CN105250972A - Traditional Chinese medicine composition for preventing and treating poultry proventriculitis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating poultry proventriculitis and preparation method and application thereof Download PDFInfo
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- CN105250972A CN105250972A CN201510778635.9A CN201510778635A CN105250972A CN 105250972 A CN105250972 A CN 105250972A CN 201510778635 A CN201510778635 A CN 201510778635A CN 105250972 A CN105250972 A CN 105250972A
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating poultry proventriculitis. The composition is prepared from flowers of poplar, honeysuckle, cortex dictamni, roots of Chinese pulsatilla, cuttlebone, elecampane, rhizoma corydalis, bletilla striata, coptis chinensis, cortex phellodendri, rheum officinale, pseudo-ginseng, fructus amomi, pericarpium citri reticulatae, dried ginger and the like. The traditional Chinese medicine composition has the functions of clearing away heat and toxic materials, cooling blood and stopping dysentery, purging intense heat for convergence, eliminating dampness and tonifying qi and the like, has remarkable curative effect on meat chicken proventriculitis and enteritis, and is free of toxic and side effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind ofly prevent and treat Chinese medicine composition of poultry proventriculitis and its production and use.
Background technology
The avian infectious gland ventriculitis of family be a kind of bad with poultry growth, become thin, regularity is poor, the outward appearance symptoms such as punishment in advance, glandular stomach enlargement, or glandular stomach applanation nipple even disappears, glandular stomach mucosa hemorrhage ulcer, come off, muscular stomach Endothelium corneum and muscular stomach mucosal surface crateriform ulcer, gizzard erosion is the epidemic diseases of principal character.Clinical symptoms, the pathological change of this disease are not quite similar, and cause of disease is had different versions; From 1978 outside Holland is in the news first, all there is this sick generation all over the world; Carry out significant damage to cultivation industrial belt, can not be ignored.
Poultry proventriculitis all can occur throughout the year, but high with sickness rate during seasonal law, and there is this pathogenetic report all parts of the country, and in the northern area of China, performance is more obvious.Morbidity age in days indefinite, just can show in the chickling of 3 ages in days, the kind chickens of 16 weeks also time have report.But morbidity age in days focuses mostly at 10 ~ 60 ages in days.Proventriculitis can betide laying hen and the broiler of different cultivars, multiple with laying chickling, broiler chicks and young chicken, is secondly broiler cockerel and cross-broiler.
Main infection laying hen before proventriculitis, and closely aquatic bird one or two years (duck, goose), rare bird (Columba livia, Carnis Coturnicis japonicae, pheasant, Gallus jabouillei, Ostriches) also all start morbidity, and the order of severity of morbidity is not second to chicken and broiler; Current primary disease at the disease rates of poultry farming chicken house up to more than 90%.
Poultry proventriculitis is commonly called as " thin disease ".Sick chicken to become thin, glandular stomach enlargement, glandular stomach crater nipple be typical characteristic.Its cause of disease is had different versions, and some scholars think reovirus; What have thinks that a kind of proventriculitis type passes a virus.Current without special effect medicine therapeutic, adopt comprehensive therapeutic plan, as interferon adds Traditional Chinese Medicine Anti virus enhancing body resistance, aminoacid has additional nutrients and improves sick chicken body constitution, and antibiotic prevents secondary infection more.Recent many areas have occurred a kind of low with chicken feed intake, undergrowth, become thin, regularity is poor, the outward appearance symptoms such as feces punishment in advance and glandular stomach enlargement as spherical, glandular stomach mucosa ulcer, come off, gizzard erosion is the epidemic diseases of principal character.
The symptom of proventriculitis and gizzard erosion
(1) the initial stage chicken group excitement of falling ill is bolted, and feed intake declines, and looks for chicken manure to eat on the net; (2) and then sick chicken shows as slow-witted vertical, necking down, lassitude, and feed intake only reaches 1/2 ~ 1/3 of normal appetite, and chicken growth retardation or stagnation cause jumpbogroup regularity seriously uneven, and size differences is very large; Average weight only reaches 2/3 ~ 1/2 of standard body weight, does not rise sleepingly; The middle body of serious chicken rack does not just have chicken movable, and what jumpbogroup was all extruded into a pile a pile on the both sides of hen house is heating sample; (3) feather pine disorderly, and hat whisker is pale, atrophy, visual mucosal pallor, and leg skin is dry, touch is sent out cool; (4) jumpbogroup feces jewelry, expensive clothing and other valuables are in strip; Chicken body is become thin, diarrhoea, and indivedual row's brownish red, to black loose stool, occurs blood in excrement sometimes, and (5) sick speed is very fast, start most to only have other dozen listless, the time of three days just can develop into more than 80% of jumpbogroup.Serious symptom person goes into a coma, until exhaustion is dead.
Cause the reason of proventriculitis and gizzard erosion
(1) feed nutrition is bad, copper sulfate is excessive, the biogenic amine of the amino acid imbalance of daily ration, daily ration is (if fish flour, Semen Maydis outsifting, soybean cake, vitamin premix, fat, Fowl meat powder and meat meal tankage etc. are containing high-caliber biogenic amine, such as histamine 3HT, 5HT, dopamine, Lizzerosine and 5-hydroxy tryptamine.Biogenic amine is the product of decarboxylation effect in amino acid catabolic, to the toxic effect of animal.Animal byproduct powder goes bad and can produce a large amount of biogenic amine.Microorganism in histamine poultry feed is carried out decarboxylation to histidine and is produced under suitable temperature and humidity condition.Chicken generation histamine poisoning can cause the bad and glandular stomach enlargement of poor growth, feather growth.), lack dietary fiber, fasting, cutting off the water supply etc. all easily occurs that this is sick;
(2) stocking density is excessive, and chickling broods bad in early days, and chickling haulage time is long, and dehydration etc. is this pathogenetic inducement;
(3) mycotoxin etc.;
(4) fowlpox especially ocular form fowlpox (taking blind as feature) is the major reason of proventriculitis morbidity;
(5) ophthalmia of unknown cause: the ophthalmia caused as infectious bronchitis, infectious laryngotracheitis, various antibacterial, vitamin A deficiency or improper ventilation, all can cause the morbidity of proventriculitis;
(6) some vertical transmissions unknown cause of disease or by the polluted Mareks disease vaccine of special cause of disease, be likely this pathogenetic main pathogen, as chicken reticuloendotheliosis (REV), chicken anemia factor (CAV) etc.;
(7) epithelial adenovirus inclusion body, reovirus infection are one of factors in histamine pathogenesis;
(8) anaerobe, if clostridium is also the secondary infection factor of ulcerative enteritis and hepatitis sequestrans sometimes.
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition preventing and treating poultry proventriculitis, said composition is prepared from by the raw material of Chinese medicine of following weight proportion:
Flower of poplar 10-30, Flos Lonicerae 10-30, Cortex Dictamni 10-20, Radix Pulsatillae 10-20, Endoconcha Sepiae 5-10, Radix Aucklandiae 1-5, Rhizoma Corydalis 5-10, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10, Rhizoma Coptidis 1-5, Cortex Phellodendri 5-10, Radix Et Rhizoma Rhei 5-10, Radix Notoginseng 1-10, Fructus Amomi 1-10, Pericarpium Citri Reticulatae 1-10, Rhizoma Zingiberis 1-10.
Preferably, said composition is prepared from by the raw material of Chinese medicine of following weight proportion:
Flower of poplar 15-25, Flos Lonicerae 15-25, Cortex Dictamni 10-15, Radix Pulsatillae 12-17, Endoconcha Sepiae 5-8, Radix Aucklandiae 1-3, Rhizoma Corydalis 5-8, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-8, Rhizoma Coptidis 3-5, Cortex Phellodendri 5-7, Radix Et Rhizoma Rhei 5-7, Radix Notoginseng 1-5, Fructus Amomi 1-5, Pericarpium Citri Reticulatae 1-5, Rhizoma Zingiberis 1-5.
Most preferably, said composition is prepared from by the raw material of Chinese medicine of following weight proportion: flower of poplar 20, Flos Lonicerae 20, Cortex Dictamni 10, the Radix Pulsatillae 15, Endoconcha Sepiae 5, the Radix Aucklandiae 1, Rhizoma Corydalis 5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5, Rhizoma Coptidis 5, Cortex Phellodendri 5, Radix Et Rhizoma Rhei 5, Radix Notoginseng 1, Fructus Amomi 1, Pericarpium Citri Reticulatae 1, Rhizoma Zingiberis 1.
Chinese medicine composition of the present invention can make various types of pharmaceutical preparation according to actual needs, such as, make powder preparation, granular preparation, oral liquid or injection preparation, preferably but be not limited to powder preparation, granular preparation, oral liquid.In order to prepare these preparations, conventional pharmaceutically acceptable auxiliaries can be added as required in the present compositions, for the selection of adjuvant, those skilled in the art can carry out according to the requirement of dosage form, such as, when preparing oral liquid formulations, sweeting agent, flavoring agent and antiseptic can be added in the compositions of the present invention.For the concrete selection of adjuvant, the present invention's specific restriction useless.
Another object of the present invention is to provide a kind of preparation method of preventing and treating the Chinese medicine composition of poultry proventriculitis, and the method comprises the following steps:
Step one: above flower of poplar, Flos Lonicerae, Cortex Dictamni, the Radix Pulsatillae, Endoconcha Sepiae, the Radix Aucklandiae, Rhizoma Corydalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Notoginseng, Fructus Amomi, Pericarpium Citri Reticulatae, the dry medicine raw material of Rhizoma Zingiberis 15 taste Chinese medicine are cleaned, cleans, dry, weigh by weight, powder becomes coarse powder, adds in extraction pot;
Step 2: add above 15 taste raw material of Chinese medicine quality 6-8 pure water doubly, open vacuum automatic converter, be decompressed to negative pressure 0.5-1MP, and be heated to boil, keep slight boiling condition, carry out economic benefits and social benefits concentrating return-flow, dynamic extraction 2-4 hour;
Step 3: collect extracting solution, extracting solution is evaporated to relative density 1.5-1.6;
Step 4: close heater, return to atmospheric pressure gradually;
Step 5: carry out spraying dry, first by drying tower at 160 DEG C of preheating temperature 10-20 minute, inlet temperature is set as 150-200 DEG C, leaving air temp setting 50-100 DEG C, pan feeding flow 1.2L/ divides;
Step 6: after all having sprayed, continues to keep air intake after 5 minutes, opens discharge bucket discharging, obtain dry powder, for subsequent use;
Step 7: laboratorian step 6 is obtained dry powder extract specimen detect, detect up to standard after, can enter workshop pack, sealing, packaging, sterilizing, must prevent and treat the powder preparation of the Chinese medicine composition of poultry proventriculitis;
Step 8: step 6 is obtained dry powder and extracts specimen and detect by laboratorian, detect up to standard after, can enter workshop pack by the conventional pelletize of pharmacy, sealing, packaging, sterilizing, must prevent and treat the granular preparation of the Chinese medicine composition of poultry proventriculitis;
Step 9: described step 6 is obtained dry powder pure water and dilute 100 times, then add orange juice, white sugar, brown sugar, and adjust total amount embedding, sterilizing, packaging, the oral liquid of the Chinese medicine composition of poultry proventriculitis must be prevented and treated.
Above-mentioned raw material and equipment are all commercially available.
It should be noted that, method of the present invention is a kind of preferred preparation technology but is not limited to this.The product prepared by the inventive method has good stability.
For many years, adopt Chinese medicine composition of the present invention be feature to broiler proventriculitis, enteritis the routine Be very effective of gastroenteropathy incomplete statistics more than 70,000, cure rate more than 95%.
In the prescription of the Chinese medicine composition of control poultry proventriculitis of the present invention: record according to Chinese medicine voluminous dictionary:
Flower of poplar: leaf is containing Quercetin (quercetin), Quercetin 3-β-D-Glucose glycoside (quercetin-3-β-D-glucoside), myricetin 3-β-D-galactoside (myricetin-3-β-D-galacloside), luteolin-7-β-D-Glucose glycoside (luteolin-7-β-D-glucoside).But poplar flower extract directly can kill pathogen, improve the resistance of body, antagonism immunosuppressant, regulates the immunologic function of body, effectively alleviates the various stress between poultry period of disease.Clinical have significant curative effect with flower of poplar or its preparation to bacillary dysentery, intestinal tract disease.Be mainly used in: 1. prevent and treat family's avian escherichia coli, Salmonella, the poultry digestive tract infection that various bacteria, the viruses such as duck pasteurellosis bacillus, Bacillus proteus, staphylococcus cause.Clinical be applicable to poultry down in spirits caused by above-mentioned cause of disease, feather pine disorderly, two wings sagging, coldness of the body and aversion to cold, Da Dui; Cut open inspection pathological changes: pericarditis, perihepatitis, fibroid airsacculitis, peritonitis, arthritis, the symptoms such as various intestinal bleeding or weight loss.2. eliminate rapidly the intractable dysentery that the not clear cause of disease causes poultry, the intestinal tract disease that diagnosis is unclear can be treated.As intractable diarrhea, feces is thin in starchiness even water sample, in yellow green or yellow-white, is sometimes mixed with a small amount of blood; Yellow scour of piglet, Hakuri, transmissible gastroenteritis, in the large disease such as pig water sample loose stool, perianal tomentum fecal pollution; 3. alleviate the various stress during the various disease incidence of poultry, supplement aminoacid.Laying rate and the feed conversion rate of chicken can be significantly improved, reduce the generation of diarrhoeal diseases.Also can improve the anti-heat stress ability of chicken summer.4. can be used as the auxiliary therapeutic agent of viral disease and coccidiosis.
Flos Lonicerae: its effect mainly heat-clearing and toxic substances removing, cures mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle furunculosis etc.Modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, stronger restraint is had to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary etc. more than 40 with other medicines compatibility and plant disease.
Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.
Cortex Dictamni: nature and flavor hardship is salty, cold.Heat clearing and damp drying Chinese medicine, cures mainly the rubella caused by wind heat noxious dampness, eczema, scabies, jaundice, damp-heat arthralgia.Modern medicine study and clinical practice prove, Cortex Dictamni contains dictamine, shaggy-fruited dittany lactone, sitosterol, choline, Ash skin ketone etc.Inhibitory action in various degree is all had to multiple pathomycete.Cortex Dictamni also has refrigeration function.
The Radix Pulsatillae: root is containing anemoside, Anemonin, protoanemonin etc.Radix Pulsatillae decoct is better to the effect killing Entamoeba histolytica.Cao Jinghua etc. record Radix Pulsatillae Aqueous extracts with K-B disk diffusion method and have obvious inhibitory action to staphylococcus aureus, bacillus pyocyaneus, anthrax bacillus, Bacillus typhi, alpha streptococcus, group B streptococcus.
Endoconcha Sepiae: salty in the mouth, puckery, slightly warm in nature, nontoxic, return liver, kidney channel.There is the effects such as warm puckery convergence, relieving gastric hyperacidity to alleviate stomachache, hemostasis, effectively control poultry glandular stomach, the secretion of muscular stomach Inflammatory substances, hemostasis and pain-relieving.
The Radix Aucklandiae: effect: circulation of qi promoting, pain relieving, spleen invigorating, helps digestion.Cure mainly: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia
Rhizoma Coptidis: property bitter cold, attacks effect heat-clearing and toxic substances removing, heat-clearing and toxic substances removing, clearing away heat-fire, clearing away heat to cure dysentery.
Cortex Phellodendri: bitter in the mouth, cold, returns kidney, bladder, large intestine channel.The sedimentation of this product bitter cold, heat clearing and damp drying, is longer than and rushes down damp-heat in lower-JIAO clearly, eliminating fire and detoxication, brings down a fever except steaming, and is longer than fire clearly mutually, reducing the asthenic fever.
Radix Et Rhizoma Rhei: bitter in the mouth, cold.Return spleen, stomach, large intestine, liver, pericardium channel.This product has relieving constipation by purgation, cleanses gastrointestinal retention, bitter cold fall let out, the effect such as clearing away heat to stop bleeding, blood circulation promoting and blood stasis dispelling.
Radix Notoginseng: containing Saponin and alcohol constituents, mainly effect of the hemostasis of energy dissipating blood stasis, subduing swelling and relieving pain, blood circulation promoting, unimpeded blood vessels;
The Pseudobulbus Bletillae (Rhizoma Bletillae): strengthen the merit that restores menstrual flow and invigorates blood circulation, holds concurrently with astringing to arrest bleeding again, the effect of detumescence and promoting granulation, is formed logical and does not let out, and receives and not puckery, is conducive to promoting focus healing.Effect that Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae) have invigorating blood circulation, stop blooding, it is attached to rotten to the corn face and ulcer surface place, can Promotive union, has the effect of relieving spasm to stop pain;
Rhizoma Corydalis: can invigorate blood circulation, regulate the flow of vital energy, pain relieving, can alleviate gastrointestinal convulsion, can increase again the power air emptying function of stomach;
Fructus Amomi: return stomach through spleen, kidney channel, removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive; , Deficiency and coldness of spleen and stomach not hungry for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass, vomiting are had loose bowels, pregnant malignant histocytosis, frequent fetal movement.
Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Function: promoting the circulation of QI spleen invigorating, drying dampness to eliminate phlegm.
Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.Cure mainly: for coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, cold fluid-retention is breathed with cough.
The invention has the beneficial effects as follows: the present invention containing any chemical medicine and antibiotic composition, does not have the effects such as heat-clearing and toxic substances removing, relieving diarrhea with astringents, removing dampness dysentery relieving, strengthening the spleen and nourishing the stomach; Rotten to the corn face and ulcer surface place can be attached to, can Promotive union, there is the effect of relieving spasm to stop pain; Can gastrointestinal convulsion be alleviated, the air emptying function of gastrointestinal can be increased again; Can also antiphlogistic and bactericidal, eliminate rapidly the intractable dysentery that the not clear cause of disease causes poultry, alleviate the various stress during the various disease incidence of poultry, conditioner body immunity function, improves intestinal environment, removes evil poison, fundamentally solves an intestinal difficult problem; Can use by substitute antibiotics, but do not produce antibiotic side effect.The present invention has specially good effect to proventriculitis, gizzard erosion, all kinds of enteritis, and the present invention is pure Chinese medicine high-efficient compound preparation, and instant effect, no drug residue, does not produce drug resistance, is applicable to all kinds of scale livestock farming.
For this reason, another object of the present invention is to provide the application of a kind of present composition in control poultry proventriculitis medicine.
Detailed description of the invention
The present invention is further illustrated below in conjunction with embodiment, but not as a limitation of the invention.
Embodiment 1
Powder (ProductName: poultry glandular stomach health powder)
Raw material of Chinese medicine and consumption:
Flower of poplar 20kg, Flos Lonicerae 20kg, Cortex Dictamni 10kg, Radix Pulsatillae 15kg, Endoconcha Sepiae 5kg, Radix Aucklandiae 1kg, Rhizoma Corydalis 5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 5kg, Rhizoma Coptidis 5kg, Cortex Phellodendri 5kg, Radix Et Rhizoma Rhei 5kg, Radix Notoginseng 1kg, Fructus Amomi 1kg, Pericarpium Citri Reticulatae 1kg, Rhizoma Zingiberis 1kg;
Preparation method concrete steps are as follows:
Step one: above flower of poplar, Flos Lonicerae, Cortex Dictamni, the Radix Pulsatillae, Endoconcha Sepiae, the Radix Aucklandiae, Rhizoma Corydalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Notoginseng, Fructus Amomi, Pericarpium Citri Reticulatae, the dry medicine raw material of Rhizoma Zingiberis 15 taste Chinese medicine are cleaned, cleans, dry, weigh by weight: flower of poplar 20kg, Flos Lonicerae 20kg, Cortex Dictamni 10kg, Radix Pulsatillae 15kg, Endoconcha Sepiae 5kg, Radix Aucklandiae 1kg, Rhizoma Corydalis 5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 5kg, Rhizoma Coptidis 5kg, Cortex Phellodendri 5kg, Radix Et Rhizoma Rhei 5kg, Radix Notoginseng 1kg, Fructus Amomi 1kg, Pericarpium Citri Reticulatae 1kg, Rhizoma Zingiberis 1kg, powder becomes coarse powder, adds in extraction pot;
Step 2: add above 15 taste raw material of Chinese medicine quality 6-8 pure water doubly, open vacuum automatic converter, be decompressed to negative pressure 0.5-1MP, and be heated to boil, keep slight boiling condition, carry out economic benefits and social benefits concentrating return-flow, dynamic extraction 2-4 hour;
Step 3: collect extracting solution, extracting solution is evaporated to relative density 1.5-1.6;
Step 4: close heater, return to atmospheric pressure gradually;
Step 5: carry out spraying dry, first by drying tower at 160 DEG C of preheating temperature 10-20 minute, inlet temperature is set as 150-200 DEG C, leaving air temp setting 50-100 DEG C, pan feeding flow 1.2L/ divides;
Step 6: after all having sprayed, continues to keep air intake after 5 minutes, opens discharge bucket discharging, obtain dry powder, for subsequent use;
Step 7: laboratorian step 6 is obtained dry powder extract specimen detect, detect up to standard after, can enter workshop pack, sealing, packaging, sterilizing, must prevent and treat the Chinese medicine composition powder preparation of poultry proventriculitis;
Using method: add this poultry glandular stomach health powder 100-200 gram in poultry water per ton, freely drink, be used in conjunction 3-5 days, serious symptom doubles.
Embodiment 2
Granule (ProductName: poultry glandular stomach Kang Granules)
Raw material of Chinese medicine and consumption:
Flower of poplar 30kg, Flos Lonicerae 10kg, Cortex Dictamni 10kg, Radix Pulsatillae 10kg, Endoconcha Sepiae 5kg, Radix Aucklandiae 1kg, Rhizoma Corydalis 5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 5kg, Rhizoma Coptidis 1kg, Cortex Phellodendri 5kg, Radix Et Rhizoma Rhei 5kg, Radix Notoginseng 1kg, Fructus Amomi 1kg, Pericarpium Citri Reticulatae 1kg, Rhizoma Zingiberis 1kg;
Preparation method concrete steps are as follows:
Step one: above flower of poplar, Flos Lonicerae, Cortex Dictamni, the Radix Pulsatillae, Endoconcha Sepiae, the Radix Aucklandiae, Rhizoma Corydalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Notoginseng, Fructus Amomi, Pericarpium Citri Reticulatae, the dry medicine raw material of Rhizoma Zingiberis 15 taste Chinese medicine are cleaned, cleans, dry, weigh by weight: flower of poplar 30kg, Flos Lonicerae 10kg, Cortex Dictamni 10kg, Radix Pulsatillae 10kg, Endoconcha Sepiae 5kg, Radix Aucklandiae 1kg, Rhizoma Corydalis 5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 5kg, Rhizoma Coptidis 1kg, Cortex Phellodendri 5kg, Radix Et Rhizoma Rhei 5kg, Radix Notoginseng 1kg, Fructus Amomi 1kg, Pericarpium Citri Reticulatae 1kg, Rhizoma Zingiberis 1kg, powder becomes coarse powder, adds in extraction pot;
Step 2: add above 15 taste raw material of Chinese medicine quality 6-8 pure water doubly, open vacuum automatic converter, be decompressed to negative pressure 0.5-1MP, and be heated to boil, keep slight boiling condition, carry out economic benefits and social benefits concentrating return-flow, dynamic extraction 2-4 hour;
Step 3: collect extracting solution, extracting solution is evaporated to relative density 1.5-1.6;
Step 4: close heater, return to atmospheric pressure gradually;
Step 5: carry out spraying dry, first by drying tower at 160 DEG C of preheating temperature 10-20 minute, inlet temperature is set as 150-200 DEG C, leaving air temp setting 50-100 DEG C, pan feeding flow 1.2L/ divides;
Step 6: after all having sprayed, continues to keep air intake after 5 minutes, opens discharge bucket discharging, obtain dry powder, for subsequent use;
Step 7: step 6 is obtained dry powder and extracts specimen and detect by laboratorian, detect up to standard after, can enter workshop pack by the conventional pelletize of pharmacy, sealing, packaging, sterilizing, must prevent and treat the granular preparation of the Chinese medicine composition of poultry proventriculitis;
Using method: after above-mentioned obtained poultry glandular stomach Kang Granules 200 grams is added 1000 kilograms of chicken feedstuff mix homogeneously, directly to chicken feeding, be used in conjunction 3-5 days.
Embodiment 3
Oral fluid agent (ProductName: poultry glandular stomach recovery oral liquid)
Raw material of Chinese medicine and consumption:
Flower of poplar 10, Flos Lonicerae 30, Cortex Dictamni 20, the Radix Pulsatillae 20, Endoconcha Sepiae 10, the Radix Aucklandiae 5, Rhizoma Corydalis 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Rhizoma Coptidis 5, Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10, Radix Notoginseng 10, Fructus Amomi 10, Pericarpium Citri Reticulatae 10, Rhizoma Zingiberis 10;
Preparation method concrete steps are as follows:
Step one: above flower of poplar, Flos Lonicerae, Cortex Dictamni, the Radix Pulsatillae, Endoconcha Sepiae, the Radix Aucklandiae, Rhizoma Corydalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Notoginseng, Fructus Amomi, Pericarpium Citri Reticulatae, the dry medicine raw material of Rhizoma Zingiberis 15 taste Chinese medicine are cleaned, cleans, dry, weigh by weight: flower of poplar 10, Flos Lonicerae 30, Cortex Dictamni 20, the Radix Pulsatillae 20, Endoconcha Sepiae 10, the Radix Aucklandiae 5, Rhizoma Corydalis 10, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Rhizoma Coptidis 5, Cortex Phellodendri 10, Radix Et Rhizoma Rhei 10, Radix Notoginseng 10, Fructus Amomi 10, Pericarpium Citri Reticulatae 10, Rhizoma Zingiberis 10, powder becomes coarse powder, adds in extraction pot;
Step 2: add above 15 taste raw material of Chinese medicine quality 6-8 pure water doubly, open vacuum automatic converter, be decompressed to negative pressure 0.5-1MP, and be heated to boil, keep slight boiling condition, carry out economic benefits and social benefits concentrating return-flow, dynamic extraction 2-4 hour;
Step 3: collect extracting solution, extracting solution is evaporated to relative density 1.5-1.6;
Step 4: close heater, return to atmospheric pressure gradually;
Step 5: carry out spraying dry, first by drying tower at 160 DEG C of preheating temperature 10-20 minute, inlet temperature is set as 150-200 DEG C, leaving air temp setting 50-100 DEG C, pan feeding flow 1.2L/ divides;
Step 6: after all having sprayed, continues to keep air intake after 5 minutes, opens discharge bucket discharging, obtain dry powder, for subsequent use;
Step 7: described step 6 is obtained dry powder pure water and dilute 100 times, then add orange juice, white sugar, brown sugar, and adjust total amount embedding, sterilizing, packaging, the oral liquid of the Chinese medicine composition of poultry proventriculitis must be prevented and treated.
Using method: by above-mentioned obtained poultry glandular stomach recovery oral liquid, by every direct administration of chicken 1ml.Be used in conjunction 3-5 days.
Embodiment 4
Start at the beginning of autumn late summer in 2013, proventriculitis is popular in Shandong, causes egg drop reduction, causes heavy loss to local poultry husbandry.
This popular main feature is: propagate fast, extensively popular, easily recur.Course of disease 6-7 days, sickness rate 100%, peak mortality is 2-4 days after morbidity, mortality rate 1-6%, and high reaches more than 20%, laying rate decline 10-60%, the stopping production completely had, and the chicken of 5-10% produces abnormal-shape egg and soft-shelled egg, and most of eggshell color is thin out.Sick chicken spirit is depressed, and few food or refusing to eat, close one's eyes, hat and wattle blackout, head swelling, and shin is dry, general red, draws Huang, green, white loose stool, dyspnea, and mouth, nose stream volume mucus, shake the head, and some Caput Gallus domesticuss backward or side torsion.Hemorrhage concentrate on glandular stomach, muscular stomach horny layer under and duodenum, pericardial effusion, subcutaneous popularity is congested.Ovary and tubal hemorrhage or hyperemia, tube wall swelling, yolk breaks, and volume pale red yolk liquid is gathered in abdominal cavity.About have the chicken of 1-10% not lay eggs throughout one's life after being ill, have up to 20%.Chicken group secondary ehec infection or Salmonella mushroom disease after primary disease outburst of 80-90%.
Because the cause of disease is complicated, there is no effective vaccine prevention at present, commercially available various antimicrobial drug is not obvious to primary disease curative effect in addition.We just adopt the glandular stomach recovering particles preparation made by example 3 to carry out small size controlling experiment, and effect is rather good, is now reported as follows:
One, materials and methods
1, test period: from December in 2013 15 days to 2013 on Decembers 21, totally 7 days.
2, test site: select the popular more serious Jia Zhuan village of He Dian township, Shenxian County of primary disease to do test site.
3, test chicken is selected and grouping: test arrangement is being in three raisers in different onset stage.834, first family, is divided into test group 113 at random, matched group 721; 457, second family, is divided into test group 228 at random, matched group 229; Third 1286, family, is divided into test group 319 at random, matched group 967.Three families are Luo Man commodity laying hen in 28 week age for test chicken.First family chicken group is morbidity the 2nd age in days, and second family chicken group not yet falls ill (or not yet showing condition of illness), and the third family chicken group is the 16th age in days after morbidity.
4, feeding and management: carry out feeding and management by the normal feeding and management way in each family.Each test group its corresponding matched group management method is just the same.
5, test method: the ciprofloxacin of each matched group use in conjunction 100ppm and 60ppm enrofloxacin spice; The glandular stomach health spice of test first group 200ppm, test second, third group of glandular stomach health spice with 100ppm, if dosage changes 200ppm into during morbidity.Observe every day and record spirit, diet, feces, egg number, the situation such as morbidity number and death toll of each group of chicken.
Two, results and analysis
Result of the test unit: %
In this test, second family chicken group test the 2nd day two groups all start morbidity, the matched group of the third family chicken group is at the 4th day the 20th age in days recurrence primary disease after onset of test.
Result as can be seen from table, during on-test, each test group and matched group laying rate are on close level (P > 0.05).In the in-test, each test group is obviously better than corresponding matched group in all indexs.Each test group compares with corresponding matched group, and on sickness rate, first, second two family is identical, the third performance pole, family significant difference (P < 0.01); On mortality rate, first, the third liang family significant difference (P < 0.05), second family difference is extremely significantly (P < 0.01); On laying rate declines, three family differences all have extremely significantly meaning (P < 0.01); In deformity (soft shell) egg rate, not significantly (P > 0.05), there is significant difference (P < 0.05) at the third family to first, second two family difference.
Three, brief summary
By the result of this controlling experiment, in conjunction with the epidemic characteristic of primary disease in locality, these points conclusion can be drawn:
1, before, during and after illness outbreak, three phases application glandular stomach health adds control, all greatly can reduce the mortality rate of chicken and the amplitude of egg drop reduction.
Although 2, the resistance to chicken group excessively of first attack obtains certain immunity to this condition of disease, break with tremendous force because this is popular, many chicken groups often still can recur primary disease in 20-30 days after onset to some extent.If add poultry glandular stomach health of the present invention after onset in time effectively can prevent this palindromia.
3, apply poultry glandular stomach health of the present invention control and be obviously better than the antibacterial such as xacin-series.
4, plant chicken and be in a good state of nutrition, the chicken group of body constitution stalwartness has good immunocompetence to primary disease, although infect, various disease is light and slow, loses very little.
5, primary disease Prevalent district, add prevention by glandular stomach health, effect is ideal.
Above example of the present invention has been described in detail, but described content being only preferred embodiments of the present invention, can not being considered to for limiting practical range of the present invention.All equalizations done according to the present patent application scope change and improve, and all should belong within patent covering scope of the present invention.
Claims (8)
1. prevent and treat a Chinese medicine composition for poultry proventriculitis, it is characterized in that: said composition is prepared from by the raw material of Chinese medicine of following weight proportion:
Flower of poplar 10-30, Flos Lonicerae 10-30, Cortex Dictamni 10-20, Radix Pulsatillae 10-20, Endoconcha Sepiae 5-10, Radix Aucklandiae 1-5, Rhizoma Corydalis 5-10, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10, Rhizoma Coptidis 1-5, Cortex Phellodendri 5-10, Radix Et Rhizoma Rhei 5-10, Radix Notoginseng 1-10, Fructus Amomi 1-10, Pericarpium Citri Reticulatae 1-10, Rhizoma Zingiberis 1-10.
2. a kind of Chinese medicine composition preventing and treating poultry proventriculitis according to claim 1, is characterized in that: said composition is prepared from by the raw material of Chinese medicine of following weight proportion:
Flower of poplar 15-25, Flos Lonicerae 15-25, Cortex Dictamni 10-15, Radix Pulsatillae 12-17, Endoconcha Sepiae 5-8, Radix Aucklandiae 1-3, Rhizoma Corydalis 5-8, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-8, Rhizoma Coptidis 3-5, Cortex Phellodendri 5-7, Radix Et Rhizoma Rhei 5-7, Radix Notoginseng 1-5, Fructus Amomi 1-5, Pericarpium Citri Reticulatae 1-5, Rhizoma Zingiberis 1-5.
3. a kind of Chinese medicine composition preventing and treating poultry proventriculitis according to claim 1, is characterized in that: said composition is prepared from by the raw material of Chinese medicine of following weight proportion:
Flower of poplar 20, Flos Lonicerae 20, Cortex Dictamni 10, the Radix Pulsatillae 15, Endoconcha Sepiae 5, the Radix Aucklandiae 1, Rhizoma Corydalis 5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5, Rhizoma Coptidis 5, Cortex Phellodendri 5, Radix Et Rhizoma Rhei 5, Radix Notoginseng 1, Fructus Amomi 1, Pericarpium Citri Reticulatae 1, Rhizoma Zingiberis 1.
4. the Chinese medicine composition of any one group of control poultry proventriculitis according to claim 1-3, is characterized in that: described compositions is powder preparation.
5. the Chinese medicine composition of any one group of control poultry proventriculitis according to claim 1-3, is characterized in that: described compositions is granular preparation.
6. the Chinese medicine composition of any one group of control poultry proventriculitis according to claim 1-3, is characterized in that: described compositions is oral liquid.
7., according to the preparation method of the Chinese medicine composition of claim 1-3 described in one of them, it is characterized in that: the method comprises the following steps:
Step one: above flower of poplar, Flos Lonicerae, Cortex Dictamni, the Radix Pulsatillae, Endoconcha Sepiae, the Radix Aucklandiae, Rhizoma Corydalis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Notoginseng, Fructus Amomi, Pericarpium Citri Reticulatae, the dry medicine raw material of Rhizoma Zingiberis 15 taste Chinese medicine are cleaned, cleans, dry, weigh by weight, powder becomes coarse powder, adds in extraction pot;
Step 2: add above 15 taste raw material of Chinese medicine weight 6-8 pure water doubly, open vacuum automatic converter, be decompressed to negative pressure 0.5-1MP, and be heated to boil, keep slight boiling condition, carry out economic benefits and social benefits concentrating return-flow, dynamic extraction 2-4 hour;
Step 3: collect extracting solution, extracting solution is evaporated to relative density 1.5-1.6;
Step 4: close heater, return to atmospheric pressure gradually;
Step 5: carry out spraying dry, first by drying tower at 160 DEG C of preheating temperature 10-20 minute, inlet temperature is set as 150-200 DEG C, leaving air temp setting 50-100 DEG C, pan feeding flow 1.2L/ divides;
Step 6: after all having sprayed, continues to keep air intake after 5 minutes, opens discharge bucket discharging, obtain dry powder, for subsequent use;
Step 7: laboratorian step 6 is obtained dry powder extract specimen detect, detect up to standard after, can enter workshop pack, sealing, packaging, sterilizing, must prevent and treat the Chinese medicine composition powder preparation of poultry proventriculitis;
Step 8: step 6 is obtained dry powder and extracts specimen and detect by laboratorian, detect up to standard after, can enter workshop pack by the conventional pelletize of pharmacy, sealing, packaging, sterilizing, must prevent and treat the traditional Chinese medicine particle preparation of poultry proventriculitis;
Step 9: described step 6 is obtained dry powder pure water and dilute 100 times, then add orange juice, white sugar, brown sugar, and adjust total amount embedding, sterilizing, packaging, namely obtain the Chinese medicine composition oral liquid formulations of control poultry proventriculitis.
8. the Chinese medicine composition of any one group of control poultry proventriculitis according to claim 1-3, is characterized in that: the application of this Chinese medicine composition in control poultry proventriculitis medicine.
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| CN106038722A (en) * | 2016-08-11 | 2016-10-26 | 王华伟 | Traditional Chinese medicine for treating chicken proventriculitis |
| CN107156518A (en) * | 2017-06-06 | 2017-09-15 | 辽东学院 | One kind improves meat chicken production performance Chinese herb feed additive |
| CN107753568A (en) * | 2016-08-22 | 2018-03-06 | 北京大伟嘉生物技术股份有限公司 | A kind of Chinese medicine composition for being used to prevent and treat poultry proventriculitis, ventriculitis |
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