CN101987840B - 一种5-羟基-4-甲基-2-5[h]-呋喃酮的分离方法 - Google Patents
一种5-羟基-4-甲基-2-5[h]-呋喃酮的分离方法 Download PDFInfo
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- CN101987840B CN101987840B CN2009100891664A CN200910089166A CN101987840B CN 101987840 B CN101987840 B CN 101987840B CN 2009100891664 A CN2009100891664 A CN 2009100891664A CN 200910089166 A CN200910089166 A CN 200910089166A CN 101987840 B CN101987840 B CN 101987840B
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- Prior art keywords
- ether
- sodium
- hydroxy
- methyl
- furanone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
实施例 | 无机盐 | 提取溶剂 | 结晶溶剂 | 收率(%) | 纯度(%) |
2 | 硫酸镁22g | 异丙醚 | 异丙醚 | 82.5 | 97.3 |
3 | 氯化钠8g+磷酸钠6g | 乙酸乙酯 | 丙酮 | 79.7 | 98.2 |
4 | 硝酸铵17g | 乙酸乙酯 | 丙酮/正己烷 | 84.6 | 96.5 |
5 | 氯化钾25g | 乙酸乙酯 | 异丙醚/正己烷 | 85.5 | 95.6 |
Claims (8)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100891664A CN101987840B (zh) | 2009-08-05 | 2009-08-05 | 一种5-羟基-4-甲基-2-5[h]-呋喃酮的分离方法 |
PCT/CN2010/075274 WO2011015101A1 (zh) | 2009-08-05 | 2010-07-20 | 一种5-羟基-4-甲基-2-5[h]-呋喃酮的分离方法 |
Applications Claiming Priority (1)
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CN2009100891664A CN101987840B (zh) | 2009-08-05 | 2009-08-05 | 一种5-羟基-4-甲基-2-5[h]-呋喃酮的分离方法 |
Publications (2)
Publication Number | Publication Date |
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CN101987840A CN101987840A (zh) | 2011-03-23 |
CN101987840B true CN101987840B (zh) | 2012-07-25 |
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CN2009100891664A Active CN101987840B (zh) | 2009-08-05 | 2009-08-05 | 一种5-羟基-4-甲基-2-5[h]-呋喃酮的分离方法 |
Country Status (2)
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CN (1) | CN101987840B (zh) |
WO (1) | WO2011015101A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102775338B (zh) | 2011-05-13 | 2016-09-21 | 重庆华邦胜凯制药有限公司 | 全反式维甲酸合成方法 |
CN105330628B (zh) * | 2015-12-09 | 2021-10-26 | 苏州大学 | 一种利用酮酸与炔制备4-羟基丁烯内酯的方法 |
CN110563676A (zh) * | 2019-08-15 | 2019-12-13 | 安徽金禾实业股份有限公司 | 2,5-二甲基-4-羟基-3(2h)-呋喃酮的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5654444A (en) * | 1995-03-27 | 1997-08-05 | Basf Aktiengesellschaft | Preparation of 5-hydroxy-4-methyl-2(5H)-furanone |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10298173A (ja) * | 1997-04-30 | 1998-11-10 | Kuraray Co Ltd | 4−ヒドロキシ−2−ブテノリド類の製造方法 |
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2009
- 2009-08-05 CN CN2009100891664A patent/CN101987840B/zh active Active
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2010
- 2010-07-20 WO PCT/CN2010/075274 patent/WO2011015101A1/zh active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5654444A (en) * | 1995-03-27 | 1997-08-05 | Basf Aktiengesellschaft | Preparation of 5-hydroxy-4-methyl-2(5H)-furanone |
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Publication number | Publication date |
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CN101987840A (zh) | 2011-03-23 |
WO2011015101A1 (zh) | 2011-02-10 |
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Owner name: CHONGQING HUAPONT PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HUABANG PHARMACEUTICAL CO., LTD., CHONGQING Effective date: 20130217 |
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Effective date of registration: 20130217 Address after: 401121 Chongqing, Yubei District and the number of stars Avenue, No. 69 Patentee after: Chongqing Huapont Pharm. Co., Ltd. Address before: 401121 Chongqing, Yubei District and the number of stars Avenue, No. 69 Patentee before: Huabang Pharmaceutical Co., Ltd., Chongqing |