24.1±1.5 | 34.3±1.7 |
| CD8+ (%) | 20.1±1.5 | 25.4±1.1 |
As known from Table 3, the present invention can be effectively improved every immune indexes, therefore shows for infantile respiratory tract infection repeatedly curative effect
Write.
Model case
1: Zhang, female, 4.5 years old.Travelling outdoors and open wide automobile window in return home way, sleep soundly and catch cold, that night is with sending out hot body high
Temperature 39.4 DEG C, selects antibiotic, Western medicine of bringing down a fever, moves back (being not below 38 DEG C all the time), but soon bounce, repeatedly exhale during high heat
Inhaling road to infect 2 months, Western medicine has been used a lot, does not effects a permanent cure, it is desirable to use treatment by Chinese herbs.Quarter examines: body temperature 38 DEG C, One's spirits are drooping,
Whole body is lossless, and neck, body are scorching hot, Shou Zuleng, throat hypodynia, and dry thinks drink, receives difference, dry and hard excrement, and urine Huang is few,
Tongue is the reddest, the thin Huang of tongue, superficial and rapid pulse.Disable all Western medicine, take the Chinese medicine preparation 7 days of the embodiment of the present invention 5.Start micro-
Micro-sweating, head body heat subtracts, and brothers turn temperature, and two just lead to unblocked, and spirit is slightly shaken, and body temperature is down to 37.5 DEG C；Continue and take 7 days
After, body temperature is normal, spirit amelioration, pharyngalgia only, lip profit mouth and, know hungry rope food.Drug withdrawal is observed one week, and rehabilitation is as before.With
Visit half a year without recurrence.
2: Korea Spro, man, 4 years old, infect flu in kindergarten, infant cough is more than, medical, intermittently behind more than 14 skies
Still cough, and flu；First quarter moon cause flu of suffering from cold draws cough, runny nose, then syndrome characterized by dyspnea, heating, once arrived his institute and goes to a doctor and is
Zhi Suoguan is scorching, takes Western medicine heat and moves back asthma and slightly subtract, but cough is more than, has phlegm to be difficult to bring up, and coughs weight night, in paroxysmal, and companion
Vomiting sputum or food.Receive can, stool is dry, and urine is many.Disease see spirit still can, runny nose, pharynx is red and swollen big, and tongue color is micro-red,
In tongue Huang greasy, fingerprint is purple.Disable all Western medicine, take the Chinese medicine preparation of the embodiment of the present invention 5, take 7 days, start micro-
Micro-sweating, head body heat subtracts, and brothers turn temperature, and two just lead to unblocked, and spirit is slightly shaken, and after 3 days, body temperature is normal, spirit amelioration,
Pharyngalgia only, lip profit mouth and, know hungry rope food.Drug withdrawal is observed one week, and rehabilitation is as before.Follow up a case by regular visits to half a year without recurrence.
3: Wang, 4 years old, man, upper kindergarten infection one week of flu, select antibiotic, Western medicine of bringing down a fever, move back during high heat,
Repeated coughing 2 months, cough syrup, Western medicine has been used and has much been loseed recovery from illness, it is desirable to use treatment by Chinese herbs.Quarter examines: body temperature 39 DEG C,
One's spirits are drooping, whole body is lossless, and neck, body are scorching hot, throat hypodynia, and dysphagia is had a medical check-up and seen antiadoncus, speaks
Hoarse, there is tear sound.Disable all Western medicine, take the prepared Chinese medicine preparation of the embodiment of the present invention 47 days, start head body heat
Subtracting, brothers turn temperature, and two just lead to unblocked, and spirit is slightly shaken, pharyngalgia only, lip profit mouth and, sound of speaking starts normally；3
After it, body temperature is normal, and spirit amelioration, throat enlargement is the best, and tonsillotome no longer aches.Drug withdrawal is observed one week, and rehabilitation is as before.
Follow up a case by regular visits to half a year without recurrence.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and do not carrying on the back
In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter from
From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim
Change is included in the present invention.
Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only comprises
One independent technical scheme, this narrating mode of specification is only the most for clarity sake, and those skilled in the art should be by
Specification is as an entirety, and the technical scheme in each embodiment can also be through appropriately combined, and forming those skilled in the art can
With other embodiments understood.
Claims (5)
1. treat the Chinese medicine preparation of infantile respiratory tract infection repeatedly, it is characterised in that be made up of according to the raw material of weight portion following:
Swollen foot fern 3-8 part, fruit of Rangoon creeper's 12-16 part, exceedingly high candle 2-7 part, achene of Siberian cocklebur 15-22 part.
The Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly the most according to claim 1, it is characterised in that by following
Form according to the raw material of weight portion: swollen foot fern 4-7 part, fruit of Rangoon creeper's 13-15 part, exceedingly high candle 3-6 part, achene of Siberian cocklebur 17-20
Part.
The Chinese medicine preparation for the treatment of infantile respiratory tract infection repeatedly the most according to claim 2, it is characterised in that by following
Form according to the raw material of weight portion: swollen foot fern 5 parts, the fruit of Rangoon creeper 14 parts, 5 parts of exceedingly high candle, the achene of Siberian cocklebur 18 parts.
4. the preparation method of the Chinese medicine preparation of the treatment infantile respiratory tract infection repeatedly as described in claim 1-3 is arbitrary, it is special
Levy and be, comprise the steps of:
1) weigh swollen foot fern and exceedingly high candle, insert in pulverizer and pulverize, obtain mixture A, be 1: 7 according to solid-liquid ratio,
Adding absolute ethyl alcohol, ultrasonically treated 70-90min in mixture A, wherein ultrasonic power is 800-900W, filters,
To filtrate；
2) take the fruit of Rangoon creeper, the achene of Siberian cocklebur, pulverize, obtain mixture B, be 1: 7 according to solid-liquid ratio, add in mixture B
Entering absolute ethyl alcohol, put in microwave extracting apparatus and carry out microwave abstracting, extraction power is 700-800W, extracts 3 times, every time
2-3 minute, combination system obtained extract；
3) filtrate being merged with extract, then carry out ultrasonically treated, ultrasonic power is 800-900W, and ultrasonic time is
30-40min, is concentrated into the 30-40% of original volume, is added on large pore resin absorption column, 50% ethanol elution, collects eluent,
Decompression recycling ethanol, is concentrated and dried, and obtains extract, adds medically acceptable auxiliary material and makes Chinese medicine preparation.
5. the answering in preparation treatment infantile respiratory tract infection repeatedly medicine of the Chinese medicine preparation as described in claim 1-3 is arbitrary
With.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281418A (en) * | 2017-06-21 | 2017-10-24 | 成都中医药大学 | A kind of food, functional food or pharmaceutical composition and its production and use |
| CN108543008A (en) * | 2018-04-25 | 2018-09-18 | 惠州嘉联生物科技开发有限公司 | A kind of composite enzyme of preventing respiratory tract infection and preparation method thereof |
-
2016
- 2016-04-11 CN CN201610235340.1A patent/CN105853486A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 张静等: "小儿反复呼吸道感染中医辨证治疗研究概况", 《云南中医学院学报》 * |
| 胡小勤等: "《中药学》", 31 January 2014, 西安交通大学出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107281418A (en) * | 2017-06-21 | 2017-10-24 | 成都中医药大学 | A kind of food, functional food or pharmaceutical composition and its production and use |
| CN107281418B (en) * | 2017-06-21 | 2021-01-15 | 成都中医药大学 | Pharmaceutical composition and preparation method and application thereof |
| CN108543008A (en) * | 2018-04-25 | 2018-09-18 | 惠州嘉联生物科技开发有限公司 | A kind of composite enzyme of preventing respiratory tract infection and preparation method thereof |
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Application publication date: 20160817 |