CN105012610A - Superfine powder traditional Chinese veterinary medicine for treating trichodiniasis of loach and preparing method - Google Patents
Superfine powder traditional Chinese veterinary medicine for treating trichodiniasis of loach and preparing method Download PDFInfo
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- CN105012610A CN105012610A CN201510475041.0A CN201510475041A CN105012610A CN 105012610 A CN105012610 A CN 105012610A CN 201510475041 A CN201510475041 A CN 201510475041A CN 105012610 A CN105012610 A CN 105012610A
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- superfine powder
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- trichodinasis
- misgurni anguillicaudati
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Abstract
The invention discloses superfine powder traditional Chinese veterinary medicine for treating trichodiniasis of loach. The superfine powder traditional Chinese veterinary medicine comprises, by weight, 10 parts to 60 parts of radix sophorae flavescentis, 10 parts to 35 parts of artemisia apiacea, 25 parts to 40 parts of betel nuts and 0.01 part to 0.1 part of sodium carboxymethylcellulose. The particle size of the superfine powder traditional Chinese veterinary medicine ranges from 300 meshes to 500 meshes. By means of the superfine powder traditional Chinese veterinary medicine, the immunologic function can be improved, cost is low, the toxic and side effects are small, and absorption is easy. The invention further provides a preparing method of the superfine powder traditional Chinese veterinary medicine for treating trichodiniasis of loach.
Description
technical field:
What the present invention relates to is field of medicaments, particularly be a kind of superfine powder herbal medicine and preparation method for the treatment of Misgurni anguillicaudati trichodinasis.
background technology:
Trichodina, be under the jurisdiction of Ciliata, peritricha, Mobilina, Hu Xing section, Trichodina subfamily, the health side of Trichodina is seen as plate shape, and the one side of health protuberance is actinal surface, and relative one side is anti-actinal surface, recessed to centre, be adsorbed on host with it be attachment dish, the spoke wire loop having many spoke wire can be seen under microscope, have a circle cilium at spoke wire loop surrounding edge.Trichodina invasion and attack Misgurni anguillicaudati health and the gill, aspirates tissue cell does nutrition, the skin of young Misgurni anguillicaudati and gill tissue is made to suffer major injury, rot, cause tissue inflammation, have a strong impact on the breathing function of Misgurni anguillicaudati, bringing out gill rot, furunculosis and enteritis disease, is the main bacteria seed causing the death of loach Seedling, is one of disease the most serious in loach breeding.
Trichodinasis is the commonly encountered diseases of Misgurni anguillicaudati, popular more extensive, the early spring and early summer and Wintering Period more, particularly high at cultivation density, it is more easily infected when water quality is more fertile, this kind of disease has been subjected to the great attention of domestic and international herding worker, and more research has been carried out in the aspect such as nosetiology, epidemiology, pathogenesis, prevention and corntrol around them, defines some achievements in research.
The prophylactic treatment drug main of current use will comprise: copper sulfate, mixture of ferrous sulfate; Avilamycin, the chemicalses such as metrifonate, have a strong impact on Misgurni anguillicaudati meat and safety.This kind of medicine is all prohibited from using now substantially, is difficult to large-scale promotion application.
summary of the invention:
The object of the invention is to overcome above deficiency, provide one to strengthen immunologic function, cost is low, and toxic and side effects is little, the superfine powder herbal medicine of the treatment Misgurni anguillicaudati trichodinasis easily absorbed.
Another object of the present invention is the preparation method of the superfine powder herbal medicine in order to provide treatment Misgurni anguillicaudati trichodinasis.
The object of the present invention is achieved like this:
The present invention treats the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis, composed of the following components by weight:
Radix Sophorae Flavescentis 10 ~ 60,
Herba Artemisiae Annuae 10 ~ 35,
Semen Arecae 25 ~ 40,
Sodium carboxymethyl cellulose 0.01 ~ 0.1,
The particle diameter of above-mentioned ultra micro herbal medicine is 300 ~ 500 orders.
Above-mentioned is composed of the following components by weight:
Radix Sophorae Flavescentis 45,
Herba Artemisiae Annuae 20,
Semen Arecae 35,
Sodium carboxymethyl cellulose 0.02.
The present invention treats the preparation method of the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis, comprises the following steps:
1) respectively Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Semen Arecae, sodium carboxymethyl cellulose are pulverized;
2) prepare burden in proportion, mix homogeneously;
3) compound and dry air being injected jointly super micron mill pulverizes particle diameter is the superfine powder herbal medicine of 300 ~ 500 therapeutic interest Misgurni anguillicaudati trichodinasis.
Radix Sophorae Flavescentis heat clearing and damp drying in superfine powder herbal medicine of the present invention, main parasite killing, diuresis; Herba Artemisiae Annuae main scabies scabies crust is itched, and malignant boil kills louse (Shennong's Herbal), the main anthelmintic of Semen Arecae, removing food stagnancy, the therapeutic method to keep the adverse QI flowing downwards, row water, preventing the attack (or recurrence) of malaria; Add binding agent sodium carboxymethyl cellulose in three medicines, drug adhesion is stronger, and active drug is attached to Misgurni anguillicaudati body time length and is more easily share the effect of playing preventing the attack (or recurrence) of malaria, anthelmintic altogether by absorption four medicine.
Herbal medicine superfine powder of the present invention mainly strengthens immunologic function of livestock and birds, and in herbal medicine, each component all adopts natural raw material of Chinese medicine, and its configuration is simple, and medicine source is wide, cost is low, and medicine noresidue, toxic and side effects is little.The present invention adopts micronizing, and medicine is more easily absorbed.Not only the good therapeutical effect of the prevention that Misgurni anguillicaudati trichodinasis of the present invention has had, reaches prevention but also reach therapeutic effect in the phase of breeding of loach Seedling, reduce cultivation risk to greatest extent.
Herbal medicine preparation method of the present invention is simple
:
Misgurni anguillicaudati disease and pest Chinese herb prevention of the present invention technical research:
Superfine powder herbal medicine of the present invention clinical trial:
1. materials and methods:
1) trial drug is prepared; Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Semen Arecae, sodium carboxymethyl cellulose;
2) preparation and the management of Misgurni anguillicaudati is tested;
Chengdu double fluid woman's bow aquaculture field morbidity Misgurni anguillicaudati totally 8000 tails.
3) test period:
On April 30,24 days ~ 2013 April in 2013;
1) test method:
(1) divide into groups:
Choose that the length of side in specification × wide is respectively 58 × 46cm, the lower length of side × wide is respectively 53 × 40cm, the plastic box of high 32cm 4, is divided into 1,2,3,4 group.Often group supports the Misgurni anguillicaudati that 2000 tails suffer from trichodinasis temporarily, and be convenient to carry out variable concentrations drug test, the 4th group is matched group.Put Misgurni anguillicaudati specification in a suitable place to breed close, every tail length is 1.0 ~ 1.2 cm, heavy about 5g, pulverizing Limnodrilus hoffmeisteri of throwing something and feeding during supporting temporarily.Day to throw and raise 2 times, throw the time of raising in the morning is 10:00, afternoon 18:00, each, every case is thrown something and fed 10g, increases and decreases depending on feeding situation.In experimental period, each plastic box keeps 24h oxygenation.
(2) drug test:
Test adopts self-control drug products, splashes respectively carry out drug test by 0.1 g/L, 0.2 g/L, 0.5 g/L in plastic box.
(3) experiment process:
Control water temperature at about 21 ~ 23 DEG C, pH value 7.0 ~ 8.0 in each plastic box as far as possible.Adopt method of splashing to splash in plastic box by each variable concentrations medicine to be measured respectively by the concentration of test setting, every day 2 times, use 5 days continuously, the gill filament or the epidermal mucus of live fish is got after one week, make slide, the survival condition of basis of microscopic observation Trichodina, and make a record.
2. test results and analysis:
1) result of the test:
Fish quantity * 100 %(of fish mortality rate=(macrura reevesii amount of survival tested by the quantity-mirror putting fish)/input is 1 in Table).
The ill Misgurni anguillicaudati experience table of each test group of table 1
Suffer from as seen from the above table trichodinasis Misgurni anguillicaudati concentration be put in a suitable place to breed one week in the Chinese herbal medicine pond of 0.1g/L, 0.2g/L, 0.5g/L after, mortality rate be respectively 16.0 %, 6%, 3.0 %, 2.4 %.The mortality rate of i.e. treatment by Chinese herbs group and matched group difference are all extremely significantly (P<0.1); High, middle dosage group contrast low dose group significant difference (P>0.5); Without significant difference between high, middle dosage group group.
2) herbal medicine of the present invention is to the Toxicity Observation of Misgurni anguillicaudati:
This test selects specification to be that the healthy loach fish of about 3g is done experiment fish, and 20 tails put in a suitable place to breed by every case, totally 4 casees.Support after 1 week temporarily, the self-control drug products of 4 kinds of variable concentrations of splashing, concentration is respectively 0.1 g/L, 0.2 g/L, 0.5 g/L, 1.0 g/L.Through the Continuous Observation of 96h, each concentration all has no the test obvious abnormal conditions of fish and dead generation.
3. discuss:
(1) herbal medicine of the present invention is added and subtracted by pure Chinese medicine to form, although the Chinese medicine ingredients of the simple complexity of tissue types determines its insecticidal effect, in the test of clinical treatment Misgurni anguillicaudati trichodinasis, the working concentration of medicine is crucial.
(2) use herbal medicine of the present invention control Fish parasitic disease to adhere to scientific formula, suit the remedy to the case, the principle of Regular application.
(3) parasitic chemical drug resistance and antibiotic residual and abuse are still more scabrous problem at present, so this research products is as the medicine avoiding and solve above two difficult problems, there are good development prospect and application prospect in its parasiticide aspect.The dosage form of this product is that powder more or less has certain pollution to water body at present, along with the Chinese herbal medicine containing this scientific research product composition is changed over an important channel and the target that solution will become this seminar by the further investigation of seminar.
(4) this test is killed Trichodina mainly for medicine and is explored.As for envirment factor as temperature, acid-base value, Organic substance in water and float etc. also need further research to the impact of medicine.
4. example: double fluid woman's bow aquaculture field, Chengdu
Test tank C1 pond, area 1.4 mu, the depth of water 0.4 m, puts mud fish fry 300,000 tail in a suitable place to breed, and specification is 1.2 ~ 1.5cm.
Test period: 14 ~ 20 May.
Test data sheet:
May 13, find that Misgurni anguillicaudati is slowly travelling at pool side, microscopy finds that body surface has a large amount of Trichodina.
May 14, self-control drug products of splashing, concentration is 0.5 g/L water, each 1 time of every day at upper and lower noon.
May 15, the dead loach Seedling of microscopy finds that caudal peduncle has live body parasite.
May 16, the dead loach Seedling of microscopy does not find that caudal peduncle has live body parasite.
May 17, the dead loach Seedling of microscopy does not find live body parasite.
May 18, microscopy does not find live body parasite.
May 19, do not find dead loach Seedling again, microscopy does not find live body parasite.
May 20, do not find dead loach Seedling again, microscopy does not find live body parasite.
detailed description of the invention:
Embodiment 1:
The present embodiment 1 treats the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis, composed of the following components by weight:
Radix Sophorae Flavescentis 45,
Herba Artemisiae Annuae 20,
Semen Arecae 35,
Sodium carboxymethyl cellulose 0.02,
The particle diameter of above-mentioned ultra micro herbal medicine is 300 ~ 500 orders.
The present embodiment 1 treats the preparation method of the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis, comprises suddenly following:
1) respectively Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Semen Arecae, sodium carboxymethyl cellulose are pulverized;
2) prepare burden in proportion, mix homogeneously;
3) compound and dry air being injected jointly super micron mill pulverizes particle diameter is the superfine powder herbal medicine of 300 ~ 500 therapeutic interest Misgurni anguillicaudati trichodinasis.
Embodiment 2:
The present embodiment 2 treats the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis, composed of the following components by weight:
Radix Sophorae Flavescentis 60,
Herba Artemisiae Annuae 35,
Semen Arecae 40,
Sodium carboxymethyl cellulose 0.1,
The particle diameter of above-mentioned ultra micro herbal medicine is 300 ~ 500 orders.
The present embodiment 2 treat the preparation method of the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis and embodiment 1 with.
Embodiment 3:
The present embodiment 3 treats the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis, composed of the following components by weight:
Radix Sophorae Flavescentis 30,
Herba Artemisiae Annuae 30,
Semen Arecae 40,
Sodium carboxymethyl cellulose 0.05,
The particle diameter of above-mentioned ultra micro herbal medicine is 300 ~ 500 orders.
The present embodiment 3 treat the preparation method of the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis and embodiment 1 with.
Above-described embodiment is described further foregoing of the present invention, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to above-described embodiment.All technology realized based on foregoing all belong to protection scope of the present invention.
Claims (3)
1. treat the superfine powder herbal medicine of Misgurni anguillicaudati trichodinasis, composed of the following components by weight:
Radix Sophorae Flavescentis 10 ~ 60,
Herba Artemisiae Annuae 10 ~ 35,
Semen Arecae 25 ~ 40,
Sodium carboxymethyl cellulose 0.01 ~ 0.1,
The particle diameter of above-mentioned ultra micro herbal medicine is 300 ~ 500 orders.
2. the superfine powder herbal medicine for the treatment of Misgurni anguillicaudati trichodinasis as claimed in claim 1, is characterized in that composed of the following components by weight:
Radix Sophorae Flavescentis 45,
Herba Artemisiae Annuae 20,
Semen Arecae 35,
Sodium carboxymethyl cellulose 0.02.
3. the preparation method of the superfine powder herbal medicine for the treatment of Misgurni anguillicaudati trichodinasis as claimed in claim 1 or 2, is characterized in that comprising suddenly following:
1) respectively Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Semen Arecae, sodium carboxymethyl cellulose are pulverized;
2) prepare burden in proportion, mix homogeneously;
3) compound and dry air being injected jointly super micron mill pulverizes particle diameter is the superfine powder herbal medicine of 300 ~ 500 therapeutic interest Misgurni anguillicaudati trichodinasis.
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Citations (4)
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|---|---|---|---|---|
| CN101040936A (en) * | 2007-04-28 | 2007-09-26 | 大连水产学院 | Compound Chinese traditional medicine agent for preventing fish verminosis |
| CN101223878A (en) * | 2008-01-29 | 2008-07-23 | 北京伟嘉人生物技术有限公司 | Ivermectin compound plant source pesticide and preparing method thereof |
| CN101711528A (en) * | 2008-10-06 | 2010-05-26 | 北京大北农科技集团股份有限公司 | Compound medicinal composition for destroying and expelling rotifers and protozoa and preparation method thereof |
| CN101961368A (en) * | 2010-06-23 | 2011-02-02 | 天津生机集团股份有限公司 | Preparation method of aquatic animal insect repellent |
-
2015
- 2015-08-06 CN CN201510475041.0A patent/CN105012610A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040936A (en) * | 2007-04-28 | 2007-09-26 | 大连水产学院 | Compound Chinese traditional medicine agent for preventing fish verminosis |
| CN101223878A (en) * | 2008-01-29 | 2008-07-23 | 北京伟嘉人生物技术有限公司 | Ivermectin compound plant source pesticide and preparing method thereof |
| CN101711528A (en) * | 2008-10-06 | 2010-05-26 | 北京大北农科技集团股份有限公司 | Compound medicinal composition for destroying and expelling rotifers and protozoa and preparation method thereof |
| CN101961368A (en) * | 2010-06-23 | 2011-02-02 | 天津生机集团股份有限公司 | Preparation method of aquatic animal insect repellent |
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Application publication date: 20151104 |
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