CN102973842B - 一种治疗干眼症的中药熏洗液 - Google Patents
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Abstract
本发明公开了一种治疗干眼症的中药熏洗液。干眼症属中医学“白涩证”、“燥证”范畴，肝肾功能失调或肝血不足，会导致目失肝血及津液的濡养，从而导致眼目干燥，引发本病。为此，本发明选择中药千里光、小画眉草、青黛、蕨麻、寸金草、赤芍、土千年健、王不留行、玉竹、女贞子、菟丝子、薏苡仁，制成中药熏洗液。经我院临床试验，治疗组总有效率达到93.0％，明显优于对照组，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗干眼症的中药熏洗液。
背景技术
干眼症是眼科常见的眼表疾病之一，发病率逐年增高。美国的调查显示，30～60岁人群，发病率为11％，多发于46～55岁之间的女性。近年来，随着社会的发展，干眼症的发病率较以前明显增加。社会老龄化、视频终端工作者及角膜接触镜配戴者的增多，导致干眼症的发病率逐年升高，发病年龄也趋于年轻化，严重的干眼症将导致角膜表面磨损、丝状角膜炎和角膜溃疡。最终发生角膜混浊和视力丧失等严重后果。目前治疗手段繁多而杂，但疗效均不明显，严重者长期用人工泪液维持。
发明内容
本发明的目的是提供一种治疗干眼症的中药熏洗液。干眼症属中医学“白涩证”、“神水将枯”、“神水枯痒”、“燥证”范畴，在我国古代医学中早有论述。《素问·通调虚实论》说：“肾者水脏，主津液”，即肾主津液，上润目珠。可见，泪为肝液，肾主津液，肝肾同源。肝肾功能失调或肝血不足，会导致目失肝血及津液的濡养，从而导致眼目干燥，引发本病。故治疗本病应以补肝益肾，滋阴生津为主，兼之活血通络。
本发明的目的是通过以下技术方案实现的，该治疗干眼症的中 药熏洗液由以下重量份的中药制成：千里光9-11份、小画眉草9—11份、青黛8—10份、蕨麻8—10份、寸金草7—9份、赤芍8-10份、土千年健7—9份、王不留行10—12份、玉竹7—9份、女贞子8-11份、菟丝子12—15份、薏苡仁10-15份。
优选的，千里光10份、小画眉草10份、青黛9份、蕨麻9份、寸金草8份、赤芍9份、土千年健8份、王不留行11份、玉竹8份、女贞子10份、菟丝子13份、薏苡仁14份。
制备方法将上述中药放于砂锅内，加入清水适量，浸泡30min，煮沸30min后，取汁备用。
方中：千里光清热解毒，杀虫明目；小画眉草清热解毒，疏风利尿；青黛清热解毒，凉血消斑，清肝泻火，定惊；蕨麻健脾益胃，生津止渴，益气补血；寸金草清热平肝；赤芍清热凉血，散瘀止痛；土千年健舒筋通络，活血止血，消炎；王不留行活血通络，消痈，利尿通淋；玉竹养阴润燥，生津止渴；女贞子补肝肾阴，乌须明目；菟丝子补肾固精，养肝明目，止泻安胎；薏苡仁利水渗湿，健脾，除痹，清热排脓。
临床资料
一般资料2008年11月～2010年3月就诊的干眼症患者120例240眼，随机分为治疗组和对照组各60例，治疗组男24例，女36例，平均年龄(48.65±14.73)岁；对照组男28例，女32例，平均年龄(54.75±13.91)岁；两组性别、年龄、病程等均无统计学差异，(P＞0.05)具有可比性。
诊断标准①有干眼症；②眼膜破裂时间(BUT)≤10s；③角膜 荧光素钠染色体(FL)后可见上皮散在点状着色；④泪液分泌物试验(S|T)分泌量≤10mm／5min。
治疗方法治疗组使用上述中药煎汁熏洗，将药汁倒入容器内，患者俯面以热气薰眼10-15分钟，待温度降至能耐受时用消毒棉球浸药液洗眼，再用浸药液的纱布块热敷患眼3—5分钟，每日2次。对照组口服维生素A1丸／d(2.5万U)，局部用人工泪液常规点眼。两组治疗时间均定为30d，每10d为1疗程，每个疗程后进行复查统计，30d后对照治疗结果。
疗效标准参照***颁布的《中医病征诊断疗效标准》，以临床症状、S|T分泌量、BUT、FL为观察指标。显效：症状消失，S|T分泌量多次测定＞10mm／5min，BUT＜10s，FL着色减少。有效：症状减轻，S|T分泌量多次测定有所增加，BUT较前延长，FL着色减少；无效：症状无改善，S|T分泌量多次测定未增加，BUT无变化，FL着色无变化。
治疗结果(1)两组治疗前后S|T分泌量比较见表1。
表1 两组治疗前后S|T分泌量比较
mm／5min
与治疗前比较，①P＜0.05；与对照组治疗前后比较，②P＜0.05
(2)两组治疗前后BUT比较见表2。
表2 两组治疗前后BUT比较
s
与治疗前比较，①P＜0.05；与对照组治疗后比较，②P＜0.05
(3)两组治疗前后FL比较见表3。
表3 两组治疗前后FL计分比较分
与治疗前比较，①P＜0.05；与对照组治疗后比较，②P＞0.05
(4)两组临床疗效比较见表4。
表4 两组治疗三个疗程后临床疗效比较
与对照组治疗后比较，①P＜0.05
总有效率治疗组为93.0％，对照组为78.3％；两组比较，差异有显著性意义(P＜0.05)。
具体实施方式
实施例一：称取千里光10g、小画眉草10g、青黛9g、蕨麻9g、寸金草8g、赤芍9g、土千年健8g、王不留行11g、玉竹8g、女贞子10g、菟丝子13g、薏苡仁14g，将上述中药放于砂锅内，加入清水适量，浸泡30min，煮沸30min后，制成中药薰洗液。薰洗方法：将中药熏洗液倒入容器内，患者俯面以热气薰眼10—15分钟，待温度降至能耐受时用消毒棉球浸药液洗眼，再用浸药液的纱布块热敷患眼3—5分钟，每日2次。
实施例二：称取千里光9g、小画眉草9g、青黛8g、蕨麻8g、寸金草7g、赤芍8g、土千年健7g、王不留行10g、玉竹7g、女贞子8g、菟丝子12g、薏苡仁10g，将上述中药放于砂锅内，加入清水适量，浸泡30min，煮沸30min后，制成中药薰洗液。薰洗方法同实施例一。
实施例三：称取千里光11g、小画眉草11g、青黛10g、蕨麻10g、 寸金草9g、赤芍10g、土千年健9g、王不留行12g、玉竹9g、女贞子11g、菟丝子15g、薏苡仁15g，将上述中药放于砂锅内，加入清水适量，浸泡30min，煮沸30min后，制成中药薰洗液。薰洗方法同实施例一。
Claims (2)
1.一种治疗干眼症的中药熏洗液，其特征在于该中药熏洗液由以下重量份的中药制成：千里光9-11份、小画眉草9-11份、青黛8-10份、蕨麻8-10份、寸金草7-9份、赤芍8-10份、土千年健7-9份、王不留行10-12份、玉竹7-9份、女贞子8-11份、菟丝子12-15份、薏苡仁10-15份。
2.根据权利要求1所述一种治疗干眼症的中药熏洗液，其特征在于该中药熏洗液由以下重量份的中药制成：千里光10份、小画眉草10份、青黛9份、蕨麻9份、寸金草8份、赤芍9份、土千年健8份、王不留行11份、玉竹8份、女贞子10份、菟丝子13份、薏苡仁14份。
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