CN104435442A - 一种治疗阴虚湿热型干眼症的中药制剂 - Google Patents
一种治疗阴虚湿热型干眼症的中药制剂 Download PDFInfo
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Abstract
本发明公开了一种治疗阴虚湿热型干眼症的中药制剂。中医认为干眼的病因病机涉及脏腑功能失调、六淫外侵、七情内郁,辩证治疗阴虚湿热型干眼症应以补肝肾,清湿热为原则。本发明选择中药泽泻实、凤尾七、女贞子、香木菌桂、芜菁花、茱苓草、珍珠草、望江南子、小白花苏、土木贼,水煎成汤剂供患者服用,经临床试验,总有效率92%,明显优于对照组的72%,而且副作用小,值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物,尤其涉及一种治疗阴虚湿热型干眼症的中药制剂。
背景技术
干眼症(dry-eye syndrome,xerophthamia)亦称角结膜干燥症(Keratoconjunctivitis sicca,KCS),是指因泪液质和量或动力学异常导致的泪膜稳定性下降,并伴有眼部不适,引起眼表病变为特征的多种疾病的总称。临床表现为干涩感、异物感、烧灼感、痒感、畏光、眼红、视物模糊、视力波动及视疲劳。流行病学及临床调查发现干眼症的发病率逐渐升高。西医治疗方法很多,其中泪液替代疗法因使用方便,疗效确切,副作用小,是目前治疗干眼症的主要药物,但没有一种人工泪液能完全与泪液成分一致,人工泪液中的防腐剂尤其是苯扎氯铵,经研究证实,本身就对眼表有一定损伤。抗炎药物可用于干眼症的短期治疗,但同样也有角膜上皮毒性。雄激素能使泪腺和其他眼表组织保持在非炎症状态,下调免疫活性,促进蛋白质的合成,对泪液分泌过程有放大作用等,但是性激素的全身应用可能导致较严重的副作用。手术治疗也因存在诸多风险而不能被广泛应用。申请人在多年的临床实践中,应用中药治疗干眼症取得了较好的疗效。
发明内容
本发明的目的是提供一种治疗阴虚湿热型干眼症的中药制剂。干眼的病因病机涉及脏腑阴阳、气血津液、六淫七情等多方面。脏腑功能失调、六淫外侵、七情内郁,均可影响气血津液的生成、输布,从而使目窍受累形成干眼。辩证治疗阴虚湿热型干眼症应以补肝肾,清湿热为原则。
本发明的目的是通过以下技术方案实现的,该治疗阴虚湿热型干眼症的中药制剂由以下重量份的中药制成:泽泻实3-9份、凤尾七5-10份、女贞子5-9份、香木菌桂3-9份、芜菁花3-6份、茱苓草6-9份、珍珠草10-20份、望江南子3-9份、小白花苏10-20份、土木贼3-6份。
优选的,泽泻实6份、凤尾七7份、女贞子7份、香木菌桂6份、芜菁花4份、茱苓草7份、珍珠草15份、望江南子6份、小白花苏15份、土木贼4份。
制备方法 将上述中药水煎制成汤剂。
方中:泽泻实益肾气、滋阴消渴、祛风湿;凤尾七补肾、调经活血、养心安神、明目;女贞子、香木菌桂补肝肾、强腰膝;芜菁花补肝明目;茱苓草清肝明目、利小便、调经活血;珍珠草清肝明目、渗湿利尿、解毒;望江南子清热明目、解毒、通便、健胃;小白花苏清热渗湿、利尿明目;土木贼清热利湿、明目。
临床资料
1、一般资料 2010年1月至2011年1月在我院门诊和住院的阴虚湿热型干眼症共50例,其中男20例,女30例;治疗组25例,男10例,女15例,年龄最小23岁,最大66岁,平均35.18岁,均为双眼患病。对照组25例,男10例,女15例,最小22岁,最大58岁,平均33.63岁,均为双眼患病。两组患者间性别、年龄、病情无统计学差异(P>0.05)。
2、诊断标准 (参照国家中医药管理局颁发的《中医病证诊断疗效标准》)(1)目珠干燥失却莹润光泽,白晴微红有皱褶,眵粘稠呈拉丝状。(2)泪液分泌量测定(Schirmer I Test)少于10mm/5min。(3)泪膜破裂时间(BUT)<10s。((1)+(2)或者(1)+(3)即可诊断)
辨证标准:目珠干燥乏泽,干涩,疼痛,畏光,视物模糊,口鼻干燥,关节疼痛,溲黄,便干,舌红,苔薄黄,脉数。
3、治疗及护理方法 治疗组患者服用本发明所述中药制剂,称取泽泻实6g、凤尾七7g、女贞子7g、香木菌桂6g、芜菁花4g、茱苓草7g、珍珠草15g、望江南子6g、小白花苏15g、土木贼4g,每日1剂水煎,分2次服用。对照组使用右旋糖配轻丙甲纤维素滴眼液(爱尔康公司生产),每天4次,每次每眼1~2滴,疗程8周。
护理上注意生活起居:注意安静,舒适,通风良好,避免噪声。饮食调护:饮食宜清淡易消化补肝滋阴之品如核桃仁、黑芝麻、木耳汤、香蕉、梨等,忌辛辣香燥之物,可以黄芩叶、茶叶、菊花适量泡荼频饮;陈皮代茶饮以理肝理气。
4、疗效标准 (1)临床疗效评定依据:治疗前后泪液分泌量检测;治疗前后泪膜破裂时间检测;治疗前后角膜染色检测;
(2)临床症状疗效评定标准:(参照国家中医药管理局《中医病证诊断疗效标准》)临床痊愈:治疗后症状和体征基本消失(疗效指数≥95%)。显效:治疗后症状和体征明显改善(95%>疗效指标≥70%)。有效:治疗后症状和体征有改善(70%>疗效指数≥30%)无效:治疗后症状和体征无明显改善(疗效指数<30%)。
5、治疗结果 患者治疗8周后观察疗效,治疗组其中痊愈15例(60%),显效5例(20%),有效3例(12%),无效2例(8%),总有效率92%。对照组其中痊愈5例(20%),显效10例(40%),有效3例(12%),无效7例(28%),总有效率72%。对于本病进行血、尿、便常规及肝、肾功能,心电图等相关理化检查,进行治疗前后对照,没有任何异常变化。治疗组患者有1例出现眼睛酸涩的症状,对照组患者有9例出现不同程度的眼部疼痛、视物模糊、持续性充血及刺激感,停药后症状均消失。
具体实施方式
实施例一:称取泽泻实6g、凤尾七7g、女贞子7g、香木菌桂6g、芜菁花4g、茱苓草7g、珍珠草15g、望江南子6g、小白花苏15g、土木贼4g,将上述中药水煎成汤剂。
实施例二:称取泽泻实9g、凤尾七5g、女贞子9g、香木菌桂3g、芜菁花6g、茱苓草6g、珍珠草20g、望江南子3g、小白花苏20g、土木贼3g,将上述中药水煎成汤剂。
实施例三:称取泽泻实3g、凤尾七10g、女贞子5g、香木菌桂9g、芜菁花3g、茱苓草9g、珍珠草10g、望江南子9g、小白花苏10g、土木贼6g,将上述中药水煎成汤剂。
Claims (2)
1.一种治疗阴虚湿热型干眼症的中药制剂,其特征在于该中药制剂由以下重量份的中药制成:泽泻实3-9份、凤尾七5-10份、女贞子5-9份、香木菌桂3-9份、芜菁花3-6份、茱苓草6-9份、珍珠草10-20份、望江南子3-9份、小白花苏10-20份、土木贼3-6份。
2.根据权利要求1所述的一种治疗阴虚湿热型干眼症的中药制剂,其特征在于该中药制剂由以下重量份的中药制成:泽泻实6份、凤尾七7份、女贞子7份、香木菌桂6份、芜菁花4份、茱苓草7份、珍珠草15份、望江南子6份、小白花苏15份、土木贼4份。
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