CN102973702A - Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof - Google Patents
Piglet yellow and white scour treatment compound traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a piglet yellow and white scour treatment compound traditional Chinese medicine composition and a preparation method thereof. The preparation method specifically comprises: carrying out decoction, filtration, concentration and spray drying on Chinese pulsatilla root, tomentose populus ament, coptis chinensis, amur corktree bark and medicine terminalia fruit, then adding western medicine such as mequindox, gentamycin sulfate and sodium salicylate and auxiliary materials such as sucrose and Jiayi powder, and carrying out mixing, crushing, soft material preparation and drying. The piglet yellow and white scour treatment compound traditional Chinese medicine composition has the following characteristics that: significant treatment effects are provided; water drinking and material stirring are adopted to direct take the composition; the composition is subjected to complete metabolism absorption in the body; and the composition has characteristics of good treatment efficacy, easy use, no toxic-side effect, safety and reliability, and is suitable for piglet dysentery treatment, especially for piglet yellow and white scour treatment.
Description
Technical field
The present invention relates to a kind of herbal mixture composition and method of making the same for the treatment of yellow and white dysentery of piglet, belong to field of medicaments for animals.
Background technology
Along with the development of animal husbandry, the industry of raising pigs is increasing in the scale of livestock, and thereupon as seen also thereupon as seen yellow and white dysentery of piglet treat the medicine of yellow and white dysentery of piglet clinically, and therapeutic effect is not very desirable, and easily recurrence, does not have basic purpose.
Yellow and white dysentery of piglet is the abbreviation of yellow scour of piglet, Hakuri, usually, 3～10 days is yellow scours after the piglet birth, and the Hakuri that is called more than 10 days of being born, also and can judge that the two all is a kind of acute infectious disease that is caused newborn piglet by antibacterial characteristic of disease escherichia coli, if untimely treatment by observing stool colour, be easy to cause piglet dead, bring huge economic loss for pig farm and raiser.
Yellow scour of piglet (early onset large intestine bar sick) claims again the newborn piglet colibacillosis, a kind of acute, the height lethal infectious disease of the newborn piglet that is caused by dust Xi Shi escherichia coli (E.Coli).After escherichia coli entered intestine of young pigs, facility was adsorbed on the intestinal mucosa with pili, settles down by this propagation, produces a large amount of enterotoxins, and the piglet dehydration is had loose bowels.Be characterized as violent diarrhoea, discharge yellow or yellow-white loose stool and rapidly dehydration.Bacillus coli antigen is complicated, and O, H, three kinds of antigens of K are arranged; Serotype is many, has several thousand kinds; The resistance of environment is not strong to external world.Colibacillaryly pathogenicly depend on that it is in the ability of small intestinal adhesion, field planting, propagation and its toxigenic ability, adhesion factor or cilium determine the ability of bacteria planting, in case generation bacteria planting, will cause because of the generation of toxin diarrhoea, most important adhesion factor is F4(K88ab, K88ac), F5(K99), F6(987P).The morbidity age in days is early mainly encroached on 1～3 age in days piglet, and morbidity is anxious, symptom is obvious, mortality rate is high.Without seasonal, but sickness rate is higher when cold, and the delivery room is moist, and sickness rate was higher when sanitary condition was bad, pig farm in case morbidity be difficult to eradicate.Mainly be digestive tract infection, the sow that carries disease germs is Infectious Diseases.
Piglet pujos blancos has another name called the Delayed onset escherichia coli, is piglet common diarrhoeal diseases within age of sucking.Mainly be to pass through digestive tract infection.Be characterized as the stench loose stool of disease piglet milk ejection white or canescence, sickness rate is higher and fatality rate is not very high, but the speed of growth of piglet obviously slows down.The cause of disease is complicated, can not affirm fully that still it is generally acknowledged the dysbacteriosis of Intestinum Sus domestica road, the excessive breeding of escherichia coli is the major reason of primary disease, now confirms, it is one of cause of disease of piglet pujos blancos that the pig wheel turns virus.Primary disease is multiple is born in 10～30 age in days piglets (with the morbidity of 10～20 ages in days at most, 7 ages in days are seldom fallen ill with interior and the above piglet of 30 ages in days).Bring out and to aggravate the factor of piglet pujos blancos disease also a lot, as improper because of sow feeding management, the pig house health is bad, the growth of livestock girth of a garment differs, hypogalactia, dense rare variation are too large, without seasonal, perhaps weather turns cold suddenly, and humidity strengthens, overcast and rainy or warming bad, all can bring out the generation of Hakuri.If condition is better, curing in time can very fast recovery from illness, and mortality rate is lower, and condition is bad, can cause the piglet thin and weak death of dewatering.
Summary of the invention
The purpose of this invention is to provide a kind of herbal mixture compositions for the treatment of yellow and white dysentery of piglet.
The present invention also aims to provide a kind of preparation method for the treatment of the herbal mixture compositions of yellow and white dysentery of piglet.
In order to realize above purpose, the technical solution adopted in the present invention is: compositions of the present invention comprises the raw material of following parts by weight: 10～25 parts of the Radix Pulsatillaes, 30～40 parts of flower of poplar, 5～10 parts of Rhizoma Coptidis, 8～15 parts of Cortex Phellodendris, 5～10 parts of Fructus Chebulaes, 3～5 parts of LIJUNJING, 1～2 part of gentamycin sulfate, 2～3 parts of sodium salicylate.
Preparation method may further comprise the steps:
(1) 10～25 parts of the Radix Pulsatillaes, 30～40 parts of flower of poplar, 5～10 parts of Rhizoma Coptidis, 8～15 parts of Cortex Phellodendris, 5～10 parts of five kinds of medical materials of Fructus Chebulae are added respectively 8～10 times, 6～8 times decoctings and boil 2 times, 1.5～2h for the first time, 1～1.5h for the second time, collecting decoction;
(2) above-mentioned decocting liquid is filtered, filtrate is concentrated into thick paste, and relative density is 1.0～1.2;
(3) in step (2), add 95% ethanol in the thick paste and make and contain the alcohol amount and reach 45～50%, leave standstill, again filter, collect filtrate, Recycled ethanol;
(4) with above-mentioned filtrate spray drying, add LIJUNJING 3～5%, 1～2 part of gentamycin sulfate, 2～3 parts of sodium salicylate and adjuvant sucrose and add beneficial powder, crushing screening mixes soft material processed, oven dry.
The effect of main component pharmacological action and drug combination: LIJUNJING is broad spectrum antibiotic, and this product mainly is that the DNA (deoxyribonucleic acid) (DNA) that suppresses thalline is synthesized.Most antibacterials there is stronger inhibitory action, stronger to the gram negative bacteria effect, also effective to treponema.Be mainly used in the swine dysentery due to the treponema, yellow scour of piglet, Hakuri, diarrhea of pigs etc.; Gentamycin sulfate is used for golden Portugal bacterium, bacillus pyocyaneus, escherichia coli, dysentery bacterium etc. clinically, is mainly used in the specially good effects such as antibiotic, treatment escherichia coli in prescription; The main chemical constituent of flower of poplar is that leaf contains Quercetin, Quercetin 3-β-D-Glucose glycoside, and myricetin 3-β-D-galactoside, luteolin-7-β D-Glucose glycoside has the specially good effect of removing dampness dysentery relieving; The Fructus Chebulae is effective for dysentery bacterium clinically, especially take Fructus Chebulae's shell as good; LIJUNJING and gentamycin sulfate associating compatibility are to the specific effect for the treatment of yellow and white dysentery of piglet tool.
Said composition is all used raw material of Chinese medicine, and not by any side effect, and granule is easy to use to piglet, absorbs soon, does not affect the charge ratio of feedstuff, has greatly improved therapeutic effect.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Embodiment 1
Prescription: Radix Pulsatillae 20g, flower of poplar 35g, Rhizoma Coptidis 8g, Cortex Phellodendri 10g, Fructus Chebulae 7g, LIJUNJING 3g, gentamycin sulfate 2g, sodium salicylate 2g, sucrose 400g, add beneficial powder 450g.
Concrete preparation process is as follows:
(1) gets the Radix Pulsatillae, flower of poplar, Rhizoma Coptidis, Cortex Phellodendri, five kinds of medical materials of Fructus Chebulae and add respectively 9 times, 6 times decoctings and boil 2 times, 1.6h for the first time, 1.5h for the second time, collecting decoction;
(2) above-mentioned decocting liquid is filtered, it is 1.0 thick paste at 70 ℃ that filtrate is concentrated into relative density;
(3) in step (2), add 95% ethanol in the thick paste and make and contain the alcohol amount and reach 50%, leave standstill, filter filtrate recycling ethanol;
(4) with above-mentioned filtrate spray drying, add LIJUNJING, gentamycin sulfate, sodium salicylate and adjuvant, crushing screening mixes soft material processed, oven dry.
Embodiment 2
Prescription: Radix Pulsatillae 25g, flower of poplar 40g, Rhizoma Coptidis 10g, Cortex Phellodendri 15g, Fructus Chebulae 10g, LIJUNJING 5g, gentamycin sulfate 1g, sodium salicylate 2.5g, sucrose 450g, add beneficial powder 400g.
Concrete preparation process is as follows:
(1) gets the Radix Pulsatillae, flower of poplar, Rhizoma Coptidis, Cortex Phellodendri, five kinds of medical materials of Fructus Chebulae and add respectively 10 times, 7 times decoctings and boil 2 times, 1.5h for the first time, 1.2h for the second time, collecting decoction;
(2) above-mentioned decocting liquid is filtered, it is 1.1 thick paste at 70 ℃ that filtrate is concentrated into relative density;
(3) in step (2), add 95% ethanol in the thick paste and make and contain the alcohol amount and reach 48%, leave standstill, filter filtrate recycling ethanol;
(4) with above-mentioned filtrate spray drying, add LIJUNJING, gentamycin sulfate, sodium salicylate and adjuvant, crushing screening mixes soft material processed, oven dry.
Embodiment 3
Prescription: Radix Pulsatillae 10g, flower of poplar 30g, Rhizoma Coptidis 5g, Cortex Phellodendri 8g, Fructus Chebulae 5g, LIJUNJING 4g, gentamycin sulfate 1.5g, sodium salicylate 3g, add beneficial powder 420g at sucrose 420g
Concrete preparation process is as follows:
(1) gets the Radix Pulsatillae, flower of poplar, Rhizoma Coptidis, Cortex Phellodendri, five kinds of medical materials of Fructus Chebulae and add respectively 8 times of decoctings and boil 2 times, 2h for the first time, 1h for the second time, collecting decoction;
(2) above-mentioned decocting liquid is filtered, it is 1.2 thick paste at 70 ℃ that filtrate is concentrated into relative density;
(3) in step (2), add 95% ethanol in the thick paste and make and contain the alcohol amount and reach 45%, leave standstill, filter filtrate recycling ethanol;
(4) with above-mentioned filtrate spray drying, add LIJUNJING, gentamycin sulfate, sodium salicylate and adjuvant, crushing screening mixes soft material processed, oven dry.
Animal experiment
40 sodium selenites, body weight 9.5-10.5kg, male and female has concurrently, be divided at random 4 groups of contrasts, blank, test, city's medicine group, 10/group, 4 groups of test pig adapt to two days later in new feeding environment, contrast, test group, every pig artificial vaccination of city's medicine group pathogenic bacteria 5mL coli-infection pig, blank winding kind normal saline is freely drunk water and is searched for food, and carries out clinical treatment according to operation instruction of the present invention.
Table 1 animal test results statistical table
Experimental group and city's medicine group are compared with matched group and can be found out, street drug and Chinese medicine of the present invention all can be resisted coli-infection well, but obviously are better than the antibiotic therapy group with the Chinese medicine preparation therapeutic effect, and cure rate is respectively 100% and 89%.
Claims (7)
1. a herbal mixture compositions that is used for the treatment of yellow and white dysentery of piglet is characterized in that: the raw material that comprises following parts by weight: 10～25 parts of the Radix Pulsatillaes, 30～40 parts of flower of poplar, 5～10 parts of Rhizoma Coptidis, 8～15 parts of Cortex Phellodendris, 5～10 parts of Fructus Chebulaes, 3～5 parts of LIJUNJING, 1～2 part of gentamycin sulfate, 2～3 parts of sodium salicylate.
2. a kind of herbal mixture compositions that is used for the treatment of yellow and white dysentery of piglet as claimed in claim 1, it is characterized in that: product forms can be acceptable dosage form on oral liquid, powder, tablet, granule, injection or other pharmaceutics.
3. a kind of herbal mixture compositions that is used for the treatment of yellow and white dysentery of piglet as claimed in claim 2, it is characterized in that: product forms is granule.
4. preparation method that is used for the treatment of the herbal mixture compositions of yellow and white dysentery of piglet as claimed in claim 3 is characterized in that: may further comprise the steps:
(1) 10～25 parts of the Radix Pulsatillaes, 30～40 parts of flower of poplar, 5～10 parts of Rhizoma Coptidis, 8～15 parts of Cortex Phellodendris, 5～10 parts of five kinds of medical materials of Fructus Chebulae are added respectively 8～10 times, 6～8 times decoctings and boil 2 times, 1.5～2h for the first time, 1～1.5h for the second time, collecting decoction;
(2) above-mentioned decocting liquid is filtered, filtrate is concentrated into thick paste;
(3) in step (2), add ethanol in the thick paste, make to contain alcohol amount and reach 45～50%, leave standstill, again filter, collect filtrate, Recycled ethanol;
(4) with above-mentioned filtrate spray drying, add 3～5 parts of LIJUNJING, 1～2 part of gentamycin sulfate, 2～3 parts of sodium salicylate and adjuvant, crushing screening mixes soft material processed, oven dry.
5. the preparation method that is used for the treatment of the herbal mixture compositions of yellow and white dysentery of piglet as claimed in claim 4, it is characterized in that: the relative density that filtrate is concentrated into thick paste is 1.0～1.2 at 70 ℃.
6. the preparation method that is used for the treatment of the herbal mixture compositions of yellow and white dysentery of piglet as claimed in claim 4, it is characterized in that: used ethanol is 95% ethanol.
7. the preparation method that is used for the treatment of the herbal mixture compositions of yellow and white dysentery of piglet as claimed in claim 4 is characterized in that: adjuvant is sucrose and adds beneficial powder that addition is respectively: 400～450 parts and 400～450 parts.
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| CN103404729A (en) * | 2013-08-09 | 2013-11-27 | 青岛根源生物技术集团有限公司 | Composite microecologics capable of improving growth rate of stichopus japonicus and application of composite microecologics |
| CN103585338A (en) * | 2013-11-27 | 2014-02-19 | 镇江天和生物技术有限公司 | Five-medicine oral liquid for dysentery stopping, and preparation method thereof |
| CN104274539A (en) * | 2013-07-01 | 2015-01-14 | 牙韩温 | Herbal medicine for treating poultry white scour |
| CN104288436A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Veterinary injection with effects of astringing intestine to stop diarrhea and preparation method of veterinary injection |
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| CN104288436A (en) * | 2014-09-30 | 2015-01-21 | 天津瑞贝特科技发展有限公司 | Veterinary injection with effects of astringing intestine to stop diarrhea and preparation method of veterinary injection |
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Address after: 451162 Zhengzhou economic comprehensive experimentation area, Zhengzhou air port, Henan, Xingang Province Patentee after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451162 Xingang, Henan, Zhengzhou, Hong Kong airport on the eastern side of the road on the eastern side of Zhengzhou Patentee before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |