CN104435442A - 一种治疗阴虚湿热型干眼症的中药制剂 - Google Patents

一种治疗阴虚湿热型干眼症的中药制剂 Download PDF

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CN104435442A
CN104435442A CN201410636752.7A CN201410636752A CN104435442A CN 104435442 A CN104435442 A CN 104435442A CN 201410636752 A CN201410636752 A CN 201410636752A CN 104435442 A CN104435442 A CN 104435442A
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项玉荣
王霞
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Abstract

本发明公开了一种治疗阴虚湿热型干眼症的中药制剂。中医认为干眼的病因病机涉及脏腑功能失调、六淫外侵、七情内郁，辩证治疗阴虚湿热型干眼症应以补肝肾，清湿热为原则。本发明选择中药泽泻实、凤尾七、女贞子、香木菌桂、芜菁花、茱苓草、珍珠草、望江南子、小白花苏、土木贼，水煎成汤剂供患者服用，经临床试验，总有效率92％，明显优于对照组的72％，而且副作用小，值得临床推广应用。

Description

一种治疗阴虚湿热型干眼症的中药制剂
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗阴虚湿热型干眼症的中药制剂。
背景技术
干眼症(dry-eye syndrome，xerophthamia)亦称角结膜干燥症(Keratoconjunctivitis sicca，KCS)，是指因泪液质和量或动力学异常导致的泪膜稳定性下降，并伴有眼部不适，引起眼表病变为特征的多种疾病的总称。临床表现为干涩感、异物感、烧灼感、痒感、畏光、眼红、视物模糊、视力波动及视疲劳。流行病学及临床调查发现干眼症的发病率逐渐升高。西医治疗方法很多，其中泪液替代疗法因使用方便，疗效确切，副作用小，是目前治疗干眼症的主要药物，但没有一种人工泪液能完全与泪液成分一致，人工泪液中的防腐剂尤其是苯扎氯铵，经研究证实，本身就对眼表有一定损伤。抗炎药物可用于干眼症的短期治疗，但同样也有角膜上皮毒性。雄激素能使泪腺和其他眼表组织保持在非炎症状态，下调免疫活性，促进蛋白质的合成，对泪液分泌过程有放大作用等，但是性激素的全身应用可能导致较严重的副作用。手术治疗也因存在诸多风险而不能被广泛应用。申请人在多年的临床实践中，应用中药治疗干眼症取得了较好的疗效。
发明内容
本发明的目的是提供一种治疗阴虚湿热型干眼症的中药制剂。干眼的病因病机涉及脏腑阴阳、气血津液、六淫七情等多方面。脏腑功能失调、六淫外侵、七情内郁，均可影响气血津液的生成、输布，从而使目窍受累形成干眼。辩证治疗阴虚湿热型干眼症应以补肝肾，清湿热为原则。
本发明的目的是通过以下技术方案实现的，该治疗阴虚湿热型干眼症的中药制剂由以下重量份的中药制成：泽泻实3-9份、凤尾七5-10份、女贞子5-9份、香木菌桂3-9份、芜菁花3-6份、茱苓草6-9份、珍珠草10-20份、望江南子3-9份、小白花苏10-20份、土木贼3-6份。
优选的，泽泻实6份、凤尾七7份、女贞子7份、香木菌桂6份、芜菁花4份、茱苓草7份、珍珠草15份、望江南子6份、小白花苏15份、土木贼4份。
制备方法  将上述中药水煎制成汤剂。
方中：泽泻实益肾气、滋阴消渴、祛风湿；凤尾七补肾、调经活血、养心安神、明目；女贞子、香木菌桂补肝肾、强腰膝；芜菁花补肝明目；茱苓草清肝明目、利小便、调经活血；珍珠草清肝明目、渗湿利尿、解毒；望江南子清热明目、解毒、通便、健胃；小白花苏清热渗湿、利尿明目；土木贼清热利湿、明目。
临床资料
1、一般资料  2010年1月至2011年1月在我院门诊和住院的阴虚湿热型干眼症共50例，其中男20例，女30例；治疗组25例，男10例，女15例，年龄最小23岁，最大66岁，平均35.18岁，均为双眼患病。对照组25例，男10例，女15例，最小22岁，最大58岁，平均33.63岁，均为双眼患病。两组患者间性别、年龄、病情无统计学差异(P＞0.05)。
2、诊断标准  (参照国家中医药管理局颁发的《中医病证诊断疗效标准》)(1)目珠干燥失却莹润光泽，白晴微红有皱褶，眵粘稠呈拉丝状。(2)泪液分泌量测定(Schirmer I Test)少于10mm/5min。(3)泪膜破裂时间(BUT)＜10s。((1)+(2)或者(1)+(3)即可诊断)
辨证标准：目珠干燥乏泽，干涩，疼痛，畏光，视物模糊，口鼻干燥，关节疼痛，溲黄，便干，舌红，苔薄黄，脉数。
3、治疗及护理方法  治疗组患者服用本发明所述中药制剂，称取泽泻实6g、凤尾七7g、女贞子7g、香木菌桂6g、芜菁花4g、茱苓草7g、珍珠草15g、望江南子6g、小白花苏15g、土木贼4g，每日1剂水煎，分2次服用。对照组使用右旋糖配轻丙甲纤维素滴眼液(爱尔康公司生产)，每天4次，每次每眼1～2滴，疗程8周。
护理上注意生活起居：注意安静，舒适，通风良好，避免噪声。饮食调护：饮食宜清淡易消化补肝滋阴之品如核桃仁、黑芝麻、木耳汤、香蕉、梨等，忌辛辣香燥之物，可以黄芩叶、茶叶、菊花适量泡荼频饮；陈皮代茶饮以理肝理气。
4、疗效标准  (1)临床疗效评定依据：治疗前后泪液分泌量检测；治疗前后泪膜破裂时间检测；治疗前后角膜染色检测；
(2)临床症状疗效评定标准：(参照国家中医药管理局《中医病证诊断疗效标准》)临床痊愈：治疗后症状和体征基本消失(疗效指数≥95％)。显效：治疗后症状和体征明显改善(95％＞疗效指标≥70％)。有效：治疗后症状和体征有改善(70％＞疗效指数≥30％)无效：治疗后症状和体征无明显改善(疗效指数＜30％)。
5、治疗结果  患者治疗8周后观察疗效，治疗组其中痊愈15例(60％)，显效5例(20％)，有效3例(12％)，无效2例(8％)，总有效率92％。对照组其中痊愈5例(20％)，显效10例(40％)，有效3例(12％)，无效7例(28％)，总有效率72％。对于本病进行血、尿、便常规及肝、肾功能，心电图等相关理化检查，进行治疗前后对照，没有任何异常变化。治疗组患者有1例出现眼睛酸涩的症状，对照组患者有9例出现不同程度的眼部疼痛、视物模糊、持续性充血及刺激感，停药后症状均消失。
具体实施方式
实施例一：称取泽泻实6g、凤尾七7g、女贞子7g、香木菌桂6g、芜菁花4g、茱苓草7g、珍珠草15g、望江南子6g、小白花苏15g、土木贼4g，将上述中药水煎成汤剂。
实施例二：称取泽泻实9g、凤尾七5g、女贞子9g、香木菌桂3g、芜菁花6g、茱苓草6g、珍珠草20g、望江南子3g、小白花苏20g、土木贼3g，将上述中药水煎成汤剂。
实施例三：称取泽泻实3g、凤尾七10g、女贞子5g、香木菌桂9g、芜菁花3g、茱苓草9g、珍珠草10g、望江南子9g、小白花苏10g、土木贼6g，将上述中药水煎成汤剂。

Claims (2)

1.一种治疗阴虚湿热型干眼症的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：泽泻实3-9份、凤尾七5-10份、女贞子5-9份、香木菌桂3-9份、芜菁花3-6份、茱苓草6-9份、珍珠草10-20份、望江南子3-9份、小白花苏10-20份、土木贼3-6份。
2.根据权利要求1所述的一种治疗阴虚湿热型干眼症的中药制剂，其特征在于该中药制剂由以下重量份的中药制成：泽泻实6份、凤尾七7份、女贞子7份、香木菌桂6份、芜菁花4份、茱苓草7份、珍珠草15份、望江南子6份、小白花苏15份、土木贼4份。
CN201410636752.7A 2014-11-01 2014-11-01 一种治疗阴虚湿热型干眼症的中药制剂 Pending CN104435442A (zh)

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Application publication date: 20150325